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The map label for this gene is mutA [H]

Identifier: 29347501

GI number: 29347501

Start: 2620284

End: 2622185

Strand: Reverse

Name: mutA [H]

Synonym: BT_2091

Alternate gene names: 29347501

Gene position: 2622185-2620284 (Counterclockwise)

Preceding gene: 29347503

Following gene: 29347500

Centisome position: 41.89

GC content: 46.48

Gene sequence:

>1902_bases
ATGGCAGACAAAAAAGAAAAACTCTTCTCAGACTTTTCTCCTGTCTCCACCGAACAATGGATGGAGAAGGTTACAGCCGA
CTTGAAAGGTGCTGATTTTGAGAAGAAGCTCGTTTGGAAGACAAACGAAGGGTTCAAAGTGAAACCTTTCTACCGGATGG
AAGATCTGGAGGGTTTGAAAACAACAGATGCACTTCCCGGAGAATTTCCCTATCTGAGAGGCACCAAGAAGAGCAATAAT
GAGTGGCTGGTTCGCCAGGAAATCAAAGTTGAATGTCCGAAGGAAGCCAATGCCAAAGCACTGGATATTCTGAACAAAGG
TGTGGATTCACTTTCTTTCCACGTAAAAGCGAAAGAACTCAATGCGGAATACATTGAAACACTGTTGAATGGTATTCAGG
CTGAGTGTGTAGAACTGAACTTCTCTACTTGTCAGGGACATGTGGTTGAATTGGCTGGTCTGCTGGTGGCTTATTTCCAG
AAGAAGGATTATGACGTGAAGAAACTGAGAGGTTCTGTCAATTATGACTTCTTTAACAAGATGCTGACTCGCGGTAAAGA
AAAAGGCGATATGGTTCAAACTGCCAAAGCCCTGATCGAAGCTATCCAACCGCTTCCTTTCTATCGTGTACTGAATGTAA
ATGCAATCTCGCTGAACAATGCCGGAGCTTACATTTCTCAGGAATTGGGCTATGCATTGGCATGGGGTAATGAATACATG
AACCAGCTGACAGACGCAGGTATCCCTGCTGCTACAGTTGCCAAGAAAATTAAGTTCAACTTCGGTATCAGTTCCAACTA
CTTCCTTGAAATCGCTAAATTCCGTGCAGCACGTATGCTGTGGGCAAACATCGTAGCTTCCTACCATCCTGAATGCCTGC
GTGATTGCGACAATAAGGGGGCTAATGGAGAATGTCGTTGTGCTGCGAAGATGGCGGTTCATGCCGAAACTTCCACTTTC
AATCTTACTTTGTTTGATGCTCATGTGAACTTGCTTCGTACACAGACTGAAGCGATGAGTGCTGCATTGGCCGGTGTGGA
TTCAATGACAGTCGTTCCGTTCGATAAGACTTATTCGACTCCGGATGAATTCTCTGAACGCCTTGCACGTAACCAGCAGT
TGTTACTGAAAGAAGAATCTCATTTTGATAAGGTGATTGACCCGGCTGCCGGTTCTTATTATATCGAGAATCTGACAGTG
TCTATCGCTAAACAGGCGTGGGAACTCTTCCTTGCCGTAGAAGAGGCAGGCGGTTTCTATGCTGCATTGAAAGCCGGTAC
AGTTCAGGCAGCAGTGAACGAAAGCAACAAGGCCCGTCATAAAGCAGTTGCTCAACGTCGTGAAGTGCTGCTGGGTACCA
ACCAGTTCCCGAACTTCAATGAAAAAGCAGGTGAGAAACAGCCGATAGAAGCAAAATGCTGCTGCGGAGGTGATGCTCAT
ACTTGCGAGAAAGATGTGGATACTTTGGTATTCGACCGTGCAGCCAGCGAATTTGAGGCATTACGCCTTGAAACGGAGGC
TTCCGGCAAACGTCCGAAAGCGTTCATGCTGACTATCGGTAATCTGGCTATGCGTCAGGCACGTGCGCAATACTCTTGCA
ACTTCCTCGCTTGTGCCGGATATGAAGTTATTGACAATCTCGGATTCGAAACGGTGGAAGCCGGAGTAGAAGCTGCTATG
GCTGCTAAAGCTGACATTGTAGTTCTCTGTTCAAGCGATGACGAATATGCGGAATATGCGGTGCCGGCTTTCAAAGCATT
GGACGGCCGTGCTATGTTTATCGTAGCAGGTGCTCCCGCCTGTATGGATGAACTGAAGGCAGCAGGTATCGAGAACTTCA
TCCACGTGCGTGTCAACGTATTGGATACCTTGAAAGAGTTTAACGCCAAACTATTGAAGTAA

Upstream 100 bases:

>100_bases
GAACTTATTAATTATATTTGCAAGTCGAACGACTGACATTTAGAAAGAGACAAATAAAAATAAAGACAATATTAATTCTT
GTTTTAATTTTAAATAAACT

Downstream 100 bases:

>100_bases
GATGAGAAAAGATTTTAAAAACTTAGATATATATGCTGCATTTCAGCCCGCTAACGGTGCTGAATGGCAAAAGGCTAACG
GTATTTCCGCTGATTGGAAT

Product: methylmalonyl-CoA mutase small subunit

Products: NA

Alternate protein names: MCM-beta [H]

Number of amino acids: Translated: 633; Mature: 632

Protein sequence:

>633_residues
MADKKEKLFSDFSPVSTEQWMEKVTADLKGADFEKKLVWKTNEGFKVKPFYRMEDLEGLKTTDALPGEFPYLRGTKKSNN
EWLVRQEIKVECPKEANAKALDILNKGVDSLSFHVKAKELNAEYIETLLNGIQAECVELNFSTCQGHVVELAGLLVAYFQ
KKDYDVKKLRGSVNYDFFNKMLTRGKEKGDMVQTAKALIEAIQPLPFYRVLNVNAISLNNAGAYISQELGYALAWGNEYM
NQLTDAGIPAATVAKKIKFNFGISSNYFLEIAKFRAARMLWANIVASYHPECLRDCDNKGANGECRCAAKMAVHAETSTF
NLTLFDAHVNLLRTQTEAMSAALAGVDSMTVVPFDKTYSTPDEFSERLARNQQLLLKEESHFDKVIDPAAGSYYIENLTV
SIAKQAWELFLAVEEAGGFYAALKAGTVQAAVNESNKARHKAVAQRREVLLGTNQFPNFNEKAGEKQPIEAKCCCGGDAH
TCEKDVDTLVFDRAASEFEALRLETEASGKRPKAFMLTIGNLAMRQARAQYSCNFLACAGYEVIDNLGFETVEAGVEAAM
AAKADIVVLCSSDDEYAEYAVPAFKALDGRAMFIVAGAPACMDELKAAGIENFIHVRVNVLDTLKEFNAKLLK

Sequences:

>Translated_633_residues
MADKKEKLFSDFSPVSTEQWMEKVTADLKGADFEKKLVWKTNEGFKVKPFYRMEDLEGLKTTDALPGEFPYLRGTKKSNN
EWLVRQEIKVECPKEANAKALDILNKGVDSLSFHVKAKELNAEYIETLLNGIQAECVELNFSTCQGHVVELAGLLVAYFQ
KKDYDVKKLRGSVNYDFFNKMLTRGKEKGDMVQTAKALIEAIQPLPFYRVLNVNAISLNNAGAYISQELGYALAWGNEYM
NQLTDAGIPAATVAKKIKFNFGISSNYFLEIAKFRAARMLWANIVASYHPECLRDCDNKGANGECRCAAKMAVHAETSTF
NLTLFDAHVNLLRTQTEAMSAALAGVDSMTVVPFDKTYSTPDEFSERLARNQQLLLKEESHFDKVIDPAAGSYYIENLTV
SIAKQAWELFLAVEEAGGFYAALKAGTVQAAVNESNKARHKAVAQRREVLLGTNQFPNFNEKAGEKQPIEAKCCCGGDAH
TCEKDVDTLVFDRAASEFEALRLETEASGKRPKAFMLTIGNLAMRQARAQYSCNFLACAGYEVIDNLGFETVEAGVEAAM
AAKADIVVLCSSDDEYAEYAVPAFKALDGRAMFIVAGAPACMDELKAAGIENFIHVRVNVLDTLKEFNAKLLK
>Mature_632_residues
ADKKEKLFSDFSPVSTEQWMEKVTADLKGADFEKKLVWKTNEGFKVKPFYRMEDLEGLKTTDALPGEFPYLRGTKKSNNE
WLVRQEIKVECPKEANAKALDILNKGVDSLSFHVKAKELNAEYIETLLNGIQAECVELNFSTCQGHVVELAGLLVAYFQK
KDYDVKKLRGSVNYDFFNKMLTRGKEKGDMVQTAKALIEAIQPLPFYRVLNVNAISLNNAGAYISQELGYALAWGNEYMN
QLTDAGIPAATVAKKIKFNFGISSNYFLEIAKFRAARMLWANIVASYHPECLRDCDNKGANGECRCAAKMAVHAETSTFN
LTLFDAHVNLLRTQTEAMSAALAGVDSMTVVPFDKTYSTPDEFSERLARNQQLLLKEESHFDKVIDPAAGSYYIENLTVS
IAKQAWELFLAVEEAGGFYAALKAGTVQAAVNESNKARHKAVAQRREVLLGTNQFPNFNEKAGEKQPIEAKCCCGGDAHT
CEKDVDTLVFDRAASEFEALRLETEASGKRPKAFMLTIGNLAMRQARAQYSCNFLACAGYEVIDNLGFETVEAGVEAAMA
AKADIVVLCSSDDEYAEYAVPAFKALDGRAMFIVAGAPACMDELKAAGIENFIHVRVNVLDTLKEFNAKLLK

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=482, Percent_Identity=27.5933609958506, Blast_Score=176, Evalue=8e-44,
Organism=Escherichia coli, GI1789284, Length=449, Percent_Identity=29.6213808463252, Blast_Score=201, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI25144500, Length=475, Percent_Identity=26.5263157894737, Blast_Score=180, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 70108; Mature: 69976

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADKKEKLFSDFSPVSTEQWMEKVTADLKGADFEKKLVWKTNEGFKVKPFYRMEDLEGLK
CCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCEEECCEECHHHCCCCC
TTDALPGEFPYLRGTKKSNNEWLVRQEIKVECPKEANAKALDILNKGVDSLSFHVKAKEL
CCCCCCCCCCCCCCCCCCCCCEEEEEECEEECCCCCCCHHHHHHHCCCCCEEEEEEHHHC
NAEYIETLLNGIQAECVELNFSTCQGHVVELAGLLVAYFQKKDYDVKKLRGSVNYDFFNK
CHHHHHHHHHCCCEEEEEEECHHCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHH
MLTRGKEKGDMVQTAKALIEAIQPLPFYRVLNVNAISLNNAGAYISQELGYALAWGNEYM
HHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCHHHHHCCEEEEECHHHH
NQLTDAGIPAATVAKKIKFNFGISSNYFLEIAKFRAARMLWANIVASYHPECLRDCDNKG
HHHHHCCCCHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCC
ANGECRCAAKMAVHAETSTFNLTLFDAHVNLLRTQTEAMSAALAGVDSMTVVPFDKTYST
CCCCEEEEEEEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
PDEFSERLARNQQLLLKEESHFDKVIDPAAGSYYIENLTVSIAKQAWELFLAVEEAGGFY
HHHHHHHHHCCCCEEECCHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHEEEECCCCEE
AALKAGTVQAAVNESNKARHKAVAQRREVLLGTNQFPNFNEKAGEKQPIEAKCCCGGDAH
EEEECCEEEEHHCCCHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCEEEECCCCCC
TCEKDVDTLVFDRAASEFEALRLETEASGKRPKAFMLTIGNLAMRQARAQYSCNFLACAG
CHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCEEEEEHHHHHHHHHHHHHCCCEEEECC
YEVIDNLGFETVEAGVEAAMAAKADIVVLCSSDDEYAEYAVPAFKALDGRAMFIVAGAPA
HHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCHH
CMDELKAAGIENFIHVRVNVLDTLKEFNAKLLK
HHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ADKKEKLFSDFSPVSTEQWMEKVTADLKGADFEKKLVWKTNEGFKVKPFYRMEDLEGLK
CCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCEEECCEECHHHCCCCC
TTDALPGEFPYLRGTKKSNNEWLVRQEIKVECPKEANAKALDILNKGVDSLSFHVKAKEL
CCCCCCCCCCCCCCCCCCCCCEEEEEECEEECCCCCCCHHHHHHHCCCCCEEEEEEHHHC
NAEYIETLLNGIQAECVELNFSTCQGHVVELAGLLVAYFQKKDYDVKKLRGSVNYDFFNK
CHHHHHHHHHCCCEEEEEEECHHCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHH
MLTRGKEKGDMVQTAKALIEAIQPLPFYRVLNVNAISLNNAGAYISQELGYALAWGNEYM
HHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCHHHHHCCEEEEECHHHH
NQLTDAGIPAATVAKKIKFNFGISSNYFLEIAKFRAARMLWANIVASYHPECLRDCDNKG
HHHHHCCCCHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCC
ANGECRCAAKMAVHAETSTFNLTLFDAHVNLLRTQTEAMSAALAGVDSMTVVPFDKTYST
CCCCEEEEEEEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
PDEFSERLARNQQLLLKEESHFDKVIDPAAGSYYIENLTVSIAKQAWELFLAVEEAGGFY
HHHHHHHHHCCCCEEECCHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHEEEECCCCEE
AALKAGTVQAAVNESNKARHKAVAQRREVLLGTNQFPNFNEKAGEKQPIEAKCCCGGDAH
EEEECCEEEEHHCCCHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCEEEECCCCCC
TCEKDVDTLVFDRAASEFEALRLETEASGKRPKAFMLTIGNLAMRQARAQYSCNFLACAG
CHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCEEEEEHHHHHHHHHHHHHCCCEEEECC
YEVIDNLGFETVEAGVEAAMAAKADIVVLCSSDDEYAEYAVPAFKALDGRAMFIVAGAPA
HHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCHH
CMDELKAAGIENFIHVRVNVLDTLKEFNAKLLK
HHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8566763; 12949112 [H]