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The map label for this gene is hmuU [H]

Identifier: 29347361

GI number: 29347361

Start: 2449832

End: 2450812

Strand: Reverse

Name: hmuU [H]

Synonym: BT_1951

Alternate gene names: 29347361

Gene position: 2450812-2449832 (Counterclockwise)

Preceding gene: 29347362

Following gene: 29347360

Centisome position: 39.15

GC content: 50.76

Gene sequence:

>981_bases
ATGCGTTCCCGTTCGACTATATTATTCTCCATATTGATTACGCTCACGGTCGGTCTTTTTTTACTGGACTTGGCCGTGGG
AGCTGTCAACATTCCGATCCGCGATGTATGGGCAGCACTGACCGGGGGAAATTGTTCCCGTGCCACGGAAAAAATCGTAC
TCAACATACGCCTCATAAAAGCTATAGTGGCACTGTTGGCCGGGGCTGCCTTATCGGTCAGCGGTCTTCAGATGCAGACC
CTCTTCCGTAATCCTCTTGCCGGTCCCTATGTCCTTGGCATCAGTTCCGGTGCAAGTCTCGGTGTGGCACTTGTGGTACT
TGCCGGGATCGGTTCATCAATAGGCATTGCCGGAGCAGCGTGGGTGGGTGCGGCTGTCGTGTTGCTCGTGATAACTGCCG
TCGGACAGCGAATAAAAGACATCATGGTAATCCTGATTCTGGGCATGATGTTCTCATCGGGCGTAGGTGCTGTCGTGCAG
ATATTGCAGTACCTCAGCAAAGAGGAATCGCTGAAAGCCTTTGTCATTTGGACGATGGGGGCTTTGGGTGACGTCACCTC
CGGACAACTTCTGATTCTTGTTCCATCGGTGTTTGCCGGACTGCTGTTGGCGGTACTGACCATCAAACCGCTTAACCTCC
TGCTGTTCGGAGAGGAATATGCCGTAACAATGGGACTGAATATTCGGCGTTCACGCAGCCTGTTGTTTCTCTCGACAACG
CTGCTCGCCGGAACGATAACCGCTTTTTGCGGTCCGATAGGTTTCATAGGTCTCGCTATGCCTCATGTCACAAGAATGCT
TTTCCAAAATAGCGATCATCATGTCCTTCTGCCCGGAACAATTCTTTCGGGAGCATCGATATTGCTTCTTTGCGACATCA
TTTCTAAAATATTCACCTTGCCGATCAACGCCATTACAGCTCTATTGGGAATCCCAATCGTCGTATGGGTGGTTTTACGC
AACAAATCCATCACCGCATGA

Upstream 100 bases:

>100_bases
TGCCGTCGTGAATCCTGACATCGTGCTCCGCGACCTCGTGAAGATATTCCATCCTGAACTGGTGCAGGAAGAGTGTGTGT
ATTACAAGCAACTGAAATAG

Downstream 100 bases:

>100_bases
TAGAATTACAGCATTTTTCCATAGGTTACAAAGAAAACTCGTTGCTCCACGAGGTAAATGCCACGATAAAAAAAGGTCAA
CTGACAGCCCTTATCGGAAG

Product: Fe3+ ABC transporter permease

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MRSRSTILFSILITLTVGLFLLDLAVGAVNIPIRDVWAALTGGNCSRATEKIVLNIRLIKAIVALLAGAALSVSGLQMQT
LFRNPLAGPYVLGISSGASLGVALVVLAGIGSSIGIAGAAWVGAAVVLLVITAVGQRIKDIMVILILGMMFSSGVGAVVQ
ILQYLSKEESLKAFVIWTMGALGDVTSGQLLILVPSVFAGLLLAVLTIKPLNLLLFGEEYAVTMGLNIRRSRSLLFLSTT
LLAGTITAFCGPIGFIGLAMPHVTRMLFQNSDHHVLLPGTILSGASILLLCDIISKIFTLPINAITALLGIPIVVWVVLR
NKSITA

Sequences:

>Translated_326_residues
MRSRSTILFSILITLTVGLFLLDLAVGAVNIPIRDVWAALTGGNCSRATEKIVLNIRLIKAIVALLAGAALSVSGLQMQT
LFRNPLAGPYVLGISSGASLGVALVVLAGIGSSIGIAGAAWVGAAVVLLVITAVGQRIKDIMVILILGMMFSSGVGAVVQ
ILQYLSKEESLKAFVIWTMGALGDVTSGQLLILVPSVFAGLLLAVLTIKPLNLLLFGEEYAVTMGLNIRRSRSLLFLSTT
LLAGTITAFCGPIGFIGLAMPHVTRMLFQNSDHHVLLPGTILSGASILLLCDIISKIFTLPINAITALLGIPIVVWVVLR
NKSITA
>Mature_326_residues
MRSRSTILFSILITLTVGLFLLDLAVGAVNIPIRDVWAALTGGNCSRATEKIVLNIRLIKAIVALLAGAALSVSGLQMQT
LFRNPLAGPYVLGISSGASLGVALVVLAGIGSSIGIAGAAWVGAAVVLLVITAVGQRIKDIMVILILGMMFSSGVGAVVQ
ILQYLSKEESLKAFVIWTMGALGDVTSGQLLILVPSVFAGLLLAVLTIKPLNLLLFGEEYAVTMGLNIRRSRSLLFLSTT
LLAGTITAFCGPIGFIGLAMPHVTRMLFQNSDHHVLLPGTILSGASILLLCDIISKIFTLPINAITALLGIPIVVWVVLR
NKSITA

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=282, Percent_Identity=37.2340425531915, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI1790740, Length=327, Percent_Identity=29.3577981651376, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1790741, Length=305, Percent_Identity=33.1147540983607, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1786805, Length=311, Percent_Identity=33.7620578778135, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786804, Length=246, Percent_Identity=35.3658536585366, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786347, Length=276, Percent_Identity=30.7971014492754, Blast_Score=85, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 34118; Mature: 34118

Theoretical pI: Translated: 10.52; Mature: 10.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSRSTILFSILITLTVGLFLLDLAVGAVNIPIRDVWAALTGGNCSRATEKIVLNIRLIK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AIVALLAGAALSVSGLQMQTLFRNPLAGPYVLGISSGASLGVALVVLAGIGSSIGIAGAA
HHHHHHCCHHHHHCCHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCHHHH
WVGAAVVLLVITAVGQRIKDIMVILILGMMFSSGVGAVVQILQYLSKEESLKAFVIWTMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEECC
ALGDVTSGQLLILVPSVFAGLLLAVLTIKPLNLLLFGEEYAVTMGLNIRRSRSLLFLSTT
CCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCEEEECCCEEEEECCEEECCCCCHHHHHH
LLAGTITAFCGPIGFIGLAMPHVTRMLFQNSDHHVLLPGTILSGASILLLCDIISKIFTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHCCHHHHHHHHHHHHHHHC
PINAITALLGIPIVVWVVLRNKSITA
CHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRSRSTILFSILITLTVGLFLLDLAVGAVNIPIRDVWAALTGGNCSRATEKIVLNIRLIK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AIVALLAGAALSVSGLQMQTLFRNPLAGPYVLGISSGASLGVALVVLAGIGSSIGIAGAA
HHHHHHCCHHHHHCCHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCHHHH
WVGAAVVLLVITAVGQRIKDIMVILILGMMFSSGVGAVVQILQYLSKEESLKAFVIWTMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEECC
ALGDVTSGQLLILVPSVFAGLLLAVLTIKPLNLLLFGEEYAVTMGLNIRRSRSLLFLSTT
CCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCEEEECCCEEEEECCEEECCCCCHHHHHH
LLAGTITAFCGPIGFIGLAMPHVTRMLFQNSDHHVLLPGTILSGASILLLCDIISKIFTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHCCHHHHHHHHHHHHHHHC
PINAITALLGIPIVVWVVLRNKSITA
CHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]