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The map label for this gene is lytS [H]

Identifier: 29347205

GI number: 29347205

Start: 2245451

End: 2246656

Strand: Reverse

Name: lytS [H]

Synonym: BT_1795

Alternate gene names: 29347205

Gene position: 2246656-2245451 (Counterclockwise)

Preceding gene: 29347206

Following gene: 29347204

Centisome position: 35.89

GC content: 40.8

Gene sequence:

>1206_bases
ATGGAAAGACTGCGTAAACAACAATTGCTGGAGCAGAGCATTTATGGGGCTATCTGGACAGTTATTTTTCTTCTCCCACT
GATAGGCGGATACTTTGCCGTCAGTGGTGGACTCGAAAAAGAAGAAATCCGTGTAATTGTTCATGATTCATGGTTGAGCA
TCCTTCCTTTTTTCGTCTTGTTTTTGTTGAATAATTATGGATTAGTTCCATATTTCCTGTTTAAGAAAAAGTACTGGCAA
TATATTATTTCTTTGGCTTTTCTAATCTCTACTGCTTGTTGGGTTATTCCCGGTCCCTCTATGCAGCGTTTTCCAAAGGA
ATTCAGATATGGCGATCTACGCAAGGGTAAAGGAAAAAGTCAGAGAGACCTGATTATTAAGATGAGAGAGAAGGCTCGAC
AGGAAGAGTCTGTTCATTGGGAAGCGCCTCAGGCAAACGATCCGGTTTTGGAAAAACCGCAACGACCGGGCGGCTTCCCT
AAACCGACTCCTTATCCCATTCCTCCCTTCACCATCCGTTACCTTATTCATTGTGTAATTGCCTTTTTGATGGTAGGATT
TAATATTGCCGTCAAACTGTTTTTTAAATCCTTTCGTGATGAAGAAATGCTGAAAGAACTGGAGCATCAGCGTTTACAGT
CGGAATTGCAGTATCTGAAGTATCAGATAAACCCGCATTTCTTTATGAATACGCTGAATAATATTCACGCTTTGGTCGAT
ATCGATACGGGGAAGGCAAAGAGTACGATTGTGGAACTTTCTAAGCTCATGCGCTATGTGCTTTATGAGGCCAGTAATAA
AACCATTCTGCTTTCGCGCGAGGTTCAGTTTTTGGAGAATTATGTTACTTTGATGAGTTTGCGCTATCCTGAGAAAGTTT
CTATTGAAAAGAATTTCCCTCTCGAAGTGCCCGAAGTTCAAATTCCTCCTTTACTTTTTATTTCTTTTGTGGAGAATGCT
TTTAAACATGGAGTGAGCTACAGGAAAGAGTCATTTGTTCATGTTGTGATGCAACTGGAAGAAGGAAACCGCCTTGCTTT
CAGATGTACCAATAGCACGGGGACTTCGTCTGACGAGCAACATCACGGCATCGGTCTGGAGAATATACGCAAACGGTTGC
GGTTGTTGTTTGGTAATGATTACACTCTCTCCATTACTGAGGAAGATGATAAATTTGATGTCTTACTTATTATACCTTTA
TTATAA

Upstream 100 bases:

>100_bases
AAATAGCAGTTTACCGTTGAAATAAGTCCTTTGGTCGATTATTTTTGTGGAGAAGAAGTAACGGTTCTATCTTTGTATCA
GTAATTTGGAACAATGAAGC

Downstream 100 bases:

>100_bases
TGAAATGTATAGCGATTGATGATGAACCTTTGGCATTGAAGCAATTGACGGATTATATATCCCGTGTTCCTTTTCTATCT
TTAGTCAAGTCCTGTCAGGA

Product: two-component system sensor

Products: NA

Alternate protein names: Autolysin sensor kinase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MERLRKQQLLEQSIYGAIWTVIFLLPLIGGYFAVSGGLEKEEIRVIVHDSWLSILPFFVLFLLNNYGLVPYFLFKKKYWQ
YIISLAFLISTACWVIPGPSMQRFPKEFRYGDLRKGKGKSQRDLIIKMREKARQEESVHWEAPQANDPVLEKPQRPGGFP
KPTPYPIPPFTIRYLIHCVIAFLMVGFNIAVKLFFKSFRDEEMLKELEHQRLQSELQYLKYQINPHFFMNTLNNIHALVD
IDTGKAKSTIVELSKLMRYVLYEASNKTILLSREVQFLENYVTLMSLRYPEKVSIEKNFPLEVPEVQIPPLLFISFVENA
FKHGVSYRKESFVHVVMQLEEGNRLAFRCTNSTGTSSDEQHHGIGLENIRKRLRLLFGNDYTLSITEEDDKFDVLLIIPL
L

Sequences:

>Translated_401_residues
MERLRKQQLLEQSIYGAIWTVIFLLPLIGGYFAVSGGLEKEEIRVIVHDSWLSILPFFVLFLLNNYGLVPYFLFKKKYWQ
YIISLAFLISTACWVIPGPSMQRFPKEFRYGDLRKGKGKSQRDLIIKMREKARQEESVHWEAPQANDPVLEKPQRPGGFP
KPTPYPIPPFTIRYLIHCVIAFLMVGFNIAVKLFFKSFRDEEMLKELEHQRLQSELQYLKYQINPHFFMNTLNNIHALVD
IDTGKAKSTIVELSKLMRYVLYEASNKTILLSREVQFLENYVTLMSLRYPEKVSIEKNFPLEVPEVQIPPLLFISFVENA
FKHGVSYRKESFVHVVMQLEEGNRLAFRCTNSTGTSSDEQHHGIGLENIRKRLRLLFGNDYTLSITEEDDKFDVLLIIPL
L
>Mature_401_residues
MERLRKQQLLEQSIYGAIWTVIFLLPLIGGYFAVSGGLEKEEIRVIVHDSWLSILPFFVLFLLNNYGLVPYFLFKKKYWQ
YIISLAFLISTACWVIPGPSMQRFPKEFRYGDLRKGKGKSQRDLIIKMREKARQEESVHWEAPQANDPVLEKPQRPGGFP
KPTPYPIPPFTIRYLIHCVIAFLMVGFNIAVKLFFKSFRDEEMLKELEHQRLQSELQYLKYQINPHFFMNTLNNIHALVD
IDTGKAKSTIVELSKLMRYVLYEASNKTILLSREVQFLENYVTLMSLRYPEKVSIEKNFPLEVPEVQIPPLLFISFVENA
FKHGVSYRKESFVHVVMQLEEGNRLAFRCTNSTGTSSDEQHHGIGLENIRKRLRLLFGNDYTLSITEEDDKFDVLLIIPL
L

Specific function: Member of the two-component regulatory system lytR/lytS that probably regulates genes involved in cell wall metabolism [H]

COG id: COG2972

COG function: function code T; Predicted signal transduction protein with a C-terminal ATPase domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788446, Length=181, Percent_Identity=29.8342541436464, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1788723, Length=188, Percent_Identity=29.2553191489362, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR010559
- InterPro:   IPR011620 [H]

Pfam domain/function: PF07694 5TM-5TMR_LYT; PF02518 HATPase_c; PF06580 His_kinase [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 46851; Mature: 46851

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEEECC
>Mature Secondary Structure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CCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA