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The map label for this gene is nadC [H]

Identifier: 29346970

GI number: 29346970

Start: 1926988

End: 1927836

Strand: Reverse

Name: nadC [H]

Synonym: BT_1560

Alternate gene names: 29346970

Gene position: 1927836-1926988 (Counterclockwise)

Preceding gene: 29346971

Following gene: 29346969

Centisome position: 30.79

GC content: 48.17

Gene sequence:

>849_bases
ATGAATAAGGAAAAAGAACTGATCGACAAACTGATCGATCTTGCTTTTGCAGAAGATATAGGTGATGGTGACCATACCAC
CCTTTCGTGTATTCCCGCTACTGCAATGGGAAAATCAAAACTACTGATCAAAGAAGCCGGTGTACTGGCCGGAATCGAAG
TTGCCAAAGAAATCTTCAACCGTTTCGACCCGTCCATGAAAGTGGAAGTGTTTATCAATGACGGCACCGAAGTGAAACCG
GGCGACGTAGCCATGATCGTAGAAGGAAAAGTACAATCCTTGCTCCAGACCGAACGCCTGATGCTGAACGTCATGCAGCG
TATGAGCGGTATCGCAACCATGACCCGCAAGTATGCCAGACAACTGGAAGGCACTCACACCCGCGTGTTGGATACCCGCA
AGACAACTCCGGGTATGCGTATCCTCGAAAAGATGGCAGTCAAAATCGGTGGAGGTGTAAACCATCGTATCGGTCTGTTC
GACATGATTCTGCTGAAAGACAATCACGTGGATTTTGCCGGAGGCATCGACAAAGCGATCAACCGTGCCAAGGATTACTG
CAAGGAAAAGGGCAAGGACCTGAAGATTGAAATCGAAGTACGCAACTTCGACGAATTGCAGCAAGTGCTTGACTTGGGTG
GCGTAGACCGCATCATGTTCGACAACTTTACACCCGAAATGACTAAGAAGGCAGTCGATATGGTAGCCGGCAAATACGAA
ACAGAATCTTCCGGCGGTATCACTTTCGATACCCTTCGCGACTATGCCGAATGTGGCGTAGACTTTATCTCTGTTGGAGC
TCTGACTCATTCGGTGAAAGGACTTGACATGAGTTTCAAAGCATGCTGA

Upstream 100 bases:

>100_bases
GGTACGCTGACGACTACAAAAGGGAAATTCCGTGTGAACTGCTTCCTGAAAAAAGTGCAGACTCAATATTTAATACACCA
AATAAGAATTGACAAGATCA

Downstream 100 bases:

>100_bases
ATCTATAAGTGATGAACTGATAATAAATAAACGGTGAACAGTGCTGTTGCTATCGTGCTGCAGCTGTTCACCGTTTATTA
TTTACGAATCACATTTCTTT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MNKEKELIDKLIDLAFAEDIGDGDHTTLSCIPATAMGKSKLLIKEAGVLAGIEVAKEIFNRFDPSMKVEVFINDGTEVKP
GDVAMIVEGKVQSLLQTERLMLNVMQRMSGIATMTRKYARQLEGTHTRVLDTRKTTPGMRILEKMAVKIGGGVNHRIGLF
DMILLKDNHVDFAGGIDKAINRAKDYCKEKGKDLKIEIEVRNFDELQQVLDLGGVDRIMFDNFTPEMTKKAVDMVAGKYE
TESSGGITFDTLRDYAECGVDFISVGALTHSVKGLDMSFKAC

Sequences:

>Translated_282_residues
MNKEKELIDKLIDLAFAEDIGDGDHTTLSCIPATAMGKSKLLIKEAGVLAGIEVAKEIFNRFDPSMKVEVFINDGTEVKP
GDVAMIVEGKVQSLLQTERLMLNVMQRMSGIATMTRKYARQLEGTHTRVLDTRKTTPGMRILEKMAVKIGGGVNHRIGLF
DMILLKDNHVDFAGGIDKAINRAKDYCKEKGKDLKIEIEVRNFDELQQVLDLGGVDRIMFDNFTPEMTKKAVDMVAGKYE
TESSGGITFDTLRDYAECGVDFISVGALTHSVKGLDMSFKAC
>Mature_282_residues
MNKEKELIDKLIDLAFAEDIGDGDHTTLSCIPATAMGKSKLLIKEAGVLAGIEVAKEIFNRFDPSMKVEVFINDGTEVKP
GDVAMIVEGKVQSLLQTERLMLNVMQRMSGIATMTRKYARQLEGTHTRVLDTRKTTPGMRILEKMAVKIGGGVNHRIGLF
DMILLKDNHVDFAGGIDKAINRAKDYCKEKGKDLKIEIEVRNFDELQQVLDLGGVDRIMFDNFTPEMTKKAVDMVAGKYE
TESSGGITFDTLRDYAECGVDFISVGALTHSVKGLDMSFKAC

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=278, Percent_Identity=32.3741007194245, Blast_Score=144, Evalue=1e-34,
Organism=Escherichia coli, GI1786299, Length=271, Percent_Identity=36.5313653136531, Blast_Score=165, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6321162, Length=258, Percent_Identity=32.9457364341085, Blast_Score=132, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31191; Mature: 31191

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKEKELIDKLIDLAFAEDIGDGDHTTLSCIPATAMGKSKLLIKEAGVLAGIEVAKEIFN
CCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHCCHHHHHHHHHHHHH
RFDPSMKVEVFINDGTEVKPGDVAMIVEGKVQSLLQTERLMLNVMQRMSGIATMTRKYAR
HCCCCEEEEEEECCCCEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLEGTHTRVLDTRKTTPGMRILEKMAVKIGGGVNHRIGLFDMILLKDNHVDFAGGIDKAI
HHCCCHHHEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHEEEEEEECCCCCCCCCHHHHH
NRAKDYCKEKGKDLKIEIEVRNFDELQQVLDLGGVDRIMFDNFTPEMTKKAVDMVAGKYE
HHHHHHHHHCCCCEEEEEEECCHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHCCCC
TESSGGITFDTLRDYAECGVDFISVGALTHSVKGLDMSFKAC
CCCCCCEEHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNKEKELIDKLIDLAFAEDIGDGDHTTLSCIPATAMGKSKLLIKEAGVLAGIEVAKEIFN
CCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHCCHHHHHHHHHHHHH
RFDPSMKVEVFINDGTEVKPGDVAMIVEGKVQSLLQTERLMLNVMQRMSGIATMTRKYAR
HCCCCEEEEEEECCCCEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLEGTHTRVLDTRKTTPGMRILEKMAVKIGGGVNHRIGLFDMILLKDNHVDFAGGIDKAI
HHCCCHHHEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHEEEEEEECCCCCCCCCHHHHH
NRAKDYCKEKGKDLKIEIEVRNFDELQQVLDLGGVDRIMFDNFTPEMTKKAVDMVAGKYE
HHHHHHHHHCCCCEEEEEEECCHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHCCCC
TESSGGITFDTLRDYAECGVDFISVGALTHSVKGLDMSFKAC
CCCCCCEEHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]