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The map label for this gene is yfhQ [H]

Identifier: 29346908

GI number: 29346908

Start: 1846797

End: 1847870

Strand: Reverse

Name: yfhQ [H]

Synonym: BT_1498

Alternate gene names: 29346908

Gene position: 1847870-1846797 (Counterclockwise)

Preceding gene: 29346911

Following gene: 29346907

Centisome position: 29.52

GC content: 46.18

Gene sequence:

>1074_bases
ATGTTAGATGATAGATCGAAATCAGGAATGAATATTTTTAGTGAGGCTATAGTTGAATGGTATAAAGAATACAAGCGTGA
TTTGCCTTGGAGAGAATCGTCGGACCCGTATCGGATCTGGATATCGGAGATTATTCTCCAGCAGACACGGGTGGCGCAGG
GATATGATTACTTTCTCCGGTTTATCAAACGTTTTCCTGATGTGAAGGCATTGGCAGACGCTGACGAGGATGAGGTGATG
AAATACTGGCAGGGACTGGGATATTATTCTCGTGCCCGCAACCTGCATGCTGCGGCCAAAAGTATGAATGGAGTTTTTCC
GGAAACATACCCCGAAGTGCTGGCGCTGAAAGGAGTAGGGGAGTATACGGCGGCAGCTATCTGTTCTTTTGCCTACGGTA
TGCCTTATGCGGTGGTAGACGGAAATGTGTATCGGGTACTTTCCCGTTATTTCGGCATTGATACTCCGATTGACTCGACG
GAAGGAAAGAAACTGTTTGCTGCTCTGGCGGATGAAATGCTGGATAAGAAACAGCCGGCTCTTTATAATCAGGGTATTAT
GGACTTCGGAGCGATACAGTGTACTCCACAGTCACCCGATTGTTTGTTTTGCCCGTTGGCGGATAGTTGTTCGGCACTTT
CAACAGGAAGGGTGACTCAGCTTCCGGTGAAACAACACAAGACAAAGACGACGAACCGTTACTTTAATTATATCTATGTA
CGTGCGGGCGCGCATACCTATATAAATAAGCGGACGGCAAACGATATATGGAAGAACTTGTTTGAACTGCCACTGATAGA
AACTCCGGTTGCTTTGTCCGAAGAGGAGTTTCTTGCATTGCCGGAATTTAGGTCATTAATAGCATCGGGTGAGAATCCGG
TGATACGCTTAGTCTGCCGGGGTGTGAAGCACGTGTTGTCACATCGGGTCATCTATGCCAACCTGTATGAAGTGGCTTTG
CCCGAAGACACGAAGTCCTTCGCTAACTTTCAGAGAATACGATTGGAGGAATTGGACAAGTATGCGATTTCCAAGTTGGT
GCAGACCTTAATTCAGGTAATAAGTAATAAGTAA

Upstream 100 bases:

>100_bases
ATATATTCTGCACATTTTTCTAAAAAAGTGGAGGCATTAAGTTTTCTTAGAGACAAAAGAGTTACTTTTGTACTGCTTTT
GGATAGTATATACGAGATAA

Downstream 100 bases:

>100_bases
AAAGTAGGTAATAAGTAATAGGTAATGGGTAATAGGTAATAAGCTGCGCTATAAACCGAATGGTTAATACTTAATACCTA
TTACTTATTACTTATTACCT

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MLDDRSKSGMNIFSEAIVEWYKEYKRDLPWRESSDPYRIWISEIILQQTRVAQGYDYFLRFIKRFPDVKALADADEDEVM
KYWQGLGYYSRARNLHAAAKSMNGVFPETYPEVLALKGVGEYTAAAICSFAYGMPYAVVDGNVYRVLSRYFGIDTPIDST
EGKKLFAALADEMLDKKQPALYNQGIMDFGAIQCTPQSPDCLFCPLADSCSALSTGRVTQLPVKQHKTKTTNRYFNYIYV
RAGAHTYINKRTANDIWKNLFELPLIETPVALSEEEFLALPEFRSLIASGENPVIRLVCRGVKHVLSHRVIYANLYEVAL
PEDTKSFANFQRIRLEELDKYAISKLVQTLIQVISNK

Sequences:

>Translated_357_residues
MLDDRSKSGMNIFSEAIVEWYKEYKRDLPWRESSDPYRIWISEIILQQTRVAQGYDYFLRFIKRFPDVKALADADEDEVM
KYWQGLGYYSRARNLHAAAKSMNGVFPETYPEVLALKGVGEYTAAAICSFAYGMPYAVVDGNVYRVLSRYFGIDTPIDST
EGKKLFAALADEMLDKKQPALYNQGIMDFGAIQCTPQSPDCLFCPLADSCSALSTGRVTQLPVKQHKTKTTNRYFNYIYV
RAGAHTYINKRTANDIWKNLFELPLIETPVALSEEEFLALPEFRSLIASGENPVIRLVCRGVKHVLSHRVIYANLYEVAL
PEDTKSFANFQRIRLEELDKYAISKLVQTLIQVISNK
>Mature_357_residues
MLDDRSKSGMNIFSEAIVEWYKEYKRDLPWRESSDPYRIWISEIILQQTRVAQGYDYFLRFIKRFPDVKALADADEDEVM
KYWQGLGYYSRARNLHAAAKSMNGVFPETYPEVLALKGVGEYTAAAICSFAYGMPYAVVDGNVYRVLSRYFGIDTPIDST
EGKKLFAALADEMLDKKQPALYNQGIMDFGAIQCTPQSPDCLFCPLADSCSALSTGRVTQLPVKQHKTKTTNRYFNYIYV
RAGAHTYINKRTANDIWKNLFELPLIETPVALSEEEFLALPEFRSLIASGENPVIRLVCRGVKHVLSHRVIYANLYEVAL
PEDTKSFANFQRIRLEELDKYAISKLVQTLIQVISNK

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=222, Percent_Identity=39.6396396396396, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI6912520, Length=222, Percent_Identity=39.6396396396396, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI190358497, Length=222, Percent_Identity=39.6396396396396, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI115298654, Length=222, Percent_Identity=39.6396396396396, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI115298652, Length=222, Percent_Identity=39.6396396396396, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI115298650, Length=222, Percent_Identity=39.6396396396396, Blast_Score=166, Evalue=3e-41,
Organism=Escherichia coli, GI1789331, Length=257, Percent_Identity=38.5214007782101, Blast_Score=195, Evalue=3e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 40797; Mature: 40797

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDDRSKSGMNIFSEAIVEWYKEYKRDLPWRESSDPYRIWISEIILQQTRVAQGYDYFLR
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHH
FIKRFPDVKALADADEDEVMKYWQGLGYYSRARNLHAAAKSMNGVFPETYPEVLALKGVG
HHHHCCCHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCC
EYTAAAICSFAYGMPYAVVDGNVYRVLSRYFGIDTPIDSTEGKKLFAALADEMLDKKQPA
HHHHHHHHHHHHCCCEEEECCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
LYNQGIMDFGAIQCTPQSPDCLFCPLADSCSALSTGRVTQLPVKQHKTKTTNRYFNYIYV
HHHCCCCCCCCEEECCCCCCEEECCCCCCCCHHCCCCEEECCHHHHHHHHHHCEEEEEEE
RAGAHTYINKRTANDIWKNLFELPLIETPVALSEEEFLALPEFRSLIASGENPVIRLVCR
EECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCHHHHHHHHCCCCHHHHHHHH
GVKHVLSHRVIYANLYEVALPEDTKSFANFQRIRLEELDKYAISKLVQTLIQVISNK
HHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLDDRSKSGMNIFSEAIVEWYKEYKRDLPWRESSDPYRIWISEIILQQTRVAQGYDYFLR
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHH
FIKRFPDVKALADADEDEVMKYWQGLGYYSRARNLHAAAKSMNGVFPETYPEVLALKGVG
HHHHCCCHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCC
EYTAAAICSFAYGMPYAVVDGNVYRVLSRYFGIDTPIDSTEGKKLFAALADEMLDKKQPA
HHHHHHHHHHHHCCCEEEECCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
LYNQGIMDFGAIQCTPQSPDCLFCPLADSCSALSTGRVTQLPVKQHKTKTTNRYFNYIYV
HHHCCCCCCCCEEECCCCCCEEECCCCCCCCHHCCCCEEECCHHHHHHHHHHCEEEEEEE
RAGAHTYINKRTANDIWKNLFELPLIETPVALSEEEFLALPEFRSLIASGENPVIRLVCR
EECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCHHHHHHHHCCCCHHHHHHHH
GVKHVLSHRVIYANLYEVALPEDTKSFANFQRIRLEELDKYAISKLVQTLIQVISNK
HHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]