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The map label for this gene is patB [H]

Identifier: 29346808

GI number: 29346808

Start: 1725193

End: 1726350

Strand: Reverse

Name: patB [H]

Synonym: BT_1398

Alternate gene names: 29346808

Gene position: 1726350-1725193 (Counterclockwise)

Preceding gene: 29346809

Following gene: 29346807

Centisome position: 27.58

GC content: 45.16

Gene sequence:

>1158_bases
ATGAAGTACAACTTCGATGAAATTGTTCCACGCAGAGGTACAAATTCCTATAAATGGGATTCTGCCGGAGATGCGGATGT
ATTACCAATGTGGGTAGCTGATATGGATTTCCGTACAGCTCCCTCTGTGGTGGAAGCACTGAAAAGGCGGGTGGAACATG
GTATCTTCGGATATGTGCGTGTGCCCGATGCTTACTATGAGGCGATAACAAGATGGTTTGCCGGACGTCATGGCTGGCAG
ATTGAAAAAGAATGGATTATTTATACGACCGGAGTAGTACCGGCCCTGTCAGCTGTCATCAAGGCGCTGACAACTCCCGG
TGATAAAGTAATCGTGCAGACACCTGTCTATAACTGCTTTTTCTCCTCCATCCGCAATAACGGATGCGAGGTTGTTGCAA
ATCCATTGATTTACATGAACGGAACGTATCAGATAGACTTTATCGATTTGGAACGGAAGGCGGCTGACCCGAGTGTAAAA
GTCCTGCTATTATGCAATCCGCACAATCCTGCCGGAAGAGTCTGGACAAAGCAGGAACTGACTCGCTTGGGAGAAATCTG
TCTTCGGAATAATATATGGGTAGTAGCGGACGAGATTCATTGCGAACTTGTCTTTCCGGGACACACCTATATCCCTTTTG
CATCTGTCTCAGAAGAGTTTTTGATGCATTCCGTTACTTGCACCTCGCCTAGTAAAGCCTTTAATTTGGCGGGGCTTCAG
ATTGCCAATATTGTTTCTGCTGATACGGATATACGAATGCAAATAGACAAGGCAATCAATATCAATGAAGTCTGTGATGT
AAATCCGTTTGGCGTTGAAGCCTTGATAGCTGCTTACAATGACGGGGAAGAATGGCTGGAAGAACTTAACCAATACCTGT
TTGCCAACTACCATTATTTAAGGGCTTACTTTGATGAATATCTTCCCGAATTTCCGGTGCTGCCATTGGAAGGTACCTAC
TTAGTATGGGTAGATTGCTCGGCTTTGAAACAATCGTCGGAGGATATAGTGAAAACTCTGTTGGAGAAGGAAAAGCTTTG
GGTAAACGAAGGCAATCTGTATGGAGAGGCTGGCGAAAGGTTTATCCGTATTAACATCGCGTGTCCGCGACAGCGGTTGA
TAGAAGGATTAAACAGATTGAGGCGGGCATTGAAATAA

Upstream 100 bases:

>100_bases
CCGAAAGTTTCGGGACAATCATCCTGGACGAGAACCTCAAAGCTCCGGGAAACTGCGAATTGAAACTTTGGGACGGACTG
ACTTGTTTTGATTGAAATAT

Downstream 100 bases:

>100_bases
TAAAATAATTGTCAGTTTATTAATAGGTTCCCCTTCTCACTCCCCGTAAATACAAATAAAAAGAAGTGATATGAAAAGTC
AGAATCCCTCAAAGAGGAAT

Product: putative aminotransferase B

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MKYNFDEIVPRRGTNSYKWDSAGDADVLPMWVADMDFRTAPSVVEALKRRVEHGIFGYVRVPDAYYEAITRWFAGRHGWQ
IEKEWIIYTTGVVPALSAVIKALTTPGDKVIVQTPVYNCFFSSIRNNGCEVVANPLIYMNGTYQIDFIDLERKAADPSVK
VLLLCNPHNPAGRVWTKQELTRLGEICLRNNIWVVADEIHCELVFPGHTYIPFASVSEEFLMHSVTCTSPSKAFNLAGLQ
IANIVSADTDIRMQIDKAININEVCDVNPFGVEALIAAYNDGEEWLEELNQYLFANYHYLRAYFDEYLPEFPVLPLEGTY
LVWVDCSALKQSSEDIVKTLLEKEKLWVNEGNLYGEAGERFIRINIACPRQRLIEGLNRLRRALK

Sequences:

>Translated_385_residues
MKYNFDEIVPRRGTNSYKWDSAGDADVLPMWVADMDFRTAPSVVEALKRRVEHGIFGYVRVPDAYYEAITRWFAGRHGWQ
IEKEWIIYTTGVVPALSAVIKALTTPGDKVIVQTPVYNCFFSSIRNNGCEVVANPLIYMNGTYQIDFIDLERKAADPSVK
VLLLCNPHNPAGRVWTKQELTRLGEICLRNNIWVVADEIHCELVFPGHTYIPFASVSEEFLMHSVTCTSPSKAFNLAGLQ
IANIVSADTDIRMQIDKAININEVCDVNPFGVEALIAAYNDGEEWLEELNQYLFANYHYLRAYFDEYLPEFPVLPLEGTY
LVWVDCSALKQSSEDIVKTLLEKEKLWVNEGNLYGEAGERFIRINIACPRQRLIEGLNRLRRALK
>Mature_385_residues
MKYNFDEIVPRRGTNSYKWDSAGDADVLPMWVADMDFRTAPSVVEALKRRVEHGIFGYVRVPDAYYEAITRWFAGRHGWQ
IEKEWIIYTTGVVPALSAVIKALTTPGDKVIVQTPVYNCFFSSIRNNGCEVVANPLIYMNGTYQIDFIDLERKAADPSVK
VLLLCNPHNPAGRVWTKQELTRLGEICLRNNIWVVADEIHCELVFPGHTYIPFASVSEEFLMHSVTCTSPSKAFNLAGLQ
IANIVSADTDIRMQIDKAININEVCDVNPFGVEALIAAYNDGEEWLEELNQYLFANYHYLRAYFDEYLPEFPVLPLEGTY
LVWVDCSALKQSSEDIVKTLLEKEKLWVNEGNLYGEAGERFIRINIACPRQRLIEGLNRLRRALK

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=338, Percent_Identity=23.6686390532544, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI169881279, Length=338, Percent_Identity=23.6686390532544, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI56713256, Length=165, Percent_Identity=27.2727272727273, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI56713254, Length=165, Percent_Identity=27.2727272727273, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI4507369, Length=218, Percent_Identity=25.2293577981651, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1787909, Length=389, Percent_Identity=33.4190231362468, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI1788722, Length=377, Percent_Identity=23.8726790450928, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786816, Length=300, Percent_Identity=24.6666666666667, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71994476, Length=162, Percent_Identity=27.7777777777778, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994472, Length=162, Percent_Identity=27.7777777777778, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17567369, Length=162, Percent_Identity=27.1604938271605, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17567663, Length=311, Percent_Identity=22.1864951768489, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322401, Length=277, Percent_Identity=27.4368231046931, Blast_Score=103, Evalue=6e-23,
Organism=Drosophila melanogaster, GI18859735, Length=387, Percent_Identity=21.1886304909561, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573069, Length=194, Percent_Identity=26.8041237113402, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24646114, Length=194, Percent_Identity=26.8041237113402, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573067, Length=194, Percent_Identity=26.8041237113402, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573065, Length=194, Percent_Identity=26.8041237113402, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43934; Mature: 43934

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYNFDEIVPRRGTNSYKWDSAGDADVLPMWVADMDFRTAPSVVEALKRRVEHGIFGYVR
CCCCHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEE
VPDAYYEAITRWFAGRHGWQIEKEWIIYTTGVVPALSAVIKALTTPGDKVIVQTPVYNCF
CCHHHHHHHHHHHCCCCCCEEECEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCHHHHH
FSSIRNNGCEVVANPLIYMNGTYQIDFIDLERKAADPSVKVLLLCNPHNPAGRVWTKQEL
HHHHCCCCCEEEECCEEEECCEEEEEEEEEECCCCCCCEEEEEEECCCCCCCCCCCHHHH
TRLGEICLRNNIWVVADEIHCELVFPGHTYIPFASVSEEFLMHSVTCTSPSKAFNLAGLQ
HHHHHHHHCCCEEEEEEEEEEEEEECCCCCCCCHHHHHHHHHHEEECCCCCHHHCCCCEE
IANIVSADTDIRMQIDKAININEVCDVNPFGVEALIAAYNDGEEWLEELNQYLFANYHYL
EEHHHCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
RAYFDEYLPEFPVLPLEGTYLVWVDCSALKQSSEDIVKTLLEKEKLWVNEGNLYGEAGER
HHHHHHHCCCCCCCCCCCCEEEEEEHHHHHCCHHHHHHHHHHHHHEEEECCCEEECCCCE
FIRINIACPRQRLIEGLNRLRRALK
EEEEEEECCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKYNFDEIVPRRGTNSYKWDSAGDADVLPMWVADMDFRTAPSVVEALKRRVEHGIFGYVR
CCCCHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEE
VPDAYYEAITRWFAGRHGWQIEKEWIIYTTGVVPALSAVIKALTTPGDKVIVQTPVYNCF
CCHHHHHHHHHHHCCCCCCEEECEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCHHHHH
FSSIRNNGCEVVANPLIYMNGTYQIDFIDLERKAADPSVKVLLLCNPHNPAGRVWTKQEL
HHHHCCCCCEEEECCEEEECCEEEEEEEEEECCCCCCCEEEEEEECCCCCCCCCCCHHHH
TRLGEICLRNNIWVVADEIHCELVFPGHTYIPFASVSEEFLMHSVTCTSPSKAFNLAGLQ
HHHHHHHHCCCEEEEEEEEEEEEEECCCCCCCCHHHHHHHHHHEEECCCCCHHHCCCCEE
IANIVSADTDIRMQIDKAININEVCDVNPFGVEALIAAYNDGEEWLEELNQYLFANYHYL
EEHHHCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
RAYFDEYLPEFPVLPLEGTYLVWVDCSALKQSSEDIVKTLLEKEKLWVNEGNLYGEAGER
HHHHHHHCCCCCCCCCCCCEEEEEEHHHHHCCHHHHHHHHHHHHHEEEECCCEEECCCCE
FIRINIACPRQRLIEGLNRLRRALK
EEEEEEECCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]