BacMap

Definition	Bacteroides thetaiotaomicron VPI-5482 chromosome, complete genome.
Accession	NC_004663
Length	6,260,361

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The map label for this gene is yvgN [H]

Identifier: 29346793

GI number: 29346793

Start: 1711067

End: 1711903

Strand: Reverse

Name: yvgN [H]

Synonym: BT_1383

Alternate gene names: 29346793

Gene position: 1711903-1711067 (Counterclockwise)

Preceding gene: 29346794

Following gene: 29346791

Centisome position: 27.35

GC content: 41.58

Gene sequence:

>837_bases
ATGGAAACAGTAAGATTGAACAACGGTGTTGAAATGCCGATTTTAGGCTATGGTGTATATCAGGTAACTCCTGAAGAGTG
TGAGCGCTGTGTGCTGGATGCTATTAGTGTCGGTTATCGTTCTATTGATACTGCACAGGCATATTATAATGAAGAAGGAG
TGGGTAATGCAGTCAGGAAATGCGGTGTACCACGTGAAGAACTGTTTATCACAACGAAAGTATGGATTTCGAACGGTGGA
TACGAAAAAGCAAAAGCTTCTATTGACGAATCCTTGCGTAAGCTCCAAAGTGATTATGTTGATTTGTTGCTTATTCATCA
GCCTTTCAATGATTACTATGGTACATACCGTGCCATGGAAGAGGCTTACAAGGCCGGAAAAGCTCGTGCCATTGGTGTCA
GCAATTTCTATCCGGACCGTTTCATTGATCTGGCAGAATTTTGTGAGATTAAACCGGCGGTGAATCAAGTTGAAACACAC
GTCTTCAACCAGCAAGTGAAACCGCAGGAGATTATGAAGAAATACGATACGAAGGTCATGTCATGGGGGCCATTTGCAGA
AGGACGCAATAATTTCTTCTCTAATGAAGTATTGAAAGCAATCGGAGAACAGTATGGAAAATCGGTTGCACAGGTAGCTC
TGCGCTTTCTTATTCAGCGTGATATCATCGTTATCCCGAAATCGACTCGCAAGGAACGCATGATAGAAAACTTCGATGTA
TTTGACTTCACCTTGTCCGTAAAGGATATGGAAGAGATTGCCGGACTCGATAAAAAAGAAAGTCTGTTCTTCTCCCATTA
TGACCCTGAAATGGTTAACTTTCTGATTAATTTATAA

Upstream 100 bases:

>100_bases
TTCTTCCTTAATTTTGTACTGTAATAAAATCAATTCAACTATTGATCTTGTTATTGATAAGTATGGAGGTATTGAGTTTA
ATAATTAAAATAGTGCATTT

Downstream 100 bases:

>100_bases
TAGAGGGAATATGTAGGCGGAAGATGTTTAGAAAAGAATCGTCAGGAAAGATTAATCTCTTCTGACGATTCGGAATATTG
GAACGTAGCGAAAAATGGAA

Product: oxidoreductase, aldo/keto reductase

Products: NA

Alternate protein names: GR; Methylglyoxal reductase [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
METVRLNNGVEMPILGYGVYQVTPEECERCVLDAISVGYRSIDTAQAYYNEEGVGNAVRKCGVPREELFITTKVWISNGG
YEKAKASIDESLRKLQSDYVDLLLIHQPFNDYYGTYRAMEEAYKAGKARAIGVSNFYPDRFIDLAEFCEIKPAVNQVETH
VFNQQVKPQEIMKKYDTKVMSWGPFAEGRNNFFSNEVLKAIGEQYGKSVAQVALRFLIQRDIIVIPKSTRKERMIENFDV
FDFTLSVKDMEEIAGLDKKESLFFSHYDPEMVNFLINL

Sequences:

>Translated_278_residues
METVRLNNGVEMPILGYGVYQVTPEECERCVLDAISVGYRSIDTAQAYYNEEGVGNAVRKCGVPREELFITTKVWISNGG
YEKAKASIDESLRKLQSDYVDLLLIHQPFNDYYGTYRAMEEAYKAGKARAIGVSNFYPDRFIDLAEFCEIKPAVNQVETH
VFNQQVKPQEIMKKYDTKVMSWGPFAEGRNNFFSNEVLKAIGEQYGKSVAQVALRFLIQRDIIVIPKSTRKERMIENFDV
FDFTLSVKDMEEIAGLDKKESLFFSHYDPEMVNFLINL
>Mature_278_residues
METVRLNNGVEMPILGYGVYQVTPEECERCVLDAISVGYRSIDTAQAYYNEEGVGNAVRKCGVPREELFITTKVWISNGG
YEKAKASIDESLRKLQSDYVDLLLIHQPFNDYYGTYRAMEEAYKAGKARAIGVSNFYPDRFIDLAEFCEIKPAVNQVETH
VFNQQVKPQEIMKKYDTKVMSWGPFAEGRNNFFSNEVLKAIGEQYGKSVAQVALRFLIQRDIIVIPKSTRKERMIENFDV
FDFTLSVKDMEEIAGLDKKESLFFSHYDPEMVNFLINL

Specific function: Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis [H]

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase family [H]

Homologues:

Organism=Homo sapiens, GI24497577, Length=289, Percent_Identity=31.8339100346021, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI5174391, Length=289, Percent_Identity=31.8339100346021, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI5174695, Length=296, Percent_Identity=34.4594594594595, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI24497583, Length=304, Percent_Identity=33.2236842105263, Blast_Score=154, Evalue=6e-38,
Organism=Homo sapiens, GI310109922, Length=276, Percent_Identity=34.0579710144928, Blast_Score=154, Evalue=6e-38,
Organism=Homo sapiens, GI310109920, Length=297, Percent_Identity=32.3232323232323, Blast_Score=151, Evalue=6e-37,
Organism=Homo sapiens, GI45446745, Length=297, Percent_Identity=32.3232323232323, Blast_Score=151, Evalue=7e-37,
Organism=Homo sapiens, GI4503285, Length=297, Percent_Identity=32.3232323232323, Blast_Score=151, Evalue=7e-37,
Organism=Homo sapiens, GI5453543, Length=296, Percent_Identity=32.0945945945946, Blast_Score=148, Evalue=5e-36,
Organism=Homo sapiens, GI24497585, Length=298, Percent_Identity=32.5503355704698, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI300116273, Length=278, Percent_Identity=34.1726618705036, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI4502049, Length=288, Percent_Identity=35.4166666666667, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI300116271, Length=277, Percent_Identity=33.2129963898917, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI93277124, Length=301, Percent_Identity=30.5647840531561, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI223468663, Length=290, Percent_Identity=30.6896551724138, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI291291012, Length=275, Percent_Identity=30.9090909090909, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI310109926, Length=114, Percent_Identity=41.2280701754386, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI207028673, Length=116, Percent_Identity=40.5172413793103, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI310109924, Length=152, Percent_Identity=30.2631578947368, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI87082198, Length=262, Percent_Identity=40.0763358778626, Blast_Score=207, Evalue=5e-55,
Organism=Escherichia coli, GI1786400, Length=256, Percent_Identity=36.328125, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1788081, Length=276, Percent_Identity=28.9855072463768, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87081735, Length=289, Percent_Identity=29.0657439446367, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17537077, Length=292, Percent_Identity=35.958904109589, Blast_Score=177, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17537075, Length=296, Percent_Identity=35.8108108108108, Blast_Score=177, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17550248, Length=298, Percent_Identity=36.241610738255, Blast_Score=176, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI71998625, Length=262, Percent_Identity=37.4045801526718, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17564128, Length=306, Percent_Identity=30.718954248366, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17566692, Length=295, Percent_Identity=32.5423728813559, Blast_Score=150, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17561298, Length=271, Percent_Identity=30.2583025830258, Blast_Score=148, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17537079, Length=298, Percent_Identity=31.2080536912752, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17552492, Length=279, Percent_Identity=31.5412186379928, Blast_Score=134, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17538386, Length=272, Percent_Identity=30.8823529411765, Blast_Score=131, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17561300, Length=253, Percent_Identity=29.6442687747036, Blast_Score=120, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17562292, Length=279, Percent_Identity=27.9569892473118, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320576, Length=289, Percent_Identity=32.5259515570934, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6321896, Length=303, Percent_Identity=32.013201320132, Blast_Score=152, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6324694, Length=288, Percent_Identity=31.25, Blast_Score=151, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6322556, Length=259, Percent_Identity=31.2741312741313, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6319625, Length=278, Percent_Identity=31.6546762589928, Blast_Score=126, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6320079, Length=280, Percent_Identity=30, Blast_Score=114, Evalue=1e-26,
Organism=Drosophila melanogaster, GI45553081, Length=282, Percent_Identity=34.3971631205674, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24663317, Length=285, Percent_Identity=36.8421052631579, Blast_Score=175, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24657054, Length=279, Percent_Identity=37.6344086021505, Blast_Score=171, Evalue=3e-43,
Organism=Drosophila melanogaster, GI21356425, Length=307, Percent_Identity=34.8534201954397, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24644950, Length=297, Percent_Identity=34.6801346801347, Blast_Score=168, Evalue=5e-42,
Organism=Drosophila melanogaster, GI20129731, Length=287, Percent_Identity=35.5400696864112, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI221378297, Length=317, Percent_Identity=32.4921135646688, Blast_Score=160, Evalue=8e-40,
Organism=Drosophila melanogaster, GI24662789, Length=290, Percent_Identity=35.1724137931034, Blast_Score=157, Evalue=8e-39,
Organism=Drosophila melanogaster, GI281366140, Length=248, Percent_Identity=31.8548387096774, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24662781, Length=279, Percent_Identity=32.6164874551971, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24662785, Length=272, Percent_Identity=31.9852941176471, Blast_Score=118, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: =1.1.1.283 [H]

Molecular weight: Translated: 31910; Mature: 31910

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METVRLNNGVEMPILGYGVYQVTPEECERCVLDAISVGYRSIDTAQAYYNEEGVGNAVRK
CCEEECCCCCCCCEEECCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
CGVPREELFITTKVWISNGGYEKAKASIDESLRKLQSDYVDLLLIHQPFNDYYGTYRAME
CCCCHHHEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHH
EAYKAGKARAIGVSNFYPDRFIDLAEFCEIKPAVNQVETHVFNQQVKPQEIMKKYDTKVM
HHHHCCCCEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHCCHHC
SWGPFAEGRNNFFSNEVLKAIGEQYGKSVAQVALRFLIQRDIIVIPKSTRKERMIENFDV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHCCCE
FDFTLSVKDMEEIAGLDKKESLFFSHYDPEMVNFLINL
EEEEEEHHHHHHHHCCCCHHCEEECCCCHHHHHHHHCC
>Mature Secondary Structure
METVRLNNGVEMPILGYGVYQVTPEECERCVLDAISVGYRSIDTAQAYYNEEGVGNAVRK
CCEEECCCCCCCCEEECCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
CGVPREELFITTKVWISNGGYEKAKASIDESLRKLQSDYVDLLLIHQPFNDYYGTYRAME
CCCCHHHEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHH
EAYKAGKARAIGVSNFYPDRFIDLAEFCEIKPAVNQVETHVFNQQVKPQEIMKKYDTKVM
HHHHCCCCEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHCCHHC
SWGPFAEGRNNFFSNEVLKAIGEQYGKSVAQVALRFLIQRDIIVIPKSTRKERMIENFDV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHCCCE
FDFTLSVKDMEEIAGLDKKESLFFSHYDPEMVNFLINL
EEEEEEHHHHHHHHCCCCHHCEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]