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The map label for this gene is lysC [C]

Identifier: 29346785

GI number: 29346785

Start: 1703450

End: 1704769

Strand: Reverse

Name: lysC [C]

Synonym: BT_1375

Alternate gene names: 29346785

Gene position: 1704769-1703450 (Counterclockwise)

Preceding gene: 29346786

Following gene: 29346784

Centisome position: 27.23

GC content: 44.85

Gene sequence:

>1320_bases
ATGAAAGTTTTAAAGTTTGGAGGAACTTCCGTGGGTTCTGCTCAGCGGATGAAGGAAGTAGCCAAATTGATTACCGATGG
TGAACAGAAGATTGTTGTCCTTTCTGCAATGTCAGGAACAACAAATACATTGGTGGAAATTTCGGACTATCTGTATAAGA
AGAATCCGGAGGGTGCCAACGAGATTATCAATAAGCTGGAATCAAAATATAAACAGCACGTTGATGAGCTTTTTGCAACT
CAGGAATATAAACAGAAAGGTCTGGAAGTCATCAAGTCTCACTTCGACTACATCCGCTCCTATACTAAAGACCTTTTCAC
TTTGTTCGAAGAGAAAGTGGTTTTGGCACAGGGAGAGCTTATTTCTACGGCTATGGTCAACTTCTACCTGCAGGAATGCG
GTGTGAAGTCCGTATTGCTTCCGGCTTTGGAATTCATGCGTACTGACAAGAACGCGGAACCGGACCCTGTATATATTAAG
GAGAAACTGCAGACACAACTGGAACTGTATCCGGATATGGAGATTTACATCACACAAGGTTTCATCTGCCGCAATGCTTA
CGGTGAGATAGACAACCTGCAGCGTGGTGGCAGCGATTACACCGCATCCTTGATCGGTGCTGCCGTAAAGGCTTCCGAAA
TCCAGATATGGACGGACATCGACGGTATGCACAATAACGACCCGCGCATTGTGGACAAGACAGCTCCGGTTCGTCAGCTG
CATTTCGAAGAAGCAGCCGAGCTGGCTTACTTCGGTGCAAAAATCCTGCACCCGACTTGCATCCAGCCTGCTAAATATGC
CAATATACCTGTACGTCTGCTGAATACAATGGACCCGGATGCTCCCGGAACACTAATTTCTAATGACACGGAGAAAGGTA
AGATTAAAGCCGTAGCTGCCAAAAACAATATTACAGCTATCAAGATCAAATCAAGCCGTATGTTGCTTGCTCATGGTTTC
CTGCGTAAAGTATTCGAGATCTTTGAAAGCTATCAGACTTCTATTGACATGATCTGTACCTCAGAGGTCGGTGTATCTGT
TACAATAGACAACACCAAGCATCTGAACGAGATTCTGGACGACCTGAAAAAATACGGTACTGTCACTGTTGACAAGGATA
TGTGTATTATCTGTGTAGTAGGTGACCTGGAATGGGAGAATGTCGGTTTCGAAGCTAAAGCGCTTGATGCGATGCGGGAC
ATACCTGTGCGAATGATTTCCTTCGGAGGAAGTAACTACAATATTTCCTTCCTTATCCGGGATTGCGATAAGAAGACGGC
GTTGCAGTCGCTGAGCGATATGCTTTTCAACAACAAATAA

Upstream 100 bases:

>100_bases
TGTTCCGAACATCGTATAACGGATGTGACAGACGAATACATGCCCAGACAGAGAACAATAGAAATAGATTTAAATATAGA
TAACTAAAACAGTAACGAAA

Downstream 100 bases:

>100_bases
TTCCACAAATAATACGAGCGCTTTTATTGATACTGATAAAAGCGCTCTTTTTAACTAACTAAACAAGTTTCTTGAATTAT
GAAAGGAATATTTCCAATCG

Product: aspartokinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MKVLKFGGTSVGSAQRMKEVAKLITDGEQKIVVLSAMSGTTNTLVEISDYLYKKNPEGANEIINKLESKYKQHVDELFAT
QEYKQKGLEVIKSHFDYIRSYTKDLFTLFEEKVVLAQGELISTAMVNFYLQECGVKSVLLPALEFMRTDKNAEPDPVYIK
EKLQTQLELYPDMEIYITQGFICRNAYGEIDNLQRGGSDYTASLIGAAVKASEIQIWTDIDGMHNNDPRIVDKTAPVRQL
HFEEAAELAYFGAKILHPTCIQPAKYANIPVRLLNTMDPDAPGTLISNDTEKGKIKAVAAKNNITAIKIKSSRMLLAHGF
LRKVFEIFESYQTSIDMICTSEVGVSVTIDNTKHLNEILDDLKKYGTVTVDKDMCIICVVGDLEWENVGFEAKALDAMRD
IPVRMISFGGSNYNISFLIRDCDKKTALQSLSDMLFNNK

Sequences:

>Translated_439_residues
MKVLKFGGTSVGSAQRMKEVAKLITDGEQKIVVLSAMSGTTNTLVEISDYLYKKNPEGANEIINKLESKYKQHVDELFAT
QEYKQKGLEVIKSHFDYIRSYTKDLFTLFEEKVVLAQGELISTAMVNFYLQECGVKSVLLPALEFMRTDKNAEPDPVYIK
EKLQTQLELYPDMEIYITQGFICRNAYGEIDNLQRGGSDYTASLIGAAVKASEIQIWTDIDGMHNNDPRIVDKTAPVRQL
HFEEAAELAYFGAKILHPTCIQPAKYANIPVRLLNTMDPDAPGTLISNDTEKGKIKAVAAKNNITAIKIKSSRMLLAHGF
LRKVFEIFESYQTSIDMICTSEVGVSVTIDNTKHLNEILDDLKKYGTVTVDKDMCIICVVGDLEWENVGFEAKALDAMRD
IPVRMISFGGSNYNISFLIRDCDKKTALQSLSDMLFNNK
>Mature_439_residues
MKVLKFGGTSVGSAQRMKEVAKLITDGEQKIVVLSAMSGTTNTLVEISDYLYKKNPEGANEIINKLESKYKQHVDELFAT
QEYKQKGLEVIKSHFDYIRSYTKDLFTLFEEKVVLAQGELISTAMVNFYLQECGVKSVLLPALEFMRTDKNAEPDPVYIK
EKLQTQLELYPDMEIYITQGFICRNAYGEIDNLQRGGSDYTASLIGAAVKASEIQIWTDIDGMHNNDPRIVDKTAPVRQL
HFEEAAELAYFGAKILHPTCIQPAKYANIPVRLLNTMDPDAPGTLISNDTEKGKIKAVAAKNNITAIKIKSSRMLLAHGF
LRKVFEIFESYQTSIDMICTSEVGVSVTIDNTKHLNEILDDLKKYGTVTVDKDMCIICVVGDLEWENVGFEAKALDAMRD
IPVRMISFGGSNYNISFLIRDCDKKTALQSLSDMLFNNK

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=447, Percent_Identity=32.662192393736, Blast_Score=201, Evalue=6e-53,
Organism=Escherichia coli, GI1786183, Length=473, Percent_Identity=28.9640591966173, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1790376, Length=397, Percent_Identity=26.1964735516373, Blast_Score=115, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6320893, Length=492, Percent_Identity=27.0325203252033, Blast_Score=154, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 49261; Mature: 49261

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLKFGGTSVGSAQRMKEVAKLITDGEQKIVVLSAMSGTTNTLVEISDYLYKKNPEGAN
CCEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCHH
EIINKLESKYKQHVDELFATQEYKQKGLEVIKSHFDYIRSYTKDLFTLFEEKVVLAQGEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCH
ISTAMVNFYLQECGVKSVLLPALEFMRTDKNAEPDPVYIKEKLQTQLELYPDMEIYITQG
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECC
FICRNAYGEIDNLQRGGSDYTASLIGAAVKASEIQIWTDIDGMHNNDPRIVDKTAPVRQL
EEEECCCCCCHHHHCCCCCHHHHHHHHHHHHCEEEEEECCCCCCCCCCEEEECCCCHHHH
HFEEAAELAYFGAKILHPTCIQPAKYANIPVRLLNTMDPDAPGTLISNDTEKGKIKAVAA
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEECCCCCCCCCCCCCCCCCCCEEEEEEE
KNNITAIKIKSSRMLLAHGFLRKVFEIFESYQTSIDMICTSEVGVSVTIDNTKHLNEILD
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCHHHHHHHHH
DLKKYGTVTVDKDMCIICVVGDLEWENVGFEAKALDAMRDIPVRMISFGGSNYNISFLIR
HHHHHCCEEECCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCEEEEEECCCCEEEEEEEE
DCDKKTALQSLSDMLFNNK
CCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKVLKFGGTSVGSAQRMKEVAKLITDGEQKIVVLSAMSGTTNTLVEISDYLYKKNPEGAN
CCEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCHH
EIINKLESKYKQHVDELFATQEYKQKGLEVIKSHFDYIRSYTKDLFTLFEEKVVLAQGEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCH
ISTAMVNFYLQECGVKSVLLPALEFMRTDKNAEPDPVYIKEKLQTQLELYPDMEIYITQG
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECC
FICRNAYGEIDNLQRGGSDYTASLIGAAVKASEIQIWTDIDGMHNNDPRIVDKTAPVRQL
EEEECCCCCCHHHHCCCCCHHHHHHHHHHHHCEEEEEECCCCCCCCCCEEEECCCCHHHH
HFEEAAELAYFGAKILHPTCIQPAKYANIPVRLLNTMDPDAPGTLISNDTEKGKIKAVAA
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEECCCCCCCCCCCCCCCCCCCEEEEEEE
KNNITAIKIKSSRMLLAHGFLRKVFEIFESYQTSIDMICTSEVGVSVTIDNTKHLNEILD
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCHHHHHHHHH
DLKKYGTVTVDKDMCIICVVGDLEWENVGFEAKALDAMRDIPVRMISFGGSNYNISFLIR
HHHHHCCEEECCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCEEEEEECCCCEEEEEEEE
DCDKKTALQSLSDMLFNNK
CCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]