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The map label for this gene is murB

Identifier: 29346778

GI number: 29346778

Start: 1696842

End: 1697837

Strand: Reverse

Name: murB

Synonym: BT_1368

Alternate gene names: 29346778

Gene position: 1697837-1696842 (Counterclockwise)

Preceding gene: 29346779

Following gene: 29346777

Centisome position: 27.12

GC content: 50.0

Gene sequence:

>996_bases
ATGTATTCTCTTTTATCACACAATACGTTCGGCATTGATGTCTATGCCGAACGGTTTCAGGAATATGCTTCGGTAGAAGA
ACTGAAGACATTGATAGCTCAAGGTGCCCTTACGACACCTTTTTTGCATATAGGCGGCGGAAGCAACCTGCTTTTTGTCA
AAGACTATGAAGGGCTGGTCTTACATTCCCGCATCGAAGGGATCGAGGTGACGGAAGAGGACGAACGGAGTGTAGCCGTA
CGGGTAGGAGCAGGCGTGGTCTGGGATGACTTTGTAGGCTATTGCGTAGAGCATGGCTGGTATGGAACGGAAAATCTCTC
CCTTATTCCCGGTGAAGTGGGAGCGAGTGCCGTGCAGAATATCGGTGCCTATGGCGTGGAAGTGAAAGACCTGATCACCT
CTGTCGAAACAGTGAACATTCACGGTGAGGAGCGTGTTTATGCTGTAGATGAATGTGGCTATGCCTATCGCGACAGCATT
TTCAAACGCCCGGAGAATAAATCCGTATTTGTGACCTATGTCTGCTTCCGGCTCAGTAAGGAAGAACGGTATACATTAGA
TTACGGCACCATCCGTCAGGAGCTCGAAAAATATCCCGAACTGACCTTGCCGATCCTCCGGAAAGTGATTATCGATATCC
GTGAAAGCAAATTGCCCGACCCGAAAGTGATGGGAAATGCCGGCAGTTTCTTTATGAATCCCATCGTTCCGCGCGAAAAA
CTGGAAGCCTTGCAGCAGGAATTTCCCCGAATCCCCTTCTACGAACTGAATGACGGACGAGTGAAGATTCCGGCAGGATG
GATGATTGATCAGTGCGGCTGGAAAGGAAAAGCATTAGGTCCGGCGGCAGTGCATGACAAACAGGCCTTGGTGCTCGTCA
ATCGGGGCGGAGCGAAAGGCAGCGACGTCCTTGCGCTTTCGGATGCAGTGCGGGCTTCTGTTCGTGCGAAATTCGGCATA
GACATTCATCCGGAAGTAAATTTGGTTGGAAAATGA

Upstream 100 bases:

>100_bases
AACGGCTTCTCTAATATTCTATATTTTAGGCGGAAAGCAGGCGAATGGCAACTGTATAAGTTTGAAGATACCAGTATTTA
GCAACGAAAAAACGGAAGAT

Downstream 100 bases:

>100_bases
AAGTAAGAATACTTGGAAGCGGAACATCGACGGGAGTTCCTCAGATTGGATGTACCTGTCCGGTCTGCACTTCTGCCGAT
CCGAAAGATAATCGTCTGCG

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MYSLLSHNTFGIDVYAERFQEYASVEELKTLIAQGALTTPFLHIGGGSNLLFVKDYEGLVLHSRIEGIEVTEEDERSVAV
RVGAGVVWDDFVGYCVEHGWYGTENLSLIPGEVGASAVQNIGAYGVEVKDLITSVETVNIHGEERVYAVDECGYAYRDSI
FKRPENKSVFVTYVCFRLSKEERYTLDYGTIRQELEKYPELTLPILRKVIIDIRESKLPDPKVMGNAGSFFMNPIVPREK
LEALQQEFPRIPFYELNDGRVKIPAGWMIDQCGWKGKALGPAAVHDKQALVLVNRGGAKGSDVLALSDAVRASVRAKFGI
DIHPEVNLVGK

Sequences:

>Translated_331_residues
MYSLLSHNTFGIDVYAERFQEYASVEELKTLIAQGALTTPFLHIGGGSNLLFVKDYEGLVLHSRIEGIEVTEEDERSVAV
RVGAGVVWDDFVGYCVEHGWYGTENLSLIPGEVGASAVQNIGAYGVEVKDLITSVETVNIHGEERVYAVDECGYAYRDSI
FKRPENKSVFVTYVCFRLSKEERYTLDYGTIRQELEKYPELTLPILRKVIIDIRESKLPDPKVMGNAGSFFMNPIVPREK
LEALQQEFPRIPFYELNDGRVKIPAGWMIDQCGWKGKALGPAAVHDKQALVLVNRGGAKGSDVLALSDAVRASVRAKFGI
DIHPEVNLVGK
>Mature_331_residues
MYSLLSHNTFGIDVYAERFQEYASVEELKTLIAQGALTTPFLHIGGGSNLLFVKDYEGLVLHSRIEGIEVTEEDERSVAV
RVGAGVVWDDFVGYCVEHGWYGTENLSLIPGEVGASAVQNIGAYGVEVKDLITSVETVNIHGEERVYAVDECGYAYRDSI
FKRPENKSVFVTYVCFRLSKEERYTLDYGTIRQELEKYPELTLPILRKVIIDIRESKLPDPKVMGNAGSFFMNPIVPREK
LEALQQEFPRIPFYELNDGRVKIPAGWMIDQCGWKGKALGPAAVHDKQALVLVNRGGAKGSDVLALSDAVRASVRAKFGI
DIHPEVNLVGK

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

Organism=Escherichia coli, GI1790407, Length=335, Percent_Identity=43.2835820895522, Blast_Score=244, Evalue=6e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_BACTN (Q8A806)

Other databases:

- EMBL:   AE015928
- RefSeq:   NP_810281.1
- ProteinModelPortal:   Q8A806
- SMR:   Q8A806
- GeneID:   1073012
- GenomeReviews:   AE015928_GR
- KEGG:   bth:BT_1368
- NMPDR:   fig|226186.1.peg.1368
- HOGENOM:   HBG686573
- OMA:   GAAPMQN
- PhylomeDB:   Q8A806
- ProtClustDB:   PRK00046
- BioCyc:   BTHE226186:BT_1368-MONOMER
- BRENDA:   1.1.1.158
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 36834; Mature: 36834

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 157-157 ACT_SITE 229-229 ACT_SITE 325-325

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSLLSHNTFGIDVYAERFQEYASVEELKTLIAQGALTTPFLHIGGGSNLLFVKDYEGLV
CCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEECCCCEE
LHSRIEGIEVTEEDERSVAVRVGAGVVWDDFVGYCVEHGWYGTENLSLIPGEVGASAVQN
EEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHH
IGAYGVEVKDLITSVETVNIHGEERVYAVDECGYAYRDSIFKRPENKSVFVTYVCFRLSK
CCCCCCCHHHHHHHHEEEEECCCCEEEEEHHCCCHHHHHHHCCCCCCCEEEEEEEECCCC
EERYTLDYGTIRQELEKYPELTLPILRKVIIDIRESKLPDPKVMGNAGSFFMNPIVPREK
CCCEEECHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCEECCCCCCHHH
LEALQQEFPRIPFYELNDGRVKIPAGWMIDQCGWKGKALGPAAVHDKQALVLVNRGGAKG
HHHHHHHCCCCCEEECCCCEEEECCCCEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCC
SDVLALSDAVRASVRAKFGIDIHPEVNLVGK
CCEEEEHHHHHHHHHHEECCEECCCCEECCC
>Mature Secondary Structure
MYSLLSHNTFGIDVYAERFQEYASVEELKTLIAQGALTTPFLHIGGGSNLLFVKDYEGLV
CCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEECCCCEE
LHSRIEGIEVTEEDERSVAVRVGAGVVWDDFVGYCVEHGWYGTENLSLIPGEVGASAVQN
EEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHH
IGAYGVEVKDLITSVETVNIHGEERVYAVDECGYAYRDSIFKRPENKSVFVTYVCFRLSK
CCCCCCCHHHHHHHHEEEEECCCCEEEEEHHCCCHHHHHHHCCCCCCCEEEEEEEECCCC
EERYTLDYGTIRQELEKYPELTLPILRKVIIDIRESKLPDPKVMGNAGSFFMNPIVPREK
CCCEEECHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCEECCCCCCHHH
LEALQQEFPRIPFYELNDGRVKIPAGWMIDQCGWKGKALGPAAVHDKQALVLVNRGGAKG
HHHHHHHCCCCCEEECCCCEEEECCCCEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCC
SDVLALSDAVRASVRAKFGIDIHPEVNLVGK
CCEEEEHHHHHHHHHHEECCEECCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663928