Click here to switch to the map view.

The map label for this gene is coaBC [H]

Identifier: 29346772

GI number: 29346772

Start: 1689941

End: 1691143

Strand: Reverse

Name: coaBC [H]

Synonym: BT_1362

Alternate gene names: 29346772

Gene position: 1691143-1689941 (Counterclockwise)

Preceding gene: 29346773

Following gene: 29346771

Centisome position: 27.01

GC content: 49.63

Gene sequence:

>1203_bases
ATGCTAAAAGGAAAAAAGATAATTCTTGGAATAACCGGTAGCATCGCTGCTTATAAGGCTTGTTACATTATCCGCGGACT
GATAAAGCAGGGAGCGGAAGTGCAGGTGGTCATTACTCCGGCGGGAAAAGAATTTATTACTCCCATCACTCTTTCGGCTT
TGACCAGTAAGCCGGTCATCAGCGAGTTTTTTGCCCAACGGGACGGTACGTGGAACAGCCATGTGGACTTGGGTCTGTGG
GCGGATGCCATGCTGATCGCACCCGCTACCGCCTCCACCATCGGAAAGATGGCGAACGGGATAGCAGACAATATGCTGAT
AACCACTTATCTTTCGGCCAAAGCTCCGGTATTCATTGCACCGGCTATGGACCTCGATATGTATGCACATCCTTCTACAC
AGAAGAATCTGGATATATTGCGTTCCTATGGCAACCGCATCATTGAGCCCGCAACGGGTGAACTTGCCAGCCATCTGGTC
GGTAAAGGGCGTATGGAAGAACCGGAAAACATTATCCGAGTGCTGGACGAGTTTTTCTCTGCGAGTGCCGAACTTCAGGG
AAGGAAAATTATGATAACTGCCGGACCGACTTACGAAAAGATCGATCCGGTCCGTTTTATCGGCAATTATTCTTCCGGTA
AGATGGGATTTGCTTTGGCGGAAGAATGTGCCCGTCGTGGGGCAGAGGTGACATTGATCACCGGACCGGTGCAACTGAAA
ACGCAGCATTCGCGTATCCACCGGATAGATGTGGAATCTGCTCAGGAAATGTATGAGGCAGCGCAAACCTGTTTCCCGAC
TTCCGACGTGGGGATTCTTTGTGCGGCAGTCGCCGATTTCCGCCCGGAAACGGTGGCCGGCAAAAAGATCAAACGGGAGA
AGGAAGAAGAACTGACCTTGCATCTTCAGGCTACGCAGGACATTGCTGCAAGTCTGGGAAAGATCAAAGAAGACAATCAA
CTGTTAGTGGGGTTTGCCCTCGAAACAAATAACGAACAGCAGAATGCCGAAGGAAAGCTCGAACGTAAAAACTTTGACTT
TATCGTCCTCAACTCTCTGAATGATGCGGGAGCCGGCTTCCGTCACGATACAAACAAGATTAGCATTATTGATCGCAAAG
GTCGCGAGGATTATCCTCTGAAGCCCAAACAGGAAGTAGCGCAAGACATCATCAACCATCTGGTTGCCGTTTTGACTCAC
TGA

Upstream 100 bases:

>100_bases
GATACTACAGCTGGATTTTAAACAGTGATTTCACGTTGAATACCAAGGCGGTGCTGACTAAAATCCGTCTGCGTGAAATG
AGTAATTTGATTACAAAATA

Downstream 100 bases:

>100_bases
TCTTTATTTTTTAGGTTTAATTTTTAATTTACAGAAGGTGTTACGTTCACTTTATATTCAGAATTACGCATTGATAGAAA
AACTGGATATCGGTTTTGAA

Product: flavoprotein

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MLKGKKIILGITGSIAAYKACYIIRGLIKQGAEVQVVITPAGKEFITPITLSALTSKPVISEFFAQRDGTWNSHVDLGLW
ADAMLIAPATASTIGKMANGIADNMLITTYLSAKAPVFIAPAMDLDMYAHPSTQKNLDILRSYGNRIIEPATGELASHLV
GKGRMEEPENIIRVLDEFFSASAELQGRKIMITAGPTYEKIDPVRFIGNYSSGKMGFALAEECARRGAEVTLITGPVQLK
TQHSRIHRIDVESAQEMYEAAQTCFPTSDVGILCAAVADFRPETVAGKKIKREKEEELTLHLQATQDIAASLGKIKEDNQ
LLVGFALETNNEQQNAEGKLERKNFDFIVLNSLNDAGAGFRHDTNKISIIDRKGREDYPLKPKQEVAQDIINHLVAVLTH

Sequences:

>Translated_400_residues
MLKGKKIILGITGSIAAYKACYIIRGLIKQGAEVQVVITPAGKEFITPITLSALTSKPVISEFFAQRDGTWNSHVDLGLW
ADAMLIAPATASTIGKMANGIADNMLITTYLSAKAPVFIAPAMDLDMYAHPSTQKNLDILRSYGNRIIEPATGELASHLV
GKGRMEEPENIIRVLDEFFSASAELQGRKIMITAGPTYEKIDPVRFIGNYSSGKMGFALAEECARRGAEVTLITGPVQLK
TQHSRIHRIDVESAQEMYEAAQTCFPTSDVGILCAAVADFRPETVAGKKIKREKEEELTLHLQATQDIAASLGKIKEDNQ
LLVGFALETNNEQQNAEGKLERKNFDFIVLNSLNDAGAGFRHDTNKISIIDRKGREDYPLKPKQEVAQDIINHLVAVLTH
>Mature_400_residues
MLKGKKIILGITGSIAAYKACYIIRGLIKQGAEVQVVITPAGKEFITPITLSALTSKPVISEFFAQRDGTWNSHVDLGLW
ADAMLIAPATASTIGKMANGIADNMLITTYLSAKAPVFIAPAMDLDMYAHPSTQKNLDILRSYGNRIIEPATGELASHLV
GKGRMEEPENIIRVLDEFFSASAELQGRKIMITAGPTYEKIDPVRFIGNYSSGKMGFALAEECARRGAEVTLITGPVQLK
TQHSRIHRIDVESAQEMYEAAQTCFPTSDVGILCAAVADFRPETVAGKKIKREKEEELTLHLQATQDIAASLGKIKEDNQ
LLVGFALETNNEQQNAEGKLERKNFDFIVLNSLNDAGAGFRHDTNKISIIDRKGREDYPLKPKQEVAQDIINHLVAVLTH

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=189, Percent_Identity=32.2751322751323, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI87082301, Length=396, Percent_Identity=41.9191919191919, Blast_Score=287, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17560194, Length=171, Percent_Identity=31.5789473684211, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322762, Length=204, Percent_Identity=30.3921568627451, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24657262, Length=189, Percent_Identity=33.8624338624339, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43808; Mature: 43808

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKGKKIILGITGSIAAYKACYIIRGLIKQGAEVQVVITPAGKEFITPITLSALTSKPVI
CCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEHHHHCCCHHH
SEFFAQRDGTWNSHVDLGLWADAMLIAPATASTIGKMANGIADNMLITTYLSAKAPVFIA
HHHHHHCCCCCCCCEEEEECCCEEEECCCHHHHHHHHHHHHHCCEEEEEECCCCCCEEEE
PAMDLDMYAHPSTQKNLDILRSYGNRIIEPATGELASHLVGKGRMEEPENIIRVLDEFFS
CCCCCCEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
ASAELQGRKIMITAGPTYEKIDPVRFIGNYSSGKMGFALAEECARRGAEVTLITGPVQLK
CCCCCCCCEEEEEECCCCHHCCCEEEECCCCCCCCHHHHHHHHHHCCCEEEEEECCEEEE
TQHSRIHRIDVESAQEMYEAAQTCFPTSDVGILCAAVADFRPETVAGKKIKREKEEELTL
ECCCCEEEECHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHHCCCCCEEE
HLQATQDIAASLGKIKEDNQLLVGFALETNNEQQNAEGKLERKNFDFIVLNSLNDAGAGF
EEEEHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCEECCCCCEEEEECCCCCCCCC
RHDTNKISIIDRKGREDYPLKPKQEVAQDIINHLVAVLTH
CCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLKGKKIILGITGSIAAYKACYIIRGLIKQGAEVQVVITPAGKEFITPITLSALTSKPVI
CCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEHHHHCCCHHH
SEFFAQRDGTWNSHVDLGLWADAMLIAPATASTIGKMANGIADNMLITTYLSAKAPVFIA
HHHHHHCCCCCCCCEEEEECCCEEEECCCHHHHHHHHHHHHHCCEEEEEECCCCCCEEEE
PAMDLDMYAHPSTQKNLDILRSYGNRIIEPATGELASHLVGKGRMEEPENIIRVLDEFFS
CCCCCCEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
ASAELQGRKIMITAGPTYEKIDPVRFIGNYSSGKMGFALAEECARRGAEVTLITGPVQLK
CCCCCCCCEEEEEECCCCHHCCCEEEECCCCCCCCHHHHHHHHHHCCCEEEEEECCEEEE
TQHSRIHRIDVESAQEMYEAAQTCFPTSDVGILCAAVADFRPETVAGKKIKREKEEELTL
ECCCCEEEECHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHHCCCCCEEE
HLQATQDIAASLGKIKEDNQLLVGFALETNNEQQNAEGKLERKNFDFIVLNSLNDAGAGF
EEEEHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCEECCCCCEEEEECCCCCCCCC
RHDTNKISIIDRKGREDYPLKPKQEVAQDIINHLVAVLTH
CCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]