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The map label for this gene is thiD [H]

Identifier: 29346200

GI number: 29346200

Start: 979495

End: 980331

Strand: Reverse

Name: thiD [H]

Synonym: BT_0790

Alternate gene names: 29346200

Gene position: 980331-979495 (Counterclockwise)

Preceding gene: 29346205

Following gene: 29346199

Centisome position: 15.66

GC content: 46.48

Gene sequence:

>837_bases
ATGGAACGTCATCCCGTCATTTTATCCATTGCCGGTTCCGATTGTTCGGGAGGAGCGGGCATTCAGGCAGATATCAAAAC
AATCTCGGCATTAGGAGGCTATGCGGCATCTGCTATCACCGCCGTCACTGTGCAAAACACTCTAGGGGTACGCGCCGTCC
ATGCAATACCACCCGAAATTGTTTGCGGACAAATCGAAGCGGTGATGGAGGACTTGCAGCCTGTCGCTATAAAAATAGGC
ATGGTTAACGATATTCAGATCGTTCATGTCATTGCCGACTGTATACGGAAATATTCACCGGAGCACATCATTTATGACCC
GGTGATGGTATCTACCAGCGGCCGGAAGCTGATGACAAATGAAGCCATCGAAGAGATTAAGAAAGAACTTTTGCCGCTTG
TCACATTAGTCACCCCCAATATCGATGAAGCAAAGGTGCTGACAGGCAAGAGCATCCAAAATACACAGGATATGCTGGAA
GCTGCCAAACAACTCTCCGACAGTTATCAGATCCATATCCTGATCAAAGGCGGACATCTGGAAGGCGATCAAATGTGCGA
CCTCTTATATTCTCCGGATCACACCTATTATATATATGAAGAGAAAAAGATAGAAAGTAAAAACCTGCATGGGACCGGGT
GTACCCTCTCCTCCGCTATTGCAAGCTATCTGGCAAAAGGATATTCGATGAAAGAATCCATCCGTCACGCTAAAGAATAC
ATTACTCATGCCATCATTGCAGGCAAGGACTTGAATATAGGCCATGGCAACGGACCTCTGTGGCATTTTCCCGACTCCAT
TGCACAAATGTGTACATTTTGTGCGGTCGTATCATAA

Upstream 100 bases:

>100_bases
TCTTCTCCGGCAACGGACTTATTGTATTTCAAACGATATCCCATTTTGTATCTTGCCGTTTTTATTCTATCTTTGCCGGA
TAAATATTAAAAAATCTAAA

Downstream 100 bases:

>100_bases
AAATCTGTAACTTTGCACCCGCATTTAAAAATCAATTAAATAATAAAGATATGAAAGCATTTGTATTTCCCGGTCAAGGT
GCTCAGTTCGTAGGAATGGG

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MERHPVILSIAGSDCSGGAGIQADIKTISALGGYAASAITAVTVQNTLGVRAVHAIPPEIVCGQIEAVMEDLQPVAIKIG
MVNDIQIVHVIADCIRKYSPEHIIYDPVMVSTSGRKLMTNEAIEEIKKELLPLVTLVTPNIDEAKVLTGKSIQNTQDMLE
AAKQLSDSYQIHILIKGGHLEGDQMCDLLYSPDHTYYIYEEKKIESKNLHGTGCTLSSAIASYLAKGYSMKESIRHAKEY
ITHAIIAGKDLNIGHGNGPLWHFPDSIAQMCTFCAVVS

Sequences:

>Translated_278_residues
MERHPVILSIAGSDCSGGAGIQADIKTISALGGYAASAITAVTVQNTLGVRAVHAIPPEIVCGQIEAVMEDLQPVAIKIG
MVNDIQIVHVIADCIRKYSPEHIIYDPVMVSTSGRKLMTNEAIEEIKKELLPLVTLVTPNIDEAKVLTGKSIQNTQDMLE
AAKQLSDSYQIHILIKGGHLEGDQMCDLLYSPDHTYYIYEEKKIESKNLHGTGCTLSSAIASYLAKGYSMKESIRHAKEY
ITHAIIAGKDLNIGHGNGPLWHFPDSIAQMCTFCAVVS
>Mature_278_residues
MERHPVILSIAGSDCSGGAGIQADIKTISALGGYAASAITAVTVQNTLGVRAVHAIPPEIVCGQIEAVMEDLQPVAIKIG
MVNDIQIVHVIADCIRKYSPEHIIYDPVMVSTSGRKLMTNEAIEEIKKELLPLVTLVTPNIDEAKVLTGKSIQNTQDMLE
AAKQLSDSYQIHILIKGGHLEGDQMCDLLYSPDHTYYIYEEKKIESKNLHGTGCTLSSAIASYLAKGYSMKESIRHAKEY
ITHAIIAGKDLNIGHGNGPLWHFPDSIAQMCTFCAVVS

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=257, Percent_Identity=39.2996108949416, Blast_Score=201, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6325378, Length=261, Percent_Identity=36.0153256704981, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324997, Length=274, Percent_Identity=36.1313868613139, Blast_Score=142, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6324517, Length=274, Percent_Identity=35.4014598540146, Blast_Score=141, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 30127; Mature: 30127

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERHPVILSIAGSDCSGGAGIQADIKTISALGGYAASAITAVTVQNTLGVRAVHAIPPEI
CCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHEEEEECCCCCEEEEECCCHHH
VCGQIEAVMEDLQPVAIKIGMVNDIQIVHVIADCIRKYSPEHIIYDPVMVSTSGRKLMTN
HHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEECCEEEECCCCCHHHH
EAIEEIKKELLPLVTLVTPNIDEAKVLTGKSIQNTQDMLEAAKQLSDSYQIHILIKGGHL
HHHHHHHHHHHHHHEEECCCCCCCEEECCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCC
EGDQMCDLLYSPDHTYYIYEEKKIESKNLHGTGCTLSSAIASYLAKGYSMKESIRHAKEY
CHHHHHHHEECCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
ITHAIIAGKDLNIGHGNGPLWHFPDSIAQMCTFCAVVS
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MERHPVILSIAGSDCSGGAGIQADIKTISALGGYAASAITAVTVQNTLGVRAVHAIPPEI
CCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHEEEEECCCCCEEEEECCCHHH
VCGQIEAVMEDLQPVAIKIGMVNDIQIVHVIADCIRKYSPEHIIYDPVMVSTSGRKLMTN
HHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEECCEEEECCCCCHHHH
EAIEEIKKELLPLVTLVTPNIDEAKVLTGKSIQNTQDMLEAAKQLSDSYQIHILIKGGHL
HHHHHHHHHHHHHHEEECCCCCCCEEECCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCC
EGDQMCDLLYSPDHTYYIYEEKKIESKNLHGTGCTLSSAIASYLAKGYSMKESIRHAKEY
CHHHHHHHEECCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
ITHAIIAGKDLNIGHGNGPLWHFPDSIAQMCTFCAVVS
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481431; 8246891 [H]