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The map label for this gene is cusR [H]

Identifier: 29346092

GI number: 29346092

Start: 846392

End: 847129

Strand: Reverse

Name: cusR [H]

Synonym: BT_0682

Alternate gene names: 29346092

Gene position: 847129-846392 (Counterclockwise)

Preceding gene: 29346094

Following gene: 29346091

Centisome position: 13.53

GC content: 44.04

Gene sequence:

>738_bases
ATGCCGTTTTTCTTTCTTCGGATGCAAAGAAAAAGTATCTTTGCATCTAAACAATGTAGATTTATGGCAAAGATACTATT
AGCAGAAGATGAAGTCAATATCGCCTCCTTTATCGAACGGGGACTGAAAGAGTTCGGACATTCGGTAACAGTCTGTCATG
ACGGAAATACGGGTTGGAGAATCCTTCAGGAAGAACCTTTCGACCTTGTAATCCTGGATATTATCATGCCGAAAATAAAC
GGGCTCGAACTTTGCCATCTCTATCGGCAGATGTTCGGTTACCAGGCACCGGTCATTATGCTGACGGCTTTAGGCACTAC
GGAAGACATTGTAAAAGGACTGGATGCAGGAGCAGACGATTATCTTGTCAAGCCTTTCAGTTTTCAGGAACTGGAAGCAC
GTATCAAGGCGCTGCTGCGACGAAACAAGGAGACTGTAACCAATCAACTGACTTGCGACAATCTGGTATTGGACTGTAAC
ACCAGACGGGCGAAAAGAGGTGATGCGGATATCGATCTCACCGTAAAAGAATACCGTCTGCTCGAATATTTCATGACTCA
CCAAGGGGTAGCCTTATCGCGCATTACGCTGCTCAAAGACGTATGGGACAAGAACTTTGATACGAATACCAACATCGTAG
ACGTATACGTCAATTATCTGCGGGTAAAGATAGACCGTGACTTCGACAAGAAACTGATTCATACAGTAGTAGGATTAGGA
TATATCATGAATGCCTGA

Upstream 100 bases:

>100_bases
CCCAGCACACACAGAAAAGCTCCAACTAAATGTTTTACTTTCATAGTATAATCGTCTGTTTATATATAATACAGTTCAGA
AAGGAGAAACACTTAAATGT

Downstream 100 bases:

>100_bases
ACATCCATCAAACAAATCCGTGTATGAAAATAGGTTCTAAAATAGCTCTCTTCTATACGTTGCTCAGTGTACTGACAACT
ATCATCATTATCGCCGTATT

Product: two-component system response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MPFFFLRMQRKSIFASKQCRFMAKILLAEDEVNIASFIERGLKEFGHSVTVCHDGNTGWRILQEEPFDLVILDIIMPKIN
GLELCHLYRQMFGYQAPVIMLTALGTTEDIVKGLDAGADDYLVKPFSFQELEARIKALLRRNKETVTNQLTCDNLVLDCN
TRRAKRGDADIDLTVKEYRLLEYFMTHQGVALSRITLLKDVWDKNFDTNTNIVDVYVNYLRVKIDRDFDKKLIHTVVGLG
YIMNA

Sequences:

>Translated_245_residues
MPFFFLRMQRKSIFASKQCRFMAKILLAEDEVNIASFIERGLKEFGHSVTVCHDGNTGWRILQEEPFDLVILDIIMPKIN
GLELCHLYRQMFGYQAPVIMLTALGTTEDIVKGLDAGADDYLVKPFSFQELEARIKALLRRNKETVTNQLTCDNLVLDCN
TRRAKRGDADIDLTVKEYRLLEYFMTHQGVALSRITLLKDVWDKNFDTNTNIVDVYVNYLRVKIDRDFDKKLIHTVVGLG
YIMNA
>Mature_244_residues
PFFFLRMQRKSIFASKQCRFMAKILLAEDEVNIASFIERGLKEFGHSVTVCHDGNTGWRILQEEPFDLVILDIIMPKING
LELCHLYRQMFGYQAPVIMLTALGTTEDIVKGLDAGADDYLVKPFSFQELEARIKALLRRNKETVTNQLTCDNLVLDCNT
RRAKRGDADIDLTVKEYRLLEYFMTHQGVALSRITLLKDVWDKNFDTNTNIVDVYVNYLRVKIDRDFDKKLIHTVVGLGY
IMNA

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=44.3438914027149, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=38.9908256880734, Blast_Score=160, Evalue=7e-41,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=37.10407239819, Blast_Score=140, Evalue=9e-35,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=36.3636363636364, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=35.5855855855856, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=33.0396475770925, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=37.6623376623377, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=32.7354260089686, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1787375, Length=219, Percent_Identity=29.6803652968037, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=30.9734513274336, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=33.1858407079646, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=31.0043668122271, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=31.4410480349345, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=27.7777777777778, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790437, Length=115, Percent_Identity=28.695652173913, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1787487, Length=102, Percent_Identity=35.2941176470588, Blast_Score=61, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=109, Percent_Identity=30.2752293577982, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 28296; Mature: 28165

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFFFLRMQRKSIFASKQCRFMAKILLAEDEVNIASFIERGLKEFGHSVTVCHDGNTGWR
CCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCE
ILQEEPFDLVILDIIMPKINGLELCHLYRQMFGYQAPVIMLTALGTTEDIVKGLDAGADD
EEECCCCCEEEEEHHHCCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCCCCCC
YLVKPFSFQELEARIKALLRRNKETVTNQLTCDNLVLDCNTRRAKRGDADIDLTVKEYRL
CEECCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEHHHHHH
LEYFMTHQGVALSRITLLKDVWDKNFDTNTNIVDVYVNYLRVKIDRDFDKKLIHTVVGLG
HHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHEEEHHHEEECCCHHHHHHHHHHHHH
YIMNA
HHHCC
>Mature Secondary Structure 
PFFFLRMQRKSIFASKQCRFMAKILLAEDEVNIASFIERGLKEFGHSVTVCHDGNTGWR
CEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCE
ILQEEPFDLVILDIIMPKINGLELCHLYRQMFGYQAPVIMLTALGTTEDIVKGLDAGADD
EEECCCCCEEEEEHHHCCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCCCCCC
YLVKPFSFQELEARIKALLRRNKETVTNQLTCDNLVLDCNTRRAKRGDADIDLTVKEYRL
CEECCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEHHHHHH
LEYFMTHQGVALSRITLLKDVWDKNFDTNTNIVDVYVNYLRVKIDRDFDKKLIHTVVGLG
HHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHEEEHHHEEECCCHHHHHHHHHHHHH
YIMNA
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]