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The map label for this gene is arlS [H]

Identifier: 29346091

GI number: 29346091

Start: 845037

End: 846368

Strand: Reverse

Name: arlS [H]

Synonym: BT_0681

Alternate gene names: 29346091

Gene position: 846368-845037 (Counterclockwise)

Preceding gene: 29346092

Following gene: 29346087

Centisome position: 13.52

GC content: 43.32

Gene sequence:

>1332_bases
ATGAAAATAGGTTCTAAAATAGCTCTCTTCTATACGTTGCTCAGTGTACTGACAACTATCATCATTATCGCCGTATTCTA
TCTTTTCAGCACACAGTTTATCAATAAACTCTATGCCTCCTATCTTCGTGAAAAAGCATATCTGACCGCACAAAAGCACT
GGGAGAAAGACGAAATAGACGAACAGAGTTACCAGATTATCCAGCGCAAATATGACGAACTCTTGCCCGAAGCTCATGAG
ATTCTTTTAAATATGGACAGTCTCTCCGAAGTCCGTGACACACTGAACAAATATCTGACCCAGCATCAGCAGGCACTCCT
GATAGCCGGTGAAGACAGCGTCCCTTTTTCTTTTAAATACAAAGACCAGTTGGGAGCCGCCCTTTATTATCCCGATAATG
AAGGAAATTTCATCGTCCTCGTCATGTCCCGGAATGTGTACGGTGCAGAAATCAAAGAACACCTCTTGCTTCTCTCCATC
TTTCTGGTTTTATTCAGTTCCATCCTGATTTATTTAGTCGGGAAAATCTATTCCGGCCGTATTCTTATCCCCCTGCAGCA
TATACTGAAGGAGCTGAAGAGGATACGAGCCAACAGTCTGAACCGCCGGTTAAAGACGACCGGAAACAACGATGAACTGG
AAGACATGATCGAAACACTGAATAGCATGCTCGACCGTCTGGACAGTGCTTTCAAAGCTGAAAAGTCCTTTGTCAGCCAT
GCTTCGCATGAACTGAACAACCCCATAACCGCCATACAGGGAGAATGTGAAATCAGTCTGCTGAAAGAAAGAAGTACCGG
AGAATATATCGAAGCCCTGCAACGAATCTCATCCGAAAGCAAGCGAATCTCCAATCTGATCCGCCATCTTCTTTTCCTTT
CACGTCAGGATGAAGAGCTCATAAAAAGCAATATGGAGGCAATGTCTCTGCCGGATATGCTGAATGACTTAATAAAAATG
AACGAACGAATCCGTCTCCATTATCAAGAAACAGGTAAGGCTGCCACTGTAAAGGCCAATCCTTATCTGCTCAAAATAGC
TTTAAAGAATATCATCGATAATGCCTGCAAATATTCTGAAAAGGAAGTAGACATTACGCTCAGCCAAAAAGATCAACACC
TCGTTCTTGAAATAAAAGATCAGGGCATCGGCATTCCTCCGGAAGAAATAGAACATATATTCCAGTCTTTCTATCGGGGC
AGCAACACACATGACTATGCAGGTCAGGGCATCGGCCTCAGCCTGACGCAGAAAATAGTATCTGCCTACAACGCCAGACT
GGAAATATCTTCGGAAATAGAAAAAGGAACAAAAGTACGGGTGATCTTCTGA

Upstream 100 bases:

>100_bases
GGGTAAAGATAGACCGTGACTTCGACAAGAAACTGATTCATACAGTAGTAGGATTAGGATATATCATGAATGCCTGAACA
TCCATCAAACAAATCCGTGT

Downstream 100 bases:

>100_bases
TTCAACCGACTTTTGTCCCTTCCTCACTTCTACCTACTGAAAACGAAATTAAAATTTAATCTATGCCGTTTCTTTCATAG
AAAGAATAGAAAATGAATTA

Product: two-component system sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MKIGSKIALFYTLLSVLTTIIIIAVFYLFSTQFINKLYASYLREKAYLTAQKHWEKDEIDEQSYQIIQRKYDELLPEAHE
ILLNMDSLSEVRDTLNKYLTQHQQALLIAGEDSVPFSFKYKDQLGAALYYPDNEGNFIVLVMSRNVYGAEIKEHLLLLSI
FLVLFSSILIYLVGKIYSGRILIPLQHILKELKRIRANSLNRRLKTTGNNDELEDMIETLNSMLDRLDSAFKAEKSFVSH
ASHELNNPITAIQGECEISLLKERSTGEYIEALQRISSESKRISNLIRHLLFLSRQDEELIKSNMEAMSLPDMLNDLIKM
NERIRLHYQETGKAATVKANPYLLKIALKNIIDNACKYSEKEVDITLSQKDQHLVLEIKDQGIGIPPEEIEHIFQSFYRG
SNTHDYAGQGIGLSLTQKIVSAYNARLEISSEIEKGTKVRVIF

Sequences:

>Translated_443_residues
MKIGSKIALFYTLLSVLTTIIIIAVFYLFSTQFINKLYASYLREKAYLTAQKHWEKDEIDEQSYQIIQRKYDELLPEAHE
ILLNMDSLSEVRDTLNKYLTQHQQALLIAGEDSVPFSFKYKDQLGAALYYPDNEGNFIVLVMSRNVYGAEIKEHLLLLSI
FLVLFSSILIYLVGKIYSGRILIPLQHILKELKRIRANSLNRRLKTTGNNDELEDMIETLNSMLDRLDSAFKAEKSFVSH
ASHELNNPITAIQGECEISLLKERSTGEYIEALQRISSESKRISNLIRHLLFLSRQDEELIKSNMEAMSLPDMLNDLIKM
NERIRLHYQETGKAATVKANPYLLKIALKNIIDNACKYSEKEVDITLSQKDQHLVLEIKDQGIGIPPEEIEHIFQSFYRG
SNTHDYAGQGIGLSLTQKIVSAYNARLEISSEIEKGTKVRVIF
>Mature_443_residues
MKIGSKIALFYTLLSVLTTIIIIAVFYLFSTQFINKLYASYLREKAYLTAQKHWEKDEIDEQSYQIIQRKYDELLPEAHE
ILLNMDSLSEVRDTLNKYLTQHQQALLIAGEDSVPFSFKYKDQLGAALYYPDNEGNFIVLVMSRNVYGAEIKEHLLLLSI
FLVLFSSILIYLVGKIYSGRILIPLQHILKELKRIRANSLNRRLKTTGNNDELEDMIETLNSMLDRLDSAFKAEKSFVSH
ASHELNNPITAIQGECEISLLKERSTGEYIEALQRISSESKRISNLIRHLLFLSRQDEELIKSNMEAMSLPDMLNDLIKM
NERIRLHYQETGKAATVKANPYLLKIALKNIIDNACKYSEKEVDITLSQKDQHLVLEIKDQGIGIPPEEIEHIFQSFYRG
SNTHDYAGQGIGLSLTQKIVSAYNARLEISSEIEKGTKVRVIF

Specific function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transf

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=280, Percent_Identity=26.0714285714286, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1789403, Length=354, Percent_Identity=27.9661016949153, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790346, Length=220, Percent_Identity=28.6363636363636, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1788279, Length=270, Percent_Identity=27.7777777777778, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1787374, Length=306, Percent_Identity=24.5098039215686, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790861, Length=469, Percent_Identity=22.6012793176972, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1786600, Length=218, Percent_Identity=26.605504587156, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1790551, Length=305, Percent_Identity=24.9180327868852, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1789808, Length=104, Percent_Identity=31.7307692307692, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788393, Length=258, Percent_Identity=22.8682170542636, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI145693157, Length=236, Percent_Identity=22.4576271186441, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082128, Length=305, Percent_Identity=24.9180327868852, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI48994928, Length=226, Percent_Identity=25.2212389380531, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786912, Length=216, Percent_Identity=25, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787894, Length=254, Percent_Identity=23.6220472440945, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790436, Length=212, Percent_Identity=22.6415094339623, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789149, Length=250, Percent_Identity=24.8, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1788713, Length=243, Percent_Identity=24.2798353909465, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50863; Mature: 50863

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGSKIALFYTLLSVLTTIIIIAVFYLFSTQFINKLYASYLREKAYLTAQKHWEKDEID
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
EQSYQIIQRKYDELLPEAHEILLNMDSLSEVRDTLNKYLTQHQQALLIAGEDSVPFSFKY
HHHHHHHHHHHHHHCHHHHHHHHCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCEEEEE
KDQLGAALYYPDNEGNFIVLVMSRNVYGAEIKEHLLLLSIFLVLFSSILIYLVGKIYSGR
HHHCCEEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
ILIPLQHILKELKRIRANSLNRRLKTTGNNDELEDMIETLNSMLDRLDSAFKAEKSFVSH
EEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASHELNNPITAIQGECEISLLKERSTGEYIEALQRISSESKRISNLIRHLLFLSRQDEEL
HHHHHCCCCEEECCCCCEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IKSNMEAMSLPDMLNDLIKMNERIRLHYQETGKAATVKANPYLLKIALKNIIDNACKYSE
HHCCCHHHCCHHHHHHHHHCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHCCCC
KEVDITLSQKDQHLVLEIKDQGIGIPPEEIEHIFQSFYRGSNTHDYAGQGIGLSLTQKIV
CCEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
SAYNARLEISSEIEKGTKVRVIF
HHHCCCEEEHHHHCCCCEEEEEC
>Mature Secondary Structure
MKIGSKIALFYTLLSVLTTIIIIAVFYLFSTQFINKLYASYLREKAYLTAQKHWEKDEID
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
EQSYQIIQRKYDELLPEAHEILLNMDSLSEVRDTLNKYLTQHQQALLIAGEDSVPFSFKY
HHHHHHHHHHHHHHCHHHHHHHHCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCEEEEE
KDQLGAALYYPDNEGNFIVLVMSRNVYGAEIKEHLLLLSIFLVLFSSILIYLVGKIYSGR
HHHCCEEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
ILIPLQHILKELKRIRANSLNRRLKTTGNNDELEDMIETLNSMLDRLDSAFKAEKSFVSH
EEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASHELNNPITAIQGECEISLLKERSTGEYIEALQRISSESKRISNLIRHLLFLSRQDEEL
HHHHHCCCCEEECCCCCEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IKSNMEAMSLPDMLNDLIKMNERIRLHYQETGKAATVKANPYLLKIALKNIIDNACKYSE
HHCCCHHHCCHHHHHHHHHCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHCCCC
KEVDITLSQKDQHLVLEIKDQGIGIPPEEIEHIFQSFYRGSNTHDYAGQGIGLSLTQKIV
CCEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
SAYNARLEISSEIEKGTKVRVIF
HHHCCCEEEHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA