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The map label for this gene is trpC

Identifier: 29345939

GI number: 29345939

Start: 652452

End: 653234

Strand: Reverse

Name: trpC

Synonym: BT_0529

Alternate gene names: 29345939

Gene position: 653234-652452 (Counterclockwise)

Preceding gene: 29345940

Following gene: 29345938

Centisome position: 10.43

GC content: 44.44

Gene sequence:

>783_bases
ATGAAAGATATATTATCCGAAATTATAGCTAACAAACGGTTTGAAGTCGATTTGCAAAAGCAGGCTATTTCCATCGAACA
GTTGCAGGAAGGTATCAATGAAGTTCCGGCTTCCCGTTCTATGAAACGGGCATTGGCTTCTTCCGATTCCGGTATTATAG
CCGAATTTAAGCGTCGCTCGCCATCCAAAGGGTGGATCAAACAGGAGGCACGTCCCGAAGAAATTGTTCCGTCATACCTT
GCGGCAGGTGCTTCCGCCCTCTCTATTCTCACTGATGAGAAGTTTTTTGGAGGAAGTCTGAAAGATATTCGTACAGCACG
TCCTTTGGTCGATGTGCCCATTATAAGAAAAGACTTTATCATTGATGAGTATCAGTTATATCAGGCAAAAATTGTCGGTG
CGGATGCCGTACTTCTTATCGCCGCCGCACTGAAACAGGAAAAATGTCAGGAACTGGCAGAGCAGGCGCATGAACTGGGA
CTGGAAGTATTACTTGAAATCCATAGTGCGGAAGAGTTACCTTATATTAATAGCAAAATTGATATGATTGGGATTAATAA
TCGCAATCTGGGTACTTTCTTCACAGATGTAGAAAACTCTTTCCGACTGGCAGGACAACTTCCACAAGATGCGGTATTAG
TATCAGAGAGTGGCATTTCCGATCCGGAAGTGGTAAAACGTCTTCGGACCGCCGGATTCCGGGGATTCCTCATCGGAGAG
ACATTTATGAAAACTCCGCAACCGGGAGAAACTCTGCAGAACTTTCTGAAAGCCATCCAATAA

Upstream 100 bases:

>100_bases
CATTGAATTGAATAATAAGTAATAGGTAATAAGTTATAAATGATAAGTGGTAAAGGATGAATATGCGATATCCTTTGCCT
TGATTCTAAATTTAAGATTA

Downstream 100 bases:

>100_bases
ATATATGAACTTCCAAAAACGGACAGCCCTATGATCAACGGAAAAATCATCAAAGTATGCGGTATGCGTGAAGCCCAAAA
TATACGGGATGTGGAGTCAC

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MKDILSEIIANKRFEVDLQKQAISIEQLQEGINEVPASRSMKRALASSDSGIIAEFKRRSPSKGWIKQEARPEEIVPSYL
AAGASALSILTDEKFFGGSLKDIRTARPLVDVPIIRKDFIIDEYQLYQAKIVGADAVLLIAAALKQEKCQELAEQAHELG
LEVLLEIHSAEELPYINSKIDMIGINNRNLGTFFTDVENSFRLAGQLPQDAVLVSESGISDPEVVKRLRTAGFRGFLIGE
TFMKTPQPGETLQNFLKAIQ

Sequences:

>Translated_260_residues
MKDILSEIIANKRFEVDLQKQAISIEQLQEGINEVPASRSMKRALASSDSGIIAEFKRRSPSKGWIKQEARPEEIVPSYL
AAGASALSILTDEKFFGGSLKDIRTARPLVDVPIIRKDFIIDEYQLYQAKIVGADAVLLIAAALKQEKCQELAEQAHELG
LEVLLEIHSAEELPYINSKIDMIGINNRNLGTFFTDVENSFRLAGQLPQDAVLVSESGISDPEVVKRLRTAGFRGFLIGE
TFMKTPQPGETLQNFLKAIQ
>Mature_260_residues
MKDILSEIIANKRFEVDLQKQAISIEQLQEGINEVPASRSMKRALASSDSGIIAEFKRRSPSKGWIKQEARPEEIVPSYL
AAGASALSILTDEKFFGGSLKDIRTARPLVDVPIIRKDFIIDEYQLYQAKIVGADAVLLIAAALKQEKCQELAEQAHELG
LEVLLEIHSAEELPYINSKIDMIGINNRNLGTFFTDVENSFRLAGQLPQDAVLVSESGISDPEVVKRLRTAGFRGFLIGE
TFMKTPQPGETLQNFLKAIQ

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=245, Percent_Identity=37.5510204081633, Blast_Score=138, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6322638, Length=259, Percent_Identity=34.7490347490347, Blast_Score=144, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_BACTN (Q8AAD6)

Other databases:

- EMBL:   AE015928
- RefSeq:   NP_809442.1
- ProteinModelPortal:   Q8AAD6
- SMR:   Q8AAD6
- GeneID:   1071979
- GenomeReviews:   AE015928_GR
- KEGG:   bth:BT_0529
- NMPDR:   fig|226186.1.peg.529
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- PhylomeDB:   Q8AAD6
- ProtClustDB:   PRK00278
- BioCyc:   BTHE226186:BT_0529-MONOMER
- BRENDA:   4.1.1.48
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28828; Mature: 28828

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDILSEIIANKRFEVDLQKQAISIEQLQEGINEVPASRSMKRALASSDSGIIAEFKRRS
CHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHCC
PSKGWIKQEARPEEIVPSYLAAGASALSILTDEKFFGGSLKDIRTARPLVDVPIIRKDFI
CCCCCHHCCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCHHHHHH
IDEYQLYQAKIVGADAVLLIAAALKQEKCQELAEQAHELGLEVLLEIHSAEELPYINSKI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
DMIGINNRNLGTFFTDVENSFRLAGQLPQDAVLVSESGISDPEVVKRLRTAGFRGFLIGE
EEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECH
TFMKTPQPGETLQNFLKAIQ
HHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MKDILSEIIANKRFEVDLQKQAISIEQLQEGINEVPASRSMKRALASSDSGIIAEFKRRS
CHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHCC
PSKGWIKQEARPEEIVPSYLAAGASALSILTDEKFFGGSLKDIRTARPLVDVPIIRKDFI
CCCCCHHCCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCHHHHHH
IDEYQLYQAKIVGADAVLLIAAALKQEKCQELAEQAHELGLEVLLEIHSAEELPYINSKI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
DMIGINNRNLGTFFTDVENSFRLAGQLPQDAVLVSESGISDPEVVKRLRTAGFRGFLIGE
EEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECH
TFMKTPQPGETLQNFLKAIQ
HHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663928