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The map label for this gene is mro [H]

Identifier: 29345782

GI number: 29345782

Start: 458002

End: 459099

Strand: Reverse

Name: mro [H]

Synonym: BT_0372

Alternate gene names: 29345782

Gene position: 459099-458002 (Counterclockwise)

Preceding gene: 29345811

Following gene: 29345781

Centisome position: 7.33

GC content: 46.17

Gene sequence:

>1098_bases
ATGAATAACACATTCCCAACGGAAGGGAATCTATCAGGGCTCAGCCGGAAAGATTTCCAAAAGGAGATAAATAATAAAGA
AACTGATTTATTTATCCTCAAAAATAAAAAGGGAATGGAAGTCGCCGTAACTAATTACGGATGCGCCATTCTCGCTATCA
TGGTACCGGATAAAGATGGAAAATATGCAAACGTTGTCCTCGGACACGACAGCATAGACCACGTTGTCAACAGCCCGGAA
CCCTTCCTCAGCACTACTATCGGACGCTATGGCAACCGCATCGCCAAAGGAAAATTCACATTGTACGGAGAAGAGCACGA
GCTCACCATCAACAACGGACCCAACTCCCTGCACGGAGGACCTACCGGTTTTCACGCCCGCGTTTGGGATGCCGACCAAC
TGGCTGAAAATATAATCCAGTTCAATTATGTTTCAGCCGACGGCGAAGAAGGTTTCCCCGGCAATCTGGAGGTTGAAATG
GTTTATCGCCTGGAAGAAGAAGAAAATGCACTGGTAATCGAATATCGTGCCACAACTGACAAAGCTACTGTAGTCAACCT
GACCAATCACGGTTTCTTCAATCTGGCTGGTATCAGCAATCCTACTCCTACTATCGAAAACAATATTGTTACTATCAACG
CTAATTTCTACACGCCTATCGATGAAGTTTCTATCCCAACCGGAGAAGTTGCCAAAGTAGAAGGTACTCCAATGGACTTC
ACCACTCCGCATACCGTAGGCGAACGTATCAACGATAAATTCCAACAACTGATTAACGGTGCCGGATACGACCACTGCTA
CGTACTGAACAAGATTGAAACAGGTTCACTGGATTTGGCAGCTACTTGTTTCGAACCGAATAGCGGTCGTACCATGGAAG
TATACACAACTGAAGCAGGTGTACAACTTTACACCGGTAACTGGCTGAATGGTTTCGAAGGTGCTCACGGTGCTACATTC
CCTGCAAGAAGCGCTATCTGCTTCGAGGCACAATGTTTCCCCGACACTCCGAACAAACCTCATTTCCCCTCGGCTACTTT
ATTGCCGGGCGATGAATACCAGCAGGTGACTATCTACAAATTCGGTGTGGAAAAATAA

Upstream 100 bases:

>100_bases
CGCTAAACTTTCCTAAACTACCCACCATATTTAGCCGGAATAATTTGTGAGTAACAAAGAATTTACCTTTATTTGCAAGA
AAATTTTAAGAATACCAGAC

Downstream 100 bases:

>100_bases
AAGATAAAAAATAACTAACCTAATTTTATAAACTAACATTTTTAATAGAACCATGACACAAGAAAAAAAGAATGGAAAAA
TCATTGCCATTATCACGATG

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MNNTFPTEGNLSGLSRKDFQKEINNKETDLFILKNKKGMEVAVTNYGCAILAIMVPDKDGKYANVVLGHDSIDHVVNSPE
PFLSTTIGRYGNRIAKGKFTLYGEEHELTINNGPNSLHGGPTGFHARVWDADQLAENIIQFNYVSADGEEGFPGNLEVEM
VYRLEEEENALVIEYRATTDKATVVNLTNHGFFNLAGISNPTPTIENNIVTINANFYTPIDEVSIPTGEVAKVEGTPMDF
TTPHTVGERINDKFQQLINGAGYDHCYVLNKIETGSLDLAATCFEPNSGRTMEVYTTEAGVQLYTGNWLNGFEGAHGATF
PARSAICFEAQCFPDTPNKPHFPSATLLPGDEYQQVTIYKFGVEK

Sequences:

>Translated_365_residues
MNNTFPTEGNLSGLSRKDFQKEINNKETDLFILKNKKGMEVAVTNYGCAILAIMVPDKDGKYANVVLGHDSIDHVVNSPE
PFLSTTIGRYGNRIAKGKFTLYGEEHELTINNGPNSLHGGPTGFHARVWDADQLAENIIQFNYVSADGEEGFPGNLEVEM
VYRLEEEENALVIEYRATTDKATVVNLTNHGFFNLAGISNPTPTIENNIVTINANFYTPIDEVSIPTGEVAKVEGTPMDF
TTPHTVGERINDKFQQLINGAGYDHCYVLNKIETGSLDLAATCFEPNSGRTMEVYTTEAGVQLYTGNWLNGFEGAHGATF
PARSAICFEAQCFPDTPNKPHFPSATLLPGDEYQQVTIYKFGVEK
>Mature_365_residues
MNNTFPTEGNLSGLSRKDFQKEINNKETDLFILKNKKGMEVAVTNYGCAILAIMVPDKDGKYANVVLGHDSIDHVVNSPE
PFLSTTIGRYGNRIAKGKFTLYGEEHELTINNGPNSLHGGPTGFHARVWDADQLAENIIQFNYVSADGEEGFPGNLEVEM
VYRLEEEENALVIEYRATTDKATVVNLTNHGFFNLAGISNPTPTIENNIVTINANFYTPIDEVSIPTGEVAKVEGTPMDF
TTPHTVGERINDKFQQLINGAGYDHCYVLNKIETGSLDLAATCFEPNSGRTMEVYTTEAGVQLYTGNWLNGFEGAHGATF
PARSAICFEAQCFPDTPNKPHFPSATLLPGDEYQQVTIYKFGVEK

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=326, Percent_Identity=43.2515337423313, Blast_Score=262, Evalue=4e-70,
Organism=Escherichia coli, GI1786971, Length=338, Percent_Identity=35.5029585798817, Blast_Score=203, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17557428, Length=330, Percent_Identity=29.6969696969697, Blast_Score=160, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI115533334, Length=330, Percent_Identity=29.6969696969697, Blast_Score=160, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6319493, Length=340, Percent_Identity=29.4117647058824, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6322004, Length=363, Percent_Identity=26.1707988980716, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324399, Length=295, Percent_Identity=29.4915254237288, Blast_Score=99, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24583720, Length=339, Percent_Identity=37.1681415929204, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24668278, Length=338, Percent_Identity=34.6153846153846, Blast_Score=208, Evalue=6e-54,
Organism=Drosophila melanogaster, GI24659048, Length=342, Percent_Identity=36.2573099415205, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24668282, Length=340, Percent_Identity=32.3529411764706, Blast_Score=187, Evalue=8e-48,
Organism=Drosophila melanogaster, GI24641876, Length=350, Percent_Identity=28, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 40195; Mature: 40195

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNTFPTEGNLSGLSRKDFQKEINNKETDLFILKNKKGMEVAVTNYGCAILAIMVPDKDG
CCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCEEEEEEEEECCCC
KYANVVLGHDSIDHVVNSPEPFLSTTIGRYGNRIAKGKFTLYGEEHELTINNGPNSLHGG
CEEEEEECCCCHHHHHCCCCHHHHHHHHHHCCEEECCEEEEECCCEEEEECCCCCCCCCC
PTGFHARVWDADQLAENIIQFNYVSADGEEGFPGNLEVEMVYRLEEEENALVIEYRATTD
CCCCEEEEECHHHHHHHHHEEEEEECCCCCCCCCCEEEEEEEEEECCCCEEEEEEECCCC
KATVVNLTNHGFFNLAGISNPTPTIENNIVTINANFYTPIDEVSIPTGEVAKVEGTPMDF
CEEEEEEECCCEEEECCCCCCCCCCCCCEEEEECCEECCHHHCCCCCCCEEEECCCCCCC
TTPHTVGERINDKFQQLINGAGYDHCYVLNKIETGSLDLAATCFEPNSGRTMEVYTTEAG
CCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCEEEEEEECCC
VQLYTGNWLNGFEGAHGATFPARSAICFEAQCFPDTPNKPHFPSATLLPGDEYQQVTIYK
EEEEECCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCEEECCCCCCCEEEEEE
FGVEK
ECCCC
>Mature Secondary Structure
MNNTFPTEGNLSGLSRKDFQKEINNKETDLFILKNKKGMEVAVTNYGCAILAIMVPDKDG
CCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCEEEEEEEEECCCC
KYANVVLGHDSIDHVVNSPEPFLSTTIGRYGNRIAKGKFTLYGEEHELTINNGPNSLHGG
CEEEEEECCCCHHHHHCCCCHHHHHHHHHHCCEEECCEEEEECCCEEEEECCCCCCCCCC
PTGFHARVWDADQLAENIIQFNYVSADGEEGFPGNLEVEMVYRLEEEENALVIEYRATTD
CCCCEEEEECHHHHHHHHHEEEEEECCCCCCCCCCEEEEEEEEEECCCCEEEEEEECCCC
KATVVNLTNHGFFNLAGISNPTPTIENNIVTINANFYTPIDEVSIPTGEVAKVEGTPMDF
CEEEEEEECCCEEEECCCCCCCCCCCCCEEEEECCEECCHHHCCCCCCCEEEECCCCCCC
TTPHTVGERINDKFQQLINGAGYDHCYVLNKIETGSLDLAATCFEPNSGRTMEVYTTEAG
CCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCEEEEEEECCC
VQLYTGNWLNGFEGAHGATFPARSAICFEAQCFPDTPNKPHFPSATLLPGDEYQQVTIYK
EEEEECCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCEEECCCCCCCEEEEEE
FGVEK
ECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]