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The map label for this gene is mro [H]

Identifier: 29345766

GI number: 29345766

Start: 428751

End: 429890

Strand: Reverse

Name: mro [H]

Synonym: BT_0356

Alternate gene names: 29345766

Gene position: 429890-428751 (Counterclockwise)

Preceding gene: 29345768

Following gene: 29345765

Centisome position: 6.87

GC content: 47.81

Gene sequence:

>1140_bases
ATGAAAAAACATTTTCTAATTGCAGGAATTGCCGCGCTGATGCTTGCCGCGTGCAATAACAAGCCGGCTTCCGAGCTGAC
TTTATCCGGTCTTGACCCGGCAAAATTTCAAACAGAAGTGAACAATGCCCAAACAGCTCTTTATACCTTAAAGAATAAGG
CGGGTATGGAAGTATGCATCACTAACTTCGGCGGACGCATCGTGTCCATCATGGTGCCCGACAAGAACGGCAAGATGCAG
GATGTAGTTTTAGGTTTTGACAGCATTGCTGATTATATTAATGTACCCAGTGATTTCGGTGCTTCTATCGGCCGTTACGC
CAACCGCATCAACCAAGGGCGTTTTGTACTGGACGGAGATACCATCCAACTGCCGCAAAACAACTTCGGCCACTGCCTGC
ACGGAGGCCCGAAAGGATGGCAATACCAAGTATACGAAGCCAACCTTATCGATCCGACAACACTGGAACTGACTCTTATC
TCTCCGGACGGTGACGCGAATTTCCCCGGAAATGTGACTGCTAAAGTAACCTATCAACTGACAGATGACAACGCCATCGA
CATCAAGTACAGCGCTACTACCGACAAAAAGACAATCATCAACATGACCAACCACTCTTACTTCAATCTGGCTGGTGATC
CATCAAAAACATCGACAGACAACATCATGTATGTAAATGCAGATTACTATACTCCGGTAGACAGCACCTTCATGACAACC
GGCGAAATCGCTCCGGTCAAAGATACTCCGATGGACTTCACTACTCCGAAAGCGGTAGGCAAAGATATCAACAACTACGA
CTTCGTCCAACTCAAGAACGGCAACGGATATGATCACAACTGGGTGCTCAACACCAAAGGTGACATCTCGCAGGTAGCTG
CCAGACTGACGTCTCCCGAAACCGGAATCACATTGGAAGTATATACCAACGAACCGGGTATTCAGGTATACACAGGTAAC
TTCCTCGACGGAACCGTAAGCGGAAAGAAAGGCATCGTTTACAACCAACGTGCTTCTGTCTGCCTCGAAACACAACACTA
CCCCGACAGCCCCAACAAAGCCGACTGGCCGTCCGTTGTGCTGGAACCGGGACAAACGTACAACAGCGAATGTATCTTTA
AATTCTCGACAGAGAAATAA

Upstream 100 bases:

>100_bases
TGTTGCACAACATATAAGAGTGTATTTGATACACCAAACAAAAGTGTTACTTTTACACCCAAAATAAGATAAGCATCTCA
TTTACATTAAAAATAAAACC

Downstream 100 bases:

>100_bases
TATTAACTTATAAATCAAATTTATTGTGGAAGCATTAGATTGGCTAGTAATTGGAGTCTTCTTTTTGGCTCTGATAGGTA
TTATTGTTTGGGTAGTCAGA

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MKKHFLIAGIAALMLAACNNKPASELTLSGLDPAKFQTEVNNAQTALYTLKNKAGMEVCITNFGGRIVSIMVPDKNGKMQ
DVVLGFDSIADYINVPSDFGASIGRYANRINQGRFVLDGDTIQLPQNNFGHCLHGGPKGWQYQVYEANLIDPTTLELTLI
SPDGDANFPGNVTAKVTYQLTDDNAIDIKYSATTDKKTIINMTNHSYFNLAGDPSKTSTDNIMYVNADYYTPVDSTFMTT
GEIAPVKDTPMDFTTPKAVGKDINNYDFVQLKNGNGYDHNWVLNTKGDISQVAARLTSPETGITLEVYTNEPGIQVYTGN
FLDGTVSGKKGIVYNQRASVCLETQHYPDSPNKADWPSVVLEPGQTYNSECIFKFSTEK

Sequences:

>Translated_379_residues
MKKHFLIAGIAALMLAACNNKPASELTLSGLDPAKFQTEVNNAQTALYTLKNKAGMEVCITNFGGRIVSIMVPDKNGKMQ
DVVLGFDSIADYINVPSDFGASIGRYANRINQGRFVLDGDTIQLPQNNFGHCLHGGPKGWQYQVYEANLIDPTTLELTLI
SPDGDANFPGNVTAKVTYQLTDDNAIDIKYSATTDKKTIINMTNHSYFNLAGDPSKTSTDNIMYVNADYYTPVDSTFMTT
GEIAPVKDTPMDFTTPKAVGKDINNYDFVQLKNGNGYDHNWVLNTKGDISQVAARLTSPETGITLEVYTNEPGIQVYTGN
FLDGTVSGKKGIVYNQRASVCLETQHYPDSPNKADWPSVVLEPGQTYNSECIFKFSTEK
>Mature_379_residues
MKKHFLIAGIAALMLAACNNKPASELTLSGLDPAKFQTEVNNAQTALYTLKNKAGMEVCITNFGGRIVSIMVPDKNGKMQ
DVVLGFDSIADYINVPSDFGASIGRYANRINQGRFVLDGDTIQLPQNNFGHCLHGGPKGWQYQVYEANLIDPTTLELTLI
SPDGDANFPGNVTAKVTYQLTDDNAIDIKYSATTDKKTIINMTNHSYFNLAGDPSKTSTDNIMYVNADYYTPVDSTFMTT
GEIAPVKDTPMDFTTPKAVGKDINNYDFVQLKNGNGYDHNWVLNTKGDISQVAARLTSPETGITLEVYTNEPGIQVYTGN
FLDGTVSGKKGIVYNQRASVCLETQHYPDSPNKADWPSVVLEPGQTYNSECIFKFSTEK

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=322, Percent_Identity=40.3726708074534, Blast_Score=251, Evalue=1e-66,
Organism=Escherichia coli, GI1786971, Length=334, Percent_Identity=38.3233532934132, Blast_Score=223, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17557428, Length=337, Percent_Identity=33.8278931750742, Blast_Score=187, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI115533334, Length=337, Percent_Identity=33.8278931750742, Blast_Score=187, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6319493, Length=359, Percent_Identity=29.5264623955432, Blast_Score=129, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6322004, Length=346, Percent_Identity=28.0346820809249, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324399, Length=348, Percent_Identity=28.448275862069, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24659048, Length=340, Percent_Identity=38.2352941176471, Blast_Score=224, Evalue=5e-59,
Organism=Drosophila melanogaster, GI24668282, Length=340, Percent_Identity=35.5882352941176, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24583720, Length=338, Percent_Identity=35.207100591716, Blast_Score=214, Evalue=7e-56,
Organism=Drosophila melanogaster, GI24668278, Length=340, Percent_Identity=34.4117647058824, Blast_Score=204, Evalue=9e-53,
Organism=Drosophila melanogaster, GI24641876, Length=345, Percent_Identity=28.9855072463768, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 41534; Mature: 41534

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKHFLIAGIAALMLAACNNKPASELTLSGLDPAKFQTEVNNAQTALYTLKNKAGMEVCI
CCCEEEHHHHHHHHHHHCCCCCHHHEEECCCCCHHHEECCCCCEEEEEEECCCCCCEEEE
TNFGGRIVSIMVPDKNGKMQDVVLGFDSIADYINVPSDFGASIGRYANRINQGRFVLDGD
ECCCCEEEEEEEECCCCCEEEEEEEHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCC
TIQLPQNNFGHCLHGGPKGWQYQVYEANLIDPTTLELTLISPDGDANFPGNVTAKVTYQL
EEECCCCCCCCEECCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCEEEEEEEEE
TDDNAIDIKYSATTDKKTIINMTNHSYFNLAGDPSKTSTDNIMYVNADYYTPVDSTFMTT
CCCCEEEEEEECCCCCEEEEEECCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCEEEC
GEIAPVKDTPMDFTTPKAVGKDINNYDFVQLKNGNGYDHNWVLNTKGDISQVAARLTSPE
CCCCCCCCCCCCCCCHHHHCCCCCCCEEEEEECCCCCCCEEEEECCCCHHHHHHHHCCCC
TGITLEVYTNEPGIQVYTGNFLDGTVSGKKGIVYNQRASVCLETQHYPDSPNKADWPSVV
CCEEEEEEECCCCEEEEECCCEECCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCCEEE
LEPGQTYNSECIFKFSTEK
ECCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MKKHFLIAGIAALMLAACNNKPASELTLSGLDPAKFQTEVNNAQTALYTLKNKAGMEVCI
CCCEEEHHHHHHHHHHHCCCCCHHHEEECCCCCHHHEECCCCCEEEEEEECCCCCCEEEE
TNFGGRIVSIMVPDKNGKMQDVVLGFDSIADYINVPSDFGASIGRYANRINQGRFVLDGD
ECCCCEEEEEEEECCCCCEEEEEEEHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCC
TIQLPQNNFGHCLHGGPKGWQYQVYEANLIDPTTLELTLISPDGDANFPGNVTAKVTYQL
EEECCCCCCCCEECCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCEEEEEEEEE
TDDNAIDIKYSATTDKKTIINMTNHSYFNLAGDPSKTSTDNIMYVNADYYTPVDSTFMTT
CCCCEEEEEEECCCCCEEEEEECCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCEEEC
GEIAPVKDTPMDFTTPKAVGKDINNYDFVQLKNGNGYDHNWVLNTKGDISQVAARLTSPE
CCCCCCCCCCCCCCCHHHHCCCCCCCEEEEEECCCCCCCEEEEECCCCHHHHHHHHCCCC
TGITLEVYTNEPGIQVYTGNFLDGTVSGKKGIVYNQRASVCLETQHYPDSPNKADWPSVV
CCEEEEEEECCCCEEEEECCCEECCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCCEEE
LEPGQTYNSECIFKFSTEK
ECCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]