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The map label for this gene is pbpC [H]

Identifier: 29345572

GI number: 29345572

Start: 167345

End: 169663

Strand: Reverse

Name: pbpC [H]

Synonym: BT_0162

Alternate gene names: 29345572

Gene position: 169663-167345 (Counterclockwise)

Preceding gene: 29345573

Following gene: 29345571

Centisome position: 2.71

GC content: 50.54

Gene sequence:

>2319_bases
ATGGGAAGCAAAATCTTGAATTTCTTCAAACGATTGTCCGTCACCAAAAAAGTAATACTTTGTATTCTTGCTTTTTTGGT
GACAGGATATATCTTTTGTCTTCCCCGCCACCTTTTTCATGTCCCCTACTCCACAGTAGTGACGGACCGGAACGAGGAAC
TGCTGGGTGCACGCATCGCCTCCGACGGCCAATGGAGATTTCCTCCCCGAAACACGACTCCGGAAAAGATCAAGGAATGC
CTCATTACTTTCGAAGACAAACATTTCTATCACCATTGGGGAGTCAATCCGTTCGCTATCGGAAGAGCTTTCTATCAGAA
TGTGAAGAATAAACGCATCGTAAGCGGAGGCAGTACGCTGACCATGCAGACCATCCGCCTGGCACGGAACGAATCGCGCA
CCTTCCGTGAGAAACTGATTGAAATGATCTGGGCCACCCGCCTGGAATTTCGCGCTTCCAAAGAAGAAATTCTTTCCATG
TATATCTCCCATGCCCCTTTCGGAGGAAATGTAGTGGGACTGGATGCCGCCGCATGGCGCTACTTCGGACATTCTGCCGA
TGACCTATCGTGGGCGGAGTCTGCCATGCTTGCCGTTCTTCCCAACGCGCCCGCCATGATTCATCTGTCCAAAGGACGAA
AAACGCTGCTTGACAAGCGAAACCGCCTGCTGAAACAGCTTCTCGAAAAGAAAACCATCGATTCGTCTACCTACGAACTG
GCTATCAGCGAGCCACTTCCCGATGAGCCTCATCCGCTCCCACAGATCGCACCGTATCTGGTCAGCCGGTTCTATCAGGA
ACGAAACGGCGAATACTCCCGTTCGACCATCAACAAGGGCATTCAGACTCAGATAGAAGACCTGGCGGAACGATGGAGCA
ACGAATTCAGGCGAAGTGATATTCGTAATCTGGCCATTCTGGTGATTGACATTCCGAGCAATCAAGTGGTGGCATACTGC
GGCAACGTCCATTTCGACCAAAAGCAGGGAGGAAATCAAGTGGACGTCATTCAGGCTCCGAGAAGTACGGGCAGTATTCT
CAAACCTTTCTTATATTACGCGATGTTACAGGAAGGAAGTTTACTGCCGGATATGTTGCTGCCGGACGTACCTGTCAATA
TCAACGGATTTACGCCACAGAATTTCAGTATGCAGTTCGAAGGAGCTGTTCCCGCTTCGGAAGCTCTCGCGCGTTCATTA
AATATTCCCGCAGTCACGATGCTGCAAAGATACGGAGTCCCGAAGTTTCATAGCTTCCTGCAACAGATCGGGCTAAAAAC
CATCAACCGTTCTTCTTCCCACTATGGTTTATCACTTATTCTGGGAGGAGCGGAAGCCACTTTATGGGATGTAACAAACG
CATATGCAATGATGGGACGCAGTTTGTTGCAACTGCCGCAAAGGTCTTGCAGCCTGTTGCTCCCGACAAGCCGAATCACA
GAATCAACCGATCCTTTTCAGCCAGGCGCCGTATGGCAGACATTCGATGCCTTGAAAGAAGTCAACCGTCCCGAAGAGAT
TGACTGGAAATCCATTCCTTCCATGCAGACCATTGCATGGAAAACCGGAACAAGCTACGGATTCCGGGATGCTTGGGCGG
TGGGTGTTACGCCCCGCTATGCAGTCGGCGTATGGGTAGGAAATGCCACCGGAGAAGGAAAGCCCGGACTGGTGGGTGCA
CAGACAGCGGGTCCCGTACTATTCGATATTTTTAATCTGCTTCCCGCCTCTTCGTGGTTTACACGCCCTACGGGCATCTT
TGTCGAAGCAGAGGTCTGCCGGAAATCGGGACATCTGAAAGGACGGTTCTGTGATGAAACGGACACGCTTCTTGTTTTAC
CGGCAGGACTGCGGACAGAGGCATGCCCCTATCACCACCTCGTCACTTTATCAGCCGATGAAAGCCAGCGTATTTATGAA
AATTGCGCCAACACGGAGCCTACGCTTCAGAAAAGCTGGTTCACACTGCCACCCGTATGGGAATGGTATTACAAACAACA
TCATCCGGAGTATAAACCGCTGCCTCCTTTCAAAGCCGGATGCGGAGAAGATACTTTCCAGCCGATGCAATTTATCTATC
CTCCGATGAACGCACGCATCAAACTGCCCAAGCAACTGGATGGCAGCAAAGGTTTCCTGACTGTAGAACTGGCGCACAGC
AATCCTAATGCTACCATTTTCTGGCATCTTGACGAGACCTACCAAGCCCAGACACAGGACTTTCACAAAATCTCCCTGCA
ACCCGCCGCCGGCAAACATTCGCTGACGGCAGTAGACGGTGAAGGAAATACCATCTCCACCACTTTCTTTGTTGAGTGA

Upstream 100 bases:

>100_bases
CGACGCAGCGGTACAGGCACGCACCAAAGCGGGAAGAACGACTGTCAGCCGCTGACAAGACTCTGAACAATAAGACAGCA
TTGACAGATAGCATAAGTGC

Downstream 100 bases:

>100_bases
TATTCATTATCTTTGCGGCATGAAACAGTCATTGAAAGAAAACGGAGGTCTGCCGGCATCCATCCTGTGGACGCTCGCCA
TTGTGGCAGGAGTCTCGGTA

Product: penicillin-binding protein 1C

Products: NA

Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]

Number of amino acids: Translated: 772; Mature: 771

Protein sequence:

>772_residues
MGSKILNFFKRLSVTKKVILCILAFLVTGYIFCLPRHLFHVPYSTVVTDRNEELLGARIASDGQWRFPPRNTTPEKIKEC
LITFEDKHFYHHWGVNPFAIGRAFYQNVKNKRIVSGGSTLTMQTIRLARNESRTFREKLIEMIWATRLEFRASKEEILSM
YISHAPFGGNVVGLDAAAWRYFGHSADDLSWAESAMLAVLPNAPAMIHLSKGRKTLLDKRNRLLKQLLEKKTIDSSTYEL
AISEPLPDEPHPLPQIAPYLVSRFYQERNGEYSRSTINKGIQTQIEDLAERWSNEFRRSDIRNLAILVIDIPSNQVVAYC
GNVHFDQKQGGNQVDVIQAPRSTGSILKPFLYYAMLQEGSLLPDMLLPDVPVNINGFTPQNFSMQFEGAVPASEALARSL
NIPAVTMLQRYGVPKFHSFLQQIGLKTINRSSSHYGLSLILGGAEATLWDVTNAYAMMGRSLLQLPQRSCSLLLPTSRIT
ESTDPFQPGAVWQTFDALKEVNRPEEIDWKSIPSMQTIAWKTGTSYGFRDAWAVGVTPRYAVGVWVGNATGEGKPGLVGA
QTAGPVLFDIFNLLPASSWFTRPTGIFVEAEVCRKSGHLKGRFCDETDTLLVLPAGLRTEACPYHHLVTLSADESQRIYE
NCANTEPTLQKSWFTLPPVWEWYYKQHHPEYKPLPPFKAGCGEDTFQPMQFIYPPMNARIKLPKQLDGSKGFLTVELAHS
NPNATIFWHLDETYQAQTQDFHKISLQPAAGKHSLTAVDGEGNTISTTFFVE

Sequences:

>Translated_772_residues
MGSKILNFFKRLSVTKKVILCILAFLVTGYIFCLPRHLFHVPYSTVVTDRNEELLGARIASDGQWRFPPRNTTPEKIKEC
LITFEDKHFYHHWGVNPFAIGRAFYQNVKNKRIVSGGSTLTMQTIRLARNESRTFREKLIEMIWATRLEFRASKEEILSM
YISHAPFGGNVVGLDAAAWRYFGHSADDLSWAESAMLAVLPNAPAMIHLSKGRKTLLDKRNRLLKQLLEKKTIDSSTYEL
AISEPLPDEPHPLPQIAPYLVSRFYQERNGEYSRSTINKGIQTQIEDLAERWSNEFRRSDIRNLAILVIDIPSNQVVAYC
GNVHFDQKQGGNQVDVIQAPRSTGSILKPFLYYAMLQEGSLLPDMLLPDVPVNINGFTPQNFSMQFEGAVPASEALARSL
NIPAVTMLQRYGVPKFHSFLQQIGLKTINRSSSHYGLSLILGGAEATLWDVTNAYAMMGRSLLQLPQRSCSLLLPTSRIT
ESTDPFQPGAVWQTFDALKEVNRPEEIDWKSIPSMQTIAWKTGTSYGFRDAWAVGVTPRYAVGVWVGNATGEGKPGLVGA
QTAGPVLFDIFNLLPASSWFTRPTGIFVEAEVCRKSGHLKGRFCDETDTLLVLPAGLRTEACPYHHLVTLSADESQRIYE
NCANTEPTLQKSWFTLPPVWEWYYKQHHPEYKPLPPFKAGCGEDTFQPMQFIYPPMNARIKLPKQLDGSKGFLTVELAHS
NPNATIFWHLDETYQAQTQDFHKISLQPAAGKHSLTAVDGEGNTISTTFFVE
>Mature_771_residues
GSKILNFFKRLSVTKKVILCILAFLVTGYIFCLPRHLFHVPYSTVVTDRNEELLGARIASDGQWRFPPRNTTPEKIKECL
ITFEDKHFYHHWGVNPFAIGRAFYQNVKNKRIVSGGSTLTMQTIRLARNESRTFREKLIEMIWATRLEFRASKEEILSMY
ISHAPFGGNVVGLDAAAWRYFGHSADDLSWAESAMLAVLPNAPAMIHLSKGRKTLLDKRNRLLKQLLEKKTIDSSTYELA
ISEPLPDEPHPLPQIAPYLVSRFYQERNGEYSRSTINKGIQTQIEDLAERWSNEFRRSDIRNLAILVIDIPSNQVVAYCG
NVHFDQKQGGNQVDVIQAPRSTGSILKPFLYYAMLQEGSLLPDMLLPDVPVNINGFTPQNFSMQFEGAVPASEALARSLN
IPAVTMLQRYGVPKFHSFLQQIGLKTINRSSSHYGLSLILGGAEATLWDVTNAYAMMGRSLLQLPQRSCSLLLPTSRITE
STDPFQPGAVWQTFDALKEVNRPEEIDWKSIPSMQTIAWKTGTSYGFRDAWAVGVTPRYAVGVWVGNATGEGKPGLVGAQ
TAGPVLFDIFNLLPASSWFTRPTGIFVEAEVCRKSGHLKGRFCDETDTLLVLPAGLRTEACPYHHLVTLSADESQRIYEN
CANTEPTLQKSWFTLPPVWEWYYKQHHPEYKPLPPFKAGCGEDTFQPMQFIYPPMNARIKLPKQLDGSKGFLTVELAHSN
PNATIFWHLDETYQAQTQDFHKISLQPAAGKHSLTAVDGEGNTISTTFFVE

Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]

COG id: COG4953

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=565, Percent_Identity=34.8672566371681, Blast_Score=328, Evalue=6e-91,
Organism=Escherichia coli, GI1786343, Length=527, Percent_Identity=26.5654648956357, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI87082258, Length=317, Percent_Identity=29.3375394321767, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1789601, Length=230, Percent_Identity=28.2608695652174, Blast_Score=77, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011815
- InterPro:   IPR009647
- InterPro:   IPR001460 [H]

Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 86930; Mature: 86799

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSKILNFFKRLSVTKKVILCILAFLVTGYIFCLPRHLFHVPYSTVVTDRNEELLGARIA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCHHHHHEEEC
SDGQWRFPPRNTTPEKIKECLITFEDKHFYHHWGVNPFAIGRAFYQNVKNKRIVSGGSTL
CCCCEECCCCCCCHHHHHHHHEEECCCEEEEECCCCHHHHHHHHHHCCCCCEEECCCCEE
TMQTIRLARNESRTFREKLIEMIWATRLEFRASKEEILSMYISHAPFGGNVVGLDAAAWR
EHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEECCHHHHH
YFGHSADDLSWAESAMLAVLPNAPAMIHLSKGRKTLLDKRNRLLKQLLEKKTIDSSTYEL
HHCCCCCCCHHHHCEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEE
AISEPLPDEPHPLPQIAPYLVSRFYQERNGEYSRSTINKGIQTQIEDLAERWSNEFRRSD
EECCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IRNLAILVIDIPSNQVVAYCGNVHFDQKQGGNQVDVIQAPRSTGSILKPFLYYAMLQEGS
CCCEEEEEEECCCCCEEEEECCEEEHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCC
LLPDMLLPDVPVNINGFTPQNFSMQFEGAVPASEALARSLNIPAVTMLQRYGVPKFHSFL
CCCHHHCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHCCCCHHHHHHHCCCHHHHHHH
QQIGLKTINRSSSHYGLSLILGGAEATLWDVTNAYAMMGRSLLQLPQRSCSLLLPTSRIT
HHHCHHHHCCCCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHHCCHHCCCEECCHHHCC
ESTDPFQPGAVWQTFDALKEVNRPEEIDWKSIPSMQTIAWKTGTSYGFRDAWAVGVTPRY
CCCCCCCCCHHHHHHHHHHHCCCCCCCCHHCCCCCEEEEEECCCCCCCCCEEEECCCCCE
AVGVWVGNATGEGKPGLVGAQTAGPVLFDIFNLLPASSWFTRPTGIFVEAEVCRKSGHLK
EEEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHCCCCC
GRFCDETDTLLVLPAGLRTEACPYHHLVTLSADESQRIYENCANTEPTLQKSWFTLPPVW
CEECCCCCCEEEECCCCCCCCCCCEEEEEEECCCHHHHHHHHCCCCCCHHHCCCCCCCHH
EWYYKQHHPEYKPLPPFKAGCGEDTFQPMQFIYPPMNARIKLPKQLDGSKGFLTVELAHS
HHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCEEECCHHCCCCCCEEEEEEECC
NPNATIFWHLDETYQAQTQDFHKISLQPAAGKHSLTAVDGEGNTISTTFFVE
CCCEEEEEEECCHHHHHCCCCEEEEECCCCCCCCEEEECCCCCEEEEEEEEC
>Mature Secondary Structure 
GSKILNFFKRLSVTKKVILCILAFLVTGYIFCLPRHLFHVPYSTVVTDRNEELLGARIA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCHHHHHEEEC
SDGQWRFPPRNTTPEKIKECLITFEDKHFYHHWGVNPFAIGRAFYQNVKNKRIVSGGSTL
CCCCEECCCCCCCHHHHHHHHEEECCCEEEEECCCCHHHHHHHHHHCCCCCEEECCCCEE
TMQTIRLARNESRTFREKLIEMIWATRLEFRASKEEILSMYISHAPFGGNVVGLDAAAWR
EHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEECCHHHHH
YFGHSADDLSWAESAMLAVLPNAPAMIHLSKGRKTLLDKRNRLLKQLLEKKTIDSSTYEL
HHCCCCCCCHHHHCEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEE
AISEPLPDEPHPLPQIAPYLVSRFYQERNGEYSRSTINKGIQTQIEDLAERWSNEFRRSD
EECCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IRNLAILVIDIPSNQVVAYCGNVHFDQKQGGNQVDVIQAPRSTGSILKPFLYYAMLQEGS
CCCEEEEEEECCCCCEEEEECCEEEHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCC
LLPDMLLPDVPVNINGFTPQNFSMQFEGAVPASEALARSLNIPAVTMLQRYGVPKFHSFL
CCCHHHCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHCCCCHHHHHHHCCCHHHHHHH
QQIGLKTINRSSSHYGLSLILGGAEATLWDVTNAYAMMGRSLLQLPQRSCSLLLPTSRIT
HHHCHHHHCCCCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHHCCHHCCCEECCHHHCC
ESTDPFQPGAVWQTFDALKEVNRPEEIDWKSIPSMQTIAWKTGTSYGFRDAWAVGVTPRY
CCCCCCCCCHHHHHHHHHHHCCCCCCCCHHCCCCCEEEEEECCCCCCCCCEEEECCCCCE
AVGVWVGNATGEGKPGLVGAQTAGPVLFDIFNLLPASSWFTRPTGIFVEAEVCRKSGHLK
EEEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHCCCCC
GRFCDETDTLLVLPAGLRTEACPYHHLVTLSADESQRIYENCANTEPTLQKSWFTLPPVW
CEECCCCCCEEEECCCCCCCCCCCEEEEEEECCCHHHHHHHHCCCCCCHHHCCCCCCCHH
EWYYKQHHPEYKPLPPFKAGCGEDTFQPMQFIYPPMNARIKLPKQLDGSKGFLTVELAHS
HHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCEEECCHHCCCCCCEEEEEEECC
NPNATIFWHLDETYQAQTQDFHKISLQPAAGKHSLTAVDGEGNTISTTFFVE
CCCEEEEEEECCHHHHHCCCCEEEEECCCCCCCCEEEECCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10542235; 9205837; 9278503; 9841666 [H]