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The map label for this gene is nhaC [H]

Identifier: 29345568

GI number: 29345568

Start: 163152

End: 164579

Strand: Reverse

Name: nhaC [H]

Synonym: BT_0158

Alternate gene names: 29345568

Gene position: 164579-163152 (Counterclockwise)

Preceding gene: 29345569

Following gene: 29345567

Centisome position: 2.63

GC content: 48.67

Gene sequence:

>1428_bases
ATGAAGAAAGCTCCATCTCCCCTCGTATCACTATTGCCCATTGTCGTATTAGTGATATTACTATTCGCCACCATTCGTGT
ATTTGGCAGTGATGCCCTCAATGGCGGAAGTCAGGTATCGCTGCTTACTACCACCGCCATTTGTATCCTTATCGGCATGG
CTTTCTACAAAATCCCTTGGAAAGACTACGAACTGGCAATCACGAACAACGTGGCAGGAGTGACAACAGCCATCATCATC
TTACTGATTATCGGCGCATTAAGCGGTATCTGGATGATTAGCGGAGTAGTGCCCACTTTGATTTATTACGGGATGCAGAT
TATCCATCCCAGTTTCTTCCTGACATCCACCTGTATTATTTGCGTATTGATCTCCGTTATGACCGGAAGTTCATGGACAA
CGATCGCCACTATCGGTATTGCCCTCATGGGCATCGGAAAGGCACAGGGATTTGAAGAAGGCTGGATTGCGGGAGCTATC
ATCTCCGGTGCCTATTTCGGCGATAAGGTTTCTCCCTTGTCCGAGACGACCATATTGGCGGCATCCGTCACGGACACGCC
CCTCTTCCGTCATATCCGCTACATGATGATTACTACGGTGCCCTCACTGATCATCACACTGATTATATTTACGGTAGCAG
GTCTGTCTCATGACGCCAGCAATACCCAGCACATCGCGGAAGTGGCAGCTGCCCTGAATGAAAAGTTCCATATCACCCCG
TGGCTGCTGATTATACCGATAGCAACAGGCATATTGATTGCACGGAAAGTGCCTTCCATCATTACCCTGTTTCTGTCCAC
TCTATTGGCGGGCATTTTCGCTCTGATCTTCCAACCGGATTTGTTGCGGGAAATTTCGGGGGCTGCCGTTTCCAACTTCG
ACTCCCTATTTAAAGGACTGATGATGACCATCTACGGCAAGACAAGCCTGCAGACCGACAATGCTGTTTTGACAGATTTA
ATTGCCACCCGTGGTATGTCGGGAATGATGAATACCATCTGGCTGATATTATGTGCCATGTGTTTCGGCGGGGCAATGAC
AGCCAGCGGTATGCTGGGAAGCATCACATCGCTCTTCGTACGTTTCATGAAGAAAACGGTCAGCGTCGTATCGGCTACCG
TCTGTTCGGGGCTTTTCCTCAATCTGGCAACTGCCGACCAGTACATCAGCATCATCCTGACCGGTAATATGTTTCGCGAC
ATTTATGCTAAAAAAGGTTACGAAAGCTGCCTGCTCAGCCGGACCACCGAGGATTCAGTAACCGTTACATCCGTACTGAT
CCCATGGAATACCTGCGGAATGACTCAGGCTACCATCCTGAGTGTGCCTACGCTGGTGTACCTCCCCTATTGCTTTTTCA
ACATTATCAGTCCTTTAATGAGTATCGCTGTCGCAGCTATCGGATATAAAATTGTAAAACGCCCGTGA

Upstream 100 bases:

>100_bases
GCCTGAAATCAATAAAGCATCCGACATCATTGAAGGTCCGGCAGTTACATAATAAAGAAACCTAAACCACCAGATTAAAT
AATAAAGCGTTATATTTAGA

Downstream 100 bases:

>100_bases
ACAATCTGGCATACACTTTGTTTTTGCAATAAACGAACAACGTATTAAACCTAAACAAAAAAAAGTTATGAAAAAGTTTA
TTGCATTATTAGCATTAGTT

Product: Na(+)/H(+) antiporter

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MKKAPSPLVSLLPIVVLVILLFATIRVFGSDALNGGSQVSLLTTTAICILIGMAFYKIPWKDYELAITNNVAGVTTAIII
LLIIGALSGIWMISGVVPTLIYYGMQIIHPSFFLTSTCIICVLISVMTGSSWTTIATIGIALMGIGKAQGFEEGWIAGAI
ISGAYFGDKVSPLSETTILAASVTDTPLFRHIRYMMITTVPSLIITLIIFTVAGLSHDASNTQHIAEVAAALNEKFHITP
WLLIIPIATGILIARKVPSIITLFLSTLLAGIFALIFQPDLLREISGAAVSNFDSLFKGLMMTIYGKTSLQTDNAVLTDL
IATRGMSGMMNTIWLILCAMCFGGAMTASGMLGSITSLFVRFMKKTVSVVSATVCSGLFLNLATADQYISIILTGNMFRD
IYAKKGYESCLLSRTTEDSVTVTSVLIPWNTCGMTQATILSVPTLVYLPYCFFNIISPLMSIAVAAIGYKIVKRP

Sequences:

>Translated_475_residues
MKKAPSPLVSLLPIVVLVILLFATIRVFGSDALNGGSQVSLLTTTAICILIGMAFYKIPWKDYELAITNNVAGVTTAIII
LLIIGALSGIWMISGVVPTLIYYGMQIIHPSFFLTSTCIICVLISVMTGSSWTTIATIGIALMGIGKAQGFEEGWIAGAI
ISGAYFGDKVSPLSETTILAASVTDTPLFRHIRYMMITTVPSLIITLIIFTVAGLSHDASNTQHIAEVAAALNEKFHITP
WLLIIPIATGILIARKVPSIITLFLSTLLAGIFALIFQPDLLREISGAAVSNFDSLFKGLMMTIYGKTSLQTDNAVLTDL
IATRGMSGMMNTIWLILCAMCFGGAMTASGMLGSITSLFVRFMKKTVSVVSATVCSGLFLNLATADQYISIILTGNMFRD
IYAKKGYESCLLSRTTEDSVTVTSVLIPWNTCGMTQATILSVPTLVYLPYCFFNIISPLMSIAVAAIGYKIVKRP
>Mature_475_residues
MKKAPSPLVSLLPIVVLVILLFATIRVFGSDALNGGSQVSLLTTTAICILIGMAFYKIPWKDYELAITNNVAGVTTAIII
LLIIGALSGIWMISGVVPTLIYYGMQIIHPSFFLTSTCIICVLISVMTGSSWTTIATIGIALMGIGKAQGFEEGWIAGAI
ISGAYFGDKVSPLSETTILAASVTDTPLFRHIRYMMITTVPSLIITLIIFTVAGLSHDASNTQHIAEVAAALNEKFHITP
WLLIIPIATGILIARKVPSIITLFLSTLLAGIFALIFQPDLLREISGAAVSNFDSLFKGLMMTIYGKTSLQTDNAVLTDL
IATRGMSGMMNTIWLILCAMCFGGAMTASGMLGSITSLFVRFMKKTVSVVSATVCSGLFLNLATADQYISIILTGNMFRD
IYAKKGYESCLLSRTTEDSVTVTSVLIPWNTCGMTQATILSVPTLVYLPYCFFNIISPLMSIAVAAIGYKIVKRP

Specific function: Is a secondary, electrogenic Na(+)/H(+) antiporter that catalyzes Na(+) uptake and proton efflux. Makes modest contributions to pH homeostasis in the alkaline range of pH but is not contributor to Na(+) resistance. Appears to have a repressive effect on g

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 50960; Mature: 50960

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKAPSPLVSLLPIVVLVILLFATIRVFGSDALNGGSQVSLLTTTAICILIGMAFYKIPW
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCC
KDYELAITNNVAGVTTAIIILLIIGALSGIWMISGVVPTLIYYGMQIIHPSFFLTSTCII
CCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CVLISVMTGSSWTTIATIGIALMGIGKAQGFEEGWIAGAIISGAYFGDKVSPLSETTILA
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHEEEE
ASVTDTPLFRHIRYMMITTVPSLIITLIIFTVAGLSHDASNTQHIAEVAAALNEKFHITP
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCH
WLLIIPIATGILIARKVPSIITLFLSTLLAGIFALIFQPDLLREISGAAVSNFDSLFKGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCHHHHHHHHHHHHH
MMTIYGKTSLQTDNAVLTDLIATRGMSGMMNTIWLILCAMCFGGAMTASGMLGSITSLFV
HHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
RFMKKTVSVVSATVCSGLFLNLATADQYISIILTGNMFRDIYAKKGYESCLLSRTTEDSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECHHHHHHHHHCCHHHHHHCCCCCCCE
TVTSVLIPWNTCGMTQATILSVPTLVYLPYCFFNIISPLMSIAVAAIGYKIVKRP
EEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKAPSPLVSLLPIVVLVILLFATIRVFGSDALNGGSQVSLLTTTAICILIGMAFYKIPW
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCC
KDYELAITNNVAGVTTAIIILLIIGALSGIWMISGVVPTLIYYGMQIIHPSFFLTSTCII
CCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CVLISVMTGSSWTTIATIGIALMGIGKAQGFEEGWIAGAIISGAYFGDKVSPLSETTILA
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHEEEE
ASVTDTPLFRHIRYMMITTVPSLIITLIIFTVAGLSHDASNTQHIAEVAAALNEKFHITP
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCH
WLLIIPIATGILIARKVPSIITLFLSTLLAGIFALIFQPDLLREISGAAVSNFDSLFKGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCHHHHHHHHHHHHH
MMTIYGKTSLQTDNAVLTDLIATRGMSGMMNTIWLILCAMCFGGAMTASGMLGSITSLFV
HHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
RFMKKTVSVVSATVCSGLFLNLATADQYISIILTGNMFRDIYAKKGYESCLLSRTTEDSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECHHHHHHHHHCCHHHHHHCCCCCCCE
TVTSVLIPWNTCGMTQATILSVPTLVYLPYCFFNIISPLMSIAVAAIGYKIVKRP
EEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 10903309; 11274110 [H]