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The map label for this gene is creC [H]

Identifier: 29144857

GI number: 29144857

Start: 4779459

End: 4780883

Strand: Direct

Name: creC [H]

Synonym: t4628

Alternate gene names: 29144857

Gene position: 4779459-4780883 (Clockwise)

Preceding gene: 29144856

Following gene: 29144858

Centisome position: 99.74

GC content: 58.18

Gene sequence:

>1425_bases
ATGCGCATCGGAATGCGTTTGCTGCTGGGCTACTTTCTTATTGTCGCCGTCGCCGCCGTGTTTGTGCTGTCTATCTTTGT
TCAGGAGATAAAGCCGGGCGTCCGCCGCGCGACGGAAGGGACGCTGATTGACACCGCGACGCTGCTGGCGGCGCTGGCCC
GCGACGATCTCCTTTCCGGCAACCCGACTGACGGCCAGTTGGCGAAAGCATTCGCCCAGCTGCAACATCGCCCGTTTCGC
GCCAATATCAGCGGGATCGTCAAAGTGCGTAATGAATACCATGTCTACATGACGGATGCGCAGGGGAAGGTGTTGTTTGA
TTCGGAAAACAAAGCGGTGGGGCAGGATTATTCTCGCTGGAATGACGTCTGGCTTACGTTGCGCGGACAGTATGGCGCCC
GCAGCACGGCAAAAGATTCTGCCGATCCCAATAGCACCGTGATGTACGTAGCCGCGCCGATAATCAGCGATGGACGGATC
ATCGGCGTCCTGACTGTCGGCAAACCGAATGCGGCAATGGCGCCGGTGATTAAGCGCAGCGAACGGCGCATTCTGTGGGC
CAGCGCCGTTTTACTGGGAATTGCGCTGGCGATTGGCGCGGGGATGGTCTGGTGGATTAACCGCTCCATCGCCCGGTTGA
CGCGCTATGCGGATTCCGTCACCGAAAACCGCCCGCTTGCGTTACCTGCATTAGGCAGCAGCGAGCTGCGTAAACTGGCG
CAGGCGCTGGAGAGTATGCGCATTAAGCTGGAAGGCAAGAATGACATTGAGCAGTACGTGTATGCGTTGACTCATGAGCT
GAAAAGTCCGCTGGCGGCGATACGCGGCGCGGCGGAGATTCTGCGTGAAGGACCGCCCGCGGATGTGGTTACCCGCTTTA
CAGAGAATATACTGGCGCAAAATACGCGAATGCAGGCGCTGGTAGAAACCCTGCTGCGCCAGGCGCGGCTGGAAAACCGA
CAGGATATCCCTCTCGCGCCGGTTGCTGTTGATGAGCTATTTACGCAGCTTAGCGAGGCGCGCAGTATTCAGTTGGCGGC
AAAAAAGATCACGCTTACTCTACGTCCTTCCTCGCTGGTTGTCGTCGCCGACGCGGAGCTTCTGGCGCAGGCGCTGGGCA
ATGTGTTGGACAATGCCATCGACTTTATGCCTGAAAATGGCGTTATCACATTAAGCGCTCAGCCGATGGGAGAGAAAGCG
ATCCTGCAGGTGACGGATTCCGGCTGTGGTATTCCTGATTTTGCGCTGCCGCGCATTTTCGACCGATTCTATTCGTTGCC
CCGTGAAAACGGGCGTAAAAGCAGCGGGCTTGGGCTGGCGTTTGTCAGCGAGGCGGCGCGGCTCCTCAACGGTGAGGTGA
CGTTGTGCAACCGTCCCGAAGGCGGCGTGCTGGCCTCGTTGACACTTCACCGTCACTTCACATAA

Upstream 100 bases:

>100_bases
CGCACATCAAAACCCTGCGCGCTAAACTACGCGCGATCAACCCGGATCTCTCGCCAATTAACACGCATCGTGGAATGGGA
TACAGCCTGAGGAGCATCTG

Downstream 100 bases:

>100_bases
CTTCAAATTCTCCCCACATCGCGTTCTTACACTGCTGGCATTGCAAAGGAGAACGCTATGTTGAAATCCCCCCTGTTGTG
GAAAATGATTACGTTAGGCG

Product: sensory histidine kinase CreC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MRIGMRLLLGYFLIVAVAAVFVLSIFVQEIKPGVRRATEGTLIDTATLLAALARDDLLSGNPTDGQLAKAFAQLQHRPFR
ANISGIVKVRNEYHVYMTDAQGKVLFDSENKAVGQDYSRWNDVWLTLRGQYGARSTAKDSADPNSTVMYVAAPIISDGRI
IGVLTVGKPNAAMAPVIKRSERRILWASAVLLGIALAIGAGMVWWINRSIARLTRYADSVTENRPLALPALGSSELRKLA
QALESMRIKLEGKNDIEQYVYALTHELKSPLAAIRGAAEILREGPPADVVTRFTENILAQNTRMQALVETLLRQARLENR
QDIPLAPVAVDELFTQLSEARSIQLAAKKITLTLRPSSLVVVADAELLAQALGNVLDNAIDFMPENGVITLSAQPMGEKA
ILQVTDSGCGIPDFALPRIFDRFYSLPRENGRKSSGLGLAFVSEAARLLNGEVTLCNRPEGGVLASLTLHRHFT

Sequences:

>Translated_474_residues
MRIGMRLLLGYFLIVAVAAVFVLSIFVQEIKPGVRRATEGTLIDTATLLAALARDDLLSGNPTDGQLAKAFAQLQHRPFR
ANISGIVKVRNEYHVYMTDAQGKVLFDSENKAVGQDYSRWNDVWLTLRGQYGARSTAKDSADPNSTVMYVAAPIISDGRI
IGVLTVGKPNAAMAPVIKRSERRILWASAVLLGIALAIGAGMVWWINRSIARLTRYADSVTENRPLALPALGSSELRKLA
QALESMRIKLEGKNDIEQYVYALTHELKSPLAAIRGAAEILREGPPADVVTRFTENILAQNTRMQALVETLLRQARLENR
QDIPLAPVAVDELFTQLSEARSIQLAAKKITLTLRPSSLVVVADAELLAQALGNVLDNAIDFMPENGVITLSAQPMGEKA
ILQVTDSGCGIPDFALPRIFDRFYSLPRENGRKSSGLGLAFVSEAARLLNGEVTLCNRPEGGVLASLTLHRHFT
>Mature_474_residues
MRIGMRLLLGYFLIVAVAAVFVLSIFVQEIKPGVRRATEGTLIDTATLLAALARDDLLSGNPTDGQLAKAFAQLQHRPFR
ANISGIVKVRNEYHVYMTDAQGKVLFDSENKAVGQDYSRWNDVWLTLRGQYGARSTAKDSADPNSTVMYVAAPIISDGRI
IGVLTVGKPNAAMAPVIKRSERRILWASAVLLGIALAIGAGMVWWINRSIARLTRYADSVTENRPLALPALGSSELRKLA
QALESMRIKLEGKNDIEQYVYALTHELKSPLAAIRGAAEILREGPPADVVTRFTENILAQNTRMQALVETLLRQARLENR
QDIPLAPVAVDELFTQLSEARSIQLAAKKITLTLRPSSLVVVADAELLAQALGNVLDNAIDFMPENGVITLSAQPMGEKA
ILQVTDSGCGIPDFALPRIFDRFYSLPRENGRKSSGLGLAFVSEAARLLNGEVTLCNRPEGGVLASLTLHRHFT

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=474, Percent_Identity=80.379746835443, Blast_Score=769, Evalue=0.0,
Organism=Escherichia coli, GI87082128, Length=280, Percent_Identity=27.5, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788393, Length=248, Percent_Identity=29.4354838709677, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786600, Length=209, Percent_Identity=30.1435406698565, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI48994928, Length=266, Percent_Identity=24.0601503759398, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786912, Length=238, Percent_Identity=29.4117647058824, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI87081816, Length=217, Percent_Identity=27.1889400921659, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1787374, Length=280, Percent_Identity=27.5, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790436, Length=218, Percent_Identity=28.8990825688073, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI145693157, Length=234, Percent_Identity=23.9316239316239, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1790551, Length=288, Percent_Identity=28.4722222222222, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1788549, Length=210, Percent_Identity=27.1428571428571, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786783, Length=213, Percent_Identity=27.2300469483568, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788713, Length=250, Percent_Identity=25.2, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51702; Mature: 51702

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGMRLLLGYFLIVAVAAVFVLSIFVQEIKPGVRRATEGTLIDTATLLAALARDDLLSG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHHHCCCC
NPTDGQLAKAFAQLQHRPFRANISGIVKVRNEYHVYMTDAQGKVLFDSENKAVGQDYSRW
CCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEEEECCCCEEEECCCCCCCCCCHHCC
NDVWLTLRGQYGARSTAKDSADPNSTVMYVAAPIISDGRIIGVLTVGKPNAAMAPVIKRS
CCEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEEECCCEEEEEEEECCCCCHHHHHHHCC
ERRILWASAVLLGIALAIGAGMVWWINRSIARLTRYADSVTENRPLALPALGSSELRKLA
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHH
QALESMRIKLEGKNDIEQYVYALTHELKSPLAAIRGAAEILREGPPADVVTRFTENILAQ
HHHHHCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
NTRMQALVETLLRQARLENRQDIPLAPVAVDELFTQLSEARSIQLAAKKITLTLRPSSLV
CHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCEE
VVADAELLAQALGNVLDNAIDFMPENGVITLSAQPMGEKAILQVTDSGCGIPDFALPRIF
EEECHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHH
DRFYSLPRENGRKSSGLGLAFVSEAARLLNGEVTLCNRPEGGVLASLTLHRHFT
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCC
>Mature Secondary Structure
MRIGMRLLLGYFLIVAVAAVFVLSIFVQEIKPGVRRATEGTLIDTATLLAALARDDLLSG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHHHCCCC
NPTDGQLAKAFAQLQHRPFRANISGIVKVRNEYHVYMTDAQGKVLFDSENKAVGQDYSRW
CCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEEEECCCCEEEECCCCCCCCCCHHCC
NDVWLTLRGQYGARSTAKDSADPNSTVMYVAAPIISDGRIIGVLTVGKPNAAMAPVIKRS
CCEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEEECCCEEEEEEEECCCCCHHHHHHHCC
ERRILWASAVLLGIALAIGAGMVWWINRSIARLTRYADSVTENRPLALPALGSSELRKLA
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHH
QALESMRIKLEGKNDIEQYVYALTHELKSPLAAIRGAAEILREGPPADVVTRFTENILAQ
HHHHHCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
NTRMQALVETLLRQARLENRQDIPLAPVAVDELFTQLSEARSIQLAAKKITLTLRPSSLV
CHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCEE
VVADAELLAQALGNVLDNAIDFMPENGVITLSAQPMGEKAILQVTDSGCGIPDFALPRIF
EEECHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHH
DRFYSLPRENGRKSSGLGLAFVSEAARLLNGEVTLCNRPEGGVLASLTLHRHFT
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]