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The map label for this gene is lyxK [H]

Identifier: 29144124

GI number: 29144124

Start: 3971133

End: 3972629

Strand: Reverse

Name: lyxK [H]

Synonym: t3845

Alternate gene names: 29144124

Gene position: 3972629-3971133 (Counterclockwise)

Preceding gene: 29144125

Following gene: 29144123

Centisome position: 82.9

GC content: 60.05

Gene sequence:

>1497_bases
ATGAGCAATTACTGGCTGGGGTTAGATTGTGGTGGGAGTTGGCTAAAAGCCGGGTTGTACGATGGCGCAGGCCGGGAAGT
AGCGGTGCAACGCCTGCCGCTGCACGCTTTAAGCCCGCAGCCAGGCTGGGTTGAACGCGATATGACCGAACTGTGGCAAC
AGTGCGCTTCGGTCATCAGCAAACTGCTGACGCACACGGGGGTGAGCGGCTCACAAATCCGCGGTCTGGGTATTTCAGCC
CAAGGGAAAGGCCTGTTCCTGTTAGATAAAAGCGATCGGCCATTAGGTAAAGCGATACTCTCTTCCGATCGTCGCGCCAT
GGAAATTGTCCAGCGCTGGCAAAAAGAAGCGGTTCCGCAAAAACTCTACCCACTGACCCGGCAAACCCTGTGGACCGGGC
ATCCGGTCTCCCTTTTACGCTGGGTAAAAGAGAATGAGCCGCAGCGCTACGCGCAGATAGGCAGCGTCATGATGACGCAT
GACTATCTGCGCTGGTGCTTAACCGGCGTGAAAGGCTGTGAGGAGAGCAATATCTCCGAGTCCAACCTCTACAACATGGC
GACGGGCCAGTACGACCCGCGCCTGACCGAATGGCTGGGCATCAGTGAAATCGATAGCGCGCTGCCCCCCGTGGTGGGTT
CAGCCGAAATATGCGGGGAGATCACCGCTCAGGCGGCCGCTATCACCGGTCTGGCGGCGGGTACCCCCGTCGTCGGCGGC
CTGTTTGACGTGGTTTCCACCGCCCTTTGCGCCGGTATTGAGGATGAATCAACGCTCAATGCGGTGATGGGGACCTGGGC
CGTCACCAGCGGCATCGCTCACGGTCTGCGCGACCATGAGGCCCATCCTTACGTCTATGGCCGCTACGTCAATGACGGGC
AGTATATCGTTCACGAAGCCAGCCCGACCTCTTCCGGCAACCTTGAATGGTTCACCGCCCAGTGGGGCTACCTCTCTTTT
GACGAGATCAACCAGGCGGTTGCCAGCCTGCCGAAAGCCGGTAGCGACCTTTTTTTTCTCCCGTTTCTCTACGGCAGCAA
TGCCGGGCTGGAGATGACCTGCGGCTTTTATGGCATGCAGGCGCTGCACAACCGCGCGCACCTGCTACAGGCGCTCTATG
AAGGCGTGGTCTTCAGCCATATGACCCACCTCAACCGCATGCGTGAACGCTTTACCGAGGTTTGCGCCCTGCGCGTTACC
GGCGGACCGGCCCACTCCGACGTCTGGATGCAGATGCTGTCGGACGTCAGCGGGTTACGCATCGAGCTGCCGCAGGTGGA
GGAGACCGGCTGCTTCGGCGCGGCGCTGGCAGCCCGCGTCGGCACCGGCGTATATCGCGATTTCCACGAGGCCCAACGCG
ACCTGCAGCACCCGGTACGCACGCTGCTGCCGGACATGACCGCGCACGCCCTCTACCAGCGCAAATACCGCCAATACCAG
GATTTGATTGAAGCACTACAGGGCTATCACGCCCGTATTAAGGAGCACGCATTATGA

Upstream 100 bases:

>100_bases
CTTCAGTGATGCGCTGGGCAGCCAGGTGCGCGATATGTTCCTGAAAGACAACCCGCAGGGCGCCGACCTCCTGAAAGCCG
TGGACGAGGTGCAATAAGTC

Downstream 100 bases:

>100_bases
GCCGACCATTACTGCAACTGGCGCTCGACCACACCAGTCTGGAAGCAGCCCAGCGCGATGTCGCCCTGCTACAGGATCAT
GTCGATATCGTTGAGGCCGG

Product: L-xylulose kinase

Products: NA

Alternate protein names: L-xylulokinase; 3-dehydro-L-gulonate kinase [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MSNYWLGLDCGGSWLKAGLYDGAGREVAVQRLPLHALSPQPGWVERDMTELWQQCASVISKLLTHTGVSGSQIRGLGISA
QGKGLFLLDKSDRPLGKAILSSDRRAMEIVQRWQKEAVPQKLYPLTRQTLWTGHPVSLLRWVKENEPQRYAQIGSVMMTH
DYLRWCLTGVKGCEESNISESNLYNMATGQYDPRLTEWLGISEIDSALPPVVGSAEICGEITAQAAAITGLAAGTPVVGG
LFDVVSTALCAGIEDESTLNAVMGTWAVTSGIAHGLRDHEAHPYVYGRYVNDGQYIVHEASPTSSGNLEWFTAQWGYLSF
DEINQAVASLPKAGSDLFFLPFLYGSNAGLEMTCGFYGMQALHNRAHLLQALYEGVVFSHMTHLNRMRERFTEVCALRVT
GGPAHSDVWMQMLSDVSGLRIELPQVEETGCFGAALAARVGTGVYRDFHEAQRDLQHPVRTLLPDMTAHALYQRKYRQYQ
DLIEALQGYHARIKEHAL

Sequences:

>Translated_498_residues
MSNYWLGLDCGGSWLKAGLYDGAGREVAVQRLPLHALSPQPGWVERDMTELWQQCASVISKLLTHTGVSGSQIRGLGISA
QGKGLFLLDKSDRPLGKAILSSDRRAMEIVQRWQKEAVPQKLYPLTRQTLWTGHPVSLLRWVKENEPQRYAQIGSVMMTH
DYLRWCLTGVKGCEESNISESNLYNMATGQYDPRLTEWLGISEIDSALPPVVGSAEICGEITAQAAAITGLAAGTPVVGG
LFDVVSTALCAGIEDESTLNAVMGTWAVTSGIAHGLRDHEAHPYVYGRYVNDGQYIVHEASPTSSGNLEWFTAQWGYLSF
DEINQAVASLPKAGSDLFFLPFLYGSNAGLEMTCGFYGMQALHNRAHLLQALYEGVVFSHMTHLNRMRERFTEVCALRVT
GGPAHSDVWMQMLSDVSGLRIELPQVEETGCFGAALAARVGTGVYRDFHEAQRDLQHPVRTLLPDMTAHALYQRKYRQYQ
DLIEALQGYHARIKEHAL
>Mature_497_residues
SNYWLGLDCGGSWLKAGLYDGAGREVAVQRLPLHALSPQPGWVERDMTELWQQCASVISKLLTHTGVSGSQIRGLGISAQ
GKGLFLLDKSDRPLGKAILSSDRRAMEIVQRWQKEAVPQKLYPLTRQTLWTGHPVSLLRWVKENEPQRYAQIGSVMMTHD
YLRWCLTGVKGCEESNISESNLYNMATGQYDPRLTEWLGISEIDSALPPVVGSAEICGEITAQAAAITGLAAGTPVVGGL
FDVVSTALCAGIEDESTLNAVMGTWAVTSGIAHGLRDHEAHPYVYGRYVNDGQYIVHEASPTSSGNLEWFTAQWGYLSFD
EINQAVASLPKAGSDLFFLPFLYGSNAGLEMTCGFYGMQALHNRAHLLQALYEGVVFSHMTHLNRMRERFTEVCALRVTG
GPAHSDVWMQMLSDVSGLRIELPQVEETGCFGAALAARVGTGVYRDFHEAQRDLQHPVRTLLPDMTAHALYQRKYRQYQD
LIEALQGYHARIKEHAL

Specific function: Catalyzes the phosphorylation of L-xylulose and 3-keto- L-gulonate. Is involved in L-lyxose utilization via xylulose, and may also be involved in the utilization of 2,3-diketo-L-gulonate [H]

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI164663828, Length=553, Percent_Identity=23.3273056057866, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI88196792, Length=492, Percent_Identity=23.9837398373984, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI164663830, Length=579, Percent_Identity=23.1433506044905, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1790005, Length=498, Percent_Identity=85.7429718875502, Blast_Score=896, Evalue=0.0,
Organism=Escherichia coli, GI1787789, Length=503, Percent_Identity=24.4532803180915, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1789987, Length=488, Percent_Identity=24.7950819672131, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1790361, Length=465, Percent_Identity=21.505376344086, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1789168, Length=478, Percent_Identity=22.5941422594142, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17535599, Length=438, Percent_Identity=23.5159817351598, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24655555, Length=458, Percent_Identity=24.235807860262, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24655560, Length=458, Percent_Identity=24.235807860262, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24655570, Length=458, Percent_Identity=24.235807860262, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24655574, Length=458, Percent_Identity=24.235807860262, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24655565, Length=458, Percent_Identity=24.235807860262, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI21357867, Length=495, Percent_Identity=23.030303030303, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24656367, Length=483, Percent_Identity=23.8095238095238, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24657106, Length=550, Percent_Identity=23.0909090909091, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24657102, Length=550, Percent_Identity=23.0909090909091, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.53 [H]

Molecular weight: Translated: 55045; Mature: 54914

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNYWLGLDCGGSWLKAGLYDGAGREVAVQRLPLHALSPQPGWVERDMTELWQQCASVIS
CCCCEEEECCCCHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
KLLTHTGVSGSQIRGLGISAQGKGLFLLDKSDRPLGKAILSSDRRAMEIVQRWQKEAVPQ
HHHHHCCCCCCCEECCCCCCCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHCCCH
KLYPLTRQTLWTGHPVSLLRWVKENEPQRYAQIGSVMMTHDYLRWCLTGVKGCEESNISE
HHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
SNLYNMATGQYDPRLTEWLGISEIDSALPPVVGSAEICGEITAQAAAITGLAAGTPVVGG
HHCCCCCCCCCCCHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHH
LFDVVSTALCAGIEDESTLNAVMGTWAVTSGIAHGLRDHEAHPYVYGRYVNDGQYIVHEA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEEC
SPTSSGNLEWFTAQWGYLSFDEINQAVASLPKAGSDLFFLPFLYGSNAGLEMTCGFYGMQ
CCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEHCCCCCCCEEEHHHHHHH
ALHNRAHLLQALYEGVVFSHMTHLNRMRERFTEVCALRVTGGPAHSDVWMQMLSDVSGLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHCCCCCE
IELPQVEETGCFGAALAARVGTGVYRDFHEAQRDLQHPVRTLLPDMTAHALYQRKYRQYQ
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
DLIEALQGYHARIKEHAL
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNYWLGLDCGGSWLKAGLYDGAGREVAVQRLPLHALSPQPGWVERDMTELWQQCASVIS
CCCEEEECCCCHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
KLLTHTGVSGSQIRGLGISAQGKGLFLLDKSDRPLGKAILSSDRRAMEIVQRWQKEAVPQ
HHHHHCCCCCCCEECCCCCCCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHCCCH
KLYPLTRQTLWTGHPVSLLRWVKENEPQRYAQIGSVMMTHDYLRWCLTGVKGCEESNISE
HHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
SNLYNMATGQYDPRLTEWLGISEIDSALPPVVGSAEICGEITAQAAAITGLAAGTPVVGG
HHCCCCCCCCCCCHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHH
LFDVVSTALCAGIEDESTLNAVMGTWAVTSGIAHGLRDHEAHPYVYGRYVNDGQYIVHEA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEEC
SPTSSGNLEWFTAQWGYLSFDEINQAVASLPKAGSDLFFLPFLYGSNAGLEMTCGFYGMQ
CCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEHCCCCCCCEEEHHHHHHH
ALHNRAHLLQALYEGVVFSHMTHLNRMRERFTEVCALRVTGGPAHSDVWMQMLSDVSGLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHCCCCCE
IELPQVEETGCFGAALAARVGTGVYRDFHEAQRDLQHPVRTLLPDMTAHALYQRKYRQYQ
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
DLIEALQGYHARIKEHAL
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7961955; 11741871 [H]