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The map label for this gene is cytR [H]

Identifier: 29143829

GI number: 29143829

Start: 3627867

End: 3628892

Strand: Direct

Name: cytR [H]

Synonym: t3524

Alternate gene names: 29143829

Gene position: 3627867-3628892 (Clockwise)

Preceding gene: 29143828

Following gene: 29143830

Centisome position: 75.71

GC content: 53.41

Gene sequence:

>1026_bases
GTGAAATCGAACAAGCAGGTTACTGCCGCTACGATGAAGGATGTTGCGTTGAAGGCGAAAGTCTCTACGGCAACCGTATC
CCGCGCGTTAATGAACCCCGATAAAGTCTCCCAGTCGACCCGTAGCCGGGTTGAACAGGCCGCGCTTGAAGTGGGTTATT
TCCCGCAGTCGATGGGGCGAAATGTAAAACGCAATGAATCCCGTACGATTTTGGTGATTGTCCCGGATATTTGCGATCCC
TTCTTCAGTGAAATTATCCGCGGTATCGAAGTGACCGCGGCAGAACAGGGGTATCTGGTGCTGATTGGCGATTGTGCCCA
TCAAAACCAGAAAGAAAAAACCTTTCTTAATCTCATCATCACCAAACAGATCGACGGCATGGTACTGCTCAGTTCCCGAC
TGCCCTTTGACGCCAGCGTTGAGGAGCAGCGCAATTTGCCTCCGATGGTGATGTCGAATGAGTTTGCGCCGGAGCTTGAA
TTGCCGACGGTACATATCGATAACCTGACCGCCGCGTTCAATGCCATGAACTACCTGTTGGATTTGGGCCACAAGCGGAT
TGGTTGTATTGCGGGGCCGGAAGATATGCCGCTCTGTCACTATCGCTTACAAGGTTACGTACAGGCATTAAGACGCAGTG
GCATTGTGGTCGATCCGCATTACATCGCCCGTGGCGACTTTACCTTTGAAGCCGGGGCAAACGCATTAAAGCAGTTGCTT
GAGCAACCGTTGCCGCCTACCGCCGTCTTTTGTCATAGCGACGTAATGGCGCTGGGCGCCCTCTCCTGGGCCAAGCGCCA
GGGTCTGAAAGTGCCTGACGATCTGTCGATTATCGGCTTTGACAATATCGCGCTGGCCGAGTTTTGCGACCCTCCGTTGA
CAACCGTGGCGCAGCCGCGTTTTGACATTGGTCGCGAGGCGATGCTGCTGTTGCTCGATCAGATGCAGGGGCAAAATGTG
AGCAGCGGCTCGCGTTTAATGGATTGCGAGCTGATTATTCGCGGTTCTACACGCGCTTTACCCTAA

Upstream 100 bases:

>100_bases
AAATTCTGTAACCGCTTCCACGCACTATCTGATAAAAATGTTTTCGATGAGTGTTACCAGGGATAGATCTGCGCCAGCAG
TTCCCAGGCGAGGAGAAAGA

Downstream 100 bases:

>100_bases
AGTAAATAGCTTTAAGACTCACCTGTCTGGTCAAAGGCCCGCCGCTTCAGTAACATGACGGGCTGACGAACGAATAAATA
CAGCGAAACGATAGTGGCAC

Product: DNA-binding transcriptional regulator CytR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKSNKQVTAATMKDVALKAKVSTATVSRALMNPDKVSQSTRSRVEQAALEVGYFPQSMGRNVKRNESRTILVIVPDICDP
FFSEIIRGIEVTAAEQGYLVLIGDCAHQNQKEKTFLNLIITKQIDGMVLLSSRLPFDASVEEQRNLPPMVMSNEFAPELE
LPTVHIDNLTAAFNAMNYLLDLGHKRIGCIAGPEDMPLCHYRLQGYVQALRRSGIVVDPHYIARGDFTFEAGANALKQLL
EQPLPPTAVFCHSDVMALGALSWAKRQGLKVPDDLSIIGFDNIALAEFCDPPLTTVAQPRFDIGREAMLLLLDQMQGQNV
SSGSRLMDCELIIRGSTRALP

Sequences:

>Translated_341_residues
MKSNKQVTAATMKDVALKAKVSTATVSRALMNPDKVSQSTRSRVEQAALEVGYFPQSMGRNVKRNESRTILVIVPDICDP
FFSEIIRGIEVTAAEQGYLVLIGDCAHQNQKEKTFLNLIITKQIDGMVLLSSRLPFDASVEEQRNLPPMVMSNEFAPELE
LPTVHIDNLTAAFNAMNYLLDLGHKRIGCIAGPEDMPLCHYRLQGYVQALRRSGIVVDPHYIARGDFTFEAGANALKQLL
EQPLPPTAVFCHSDVMALGALSWAKRQGLKVPDDLSIIGFDNIALAEFCDPPLTTVAQPRFDIGREAMLLLLDQMQGQNV
SSGSRLMDCELIIRGSTRALP
>Mature_341_residues
MKSNKQVTAATMKDVALKAKVSTATVSRALMNPDKVSQSTRSRVEQAALEVGYFPQSMGRNVKRNESRTILVIVPDICDP
FFSEIIRGIEVTAAEQGYLVLIGDCAHQNQKEKTFLNLIITKQIDGMVLLSSRLPFDASVEEQRNLPPMVMSNEFAPELE
LPTVHIDNLTAAFNAMNYLLDLGHKRIGCIAGPEDMPLCHYRLQGYVQALRRSGIVVDPHYIARGDFTFEAGANALKQLL
EQPLPPTAVFCHSDVMALGALSWAKRQGLKVPDDLSIIGFDNIALAEFCDPPLTTVAQPRFDIGREAMLLLLDQMQGQNV
SSGSRLMDCELIIRGSTRALP

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=341, Percent_Identity=87.0967741935484, Blast_Score=625, Evalue=1e-180,
Organism=Escherichia coli, GI1787948, Length=337, Percent_Identity=35.0148367952522, Blast_Score=212, Evalue=3e-56,
Organism=Escherichia coli, GI1790194, Length=309, Percent_Identity=35.9223300970874, Blast_Score=205, Evalue=3e-54,
Organism=Escherichia coli, GI1788474, Length=308, Percent_Identity=35.0649350649351, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1789202, Length=290, Percent_Identity=33.1034482758621, Blast_Score=174, Evalue=9e-45,
Organism=Escherichia coli, GI1789068, Length=315, Percent_Identity=31.4285714285714, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI48994940, Length=323, Percent_Identity=28.4829721362229, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1787580, Length=328, Percent_Identity=27.1341463414634, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1790715, Length=315, Percent_Identity=27.6190476190476, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1786540, Length=335, Percent_Identity=27.7611940298507, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1787906, Length=328, Percent_Identity=25.609756097561, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1789456, Length=340, Percent_Identity=27.0588235294118, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1786268, Length=309, Percent_Identity=23.6245954692557, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790689, Length=316, Percent_Identity=25.9493670886076, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37584; Mature: 37584

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSNKQVTAATMKDVALKAKVSTATVSRALMNPDKVSQSTRSRVEQAALEVGYFPQSMGR
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHCC
NVKRNESRTILVIVPDICDPFFSEIIRGIEVTAAEQGYLVLIGDCAHQNQKEKTFLNLII
CCCCCCCCEEEEEECCCCCHHHHHHHCCCEEEECCCCCEEEEECCCCCCCHHHHHEEEEE
TKQIDGMVLLSSRLPFDASVEEQRNLPPMVMSNEFAPELELPTVHIDNLTAAFNAMNYLL
EECCCCEEEEECCCCCCCCCHHHCCCCCEEECCCCCCCCCCCEEEECCHHHHHHHHHHHH
DLGHKRIGCIAGPEDMPLCHYRLQGYVQALRRSGIVVDPHYIARGDFTFEAGANALKQLL
HHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEECCCEEECCCEEHHHHHHHHHHHH
EQPLPPTAVFCHSDVMALGALSWAKRQGLKVPDDLSIIGFDNIALAEFCDPPLTTVAQPR
HCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEHHHHCCCCHHHHCCCC
FDIGREAMLLLLDQMQGQNVSSGSRLMDCELIIRGSTRALP
HHCCHHHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCCCCC
>Mature Secondary Structure
MKSNKQVTAATMKDVALKAKVSTATVSRALMNPDKVSQSTRSRVEQAALEVGYFPQSMGR
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHCC
NVKRNESRTILVIVPDICDPFFSEIIRGIEVTAAEQGYLVLIGDCAHQNQKEKTFLNLII
CCCCCCCCEEEEEECCCCCHHHHHHHCCCEEEECCCCCEEEEECCCCCCCHHHHHEEEEE
TKQIDGMVLLSSRLPFDASVEEQRNLPPMVMSNEFAPELELPTVHIDNLTAAFNAMNYLL
EECCCCEEEEECCCCCCCCCHHHCCCCCEEECCCCCCCCCCCEEEECCHHHHHHHHHHHH
DLGHKRIGCIAGPEDMPLCHYRLQGYVQALRRSGIVVDPHYIARGDFTFEAGANALKQLL
HHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEECCCEEECCCEEHHHHHHHHHHHH
EQPLPPTAVFCHSDVMALGALSWAKRQGLKVPDDLSIIGFDNIALAEFCDPPLTTVAQPR
HCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEHHHHCCCCHHHHCCCC
FDIGREAMLLLLDQMQGQNVSSGSRLMDCELIIRGSTRALP
HHCCHHHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]