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The map label for this gene is alr3

Identifier: 29143819

GI number: 29143819

Start: 3611618

End: 3612724

Strand: Reverse

Name: alr3

Synonym: t3513

Alternate gene names: 29143819

Gene position: 3612724-3611618 (Counterclockwise)

Preceding gene: 29143820

Following gene: 29143817

Centisome position: 75.39

GC content: 59.17

Gene sequence:

>1107_bases
ATGATGAAACTTGCTGAAATTCAGGCGGCGTGCGGCGTTCTTTGTGTAGATCTCGCCGCTGTCGTTGACAATTATCAAAC
GCTGGCGCGCCATGTCGCCCCCGCGCAATGCGGCGCAGTACTGAAAGCCAATGGCTATGGCTTGGGGGCGGAGGCGATTG
CGCCAGCCCTGTATGCGGCCAATTGCCGGATCTTTTTTGTCGCGCAACTTTCTGAAGGGGTGGCGCTACGTAACATCCTG
TCGGCTGACGCGATGGTGGTGTTGCTTAATGGCGTCATGCCGCAGGCGATGCCGTTTTGTTGCGCGCAACAGATCACACC
ATTGTTGAATTCCGTTGACCAGGTGATGACGTGGCTGGCGTTACAGGAGGCTCGGTCGCAGCGGCGTCCGGTCTTGATCC
AGCTTGACTCTGGTATGTCGCGGCTGGGGGTGACGCCGGAGCAACTGGCGCGGCTGGCCGCGATTTTTCGCCAGCGTGGC
TGGGCTGCGCCAGACTATATCATCAGCCATCTGGCCAACGCCGACAGGCCGGATCATGCGTTAAATGTCTATCAGCATAC
GCTACTCCAGCAGGCAAAAAAGGCATTCCCAACCAGCCGTTATTCGCTGGCAAATTCCTGCGGTATGTTTCTGCATCCGG
CCTGGCGGGAAGATCTTTGCCGTCCGGGCGTTGCGCTGTTCGGCGTCGCCCAGCCGTGGTTTTCAACGCCGTTAAAACCG
GCATTTACGCTGACGTTGACCATTTTGCGCGTGCAAGACGTGCCGGTTGGGACGCCGATTGGCTACGGCAGTACGGTTAC
TACCACTCGCCCGCTGCGTATCGCCACGGTATCCGCCGGATACGCTGATGGGATTCCGCGTAATTTGCGTCCTCCGGCGG
GCGTGTGCTGGCGCGGGGTTCGGTTGCCGGTGTTGGGGCGGGTCTGCATGGACAGCTTTATGGTGGACGCCAGCGCCATC
ATGCCAACGTCTGGCGATGTTGTGGAGTTTATTGGCGTGAGCCAGACGCTGGAAGAGGTTGCTGCCGCCTGCGATACCAT
CCCTTATGAGATTATGGCCCGGCTTGGCGCACGTTTTCGGCGCATAATGCAGCCCGCAGAAGCTTGA

Upstream 100 bases:

>100_bases
AAATTATTTTTGCCATCAAGACGCCGAATATTGCAGATATTTGCGCCGATATTCGGCAAAAAGTGACTAAATTAACCACC
AACTATCCGTTGCCTTACCA

Downstream 100 bases:

>100_bases
CTCCATTTTCAATCTCGTAGGGGGTAAACGCGGCGAATCCCAACAGCCAGCCCGTGGGCGCGGGGTGCGTCAGCCAGAAC
TGGCGCATCCCGGCGATGTT

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MMKLAEIQAACGVLCVDLAAVVDNYQTLARHVAPAQCGAVLKANGYGLGAEAIAPALYAANCRIFFVAQLSEGVALRNIL
SADAMVVLLNGVMPQAMPFCCAQQITPLLNSVDQVMTWLALQEARSQRRPVLIQLDSGMSRLGVTPEQLARLAAIFRQRG
WAAPDYIISHLANADRPDHALNVYQHTLLQQAKKAFPTSRYSLANSCGMFLHPAWREDLCRPGVALFGVAQPWFSTPLKP
AFTLTLTILRVQDVPVGTPIGYGSTVTTTRPLRIATVSAGYADGIPRNLRPPAGVCWRGVRLPVLGRVCMDSFMVDASAI
MPTSGDVVEFIGVSQTLEEVAAACDTIPYEIMARLGARFRRIMQPAEA

Sequences:

>Translated_368_residues
MMKLAEIQAACGVLCVDLAAVVDNYQTLARHVAPAQCGAVLKANGYGLGAEAIAPALYAANCRIFFVAQLSEGVALRNIL
SADAMVVLLNGVMPQAMPFCCAQQITPLLNSVDQVMTWLALQEARSQRRPVLIQLDSGMSRLGVTPEQLARLAAIFRQRG
WAAPDYIISHLANADRPDHALNVYQHTLLQQAKKAFPTSRYSLANSCGMFLHPAWREDLCRPGVALFGVAQPWFSTPLKP
AFTLTLTILRVQDVPVGTPIGYGSTVTTTRPLRIATVSAGYADGIPRNLRPPAGVCWRGVRLPVLGRVCMDSFMVDASAI
MPTSGDVVEFIGVSQTLEEVAAACDTIPYEIMARLGARFRRIMQPAEA
>Mature_368_residues
MMKLAEIQAACGVLCVDLAAVVDNYQTLARHVAPAQCGAVLKANGYGLGAEAIAPALYAANCRIFFVAQLSEGVALRNIL
SADAMVVLLNGVMPQAMPFCCAQQITPLLNSVDQVMTWLALQEARSQRRPVLIQLDSGMSRLGVTPEQLARLAAIFRQRG
WAAPDYIISHLANADRPDHALNVYQHTLLQQAKKAFPTSRYSLANSCGMFLHPAWREDLCRPGVALFGVAQPWFSTPLKP
AFTLTLTILRVQDVPVGTPIGYGSTVTTTRPLRIATVSAGYADGIPRNLRPPAGVCWRGVRLPVLGRVCMDSFMVDASAI
MPTSGDVVEFIGVSQTLEEVAAACDTIPYEIMARLGARFRRIMQPAEA

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1787439, Length=351, Percent_Identity=31.0541310541311, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1790487, Length=368, Percent_Identity=32.3369565217391, Blast_Score=135, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR3_SALTI (Q8Z300)

Other databases:

- EMBL:   AL627279
- EMBL:   AE014613
- RefSeq:   NP_457948.1
- RefSeq:   NP_807161.1
- ProteinModelPortal:   Q8Z300
- SMR:   Q8Z300
- GeneID:   1069138
- GeneID:   1250019
- GenomeReviews:   AE014613_GR
- GenomeReviews:   AL513382_GR
- KEGG:   stt:t3513
- KEGG:   sty:STY3763
- HOGENOM:   HBG712172
- OMA:   YCTPDKI
- ProtClustDB:   CLSK247080
- BioCyc:   SENT209261:T3513-MONOMER
- BioCyc:   SENT220341:STY3763-MONOMER
- BRENDA:   5.1.1.1
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 39779; Mature: 39779

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 42-42 ACT_SITE 262-262

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKLAEIQAACGVLCVDLAAVVDNYQTLARHVAPAQCGAVLKANGYGLGAEAIAPALYAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCEEEECCCCCCHHHHHHHHHHC
NCRIFFVAQLSEGVALRNILSADAMVVLLNGVMPQAMPFCCAQQITPLLNSVDQVMTWLA
CCEEEEEEEHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQEARSQRRPVLIQLDSGMSRLGVTPEQLARLAAIFRQRGWAAPDYIISHLANADRPDHA
HHHHHHCCCCEEEEECCCCHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHH
LNVYQHTLLQQAKKAFPTSRYSLANSCGMFLHPAWREDLCRPGVALFGVAQPWFSTPLKP
HHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHCCCCHHHHCCCCHHHCCCCCC
AFTLTLTILRVQDVPVGTPIGYGSTVTTTRPLRIATVSAGYADGIPRNLRPPAGVCWRGV
HHHHEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHCCC
RLPVLGRVCMDSFMVDASAIMPTSGDVVEFIGVSQTLEEVAAACDTIPYEIMARLGARFR
CHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
RIMQPAEA
HHHCCCCC
>Mature Secondary Structure
MMKLAEIQAACGVLCVDLAAVVDNYQTLARHVAPAQCGAVLKANGYGLGAEAIAPALYAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCEEEECCCCCCHHHHHHHHHHC
NCRIFFVAQLSEGVALRNILSADAMVVLLNGVMPQAMPFCCAQQITPLLNSVDQVMTWLA
CCEEEEEEEHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQEARSQRRPVLIQLDSGMSRLGVTPEQLARLAAIFRQRGWAAPDYIISHLANADRPDHA
HHHHHHCCCCEEEEECCCCHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHH
LNVYQHTLLQQAKKAFPTSRYSLANSCGMFLHPAWREDLCRPGVALFGVAQPWFSTPLKP
HHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHCCCCHHHHCCCCHHHCCCCCC
AFTLTLTILRVQDVPVGTPIGYGSTVTTTRPLRIATVSAGYADGIPRNLRPPAGVCWRGV
HHHHEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHCCC
RLPVLGRVCMDSFMVDASAIMPTSGDVVEFIGVSQTLEEVAAACDTIPYEIMARLGARFR
CHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
RIMQPAEA
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504