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The map label for this gene is dxs [H]

Identifier: 29142829

GI number: 29142829

Start: 2512400

End: 2514262

Strand: Direct

Name: dxs [H]

Synonym: t2441

Alternate gene names: 29142829

Gene position: 2512400-2514262 (Clockwise)

Preceding gene: 29142828

Following gene: 29142830

Centisome position: 52.43

GC content: 55.13

Gene sequence:

>1863_bases
ATGAGTTTTGATATAGCCAAATACCCTACCCTGGCATTGGTCGACTCCACCCAGGAGTTACGACTGTTACCGAAAGAGAG
TCTGCCGAAACTCTGCGACGAGCTACGCCGCTACTTACTCGACAGCGTAAGCCGTTCCAGCGGGCATTTCGCTTCCGGGC
TGGGCACGGTAGAACTTACCGTGGCGCTGCATTATGTCTACAACACCCCGTTTGACCAGCTAATCTGGGATGTTGGACAC
CAGGCTTATCCACATAAAATCCTTACCGGTCGTCGCGACAAAATCGGCACCATTCGCCAGAAAGGCGGTCTGCACCCGTT
CCCGTGGCGCGGAGAAAGCGAATACGATGTGCTGAGCGTTGGGCATTCCTCCACCTCCATCAGCGCCGGTATCGGTATTG
CCGTGGCGGCGGAGAAAGAAGGCAAAGATCGCCGCACCGTCTGTGTGATTGGCGACGGCGCCATCACCGCCGGTATGGCG
TTTGAAGCAATGAATCACGCAGGCGATATCCGACCCGACATGCTGGTCATTCTGAACGACAATGAAATGTCGATTTCGGA
AAACGTCGGCGCGCTCAACAACCATCTGGCGCGGCTACTTTCCGGTAAGCTTTACTCTTCTCTGCGCGAAGGCGGAAAAA
AAGTCTTCTCCGGCGTACCGCCAATTAAAGAACTGCTCAAGCGTACCGAAGAACATATTAAAGGCATGGTTGTGCCGGGA
ACACTGTTCGAAGAGCTGGGCTTTAACTACATCGGGCCGGTCGATGGTCACGATGTCATGGGGCTTATCAGCACATTGAA
GAACATGCGTGACCTGAAAGGGCCGCAGTTCCTGCATATCATGACCAAAAAAGGCCGCGGCTATGAGCCCGCGGAAAAAG
ATCCGATCACTTTCCATGCGGTGCCTAAATTTGATCCCTCCAGCGGATGTTTGCCGAAAAGCAGCGGCGGTCTGCCAGGT
TATTCAAAAATCTTCGGTGACTGGCTGTGTGAAACCGCCGCCAAAGACAGCAAGCTGATGGCGATCACCCCGGCAATGCG
CGAAGGTTCCGGCATGGTGGAATTTTCACGTAAATTCCCGGATCGCTATTTTGACGTCGCTATCGCCGAGCAGCATGCCG
TCACCTTCGCCGCAGGTCTGGCGATTGGCGGCTATAAGCCCGTCGTGGCGATCTACTCTACTTTCCTGCAACGCGCCTAC
GATCAGGTCATCCATGACGTCGCTATCCAGAAACTGCCGGTCATGTTCGCCATCGATCGCGCCGGTATCGTTGGCGCGGA
TGGGCAAACACACCAAGGCGCGTTCGATCTCTCCTATCTGCGCTGCATCCCGGATATGGTGATCATGACGCCAAGCGACG
AGAACGAATGTCGCCAGATGTTATTTACCGGGTATCACTATAACGACGGCCCGACGGCAGTACGTTATCCACGCGGTAAT
GCGCAGGGCGTGGCGCTAACCCCGCTGGAAAAACTGCCTATTGGTAAAGGTCTTGTGAAGCGTCATGGCGAAAAACTGGC
GATTCTGAACTTTGGCACCTTAATGCCTGAGGCGGCGAAAGTCGCCGAAGCGCTGAATGCCACGCTGGTCGACATGCGCT
TTGTTAAACCGCTGGACGACACGTTAATTCTGGAGATGGCCGCGCAGCATGACGCGCTGGTGACGCTGGAAGAAAACGCC
ATTATGGGCGGCGCTGGCAGCGGCGTAAACGAAGTGCTAATGGCCCATCGTAAACCTGTACCTGTGCTGAATATCGGTCT
TCCGGATTTCTTTATCCCGCAAGGAACGCAGGAAGAAGCCCGCGCGGAACTGGGGCTTGACGCCGCAGGCATTGAAGCCA
AAATCAAGGCCTGGCTGGCATAA

Upstream 100 bases:

>100_bases
ATCAGCTGGCCGCGCAATCACTGGACACCTCGGCACTGGAAGCGCTAGCGAACTACATAATCCAGCGTGATAAATAAACC
CCATATCCAATGAGCTTGCG

Downstream 100 bases:

>100_bases
TCTCCTCTTTGCTCCTGCTATGCTTGAAGAGTGACGGGTATAACAGGAGCGGAGTCATGCAATACAACACGTTAGGAAAT
ACCGATCTTCGGGTGTCCCG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 620; Mature: 619

Protein sequence:

>620_residues
MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGH
QAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKDRRTVCVIGDGAITAGMA
FEAMNHAGDIRPDMLVILNDNEMSISENVGALNNHLARLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
TLFEELGFNYIGPVDGHDVMGLISTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPG
YSKIFGDWLCETAAKDSKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAY
DQVIHDVAIQKLPVMFAIDRAGIVGADGQTHQGAFDLSYLRCIPDMVIMTPSDENECRQMLFTGYHYNDGPTAVRYPRGN
AQGVALTPLEKLPIGKGLVKRHGEKLAILNFGTLMPEAAKVAEALNATLVDMRFVKPLDDTLILEMAAQHDALVTLEENA
IMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEARAELGLDAAGIEAKIKAWLA

Sequences:

>Translated_620_residues
MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGH
QAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKDRRTVCVIGDGAITAGMA
FEAMNHAGDIRPDMLVILNDNEMSISENVGALNNHLARLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
TLFEELGFNYIGPVDGHDVMGLISTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPG
YSKIFGDWLCETAAKDSKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAY
DQVIHDVAIQKLPVMFAIDRAGIVGADGQTHQGAFDLSYLRCIPDMVIMTPSDENECRQMLFTGYHYNDGPTAVRYPRGN
AQGVALTPLEKLPIGKGLVKRHGEKLAILNFGTLMPEAAKVAEALNATLVDMRFVKPLDDTLILEMAAQHDALVTLEENA
IMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEARAELGLDAAGIEAKIKAWLA
>Mature_619_residues
SFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGHQ
AYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKDRRTVCVIGDGAITAGMAF
EAMNHAGDIRPDMLVILNDNEMSISENVGALNNHLARLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPGT
LFEELGFNYIGPVDGHDVMGLISTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPGY
SKIFGDWLCETAAKDSKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYD
QVIHDVAIQKLPVMFAIDRAGIVGADGQTHQGAFDLSYLRCIPDMVIMTPSDENECRQMLFTGYHYNDGPTAVRYPRGNA
QGVALTPLEKLPIGKGLVKRHGEKLAILNFGTLMPEAAKVAEALNATLVDMRFVKPLDDTLILEMAAQHDALVTLEENAI
MGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEARAELGLDAAGIEAKIKAWLA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=499, Percent_Identity=23.6472945891784, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI4507521, Length=499, Percent_Identity=23.6472945891784, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI225637463, Length=540, Percent_Identity=23.5185185185185, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI133778974, Length=497, Percent_Identity=23.3400402414487, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI225637459, Length=540, Percent_Identity=23.5185185185185, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI225637461, Length=540, Percent_Identity=23.5185185185185, Blast_Score=81, Evalue=4e-15,
Organism=Escherichia coli, GI1786622, Length=620, Percent_Identity=96.1290322580645, Blast_Score=1239, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=504, Percent_Identity=25, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24645119, Length=529, Percent_Identity=24.7637051039698, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45551847, Length=529, Percent_Identity=24.7637051039698, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45550715, Length=529, Percent_Identity=24.7637051039698, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24666278, Length=488, Percent_Identity=24.3852459016393, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 67497; Mature: 67365

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELT
CCCCCCCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
VALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSV
EEEEEHHCCCHHHHHHHHCCCCCCCHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEEE
GHSSTSISAGIGIAVAAEKEGKDRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVILND
CCCCCEECCCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLARLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
CCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEECCC
TLFEELGFNYIGPVDGHDVMGLISTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHA
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEEE
VPKFDPSSGCLPKSSGGLPGYSKIFGDWLCETAAKDSKLMAITPAMREGSGMVEFSRKFP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHCCCCCCHHHHHCC
DRYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYDQVIHDVAIQKLPVMFAIDR
CHHHEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
AGIVGADGQTHQGAFDLSYLRCIPDMVIMTPSDENECRQMLFTGYHYNDGPTAVRYPRGN
CCEECCCCCCCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHCCEEECCCCCEEECCCCC
AQGVALTPLEKLPIGKGLVKRHGEKLAILNFGTLMPEAAKVAEALNATLVDMRFVKPLDD
CCCEEECCHHHCCCCHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
TLILEMAAQHDALVTLEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEA
HHHHHHHHCCCEEEEEECCEEECCCCCCHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHH
RAELGLDAAGIEAKIKAWLA
HHHHCCCCCCCHHHHHHHCC
>Mature Secondary Structure 
SFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELT
CCCCCCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
VALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSV
EEEEEHHCCCHHHHHHHHCCCCCCCHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEEE
GHSSTSISAGIGIAVAAEKEGKDRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVILND
CCCCCEECCCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLARLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
CCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEECCC
TLFEELGFNYIGPVDGHDVMGLISTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHA
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEEE
VPKFDPSSGCLPKSSGGLPGYSKIFGDWLCETAAKDSKLMAITPAMREGSGMVEFSRKFP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHCCCCCCHHHHHCC
DRYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYDQVIHDVAIQKLPVMFAIDR
CHHHEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
AGIVGADGQTHQGAFDLSYLRCIPDMVIMTPSDENECRQMLFTGYHYNDGPTAVRYPRGN
CCEECCCCCCCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHCCEEECCCCCEEECCCCC
AQGVALTPLEKLPIGKGLVKRHGEKLAILNFGTLMPEAAKVAEALNATLVDMRFVKPLDD
CCCEEECCHHHCCCCHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
TLILEMAAQHDALVTLEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEA
HHHHHHHHCCCEEEEEECCEEECCCCCCHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHH
RAELGLDAAGIEAKIKAWLA
HHHHCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA