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The map label for this gene is apbA [H]

Identifier: 29142817

GI number: 29142817

Start: 2501201

End: 2502112

Strand: Direct

Name: apbA [H]

Synonym: t2430

Alternate gene names: 29142817

Gene position: 2501201-2502112 (Clockwise)

Preceding gene: 29142815

Following gene: 29142818

Centisome position: 52.2

GC content: 52.74

Gene sequence:

>912_bases
ATGAAAATTACTGTACTGGGATGCGGAGCCTTAGGACAACTTTGGCTTTCGGCACTGTGCAAACATGGACATGACGTACA
GGGCTGGCTACGGGTGCCACAACCTTATTGCAGCGTAAATCTGATCGATACCGATGGTTCCTTTTTCAACGAATCACTGA
CGGCAAACGATCCGGATTTTTTGGCGAAGAGCGAACTGTTGTTAGTCACGCTGAAAGCGTGGCAGGTTTCCGACGCAGTA
CGAACCCTGGCGTCAACCCTACCGGTGACGTCGCCTATCCTGCTCATTCATAATGGAATGGGAACCATAGAAGAACTGCA
AAGTATCCAACAGCCGATGTTGATGGGGACTATCACCCATGCTGCGCGCCGCGACGGTAATATCATTATTCATGTCGCTA
ACGGTACTACGCATATTGGCCCGGCGCGCGAGCAAGACGGCGATTACAGTTATCTCGCCGAGATCCTGCAAGGGGTACTG
CCCGATGTCGCCTGGCATAACAATATCCGCGCAGAGATGTGGCGCAAACTGGCCGTCAACTGTGTTATCAACCCGCTCAC
CGCGCTTTGGAACTGCCCGAACGGCGAGCTGCGCCATCATACTGATGAAATCAACGCGATTTGCGAAGAGGTCGCCGCCG
TGATTGAACGTGAGGGCTACCACACATCGGCAGACGATTTATGCTATTATGTTGAGCAAGTGATTGACAGTACGGCAGAA
AATATCTCATCCATGTTGCAGGACGTGCGCGCCATGCGCCATACCGAAATTGACTACATCACCGGTTATTTACTCAAGCG
CGCCCGCGTGCACGGTCTCGCCGTTCCGGAAAATAGCCGCCTGTTTGAAATGGTAAAGCGAAAGGAGAGTGAGTATGAGC
GCTCAGGCACTGGTATGCCTCGCCCCTGGTAG

Upstream 100 bases:

>100_bases
GCGTTGCATAATACCTGCAACGAGGCTTAACGAGAAGCTTAGCTGATGACGCTATAATTAGCGCCATAACACCTGGCGCT
GTTGCAGGTGAGGAGGAACA

Downstream 100 bases:

>100_bases
TGAAGAGACCGAAGCGGTCACCACTATCGATCTGCTGGTTCGCGGCGGAATCCACGTCACTACCGCCAGCGTCGCCAGCG
ATGGCAACCTGACGATTGTC

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MKITVLGCGALGQLWLSALCKHGHDVQGWLRVPQPYCSVNLIDTDGSFFNESLTANDPDFLAKSELLLVTLKAWQVSDAV
RTLASTLPVTSPILLIHNGMGTIEELQSIQQPMLMGTITHAARRDGNIIIHVANGTTHIGPAREQDGDYSYLAEILQGVL
PDVAWHNNIRAEMWRKLAVNCVINPLTALWNCPNGELRHHTDEINAICEEVAAVIEREGYHTSADDLCYYVEQVIDSTAE
NISSMLQDVRAMRHTEIDYITGYLLKRARVHGLAVPENSRLFEMVKRKESEYERSGTGMPRPW

Sequences:

>Translated_303_residues
MKITVLGCGALGQLWLSALCKHGHDVQGWLRVPQPYCSVNLIDTDGSFFNESLTANDPDFLAKSELLLVTLKAWQVSDAV
RTLASTLPVTSPILLIHNGMGTIEELQSIQQPMLMGTITHAARRDGNIIIHVANGTTHIGPAREQDGDYSYLAEILQGVL
PDVAWHNNIRAEMWRKLAVNCVINPLTALWNCPNGELRHHTDEINAICEEVAAVIEREGYHTSADDLCYYVEQVIDSTAE
NISSMLQDVRAMRHTEIDYITGYLLKRARVHGLAVPENSRLFEMVKRKESEYERSGTGMPRPW
>Mature_303_residues
MKITVLGCGALGQLWLSALCKHGHDVQGWLRVPQPYCSVNLIDTDGSFFNESLTANDPDFLAKSELLLVTLKAWQVSDAV
RTLASTLPVTSPILLIHNGMGTIEELQSIQQPMLMGTITHAARRDGNIIIHVANGTTHIGPAREQDGDYSYLAEILQGVL
PDVAWHNNIRAEMWRKLAVNCVINPLTALWNCPNGELRHHTDEINAICEEVAAVIEREGYHTSADDLCYYVEQVIDSTAE
NISSMLQDVRAMRHTEIDYITGYLLKRARVHGLAVPENSRLFEMVKRKESEYERSGTGMPRPW

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=303, Percent_Identity=86.4686468646865, Blast_Score=560, Evalue=1e-161,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 33872; Mature: 33872

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITVLGCGALGQLWLSALCKHGHDVQGWLRVPQPYCSVNLIDTDGSFFNESLTANDPDF
CEEEEEECCHHHHHHHHHHHHCCCCCCHHEECCCCCCEEEEEECCCCHHCCCCCCCCCCH
LAKSELLLVTLKAWQVSDAVRTLASTLPVTSPILLIHNGMGTIEELQSIQQPMLMGTITH
HHCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
AARRDGNIIIHVANGTTHIGPAREQDGDYSYLAEILQGVLPDVAWHNNIRAEMWRKLAVN
HHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHH
CVINPLTALWNCPNGELRHHTDEINAICEEVAAVIEREGYHTSADDLCYYVEQVIDSTAE
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
NISSMLQDVRAMRHTEIDYITGYLLKRARVHGLAVPENSRLFEMVKRKESEYERSGTGMP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCC
RPW
CCC
>Mature Secondary Structure
MKITVLGCGALGQLWLSALCKHGHDVQGWLRVPQPYCSVNLIDTDGSFFNESLTANDPDF
CEEEEEECCHHHHHHHHHHHHCCCCCCHHEECCCCCCEEEEEECCCCHHCCCCCCCCCCH
LAKSELLLVTLKAWQVSDAVRTLASTLPVTSPILLIHNGMGTIEELQSIQQPMLMGTITH
HHCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
AARRDGNIIIHVANGTTHIGPAREQDGDYSYLAEILQGVLPDVAWHNNIRAEMWRKLAVN
HHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHH
CVINPLTALWNCPNGELRHHTDEINAICEEVAAVIEREGYHTSADDLCYYVEQVIDSTAE
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
NISSMLQDVRAMRHTEIDYITGYLLKRARVHGLAVPENSRLFEMVKRKESEYERSGTGMP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCC
RPW
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]