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The map label for this gene is ghrA [H]

Identifier: 29142217

GI number: 29142217

Start: 1844904

End: 1845842

Strand: Reverse

Name: ghrA [H]

Synonym: t1785

Alternate gene names: 29142217

Gene position: 1845842-1844904 (Counterclockwise)

Preceding gene: 29142218

Following gene: 29142216

Centisome position: 38.52

GC content: 54.95

Gene sequence:

>939_bases
ATGGAGATAATTTTTTATCACCCGACATTTAACGCCGCCTGGTGGGTAAATGCGCTGGAGAAGGCTCTCCCACATGCGCG
CGTTCGTGAATGGAAGGTCGGTGATAACAACCCCGCAGACTATGCGCTTGTATGGCAGCCCCCGGTTGAAATGCTGGCCG
GAAGACGCTTAAAAGCCGTCTTTGTGCTGGGCGCGGGGGTGGATGCAATTCTGAGTAAATTAAATGCGCATCCGGAAATG
CTGGACGCCTCCATTCCTCTATTCCGTCTGGAAGATACCGGAATGGGCCTGCAAATGCAGGAGTATGCCGCCAGCCAGGT
ATTACACTGGTTCCGTCGTTTCGATGATTATCAGGCGCTGAAAAATCAGGCGCTATGGAAACCGTTGCCGGAATATACCC
GCGAAGAGTTTAGCGTCGGTATCATAGGCGCAGGGGTACTGGGCGCAAAAGTGGCAGAAAGTCTACAGGCGTGGGGGTTC
CCGTTACGTTGCTGGAGTCGTAGCCGCAAATCCTGGCCTGGCGTGGAAAGTTATGTAGGGCGTGAAGAACTGCGCGCTTT
CCTGAACCAGACGCGGGTGCTGATTAATCTGCTGCCGAATACGGCCCAAACGGTAGGAATTATTAATAGCGAATTGTTGG
ATCAATTGCCGGATGGCGCTTACGTGCTGAATCTCGCGCGCGGCGTTCATGTTCAGGAGGCGGATCTGCTGGCTGCGCTT
GATAGCGGTAAGCTAAAAGGCGCGATGTTGGATGTCTTTAGCCAGGAACCGTTACCGCAGGAAAGTCCATTATGGCGCCA
TCCGCGAGTCGCCATGACGCCGCACATTGCGGCAGTCACCCGTCCGGCGGAAGCCATCGATTATATTAGCCGCACCATTA
CCCAGCTGGAGAAGGGAGAGCCGGTGACGGGGCAGGTGGATCGGGCGAGAGGATATTGA

Upstream 100 bases:

>100_bases
TTTTTTGCCCGCGCCGGGAAATTTGCTATGCTGCACATCCCGTTGAAAACGCTGATAACAGGCGCAATCACATTCCGCAC
AATACTGCTCAGGAGATAAC

Downstream 100 bases:

>100_bases
TATCAACCCGGCGCGGGCCGGGTTTCGCTAAAAAACGCTGGCGATACCTGCTATCCTTGTCGGAAATGACTACAGGAGAG
AGCAATGTATCCCGTTGACC

Product: 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MEIIFYHPTFNAAWWVNALEKALPHARVREWKVGDNNPADYALVWQPPVEMLAGRRLKAVFVLGAGVDAILSKLNAHPEM
LDASIPLFRLEDTGMGLQMQEYAASQVLHWFRRFDDYQALKNQALWKPLPEYTREEFSVGIIGAGVLGAKVAESLQAWGF
PLRCWSRSRKSWPGVESYVGREELRAFLNQTRVLINLLPNTAQTVGIINSELLDQLPDGAYVLNLARGVHVQEADLLAAL
DSGKLKGAMLDVFSQEPLPQESPLWRHPRVAMTPHIAAVTRPAEAIDYISRTITQLEKGEPVTGQVDRARGY

Sequences:

>Translated_312_residues
MEIIFYHPTFNAAWWVNALEKALPHARVREWKVGDNNPADYALVWQPPVEMLAGRRLKAVFVLGAGVDAILSKLNAHPEM
LDASIPLFRLEDTGMGLQMQEYAASQVLHWFRRFDDYQALKNQALWKPLPEYTREEFSVGIIGAGVLGAKVAESLQAWGF
PLRCWSRSRKSWPGVESYVGREELRAFLNQTRVLINLLPNTAQTVGIINSELLDQLPDGAYVLNLARGVHVQEADLLAAL
DSGKLKGAMLDVFSQEPLPQESPLWRHPRVAMTPHIAAVTRPAEAIDYISRTITQLEKGEPVTGQVDRARGY
>Mature_312_residues
MEIIFYHPTFNAAWWVNALEKALPHARVREWKVGDNNPADYALVWQPPVEMLAGRRLKAVFVLGAGVDAILSKLNAHPEM
LDASIPLFRLEDTGMGLQMQEYAASQVLHWFRRFDDYQALKNQALWKPLPEYTREEFSVGIIGAGVLGAKVAESLQAWGF
PLRCWSRSRKSWPGVESYVGREELRAFLNQTRVLINLLPNTAQTVGIINSELLDQLPDGAYVLNLARGVHVQEADLLAAL
DSGKLKGAMLDVFSQEPLPQESPLWRHPRVAMTPHIAAVTRPAEAIDYISRTITQLEKGEPVTGQVDRARGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=270, Percent_Identity=28.1481481481481, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI6912396, Length=237, Percent_Identity=29.957805907173, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI87081824, Length=312, Percent_Identity=77.5641025641026, Blast_Score=519, Evalue=1e-149,
Organism=Escherichia coli, GI87082289, Length=146, Percent_Identity=30.8219178082192, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=164, Percent_Identity=32.9268292682927, Blast_Score=78, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6324055, Length=179, Percent_Identity=31.2849162011173, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324980, Length=175, Percent_Identity=30.8571428571429, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324964, Length=175, Percent_Identity=30.8571428571429, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574286, Length=262, Percent_Identity=28.6259541984733, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24585514, Length=243, Percent_Identity=26.3374485596708, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI28574282, Length=243, Percent_Identity=26.3374485596708, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI45552429, Length=243, Percent_Identity=26.3374485596708, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28574284, Length=243, Percent_Identity=26.3374485596708, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45551003, Length=243, Percent_Identity=26.3374485596708, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24585516, Length=239, Percent_Identity=27.1966527196653, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI19921140, Length=154, Percent_Identity=30.5194805194805, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 34989; Mature: 34989

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIIFYHPTFNAAWWVNALEKALPHARVREWKVGDNNPADYALVWQPPVEMLAGRRLKAV
CEEEEECCCCCHHHHHHHHHHHCCHHHHHEEECCCCCCCCEEEEECCCHHHHCCCCEEEE
FVLGAGVDAILSKLNAHPEMLDASIPLFRLEDTGMGLQMQEYAASQVLHWFRRFDDYQAL
EEECCCHHHHHHHHCCCHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KNQALWKPLPEYTREEFSVGIIGAGVLGAKVAESLQAWGFPLRCWSRSRKSWPGVESYVG
HHHHHCCCCHHHHHHHHCEEEEECHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCHHHHCC
REELRAFLNQTRVLINLLPNTAQTVGIINSELLDQLPDGAYVLNLARGVHVQEADLLAAL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEHHHHCCCCCHHHHHHHH
DSGKLKGAMLDVFSQEPLPQESPLWRHPRVAMTPHIAAVTRPAEAIDYISRTITQLEKGE
CCCCCCHHHHHHHCCCCCCCCCCCCCCCCEEECCCHHHHCCHHHHHHHHHHHHHHHHCCC
PVTGQVDRARGY
CCCCCCHHCCCC
>Mature Secondary Structure
MEIIFYHPTFNAAWWVNALEKALPHARVREWKVGDNNPADYALVWQPPVEMLAGRRLKAV
CEEEEECCCCCHHHHHHHHHHHCCHHHHHEEECCCCCCCCEEEEECCCHHHHCCCCEEEE
FVLGAGVDAILSKLNAHPEMLDASIPLFRLEDTGMGLQMQEYAASQVLHWFRRFDDYQAL
EEECCCHHHHHHHHCCCHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KNQALWKPLPEYTREEFSVGIIGAGVLGAKVAESLQAWGFPLRCWSRSRKSWPGVESYVG
HHHHHCCCCHHHHHHHHCEEEEECHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCHHHHCC
REELRAFLNQTRVLINLLPNTAQTVGIINSELLDQLPDGAYVLNLARGVHVQEADLLAAL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEHHHHCCCCCHHHHHHHH
DSGKLKGAMLDVFSQEPLPQESPLWRHPRVAMTPHIAAVTRPAEAIDYISRTITQLEKGE
CCCCCCHHHHHHHCCCCCCCCCCCCCCCCEEECCCHHHHCCHHHHHHHHHHHHHHHHCCC
PVTGQVDRARGY
CCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA