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The map label for this gene is cbh [H]

Identifier: 29141908

GI number: 29141908

Start: 1502243

End: 1503334

Strand: Direct

Name: cbh [H]

Synonym: t1459

Alternate gene names: 29141908

Gene position: 1502243-1503334 (Clockwise)

Preceding gene: 29141899

Following gene: 29141909

Centisome position: 31.35

GC content: 47.71

Gene sequence:

>1092_bases
ATGATGAAAAAAAGTAAAGCAATGTTATTTATCGCTCCGGCGCTGTTTTCATACGCCATGGCTGCACAGGCCTGCACAAC
CCTTGCTATTCAGGATAAACAAGGCGATATTTTTCATGGGCGTACGCTGGAATATATGCAGGATTTACCCTCATGGTTAA
CGTATTATCCGGCGGGAACGCAGTTTGATAAAAAAACGCCGGATGGCAGCCAGGGGATAAGCTATCAGGCGAAGTATCCG
ATACTGGCCATTACTTCCACCATTACTGATGGCGATAGCAGAGACATACTTGAAGGCATGAATAGCGCGGGATTGTCATT
TAGTGAAAACATGATCATGAATGCGCAGTTGCCGCCATTGCCCGCGAGTGAATATAAACAGGCAATTCCTGTCACCTCGT
TGGGAGAATGGGCGCTGGCCCGTTTTGCTACTGTCGGCGAGGTAAAACAGGCAATAAAAGAGGGCAAATTCTGGTCACCG
GAACTGCATCGGTTTGGCGATCTGAAATCGCCATTTCATTACGCGTTTTACGACAAGAAAGGAGGAAGCATTGTCGTTGA
AGTGGAAAATGGCAAATTCCATGTCTATGACAATCCCACTCGCGTGATGACAAATGGTCCCGCATTCCCCTGGCATCTGA
CAAATCTGAATAATTATACGCAATTAACCAATGTGGACCGCTCTTCAGGCACATTGGGCGGGATAAAAGTGATGCAGCCT
GATAGCGGGATTGCTATTGCAGACTTGCCATCGTCCGATACGTCGGTTTCCCGTTTTATACGCGGCGTTTATTACACCAC
ATATGCGCCGCAAGCGACATCCGCCCACGACGCAATGAATACGCTTGCACATATTATGAGCCGTTTTGATCGTCCGAAAA
ATATTACGGTTGATTATATGGGGAGTGAAGGGGAAGGCAACGCCACCCGCAAACCGGTCTCAGAATATACGGTCTGGACA
ACGCTGTCTGACTTGACGCACGGTGAGATGATGGTGCGCGGCTACAATGATATCAACTATAAAACCTGGTCCCTTTCTCA
GTTTAAGAACGCGACTGCGCCCGTGTTCGAGAAAATCAACGTCAAAGGATAA

Upstream 100 bases:

>100_bases
TTAGCTTGTAAAATAAGATCACAATTAATTACGTGCTGCATAACCATTGATAGGTTTAATTTAATATATTCATCCAATCC
ATTTTACAAACAAGGAGAGC

Downstream 100 bases:

>100_bases
ACCGCTCGTCTCTGTTTAGTTTCCCCGGTAGTCTCGGCGAAGGTAATGGAGACTACCGGCGGTTGCTTCTCTTTATCATG
CACGGTAATTAATTATCACG

Product: secreted hydrolase

Products: NA

Alternate protein names: Bile salt hydrolase; Conjugated bile acid hydrolase; CBAH [H]

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MMKKSKAMLFIAPALFSYAMAAQACTTLAIQDKQGDIFHGRTLEYMQDLPSWLTYYPAGTQFDKKTPDGSQGISYQAKYP
ILAITSTITDGDSRDILEGMNSAGLSFSENMIMNAQLPPLPASEYKQAIPVTSLGEWALARFATVGEVKQAIKEGKFWSP
ELHRFGDLKSPFHYAFYDKKGGSIVVEVENGKFHVYDNPTRVMTNGPAFPWHLTNLNNYTQLTNVDRSSGTLGGIKVMQP
DSGIAIADLPSSDTSVSRFIRGVYYTTYAPQATSAHDAMNTLAHIMSRFDRPKNITVDYMGSEGEGNATRKPVSEYTVWT
TLSDLTHGEMMVRGYNDINYKTWSLSQFKNATAPVFEKINVKG

Sequences:

>Translated_363_residues
MMKKSKAMLFIAPALFSYAMAAQACTTLAIQDKQGDIFHGRTLEYMQDLPSWLTYYPAGTQFDKKTPDGSQGISYQAKYP
ILAITSTITDGDSRDILEGMNSAGLSFSENMIMNAQLPPLPASEYKQAIPVTSLGEWALARFATVGEVKQAIKEGKFWSP
ELHRFGDLKSPFHYAFYDKKGGSIVVEVENGKFHVYDNPTRVMTNGPAFPWHLTNLNNYTQLTNVDRSSGTLGGIKVMQP
DSGIAIADLPSSDTSVSRFIRGVYYTTYAPQATSAHDAMNTLAHIMSRFDRPKNITVDYMGSEGEGNATRKPVSEYTVWT
TLSDLTHGEMMVRGYNDINYKTWSLSQFKNATAPVFEKINVKG
>Mature_363_residues
MMKKSKAMLFIAPALFSYAMAAQACTTLAIQDKQGDIFHGRTLEYMQDLPSWLTYYPAGTQFDKKTPDGSQGISYQAKYP
ILAITSTITDGDSRDILEGMNSAGLSFSENMIMNAQLPPLPASEYKQAIPVTSLGEWALARFATVGEVKQAIKEGKFWSP
ELHRFGDLKSPFHYAFYDKKGGSIVVEVENGKFHVYDNPTRVMTNGPAFPWHLTNLNNYTQLTNVDRSSGTLGGIKVMQP
DSGIAIADLPSSDTSVSRFIRGVYYTTYAPQATSAHDAMNTLAHIMSRFDRPKNITVDYMGSEGEGNATRKPVSEYTVWT
TLSDLTHGEMMVRGYNDINYKTWSLSQFKNATAPVFEKINVKG

Specific function: The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut [H]

COG id: COG3049

COG function: function code M; Penicillin V acylase and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C59 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003199 [H]

Pfam domain/function: PF02275 CBAH [H]

EC number: =3.5.1.24 [H]

Molecular weight: Translated: 40270; Mature: 40270

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKKSKAMLFIAPALFSYAMAAQACTTLAIQDKQGDIFHGRTLEYMQDLPSWLTYYPAGT
CCCCCCEEEEEHHHHHHHHHHHHHHHEEEEECCCCCEECCCHHHHHHHHHHHHEECCCCC
QFDKKTPDGSQGISYQAKYPILAITSTITDGDSRDILEGMNSAGLSFSENMIMNAQLPPL
CCCCCCCCCCCCCCEEECCCEEEEEEECCCCCCHHHHHCCCCCCCCCCCCEEEECCCCCC
PASEYKQAIPVTSLGEWALARFATVGEVKQAIKEGKFWSPELHRFGDLKSPFHYAFYDKK
CHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCEEEEEECC
GGSIVVEVENGKFHVYDNPTRVMTNGPAFPWHLTNLNNYTQLTNVDRSSGTLGGIKVMQP
CCEEEEEEECCEEEEECCCCEEEECCCCCCEEECCCCCCHHCCCCCCCCCCCCCEEEECC
DSGIAIADLPSSDTSVSRFIRGVYYTTYAPQATSAHDAMNTLAHIMSRFDRPKNITVDYM
CCCEEEEECCCCCHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEE
GSEGEGNATRKPVSEYTVWTTLSDLTHGEMMVRGYNDINYKTWSLSQFKNATAPVFEKIN
CCCCCCCCCCCCHHHEEEEEEHHHCCCCEEEEECCCCCCEEEEEHHHHCCCCCCHHHEEC
VKG
CCC
>Mature Secondary Structure
MMKKSKAMLFIAPALFSYAMAAQACTTLAIQDKQGDIFHGRTLEYMQDLPSWLTYYPAGT
CCCCCCEEEEEHHHHHHHHHHHHHHHEEEEECCCCCEECCCHHHHHHHHHHHHEECCCCC
QFDKKTPDGSQGISYQAKYPILAITSTITDGDSRDILEGMNSAGLSFSENMIMNAQLPPL
CCCCCCCCCCCCCCEEECCCEEEEEEECCCCCCHHHHHCCCCCCCCCCCCEEEECCCCCC
PASEYKQAIPVTSLGEWALARFATVGEVKQAIKEGKFWSPELHRFGDLKSPFHYAFYDKK
CHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCEEEEEECC
GGSIVVEVENGKFHVYDNPTRVMTNGPAFPWHLTNLNNYTQLTNVDRSSGTLGGIKVMQP
CCEEEEEEECCEEEEECCCCEEEECCCCCCEEECCCCCCHHCCCCCCCCCCCCCEEEECC
DSGIAIADLPSSDTSVSRFIRGVYYTTYAPQATSAHDAMNTLAHIMSRFDRPKNITVDYM
CCCEEEEECCCCCHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEE
GSEGEGNATRKPVSEYTVWTTLSDLTHGEMMVRGYNDINYKTWSLSQFKNATAPVFEKIN
CCCCCCCCCCCCHHHEEEEEEHHHCCCCEEEEECCCCCCEEEEEHHHHCCCCCCHHHEEC
VKG
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7618863; 11792842 [H]