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The map label for this gene is rspB [H]

Identifier: 29141879

GI number: 29141879

Start: 1471906

End: 1472769

Strand: Direct

Name: rspB [H]

Synonym: t1427

Alternate gene names: 29141879

Gene position: 1471906-1472769 (Clockwise)

Preceding gene: 29141878

Following gene: 29141880

Centisome position: 30.72

GC content: 51.04

Gene sequence:

>864_bases
ATGAAAAGCATCGTAATCGAAAAACCGAATACATTAACCATCGAAACGCGCGCGCTTCTGCAGCCAGCATCTGGCGAAGT
TCGTATTAAAGTGAAACTGGCGGGTATCTGCGGTTCCGACAGCCATATTTATCGGGGACATAATCCCTTTGCAAAATATC
CCCGTGTCATAGGCCATGAATTTTTCGGTGTCATCGACGCGGTAGGCGACAACGTCAATCGCGACCGGATAGGAGAACGG
GTATCCGTCGATCCGGTGATCAGTTGCGGGCATTGTTACCCTTGTTCAGTCGGTAAACCCAATGTGTGTACCTCGCTGGT
GGTGCTGGGCGTGCATCGTGACGGCGGTTTCAGCGAGTATGCGGTGGCGCCGGCCCGTAATGCTCATCGCATACCGGACA
ACATCGCAGACCATCATGCCGTCATGGTTGAGCCGTTTACCATTGCGGCAAATGTGACGGGGCAGGTGAATCCGACCGAG
CAGGACGTGGCGCTTATCTATGGCGCAGGCCCGATGGGACTGACGACCGTACAGGCGTTGAAGGGGGTTTATCAGGTTAA
AACGGTCATAGTCGTTGATCGCATTGAAGAATCGCCTGCGGCACGCATTGTCCTGATGGGATTTTCCAGCGACCCGTGTG
AGATTGTACAGCAGGGTATTACCGGAAAAGAGCTGGCTATTTATTCATCGCGTCTTAATGCCAATAAATTCCCGGTCGTG
ATTGACTGGCTGAATAAAGGGCTTATTGATCCGGATAAGCTGATAACGCATACATTTGATTATCAACATGTCACCGACGC
GATTGAGCTTTTCGAGAAAGACCAGCGTCAATGCTGCAAAGTCTTACTCACGTTTGCGAAATAA

Upstream 100 bases:

>100_bases
TTTAATGAAAAACTGGCGGCGAAATATCCGTACGATCCAGCCTATTTGCCGGTGGCCCGTCTTGAAGACGGCACACTGTG
GAACTGGTAAGGAGCGAAAA

Downstream 100 bases:

>100_bases
TATAAATACTTGCGAGTAAGTGGTACGCATCTTACCTCTTAGAGATTGCCTATATGACACAAATAAAGCATGAACGATCG
ACTCAGGATTTAGTGCGCGC

Product: starvation sensing protein RspB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MKSIVIEKPNTLTIETRALLQPASGEVRIKVKLAGICGSDSHIYRGHNPFAKYPRVIGHEFFGVIDAVGDNVNRDRIGER
VSVDPVISCGHCYPCSVGKPNVCTSLVVLGVHRDGGFSEYAVAPARNAHRIPDNIADHHAVMVEPFTIAANVTGQVNPTE
QDVALIYGAGPMGLTTVQALKGVYQVKTVIVVDRIEESPAARIVLMGFSSDPCEIVQQGITGKELAIYSSRLNANKFPVV
IDWLNKGLIDPDKLITHTFDYQHVTDAIELFEKDQRQCCKVLLTFAK

Sequences:

>Translated_287_residues
MKSIVIEKPNTLTIETRALLQPASGEVRIKVKLAGICGSDSHIYRGHNPFAKYPRVIGHEFFGVIDAVGDNVNRDRIGER
VSVDPVISCGHCYPCSVGKPNVCTSLVVLGVHRDGGFSEYAVAPARNAHRIPDNIADHHAVMVEPFTIAANVTGQVNPTE
QDVALIYGAGPMGLTTVQALKGVYQVKTVIVVDRIEESPAARIVLMGFSSDPCEIVQQGITGKELAIYSSRLNANKFPVV
IDWLNKGLIDPDKLITHTFDYQHVTDAIELFEKDQRQCCKVLLTFAK
>Mature_287_residues
MKSIVIEKPNTLTIETRALLQPASGEVRIKVKLAGICGSDSHIYRGHNPFAKYPRVIGHEFFGVIDAVGDNVNRDRIGER
VSVDPVISCGHCYPCSVGKPNVCTSLVVLGVHRDGGFSEYAVAPARNAHRIPDNIADHHAVMVEPFTIAANVTGQVNPTE
QDVALIYGAGPMGLTTVQALKGVYQVKTVIVVDRIEESPAARIVLMGFSSDPCEIVQQGITGKELAIYSSRLNANKFPVV
IDWLNKGLIDPDKLITHTFDYQHVTDAIELFEKDQRQCCKVLLTFAK

Specific function: Not known; probable catabolic enzyme [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=330, Percent_Identity=24.5454545454545, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI262073058, Length=203, Percent_Identity=25.615763546798, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI71743840, Length=203, Percent_Identity=25.615763546798, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI71565154, Length=215, Percent_Identity=26.5116279069767, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI156523966, Length=204, Percent_Identity=25, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI4501939, Length=204, Percent_Identity=25, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787863, Length=339, Percent_Identity=65.1917404129793, Blast_Score=458, Evalue=1e-130,
Organism=Escherichia coli, GI226510992, Length=177, Percent_Identity=40.1129943502825, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1790045, Length=171, Percent_Identity=38.0116959064327, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1788073, Length=337, Percent_Identity=27.5964391691395, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1788407, Length=176, Percent_Identity=33.5227272727273, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790718, Length=342, Percent_Identity=22.8070175438596, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI87082125, Length=347, Percent_Identity=25.9365994236311, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788075, Length=198, Percent_Identity=33.8383838383838, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1786825, Length=221, Percent_Identity=25.3393665158371, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI87081918, Length=232, Percent_Identity=28.0172413793103, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=195, Percent_Identity=31.2820512820513, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17562878, Length=221, Percent_Identity=27.6018099547511, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71988145, Length=171, Percent_Identity=29.8245614035088, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319258, Length=200, Percent_Identity=34.5, Blast_Score=90, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6323099, Length=201, Percent_Identity=27.8606965174129, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6322619, Length=199, Percent_Identity=29.1457286432161, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6319955, Length=199, Percent_Identity=29.1457286432161, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=198, Percent_Identity=28.7878787878788, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=137, Percent_Identity=35.036496350365, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320033, Length=229, Percent_Identity=24.8908296943231, Blast_Score=72, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=182, Percent_Identity=29.6703296703297, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323961, Length=171, Percent_Identity=30.9941520467836, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323729, Length=162, Percent_Identity=29.0123456790123, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17137530, Length=333, Percent_Identity=24.3243243243243, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI17737897, Length=335, Percent_Identity=23.8805970149254, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI221457811, Length=228, Percent_Identity=25.4385964912281, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45550770, Length=228, Percent_Identity=25.4385964912281, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45551930, Length=228, Percent_Identity=25.4385964912281, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17737895, Length=104, Percent_Identity=31.7307692307692, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 31359; Mature: 31359

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSIVIEKPNTLTIETRALLQPASGEVRIKVKLAGICGSDSHIYRGHNPFAKYPRVIGHE
CCCEEEECCCEEEEEEHEEECCCCCCEEEEEEEEEEECCCCCEECCCCCHHHHHHHHHHH
FFGVIDAVGDNVNRDRIGERVSVDPVISCGHCYPCSVGKPNVCTSLVVLGVHRDGGFSEY
HHHHHHHHCCCCCHHHCCCCCCCCCEEECCCEEECCCCCCCHHEEEEEEEEECCCCCCCE
AVAPARNAHRIPDNIADHHAVMVEPFTIAANVTGQVNPTEQDVALIYGAGPMGLTTVQAL
EECCCCCCCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHH
KGVYQVKTVIVVDRIEESPAARIVLMGFSSDPCEIVQQGITGKELAIYSSRLNANKFPVV
HHHHHHEEEEEEECCCCCCCEEEEEEECCCCHHHHHHCCCCCCEEEEEECCCCCCCCCEE
IDWLNKGLIDPDKLITHTFDYQHVTDAIELFEKDQRQCCKVLLTFAK
EEEHHCCCCCHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKSIVIEKPNTLTIETRALLQPASGEVRIKVKLAGICGSDSHIYRGHNPFAKYPRVIGHE
CCCEEEECCCEEEEEEHEEECCCCCCEEEEEEEEEEECCCCCEECCCCCHHHHHHHHHHH
FFGVIDAVGDNVNRDRIGERVSVDPVISCGHCYPCSVGKPNVCTSLVVLGVHRDGGFSEY
HHHHHHHHCCCCCHHHCCCCCCCCCEEECCCEEECCCCCCCHHEEEEEEEEECCCCCCCE
AVAPARNAHRIPDNIADHHAVMVEPFTIAANVTGQVNPTEQDVALIYGAGPMGLTTVQAL
EECCCCCCCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHH
KGVYQVKTVIVVDRIEESPAARIVLMGFSSDPCEIVQQGITGKELAIYSSRLNANKFPVV
HHHHHHEEEEEEECCCCCCCEEEEEEECCCCHHHHHHCCCCCCEEEEEECCCCCCCCCEE
IDWLNKGLIDPDKLITHTFDYQHVTDAIELFEKDQRQCCKVLLTFAK
EEEHHCCCCCHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7545940; 9097039; 9278503 [H]