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The map label for this gene is ndh [H]

Identifier: 28572931

GI number: 28572931

Start: 896339

End: 897667

Strand: Reverse

Name: ndh [H]

Synonym: TW790

Alternate gene names: 28572931

Gene position: 897667-896339 (Counterclockwise)

Preceding gene: 28572932

Following gene: 28572922

Centisome position: 96.95

GC content: 51.84

Gene sequence:

>1329_bases
ATGGCAGAAAAAGTATTGATAGTTGGCGGCGGTTTTGCGGGCTTCGGGATTGCCCGGATTTTGAGAAAAAAACTCAGATA
CTTCGAGGTTTCACTTGTGGACCCGCTTCCGTATATGACCTATCAGCCATTTTTACCGGAGGTCGCAGCCGGGTCGATTG
AACCCAGAAATGCTGTCGTGGGCCACCGCAGGCATTTAGCGGGGGTTCGCATTATTAGTGGGAGTGTCACTTCTGTTGAT
CATACGAAGCGAGTTGCGCTTGTTACTCCGCGCTGCGGCGAGCCGTGGGAGGAGGCATATGATCAGATAGTTATAACCGC
CGGTGCTGTGTCGAGAACTTTCCCTATTCCGGGCGTATCAGATTGCGCAGTTGGCCTAAAGAGCATAGAAGAGGCTGTGT
TTGTGAGAGACACTCTGTTGAGTAATTATGAGCACGCGGCGGTTTTGCCCCCTGGCCCGTTGCGTTCAAAGCTTTTGACG
CTTACGGTCATAGGCGGCGGTTTTGCGGGCATTGAAGCAATTGCAGAATTAAGGTCATTGGCCACTGCCAAGGTCAAAGG
CAGCACGAATATAGACCTCAGTGAGACCCGTTTTTATCTTGTTGAGGCGGCGAATCGGATAATGCCAGAAGTGTCTTTAA
AGTCCAGTAAGTGGGTTATTGATAACCTAACGCGCCGAGGTGTTGACATTCGTCTTGAGACCCAGCTTAAGTCTTGTGTC
GATGGCAAGATTGAGCTGTCAGATGGCCACTCGTATGAGTCTGGTCTGATACTGTGGACAGCGGGTGTTATGGCAAATCC
GGAAGTCGCAAAGGGAAGCTCTATGCCTCTTGATAATCGTGGAAGGATTACCGTATTGCCAACGCTTCAGATATGTGATG
GGGACAAATTGATTCCACATGCCTGGGCTGCTGGTGATATTGCCGCTGTTCCAGATATGTCTGGTGGTGGCGTACAGGGC
TTCTGTGTACCTAATGCGCAGCACGCTGTGCGACAGGCAAAATGTCTTGCAAAAAATCTGTGTCTTATGCAGTCCGGCCG
TATGCCGAGGAACTACCTGCATGTTACAAAGGGGAGTGTTGCCGGGCTAGGCGTTGGCGTAGGTGTCCTTCAATATGGCA
GAATTGCCGTGAGAGGCTTTTTCGGCTGGTTCGTGCACAGGGCATATCACAGCTTGGCTGTCTCTGTCGTGGAGCGCAGA
GTGCGGATCACCCTTGACTGGTTCTCGGGTTTTGTATTCAAGCGCAACACAGTCGGACTAAGGAACCTAGATAGCCCCCG
CGCAGGCTTTCAGCGCTGGGCGGCAAAAGGCGGAAAGAAGCCCTCGTAG

Upstream 100 bases:

>100_bases
TTGCGTTACTGTGACTGTTAGGTACAGTAACGCTTGTGTGTGTGCGATGCAGACGGTGAGGTTTGCTCGCCGCGATTTTG
AGAGGTAAGAGTTTTAGCTC

Downstream 100 bases:

>100_bases
CCCAATCGGCAGAGGCAGACGACTTAAAATCGTCCCAGTGTGGGTTCGAGTCCCACCGAGGGCACGTCTTGGCTAGTAAG
GCTCGGTGGGTAGGAAGGAC

Product: NADH dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MAEKVLIVGGGFAGFGIARILRKKLRYFEVSLVDPLPYMTYQPFLPEVAAGSIEPRNAVVGHRRHLAGVRIISGSVTSVD
HTKRVALVTPRCGEPWEEAYDQIVITAGAVSRTFPIPGVSDCAVGLKSIEEAVFVRDTLLSNYEHAAVLPPGPLRSKLLT
LTVIGGGFAGIEAIAELRSLATAKVKGSTNIDLSETRFYLVEAANRIMPEVSLKSSKWVIDNLTRRGVDIRLETQLKSCV
DGKIELSDGHSYESGLILWTAGVMANPEVAKGSSMPLDNRGRITVLPTLQICDGDKLIPHAWAAGDIAAVPDMSGGGVQG
FCVPNAQHAVRQAKCLAKNLCLMQSGRMPRNYLHVTKGSVAGLGVGVGVLQYGRIAVRGFFGWFVHRAYHSLAVSVVERR
VRITLDWFSGFVFKRNTVGLRNLDSPRAGFQRWAAKGGKKPS

Sequences:

>Translated_442_residues
MAEKVLIVGGGFAGFGIARILRKKLRYFEVSLVDPLPYMTYQPFLPEVAAGSIEPRNAVVGHRRHLAGVRIISGSVTSVD
HTKRVALVTPRCGEPWEEAYDQIVITAGAVSRTFPIPGVSDCAVGLKSIEEAVFVRDTLLSNYEHAAVLPPGPLRSKLLT
LTVIGGGFAGIEAIAELRSLATAKVKGSTNIDLSETRFYLVEAANRIMPEVSLKSSKWVIDNLTRRGVDIRLETQLKSCV
DGKIELSDGHSYESGLILWTAGVMANPEVAKGSSMPLDNRGRITVLPTLQICDGDKLIPHAWAAGDIAAVPDMSGGGVQG
FCVPNAQHAVRQAKCLAKNLCLMQSGRMPRNYLHVTKGSVAGLGVGVGVLQYGRIAVRGFFGWFVHRAYHSLAVSVVERR
VRITLDWFSGFVFKRNTVGLRNLDSPRAGFQRWAAKGGKKPS
>Mature_441_residues
AEKVLIVGGGFAGFGIARILRKKLRYFEVSLVDPLPYMTYQPFLPEVAAGSIEPRNAVVGHRRHLAGVRIISGSVTSVDH
TKRVALVTPRCGEPWEEAYDQIVITAGAVSRTFPIPGVSDCAVGLKSIEEAVFVRDTLLSNYEHAAVLPPGPLRSKLLTL
TVIGGGFAGIEAIAELRSLATAKVKGSTNIDLSETRFYLVEAANRIMPEVSLKSSKWVIDNLTRRGVDIRLETQLKSCVD
GKIELSDGHSYESGLILWTAGVMANPEVAKGSSMPLDNRGRITVLPTLQICDGDKLIPHAWAAGDIAAVPDMSGGGVQGF
CVPNAQHAVRQAKCLAKNLCLMQSGRMPRNYLHVTKGSVAGLGVGVGVLQYGRIAVRGFFGWFVHRAYHSLAVSVVERRV
RITLDWFSGFVFKRNTVGLRNLDSPRAGFQRWAAKGGKKPS

Specific function: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation [H]

COG id: COG1252

COG function: function code C; NADH dehydrogenase, FAD-containing subunit

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NADH dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787352, Length=408, Percent_Identity=29.4117647058824, Blast_Score=123, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323515, Length=471, Percent_Identity=23.5668789808917, Blast_Score=90, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6320118, Length=465, Percent_Identity=25.3763440860215, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323794, Length=463, Percent_Identity=24.1900647948164, Blast_Score=81, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 47825; Mature: 47694

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEKVLIVGGGFAGFGIARILRKKLRYFEVSLVDPLPYMTYQPFLPEVAAGSIEPRNAVV
CCCEEEEEECCHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCHHHCCCCCCCHHHH
GHRRHLAGVRIISGSVTSVDHTKRVALVTPRCGEPWEEAYDQIVITAGAVSRTFPIPGVS
CCHHHHCEEEEEECCCCCCCCCCEEEEECCCCCCHHHHHHCEEEEEECCCCCCCCCCCHH
DCAVGLKSIEEAVFVRDTLLSNYEHAAVLPPGPLRSKLLTLTVIGGGFAGIEAIAELRSL
HHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEEEEECCCHHHHHHHHHHHHH
ATAKVKGSTNIDLSETRFYLVEAANRIMPEVSLKSSKWVIDNLTRRGVDIRLETQLKSCV
HHEEECCCCCCCHHHHHHHEEHHHHHHCCCCCCCCCCCHHHHHHHCCCEEEEHHHHHHHC
DGKIELSDGHSYESGLILWTAGVMANPEVAKGSSMPLDNRGRITVLPTLQICDGDKLIPH
CCEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCC
AWAAGDIAAVPDMSGGGVQGFCVPNAQHAVRQAKCLAKNLCLMQSGRMPRNYLHVTKGSV
CCCCCCEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCC
AGLGVGVGVLQYGRIAVRGFFGWFVHRAYHSLAVSVVERRVRITLDWFSGFVFKRNTVGL
CCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHCCEEEEECCCCC
RNLDSPRAGFQRWAAKGGKKPS
CCCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AEKVLIVGGGFAGFGIARILRKKLRYFEVSLVDPLPYMTYQPFLPEVAAGSIEPRNAVV
CCEEEEEECCHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCHHHCCCCCCCHHHH
GHRRHLAGVRIISGSVTSVDHTKRVALVTPRCGEPWEEAYDQIVITAGAVSRTFPIPGVS
CCHHHHCEEEEEECCCCCCCCCCEEEEECCCCCCHHHHHHCEEEEEECCCCCCCCCCCHH
DCAVGLKSIEEAVFVRDTLLSNYEHAAVLPPGPLRSKLLTLTVIGGGFAGIEAIAELRSL
HHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEEEEECCCHHHHHHHHHHHHH
ATAKVKGSTNIDLSETRFYLVEAANRIMPEVSLKSSKWVIDNLTRRGVDIRLETQLKSCV
HHEEECCCCCCCHHHHHHHEEHHHHHHCCCCCCCCCCCHHHHHHHCCCEEEEHHHHHHHC
DGKIELSDGHSYESGLILWTAGVMANPEVAKGSSMPLDNRGRITVLPTLQICDGDKLIPH
CCEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCC
AWAAGDIAAVPDMSGGGVQGFCVPNAQHAVRQAKCLAKNLCLMQSGRMPRNYLHVTKGSV
CCCCCCEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCC
AGLGVGVGVLQYGRIAVRGFFGWFVHRAYHSLAVSVVERRVRITLDWFSGFVFKRNTVGL
CCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHCCEEEEECCCCC
RNLDSPRAGFQRWAAKGGKKPS
CCCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6265208; 8905232; 9278503 [H]