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The map label for this gene is hemE

Identifier: 28572890

GI number: 28572890

Start: 845400

End: 846557

Strand: Reverse

Name: hemE

Synonym: TW749

Alternate gene names: 28572890

Gene position: 846557-845400 (Counterclockwise)

Preceding gene: 28572896

Following gene: 28572889

Centisome position: 91.43

GC content: 51.3

Gene sequence:

>1158_bases
GTGACTGGTGCTTCAGGAGTTGAGGGCACACGCATTCCCTTACACAGCTTGTCTTGCAGGCCGAGTGCCGGTCGGTCTGC
AGGTTCGTTTGTTAACACAGGCATTATGGAGGCATTCAGGGGCACACGCCCGGGGTGTTTGCCTGTTTGGTTCATGCGTC
AAGCCGGGCGCTCTCTGCCAGAGTATAGGGCTGTAAGAGGCACAAATACTCTGCTCGAGGCGTGCTTAAATCCGGATCTC
GCGTGTGAAATTACTTTGCAGCCAGTCCGGCGCTATTCTGTTGATGCGGCGATACTATTCAGCGATATCGTTGTCCCCCT
GAAATTGGCGGGTGTCGGAGTTGACATATTACCCGGAACTGGACCGGTTCTGAATAACCCAATCGATACTCCAGACAGGG
TTAACACATTGCTGGCAAAAACCGCAGATTCAATTGACTTTGGGATTATCGCGGAAATAACCAGACATACCGTATCTGTG
CTAAATGGGATCCCACTAATTGGATTTGCTGGGGCACCCTACACACTCGCGTGTTATATGGTTGAGGGCGGGCCATCTAA
AACCCATATGAAGGCGCGTGCAATGATGCACGGTGACAAGAAAACTTGGCAAAAGGTTATGATGCTTGCCGCCCGTCTTT
CCGGGCAATTTTTGGCTGCGCAAATTACATCTGGCGCACAAGCGGTGCAGATTTTTGACTCATGGGCAGGTTCACTTTCG
CGGAAGGATTACGTAGATAACGTTGCACCGTTCTCAAAAATGACAATCGATCTCGCGTGTGGAATCGATGGTAATTCTGA
CTTGTCCAAAACGGGCAAGTCACTCTGGCCCAGAGTGCCAGTACTTCATTTTGCAGCAAATGCGGGTCATCTTTTAACCG
CTATACGTGATATTGGGGTTAGCGTGATGAGTGTTGACTACACAAAGCCGCTCGATGAGGCTAGCGAACTGCTCGATGAT
TCCATGCCCTTACAAGGTAATATCGATCCGGCAATGCTGTTCGCCCCGTGGGAAGTTTTGAAGCGACACGTCCTGGATAT
CGTGCAGCGTGCATCTCGCGCACCGTCACACGTTCTAAATCTCGGCCACGGGGTGCCCCCTGATGCATCGTGTGATCAGC
TTGCCAGGATTGTTGATCTGGCGCACAGTATGGTCTAA

Upstream 100 bases:

>100_bases
AAAGTCGGGACTAACGCGTGCAAGCTGCTCGAGCACAGTAAAGCTAGTCTTCTTGTGATTGGCGCTGACACATAAAAGCA
CTTAAGTTATTATAGGTCTG

Downstream 100 bases:

>100_bases
ACAACAGAGTCGAGTAGATACTCTATTTCTTTCGGATGCTAAAACAATCTGCGTTAGATACCTGTAGTTGCGAGCCTGAG
AGTGCGTATCGGACGAGATA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MTGASGVEGTRIPLHSLSCRPSAGRSAGSFVNTGIMEAFRGTRPGCLPVWFMRQAGRSLPEYRAVRGTNTLLEACLNPDL
ACEITLQPVRRYSVDAAILFSDIVVPLKLAGVGVDILPGTGPVLNNPIDTPDRVNTLLAKTADSIDFGIIAEITRHTVSV
LNGIPLIGFAGAPYTLACYMVEGGPSKTHMKARAMMHGDKKTWQKVMMLAARLSGQFLAAQITSGAQAVQIFDSWAGSLS
RKDYVDNVAPFSKMTIDLACGIDGNSDLSKTGKSLWPRVPVLHFAANAGHLLTAIRDIGVSVMSVDYTKPLDEASELLDD
SMPLQGNIDPAMLFAPWEVLKRHVLDIVQRASRAPSHVLNLGHGVPPDASCDQLARIVDLAHSMV

Sequences:

>Translated_385_residues
MTGASGVEGTRIPLHSLSCRPSAGRSAGSFVNTGIMEAFRGTRPGCLPVWFMRQAGRSLPEYRAVRGTNTLLEACLNPDL
ACEITLQPVRRYSVDAAILFSDIVVPLKLAGVGVDILPGTGPVLNNPIDTPDRVNTLLAKTADSIDFGIIAEITRHTVSV
LNGIPLIGFAGAPYTLACYMVEGGPSKTHMKARAMMHGDKKTWQKVMMLAARLSGQFLAAQITSGAQAVQIFDSWAGSLS
RKDYVDNVAPFSKMTIDLACGIDGNSDLSKTGKSLWPRVPVLHFAANAGHLLTAIRDIGVSVMSVDYTKPLDEASELLDD
SMPLQGNIDPAMLFAPWEVLKRHVLDIVQRASRAPSHVLNLGHGVPPDASCDQLARIVDLAHSMV
>Mature_384_residues
TGASGVEGTRIPLHSLSCRPSAGRSAGSFVNTGIMEAFRGTRPGCLPVWFMRQAGRSLPEYRAVRGTNTLLEACLNPDLA
CEITLQPVRRYSVDAAILFSDIVVPLKLAGVGVDILPGTGPVLNNPIDTPDRVNTLLAKTADSIDFGIIAEITRHTVSVL
NGIPLIGFAGAPYTLACYMVEGGPSKTHMKARAMMHGDKKTWQKVMMLAARLSGQFLAAQITSGAQAVQIFDSWAGSLSR
KDYVDNVAPFSKMTIDLACGIDGNSDLSKTGKSLWPRVPVLHFAANAGHLLTAIRDIGVSVMSVDYTKPLDEASELLDDS
MPLQGNIDPAMLFAPWEVLKRHVLDIVQRASRAPSHVLNLGHGVPPDASCDQLARIVDLAHSMV

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=353, Percent_Identity=33.4277620396601, Blast_Score=193, Evalue=2e-49,
Organism=Escherichia coli, GI2367337, Length=339, Percent_Identity=37.1681415929204, Blast_Score=218, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6320252, Length=359, Percent_Identity=31.1977715877437, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI221330099, Length=352, Percent_Identity=34.0909090909091, Blast_Score=208, Evalue=6e-54,
Organism=Drosophila melanogaster, GI19921920, Length=352, Percent_Identity=34.0909090909091, Blast_Score=207, Evalue=7e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_TROW8 (Q83H92)

Other databases:

- EMBL:   BX251412
- RefSeq:   NP_789670.1
- ProteinModelPortal:   Q83H92
- SMR:   Q83H92
- STRING:   Q83H92
- GeneID:   1064949
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW749
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   Q83H92
- ProtClustDB:   CLSK230257
- BioCyc:   TWHI218496:TW0715-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 41233; Mature: 41102

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 102-102 BINDING 179-179 BINDING 234-234 BINDING 363-363

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGASGVEGTRIPLHSLSCRPSAGRSAGSFVNTGIMEAFRGTRPGCLPVWFMRQAGRSLP
CCCCCCCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCC
EYRAVRGTNTLLEACLNPDLACEITLQPVRRYSVDAAILFSDIVVPLKLAGVGVDILPGT
HHHHHCCHHHHHHHHCCCCCEEEEEECHHHHHCCHHHHHHHHHHHHHHHHCCCEEECCCC
GPVLNNPIDTPDRVNTLLAKTADSIDFGIIAEITRHTVSVLNGIPLIGFAGAPYTLACYM
CCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEE
VEGGPSKTHMKARAMMHGDKKTWQKVMMLAARLSGQFLAAQITSGAQAVQIFDSWAGSLS
EECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEHHCCCHHHHHHHHHHHHCCC
RKDYVDNVAPFSKMTIDLACGIDGNSDLSKTGKSLWPRVPVLHFAANAGHLLTAIRDIGV
HHHHHHHCCCCHHEEEEEEECCCCCCCHHHHHHHHCCCCCHHEECCCCHHHHHHHHHHCC
SVMSVDYTKPLDEASELLDDSMPLQGNIDPAMLFAPWEVLKRHVLDIVQRASRAPSHVLN
EEEEECCCCCHHHHHHHHHCCCCCCCCCCHHEEECCHHHHHHHHHHHHHHHHCCHHHHHH
LGHGVPPDASCDQLARIVDLAHSMV
CCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TGASGVEGTRIPLHSLSCRPSAGRSAGSFVNTGIMEAFRGTRPGCLPVWFMRQAGRSLP
CCCCCCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCC
EYRAVRGTNTLLEACLNPDLACEITLQPVRRYSVDAAILFSDIVVPLKLAGVGVDILPGT
HHHHHCCHHHHHHHHCCCCCEEEEEECHHHHHCCHHHHHHHHHHHHHHHHCCCEEECCCC
GPVLNNPIDTPDRVNTLLAKTADSIDFGIIAEITRHTVSVLNGIPLIGFAGAPYTLACYM
CCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEE
VEGGPSKTHMKARAMMHGDKKTWQKVMMLAARLSGQFLAAQITSGAQAVQIFDSWAGSLS
EECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEHHCCCHHHHHHHHHHHHCCC
RKDYVDNVAPFSKMTIDLACGIDGNSDLSKTGKSLWPRVPVLHFAANAGHLLTAIRDIGV
HHHHHHHCCCCHHEEEEEEECCCCCCCHHHHHHHHCCCCCHHEECCCCHHHHHHHHHHCC
SVMSVDYTKPLDEASELLDDSMPLQGNIDPAMLFAPWEVLKRHVLDIVQRASRAPSHVLN
EEEEECCCCCHHHHHHHHHCCCCCCCCCCHHEEECCHHHHHHHHHHHHHHHHCCHHHHHH
LGHGVPPDASCDQLARIVDLAHSMV
CCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12606174