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The map label for this gene is thyX [H]

Identifier: 28572779

GI number: 28572779

Start: 721883

End: 722605

Strand: Reverse

Name: thyX [H]

Synonym: TW633

Alternate gene names: 28572779

Gene position: 722605-721883 (Counterclockwise)

Preceding gene: 28572780

Following gene: 28572778

Centisome position: 78.04

GC content: 43.57

Gene sequence:

>723_bases
TTGTTTTTCGTGATGGATCCTGTTTTTCTTTCGGAAATAACAGTCGAGCTTGTTAAGCATTCTGCCAGCGATTCCGATGT
TGTATTTTCGGCAAGGGTTTCTACACTAGGCTCTTTCGTGGCAGTGACTGACTGCCTTTCGAATCGGGATATTGGGCTGA
TTACCTTTTTGATGCGCGAACGACACGGCTCTCCTTTTGAGCATAGTCATATGACTTTCAGAATTAGCGCTCCGATATTT
GTTTTTCGTGAGTTTATGCGCCACAGGATTGCAAGTTACAACGAAGAGTCTGGGCGTTATAAAAACCTTGATCCTGTTTT
TTATATCCCTGATGAAAAGCGTAAACTTGTCCAAATTGGCGCTCCAGGTGCTTATAAATTCGAAGAGGGAACTTCTGAGC
AATACGGTCTTTTAATAGAGGAGATGAAAGAATTATCGCTTGCGGCATACGATACCTACAAGAGGCTTCTTGCCTGCGGT
ATAGCTCGCGAAGTCGCTCGCATGATTCTACCCCTGAATCTCTATTCAACAATGTACGTGACCATAAATGCCAGATCTCT
GATGAATTTTCTGAGTGTTAGAACCTCGCGCGCCAATAGTGCTTTTCACTCCTATCCACAGAGGGAAATTGAATTATGTG
CTGATCGAATTGAGGAAATATGGAAAGGTCTTATGCCCGAAACTCACGCAGCATTTGAAAAACAGGGCAGGGTTGCTCCT
TAA

Upstream 100 bases:

>100_bases
AACTCTTCCTCCGATGGCGAAGGGGTTGTCCTTTAGGCTCCTGTATTTTTCGACCGGGCTGCGGGGTTTCTCGTAGCCCG
GTTTTTGTTTGTTGCAATGT

Downstream 100 bases:

>100_bases
ATTCCTTACGTCTGATGTCATCTGTCTGTCTTGCATACATGTTAAGTCATGGTGCCTGCTTTTGCTATTATCGTACTGTC
CGTTTGCTTAGCGGCTCTTC

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MFFVMDPVFLSEITVELVKHSASDSDVVFSARVSTLGSFVAVTDCLSNRDIGLITFLMRERHGSPFEHSHMTFRISAPIF
VFREFMRHRIASYNEESGRYKNLDPVFYIPDEKRKLVQIGAPGAYKFEEGTSEQYGLLIEEMKELSLAAYDTYKRLLACG
IAREVARMILPLNLYSTMYVTINARSLMNFLSVRTSRANSAFHSYPQREIELCADRIEEIWKGLMPETHAAFEKQGRVAP

Sequences:

>Translated_240_residues
MFFVMDPVFLSEITVELVKHSASDSDVVFSARVSTLGSFVAVTDCLSNRDIGLITFLMRERHGSPFEHSHMTFRISAPIF
VFREFMRHRIASYNEESGRYKNLDPVFYIPDEKRKLVQIGAPGAYKFEEGTSEQYGLLIEEMKELSLAAYDTYKRLLACG
IAREVARMILPLNLYSTMYVTINARSLMNFLSVRTSRANSAFHSYPQREIELCADRIEEIWKGLMPETHAAFEKQGRVAP
>Mature_240_residues
MFFVMDPVFLSEITVELVKHSASDSDVVFSARVSTLGSFVAVTDCLSNRDIGLITFLMRERHGSPFEHSHMTFRISAPIF
VFREFMRHRIASYNEESGRYKNLDPVFYIPDEKRKLVQIGAPGAYKFEEGTSEQYGLLIEEMKELSLAAYDTYKRLLACG
IAREVARMILPLNLYSTMYVTINARSLMNFLSVRTSRANSAFHSYPQREIELCADRIEEIWKGLMPETHAAFEKQGRVAP

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 27502; Mature: 27502

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFVMDPVFLSEITVELVKHSASDSDVVFSARVSTLGSFVAVTDCLSNRDIGLITFLMRE
CEEEECHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
RHGSPFEHSHMTFRISAPIFVFREFMRHRIASYNEESGRYKNLDPVFYIPDEKRKLVQIG
HCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCEEEEEC
APGAYKFEEGTSEQYGLLIEEMKELSLAAYDTYKRLLACGIAREVARMILPLNLYSTMYV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
TINARSLMNFLSVRTSRANSAFHSYPQREIELCADRIEEIWKGLMPETHAAFEKQGRVAP
EEEHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MFFVMDPVFLSEITVELVKHSASDSDVVFSARVSTLGSFVAVTDCLSNRDIGLITFLMRE
CEEEECHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
RHGSPFEHSHMTFRISAPIFVFREFMRHRIASYNEESGRYKNLDPVFYIPDEKRKLVQIG
HCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCEEEEEC
APGAYKFEEGTSEQYGLLIEEMKELSLAAYDTYKRLLACGIAREVARMILPLNLYSTMYV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
TINARSLMNFLSVRTSRANSAFHSYPQREIELCADRIEEIWKGLMPETHAAFEKQGRVAP
EEEHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12902375 [H]