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The map label for this gene is pgsA [H]

Identifier: 28572775

GI number: 28572775

Start: 716760

End: 717365

Strand: Reverse

Name: pgsA [H]

Synonym: TW629

Alternate gene names: 28572775

Gene position: 717365-716760 (Counterclockwise)

Preceding gene: 28572776

Following gene: 28572774

Centisome position: 77.47

GC content: 43.23

Gene sequence:

>606_bases
GTGCTGCCAAACGTTATAACCTGTACAAGAATTGCTTTTGCTTTTCCGCTTTTTTTTCTATGTCTTGATAAGGATTTTCG
CTGGCTCACACTTTGCCTCTTCCTTATTGGGATGCTAACGGACGGGCTTGATGGATTTATTGCACGTAAATACAATTCTG
TCAGCAAATTTGGTGCTTTGCTAGACCCAATTGCTGACAAGATTCTTGTTGCTTCAGTTGTTCTCCCGCTTTGCATTCTT
GGTGAGATACCGTGGTGGGTATTTGTAGTTATTTTCTTGCGGGAAGTATCAGTAACCATTTTTCGTCTGATTGTCGCAAA
GAGGAAAGTAATTTCTGCAAACACGTGGGGCAAGGCTAAGACAGTAGTGCAGACACTTGCTTTTTCCGTTGCCCTCTTGC
CGATTTTTGCAGCACCGGATCAGATGTATTCTTCAAACCCGTCACTCAGCGATTATGTTGGTGGATTAGGCGATTCGGTG
ATTTTTTTTCCGCCCATTTCCACGGGGCTTTCTTTTGTGAGGACCGGACTTATTTTTGCTGCAGTTTTTATAACTGCCTG
TACGGGTATTGTGTATTGTGTTGCAGCTTGTAGGCTCAAACACTAA

Upstream 100 bases:

>100_bases
TCTTGCCGGTGTTGTGGCTTTTGATTATTGACCACCTACCGCAAAAAGCAACACATTCAGTCGCGAACATGAAAAATCGC
ATTTTGATACACTGCAACAT

Downstream 100 bases:

>100_bases
GCTTGATGCCTGAAAATTGTAATCCCTTCTGTGAAATACTCTTTTATGATTATTCACCTCAACGTATCGCCCGGGTGTGA
GGTTTTGTTATCCTTGTGGA

Product: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MLPNVITCTRIAFAFPLFFLCLDKDFRWLTLCLFLIGMLTDGLDGFIARKYNSVSKFGALLDPIADKILVASVVLPLCIL
GEIPWWVFVVIFLREVSVTIFRLIVAKRKVISANTWGKAKTVVQTLAFSVALLPIFAAPDQMYSSNPSLSDYVGGLGDSV
IFFPPISTGLSFVRTGLIFAAVFITACTGIVYCVAACRLKH

Sequences:

>Translated_201_residues
MLPNVITCTRIAFAFPLFFLCLDKDFRWLTLCLFLIGMLTDGLDGFIARKYNSVSKFGALLDPIADKILVASVVLPLCIL
GEIPWWVFVVIFLREVSVTIFRLIVAKRKVISANTWGKAKTVVQTLAFSVALLPIFAAPDQMYSSNPSLSDYVGGLGDSV
IFFPPISTGLSFVRTGLIFAAVFITACTGIVYCVAACRLKH
>Mature_201_residues
MLPNVITCTRIAFAFPLFFLCLDKDFRWLTLCLFLIGMLTDGLDGFIARKYNSVSKFGALLDPIADKILVASVVLPLCIL
GEIPWWVFVVIFLREVSVTIFRLIVAKRKVISANTWGKAKTVVQTLAFSVALLPIFAAPDQMYSSNPSLSDYVGGLGDSV
IFFPPISTGLSFVRTGLIFAAVFITACTGIVYCVAACRLKH

Specific function: This Protein Catalyzes The Committed Step To The Synthesis Of The Acidic Phospholipids. [C]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=118, Percent_Identity=36.4406779661017, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1788220, Length=137, Percent_Identity=32.1167883211679, Blast_Score=66, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24650130, Length=96, Percent_Identity=37.5, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24650126, Length=96, Percent_Identity=37.5, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24650128, Length=96, Percent_Identity=37.5, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 22069; Mature: 22069

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPNVITCTRIAFAFPLFFLCLDKDFRWLTLCLFLIGMLTDGLDGFIARKYNSVSKFGAL
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LDPIADKILVASVVLPLCILGEIPWWVFVVIFLREVSVTIFRLIVAKRKVISANTWGKAK
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
TVVQTLAFSVALLPIFAAPDQMYSSNPSLSDYVGGLGDSVIFFPPISTGLSFVRTGLIFA
HHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHH
AVFITACTGIVYCVAACRLKH
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLPNVITCTRIAFAFPLFFLCLDKDFRWLTLCLFLIGMLTDGLDGFIARKYNSVSKFGAL
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LDPIADKILVASVVLPLCILGEIPWWVFVVIFLREVSVTIFRLIVAKRKVISANTWGKAK
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
TVVQTLAFSVALLPIFAAPDQMYSSNPSLSDYVGGLGDSVIFFPPISTGLSFVRTGLIFA
HHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHH
AVFITACTGIVYCVAACRLKH
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12368430; 12218036; 10889206 [H]