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The map label for this gene is ilvC

Identifier: 28572713

GI number: 28572713

Start: 603297

End: 604298

Strand: Reverse

Name: ilvC

Synonym: TW565

Alternate gene names: 28572713

Gene position: 604298-603297 (Counterclockwise)

Preceding gene: 28572714

Following gene: 28572712

Centisome position: 65.26

GC content: 44.81

Gene sequence:

>1002_bases
ATGAGTGAAATAGGCACGAGGGTTTATACCGAATGTGATGCAGATTTATCGCTTATTCAAAATGTTCTGGTTGCTGTTAT
TGGTTACGGATCGCAGGGTCATGCGCAAGCGCTGAATCTGCGTGATTCGGGAGTAAATGTTGTAATTGGTTTGAAGGAAA
ATTCGGCTTCGCGGAAAAGCGCACAAGACTCGGGGTTTGAGGTTCTTTTGCCGCAAGAGGCAGCCAAAAAGGCGCAGCTA
ATTGCTCTGCTTGTGCCAGATCCAGCACAGCGTGATGTTTATGAAAGTGCAATAAAACATAATCTCTCAGAAGGCGATGC
TCTTTTGTTTTCACACGGATTTAACATCCGATACGGGTATATAACACCTCCAGATGGTGTTGATGTTCTTATGGTTGCCC
CTAAAGGTCCTGGACATATGGTTAGACGTGAATATCTTGATAACCGCGGGACTCCGGCTGTGTTTGCTATTGAAAAGGAT
GCAAGTGGTAGGTGTTTTGACCTTGCGCTTAGTTATGCAAAGGGCATAGGTGCTTTGCGTGCCGGGGCTATACAAACTAC
ATTTACCGAAGAGACCGAGACGGATTTATTTGGCGAGCAGGCAGTTCTATGCGGCGGTCTTGAACAGCTGATCCAGTATG
GCTATGAGACCTTGGTTGAGGCGGGTTATCAGCCAGAAGTTGCTTATTTTGAAGTTCTTCATGAATTGAAGCTAATCATT
GATCTGATAGTTGAGGGTGGGCTTAGTAAATCACGCTGGAGTATTTCTGATACGGCAGAATACGGCAGTTATGTATCAGG
TCCGCGTGTTATAGACAAACATGTCAAGGAAAATATGAAAAAAATACTTGGTGAGATTCGTTCTGGCGAGTTTGCTAATA
GATTCATAAAGGATCAAGATTCAGGTGCGAATGAATTTACACAGCTCAGAGAGATTGCTGCCCGGCATCCAATAGAAGAG
GTTGGTGCCAGGCTGCGCGCATTATTTTCGTGGAGTAAGTAA

Upstream 100 bases:

>100_bases
TGTTGGACGCGCGCTTGGACAATTATGGATAATTGATCTGTAGTTTTGTTTTTTTAGATCTCAAGTATGTTTATGTGGTC
TGGATTGTGAGGGGTTTGAA

Downstream 100 bases:

>100_bases
AGAGGTTATCGGTGTATTTGGTCTGCGCTGTATATGTTGCGCCGTGGCCTTCTTGGTTATTGCCAAATGCGGCTATTTGG
ATGTGTGAAATGGAAAAGCC

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MSEIGTRVYTECDADLSLIQNVLVAVIGYGSQGHAQALNLRDSGVNVVIGLKENSASRKSAQDSGFEVLLPQEAAKKAQL
IALLVPDPAQRDVYESAIKHNLSEGDALLFSHGFNIRYGYITPPDGVDVLMVAPKGPGHMVRREYLDNRGTPAVFAIEKD
ASGRCFDLALSYAKGIGALRAGAIQTTFTEETETDLFGEQAVLCGGLEQLIQYGYETLVEAGYQPEVAYFEVLHELKLII
DLIVEGGLSKSRWSISDTAEYGSYVSGPRVIDKHVKENMKKILGEIRSGEFANRFIKDQDSGANEFTQLREIAARHPIEE
VGARLRALFSWSK

Sequences:

>Translated_333_residues
MSEIGTRVYTECDADLSLIQNVLVAVIGYGSQGHAQALNLRDSGVNVVIGLKENSASRKSAQDSGFEVLLPQEAAKKAQL
IALLVPDPAQRDVYESAIKHNLSEGDALLFSHGFNIRYGYITPPDGVDVLMVAPKGPGHMVRREYLDNRGTPAVFAIEKD
ASGRCFDLALSYAKGIGALRAGAIQTTFTEETETDLFGEQAVLCGGLEQLIQYGYETLVEAGYQPEVAYFEVLHELKLII
DLIVEGGLSKSRWSISDTAEYGSYVSGPRVIDKHVKENMKKILGEIRSGEFANRFIKDQDSGANEFTQLREIAARHPIEE
VGARLRALFSWSK
>Mature_332_residues
SEIGTRVYTECDADLSLIQNVLVAVIGYGSQGHAQALNLRDSGVNVVIGLKENSASRKSAQDSGFEVLLPQEAAKKAQLI
ALLVPDPAQRDVYESAIKHNLSEGDALLFSHGFNIRYGYITPPDGVDVLMVAPKGPGHMVRREYLDNRGTPAVFAIEKDA
SGRCFDLALSYAKGIGALRAGAIQTTFTEETETDLFGEQAVLCGGLEQLIQYGYETLVEAGYQPEVAYFEVLHELKLIID
LIVEGGLSKSRWSISDTAEYGSYVSGPRVIDKHVKENMKKILGEIRSGEFANRFIKDQDSGANEFTQLREIAARHPIEEV
GARLRALFSWSK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=317, Percent_Identity=32.807570977918, Blast_Score=138, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6323387, Length=256, Percent_Identity=35.9375, Blast_Score=132, Evalue=8e-32,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_TROW8 (Q83HI9)

Other databases:

- EMBL:   BX251411
- RefSeq:   NP_789493.1
- ProteinModelPortal:   Q83HI9
- SMR:   Q83HI9
- STRING:   Q83HI9
- GeneID:   1064768
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW565
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- PhylomeDB:   Q83HI9
- ProtClustDB:   PRK05479
- BioCyc:   TWHI218496:TW0538-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36487; Mature: 36356

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: ACT_SITE 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIGTRVYTECDADLSLIQNVLVAVIGYGSQGHAQALNLRDSGVNVVIGLKENSASRKS
CCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCC
AQDSGFEVLLPQEAAKKAQLIALLVPDPAQRDVYESAIKHNLSEGDALLFSHGFNIRYGY
CCCCCCEEEECHHHHCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEECCCEEEEEE
ITPPDGVDVLMVAPKGPGHMVRREYLDNRGTPAVFAIEKDASGRCFDLALSYAKGIGALR
ECCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
AGAIQTTFTEETETDLFGEQAVLCGGLEQLIQYGYETLVEAGYQPEVAYFEVLHELKLII
CCCEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
DLIVEGGLSKSRWSISDTAEYGSYVSGPRVIDKHVKENMKKILGEIRSGEFANRFIKDQD
HHHHHCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCC
SGANEFTQLREIAARHPIEEVGARLRALFSWSK
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SEIGTRVYTECDADLSLIQNVLVAVIGYGSQGHAQALNLRDSGVNVVIGLKENSASRKS
CCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCC
AQDSGFEVLLPQEAAKKAQLIALLVPDPAQRDVYESAIKHNLSEGDALLFSHGFNIRYGY
CCCCCCEEEECHHHHCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEECCCEEEEEE
ITPPDGVDVLMVAPKGPGHMVRREYLDNRGTPAVFAIEKDASGRCFDLALSYAKGIGALR
ECCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
AGAIQTTFTEETETDLFGEQAVLCGGLEQLIQYGYETLVEAGYQPEVAYFEVLHELKLII
CCCEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
DLIVEGGLSKSRWSISDTAEYGSYVSGPRVIDKHVKENMKKILGEIRSGEFANRFIKDQD
HHHHHCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCC
SGANEFTQLREIAARHPIEEVGARLRALFSWSK
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12606174