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The map label for this gene is ctaD [H]

Identifier: 28572675

GI number: 28572675

Start: 564974

End: 566605

Strand: Reverse

Name: ctaD [H]

Synonym: TW526

Alternate gene names: 28572675

Gene position: 566605-564974 (Counterclockwise)

Preceding gene: 28572676

Following gene: 28572674

Centisome position: 61.19

GC content: 44.49

Gene sequence:

>1632_bases
ATGAATACTAGTGTCGCGGCGACGTTATCCGAGAGAAACAGAAAGGGTAGCGCCCTGCTGTCTATTCTTACGACCACAAA
TCATAAGACCATTGGTTATATGTATCTGGTAACTTCTTTTTTCTATTTCTGCCTTGCTGGTGTTATGGCGCTCCTTATCA
GGACGCAGCTATTCGAGCCGGGGATGCATCTTATTCAGACTCGTGAGCAGTATAACCAGCTCTTTACCATGCACGGTACG
GTGATGCTTTTTCTGTTTGCCACTCCGCTTTTCGCGGGTTTTGCTAATGTTCTAACTCCGGTTCAGATTGGCGCTCCGGA
TATGGCTTTCCCGCGTCTCAATGCCCTTTCCTACTGGCTGTATCTTGTCGGCTCTCTCATAGTTGTCTCGACTTTTCTTA
TACCACAAGGTGCAGCGAGTTTTGGATGGTTTGCTTATACCCCTCTTTCTAGTTACGAATATTCGCCCGGCGTTGGAGGA
ACGCTGTGGGTTATAGGTTTGGCTTTTTCTGGTTTTAGTTCAATTATCGGGGCCGTTAATTTCGTTACAACGATTATTAC
CATGAGGGCGCCTGGGATGACAATGTTCAGGATGTCAATTTTTAACTGGAATGTTCTTGTAACTTCCCTTTTGATTCTTG
TTGCATTTCCGGTTTTAGCTGCTGCCTTGTTTTCTCTGGGAATGGATCGAGTATTTCGCTCGGTTTTGTTTGACCCATCA
ACGGGTGGTGCAATTTTATGGCAGCACCTATTCTGGTTTTTTGGGCATCCTGAGGTATACATACTCGCGCTACCGTTCTT
TGGTATTGTGTCGGAGATATTTCCCGCGTTCAGCCGTAAGCCAATATTTGGTTATCGCTCTTTGATTTTCGCAACTATTT
CTATAGCGGCCCTGTCGGTAACTGTTTGGGCTCACCACATGTATGTTACAGGTGCAGTGCTTCTTCCGTTTTTCTCATTT
ATGACAATGCTTATAGCTGTTCCAACCGGTGTAAAGATATTCAATTGGGTGGGTACCATGTGGAGGGGTTCGATTACTTT
TGAAACACCGATGGTTTGGTCGATTGGGTTTATTACGACGTTTGTCTTGGGCGGCCTAACTGGTGTTATTTTAGCCTCCC
CTTCATTAAATGATCATCTTTCAGACAGCTATTTTGTTGTTGCGCATTTCCACTATGTTTTATTTGGGACAGTTGTTTTT
GCGATGTTTGCCGGGTTTTATTTTTGGTGGCCGAAATTTACCGGAAAAATGTTGAACGAAACTCTGGGTAAAATTCATTT
CTGGCTTACTTTTATTGGGTTTCATATGACATTTCTGATACAGCATTGGCTTGGGGTTATTGGAATGCCCCGCAGGTACT
ACACTTATCTTCCTGAAGATGGGTTTACCTGGCTTCATCAGTTGTCTACCGTTGGTTCGTTTATCCTGGCTATTAGCCTT
ATACCCTTTTTTCTGAATCTTTGGGTGACATATAGAAGGCCGAAAGTTGACCTTCCTGATGATCCTTGGGGGAATGGGTG
CAGTCTGGAGTGGGCCACGGCTTCACCCCTTCCAAGGCATAACTTTAGATCCATACCAAAAATAAGATCTGAGCGGCCTG
CATTTGATCTTCATCATCCTGATGTGCGGTAA

Upstream 100 bases:

>100_bases
ATAAAAAGCATATGGCAGATCTTGCAGGTATGGGATACATTGGTACCGTTGGGTGGGAGAGTCTTGATCCTGCCAGTAAA
AAACATTAGTTTGGGCGTGT

Downstream 100 bases:

>100_bases
GTGTTAGGGGGAATTGTTACATGGGCCAATCGATAAAGCTTTTTTTCTGGCTTGGGGTTTTTTTCATTTTTGTTTGTCTT
GTTTATACCGGTGCGCATAT

Product: cytochrome c oxidase subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1-alpha; Cytochrome c oxidase polypeptide I-alpha [H]

Number of amino acids: Translated: 543; Mature: 543

Protein sequence:

>543_residues
MNTSVAATLSERNRKGSALLSILTTTNHKTIGYMYLVTSFFYFCLAGVMALLIRTQLFEPGMHLIQTREQYNQLFTMHGT
VMLFLFATPLFAGFANVLTPVQIGAPDMAFPRLNALSYWLYLVGSLIVVSTFLIPQGAASFGWFAYTPLSSYEYSPGVGG
TLWVIGLAFSGFSSIIGAVNFVTTIITMRAPGMTMFRMSIFNWNVLVTSLLILVAFPVLAAALFSLGMDRVFRSVLFDPS
TGGAILWQHLFWFFGHPEVYILALPFFGIVSEIFPAFSRKPIFGYRSLIFATISIAALSVTVWAHHMYVTGAVLLPFFSF
MTMLIAVPTGVKIFNWVGTMWRGSITFETPMVWSIGFITTFVLGGLTGVILASPSLNDHLSDSYFVVAHFHYVLFGTVVF
AMFAGFYFWWPKFTGKMLNETLGKIHFWLTFIGFHMTFLIQHWLGVIGMPRRYYTYLPEDGFTWLHQLSTVGSFILAISL
IPFFLNLWVTYRRPKVDLPDDPWGNGCSLEWATASPLPRHNFRSIPKIRSERPAFDLHHPDVR

Sequences:

>Translated_543_residues
MNTSVAATLSERNRKGSALLSILTTTNHKTIGYMYLVTSFFYFCLAGVMALLIRTQLFEPGMHLIQTREQYNQLFTMHGT
VMLFLFATPLFAGFANVLTPVQIGAPDMAFPRLNALSYWLYLVGSLIVVSTFLIPQGAASFGWFAYTPLSSYEYSPGVGG
TLWVIGLAFSGFSSIIGAVNFVTTIITMRAPGMTMFRMSIFNWNVLVTSLLILVAFPVLAAALFSLGMDRVFRSVLFDPS
TGGAILWQHLFWFFGHPEVYILALPFFGIVSEIFPAFSRKPIFGYRSLIFATISIAALSVTVWAHHMYVTGAVLLPFFSF
MTMLIAVPTGVKIFNWVGTMWRGSITFETPMVWSIGFITTFVLGGLTGVILASPSLNDHLSDSYFVVAHFHYVLFGTVVF
AMFAGFYFWWPKFTGKMLNETLGKIHFWLTFIGFHMTFLIQHWLGVIGMPRRYYTYLPEDGFTWLHQLSTVGSFILAISL
IPFFLNLWVTYRRPKVDLPDDPWGNGCSLEWATASPLPRHNFRSIPKIRSERPAFDLHHPDVR
>Mature_543_residues
MNTSVAATLSERNRKGSALLSILTTTNHKTIGYMYLVTSFFYFCLAGVMALLIRTQLFEPGMHLIQTREQYNQLFTMHGT
VMLFLFATPLFAGFANVLTPVQIGAPDMAFPRLNALSYWLYLVGSLIVVSTFLIPQGAASFGWFAYTPLSSYEYSPGVGG
TLWVIGLAFSGFSSIIGAVNFVTTIITMRAPGMTMFRMSIFNWNVLVTSLLILVAFPVLAAALFSLGMDRVFRSVLFDPS
TGGAILWQHLFWFFGHPEVYILALPFFGIVSEIFPAFSRKPIFGYRSLIFATISIAALSVTVWAHHMYVTGAVLLPFFSF
MTMLIAVPTGVKIFNWVGTMWRGSITFETPMVWSIGFITTFVLGGLTGVILASPSLNDHLSDSYFVVAHFHYVLFGTVVF
AMFAGFYFWWPKFTGKMLNETLGKIHFWLTFIGFHMTFLIQHWLGVIGMPRRYYTYLPEDGFTWLHQLSTVGSFILAISL
IPFFLNLWVTYRRPKVDLPDDPWGNGCSLEWATASPLPRHNFRSIPKIRSERPAFDLHHPDVR

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=514, Percent_Identity=43.3852140077821, Blast_Score=374, Evalue=1e-103,
Organism=Escherichia coli, GI1786634, Length=520, Percent_Identity=43.6538461538462, Blast_Score=408, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6226519, Length=533, Percent_Identity=40.3377110694184, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6226524, Length=320, Percent_Identity=41.5625, Blast_Score=239, Evalue=9e-64,
Organism=Saccharomyces cerevisiae, GI6226523, Length=249, Percent_Identity=37.3493975903614, Blast_Score=145, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 61222; Mature: 61222

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB ; PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCC
>Mature Secondary Structure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CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11572948; 12692562 [H]