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The map label for this gene is thrS

Identifier: 28572657

GI number: 28572657

Start: 545454

End: 547376

Strand: Reverse

Name: thrS

Synonym: TW508

Alternate gene names: 28572657

Gene position: 547376-545454 (Counterclockwise)

Preceding gene: 28572661

Following gene: 28572656

Centisome position: 59.12

GC content: 45.92

Gene sequence:

>1923_bases
GTGGACGGTTTTGAATTTTTTTCTGGTCGTTCGGATGTTGTTGCCATGATTTGCGATGATAGGTTACTTGACCTGTCAGA
ATCAATTCCATCCGGTAAGGTGCCCGAGCCAATTGAGCTTGACTCGCCGCGTGGTTTGGATATACTCAGACATTCTTGTG
CGCACGTCTTGGCGCAGGCGGTTCAGAGTATTTATGGGGACGCAAAACTTGGTATTGGCCCGTTTACGGAAAACGGGTTT
TATTACGATTTTTCCGTAAACGAACCTTTTTCTTCGGATAGCTTGCGAGTTATAGAGGATAAGATGCGCGAGATAGTGCA
TAGCGATCAGAAATTTGTGCGAAAAGTTGTAGATAGGCAGTCGGCGCACAGTCAGTTTCGTGATGAACCTTTCAAATTGG
AGATTATTAACGCAACCGATGACACTCTATCGATCTATTACAATATCGATGCAGATTCTGGTTCTGTTCGTTGGATGGAT
TTTTGCCGCGGCCCGCATCTTCCATCGACTCGGTTCATAGGGGATGCATTCGCCCTGACGCATGTGTCATCTGTGTATTG
GAGGGGCAATTCGGATAATCCACAGATGCAGCGTGTTTACGGAACAGCCTGGGGCAGTGCCAAGGATCTTAAGGGGTATC
TGGATCGTGTCGAGCTTGCAAAGCTTGTTGATCACCGAAAGCTTGGGAAAGAGCTTGATTTATTCAGCCTTCCAGATGAG
ATCGGCCCGGGTCTTGCGCTCTTCCATGTTAAGGGCGGGATTATTCGCAGTGAAATGGAGCAGTACGCGCGCCTGCGTCA
TCTTGAGGAGGGTTACAATTTTGTGTACAGCCCGCATATAACAAAAAGGGATCTCTTTGAAAGAAGCGGACACCTGCAAT
GGTATGGCCAAAGTATGTTTCCACCAATGAGGCTTGATAAGGATTCGTGTTCTCAAGGGTTTGATTATTATCTGAAGCCC
ATGAATTGCCCTTTTCACAGCCTTGTGTTTAGCTCACAGCCCAGGAGTTATAGACAATTGCCTCTTAGACTTGCTGAATT
TGGGACTGTGTACCGTTATGAGCAAAGCGGGGCAATTCATGGGCTTGCCCGTGTGCGCGGGCTTACTCAGGATGACGCAC
ATATATACGCCACAAGAGAGTCTTTTGAAGACGAGGTATCCAAGGCTTTGCAATTTACAATTTCACTTCTTGGTGATTAT
GGACTGGATCAGTTTTATATTGAGATATCAACTCGGGATGCATCGGGTAAGTTTTTAGGCTCCGATGAAGATTGGGCTTA
TGCAACGCATATTTTGCAAAAAGTTGCTCAGGATTCTGGCCTTCAGACGCGAGACGACCCGGGCGGAGCGGCATTTTATG
GACCTAAAATTTCTGTTCAGGCAAAAGATGCAATAGGTCGCTATTGGCAGATGTCGACCATTCAGCTTGATTTTAATCTT
CCTGAAAGATTTGGCCTTTTCTACACAGACCGTGCCGGAGAAAGAAAACGTCCGATTATGGTTCATCGTGCCCTCTTTGG
GTCATTTGAGAGGTTTTTCGCTGTTCTTACGGAGCATTATGCTGGGGCATTCCCCCCTTGGTTATCCCCAGAACAGGTGG
TCGCCCTTCCTGTTACATCTGCCCATATACCGTATCTCGAGGAATTTGTTTCTAGATTCTCGTCGCGTTTGATCCGGGCG
AGGGTTGATTATATGCAAGATCGTTTACCGAAAAAGATCCGTAGCTATGTAAAGGAAAAAATCCCCTTTGTTCTGGTCGC
AGGTGATCGTGATTTGACAAACAGAACCGTTGCAATTAGATTTCGCGATGGAACTCAGATATCTGATTTACCCATTCAGA
AATGCTTTGATGGAATTTGTGCAAGTATAGACCGTAAAAAACAGATTCAGACGCGTATAGATTTCGATTCTGTTCTTGAA
TAG

Upstream 100 bases:

>100_bases
ACACGCGCCTTGCGTGCACACCTGTGTATTGTACACGTTTGTTATTTTTGATTGTCACTGTTACGGCCTCATATGTCCGC
TTTCGAAGTAGAATGAGTCA

Downstream 100 bases:

>100_bases
TTGATTATATGCAGGAAGGTTCATCTGATTTTGCCGGTATTCCGGATGGATATAAGAGACTTTGGACCCCACATCGTGTT
GTGTACCTGGAAGGTGCCAG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 640; Mature: 640

Protein sequence:

>640_residues
MDGFEFFSGRSDVVAMICDDRLLDLSESIPSGKVPEPIELDSPRGLDILRHSCAHVLAQAVQSIYGDAKLGIGPFTENGF
YYDFSVNEPFSSDSLRVIEDKMREIVHSDQKFVRKVVDRQSAHSQFRDEPFKLEIINATDDTLSIYYNIDADSGSVRWMD
FCRGPHLPSTRFIGDAFALTHVSSVYWRGNSDNPQMQRVYGTAWGSAKDLKGYLDRVELAKLVDHRKLGKELDLFSLPDE
IGPGLALFHVKGGIIRSEMEQYARLRHLEEGYNFVYSPHITKRDLFERSGHLQWYGQSMFPPMRLDKDSCSQGFDYYLKP
MNCPFHSLVFSSQPRSYRQLPLRLAEFGTVYRYEQSGAIHGLARVRGLTQDDAHIYATRESFEDEVSKALQFTISLLGDY
GLDQFYIEISTRDASGKFLGSDEDWAYATHILQKVAQDSGLQTRDDPGGAAFYGPKISVQAKDAIGRYWQMSTIQLDFNL
PERFGLFYTDRAGERKRPIMVHRALFGSFERFFAVLTEHYAGAFPPWLSPEQVVALPVTSAHIPYLEEFVSRFSSRLIRA
RVDYMQDRLPKKIRSYVKEKIPFVLVAGDRDLTNRTVAIRFRDGTQISDLPIQKCFDGICASIDRKKQIQTRIDFDSVLE

Sequences:

>Translated_640_residues
MDGFEFFSGRSDVVAMICDDRLLDLSESIPSGKVPEPIELDSPRGLDILRHSCAHVLAQAVQSIYGDAKLGIGPFTENGF
YYDFSVNEPFSSDSLRVIEDKMREIVHSDQKFVRKVVDRQSAHSQFRDEPFKLEIINATDDTLSIYYNIDADSGSVRWMD
FCRGPHLPSTRFIGDAFALTHVSSVYWRGNSDNPQMQRVYGTAWGSAKDLKGYLDRVELAKLVDHRKLGKELDLFSLPDE
IGPGLALFHVKGGIIRSEMEQYARLRHLEEGYNFVYSPHITKRDLFERSGHLQWYGQSMFPPMRLDKDSCSQGFDYYLKP
MNCPFHSLVFSSQPRSYRQLPLRLAEFGTVYRYEQSGAIHGLARVRGLTQDDAHIYATRESFEDEVSKALQFTISLLGDY
GLDQFYIEISTRDASGKFLGSDEDWAYATHILQKVAQDSGLQTRDDPGGAAFYGPKISVQAKDAIGRYWQMSTIQLDFNL
PERFGLFYTDRAGERKRPIMVHRALFGSFERFFAVLTEHYAGAFPPWLSPEQVVALPVTSAHIPYLEEFVSRFSSRLIRA
RVDYMQDRLPKKIRSYVKEKIPFVLVAGDRDLTNRTVAIRFRDGTQISDLPIQKCFDGICASIDRKKQIQTRIDFDSVLE
>Mature_640_residues
MDGFEFFSGRSDVVAMICDDRLLDLSESIPSGKVPEPIELDSPRGLDILRHSCAHVLAQAVQSIYGDAKLGIGPFTENGF
YYDFSVNEPFSSDSLRVIEDKMREIVHSDQKFVRKVVDRQSAHSQFRDEPFKLEIINATDDTLSIYYNIDADSGSVRWMD
FCRGPHLPSTRFIGDAFALTHVSSVYWRGNSDNPQMQRVYGTAWGSAKDLKGYLDRVELAKLVDHRKLGKELDLFSLPDE
IGPGLALFHVKGGIIRSEMEQYARLRHLEEGYNFVYSPHITKRDLFERSGHLQWYGQSMFPPMRLDKDSCSQGFDYYLKP
MNCPFHSLVFSSQPRSYRQLPLRLAEFGTVYRYEQSGAIHGLARVRGLTQDDAHIYATRESFEDEVSKALQFTISLLGDY
GLDQFYIEISTRDASGKFLGSDEDWAYATHILQKVAQDSGLQTRDDPGGAAFYGPKISVQAKDAIGRYWQMSTIQLDFNL
PERFGLFYTDRAGERKRPIMVHRALFGSFERFFAVLTEHYAGAFPPWLSPEQVVALPVTSAHIPYLEEFVSRFSSRLIRA
RVDYMQDRLPKKIRSYVKEKIPFVLVAGDRDLTNRTVAIRFRDGTQISDLPIQKCFDGICASIDRKKQIQTRIDFDSVLE

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38570111, Length=616, Percent_Identity=36.6883116883117, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI38202255, Length=599, Percent_Identity=37.3956594323873, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI20070344, Length=591, Percent_Identity=36.3790186125212, Blast_Score=327, Evalue=2e-89,
Organism=Escherichia coli, GI1788013, Length=616, Percent_Identity=36.6883116883117, Blast_Score=449, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI71984184, Length=615, Percent_Identity=34.3089430894309, Blast_Score=341, Evalue=6e-94,
Organism=Caenorhabditis elegans, GI71984192, Length=615, Percent_Identity=34.3089430894309, Blast_Score=341, Evalue=7e-94,
Organism=Saccharomyces cerevisiae, GI6322112, Length=584, Percent_Identity=34.7602739726027, Blast_Score=343, Evalue=4e-95,
Organism=Saccharomyces cerevisiae, GI6322654, Length=400, Percent_Identity=33.25, Blast_Score=233, Evalue=5e-62,
Organism=Drosophila melanogaster, GI24583842, Length=597, Percent_Identity=36.1809045226131, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI28574141, Length=597, Percent_Identity=36.1809045226131, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24583839, Length=597, Percent_Identity=36.1809045226131, Blast_Score=372, Evalue=1e-103,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_TROW8 (Q83HM3)

Other databases:

- EMBL:   BX251411
- RefSeq:   NP_789437.1
- ProteinModelPortal:   Q83HM3
- SMR:   Q83HM3
- STRING:   Q83HM3
- GeneID:   1064712
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW508
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   TAKDPEC
- ProtClustDB:   PRK12305
- BioCyc:   TWHI218496:TW0482-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 73146; Mature: 73146

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGFEFFSGRSDVVAMICDDRLLDLSESIPSGKVPEPIELDSPRGLDILRHSCAHVLAQA
CCCCCCCCCCCCEEEEEECCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
VQSIYGDAKLGIGPFTENGFYYDFSVNEPFSSDSLRVIEDKMREIVHSDQKFVRKVVDRQ
HHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHH
SAHSQFRDEPFKLEIINATDDTLSIYYNIDADSGSVRWMDFCRGPHLPSTRFIGDAFALT
HHHHHHCCCCEEEEEEECCCCEEEEEEEEECCCCCEEHHHHHCCCCCCCCCHHHHHHHHH
HVSSVYWRGNSDNPQMQRVYGTAWGSAKDLKGYLDRVELAKLVDHRKLGKELDLFSLPDE
HHHHHEECCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
IGPGLALFHVKGGIIRSEMEQYARLRHLEEGYNFVYSPHITKRDLFERSGHLQWYGQSMF
HCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHCCCEEEECCCCC
PPMRLDKDSCSQGFDYYLKPMNCPFHSLVFSSQPRSYRQLPLRLAEFGTVYRYEQSGAIH
CCCCCCHHHHCCCCCEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCEEEEECCCCHH
GLARVRGLTQDDAHIYATRESFEDEVSKALQFTISLLGDYGLDQFYIEISTRDASGKFLG
HHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCC
SDEDWAYATHILQKVAQDSGLQTRDDPGGAAFYGPKISVQAKDAIGRYWQMSTIQLDFNL
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCEEEEEEHHHHCCEEEEEEEEEEECC
PERFGLFYTDRAGERKRPIMVHRALFGSFERFFAVLTEHYAGAFPPWLSPEQVVALPVTS
HHHHCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCC
AHIPYLEEFVSRFSSRLIRARVDYMQDRLPKKIRSYVKEKIPFVLVAGDRDLTNRTVAIR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEE
FRDGTQISDLPIQKCFDGICASIDRKKQIQTRIDFDSVLE
ECCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCHHHHCC
>Mature Secondary Structure
MDGFEFFSGRSDVVAMICDDRLLDLSESIPSGKVPEPIELDSPRGLDILRHSCAHVLAQA
CCCCCCCCCCCCEEEEEECCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
VQSIYGDAKLGIGPFTENGFYYDFSVNEPFSSDSLRVIEDKMREIVHSDQKFVRKVVDRQ
HHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHH
SAHSQFRDEPFKLEIINATDDTLSIYYNIDADSGSVRWMDFCRGPHLPSTRFIGDAFALT
HHHHHHCCCCEEEEEEECCCCEEEEEEEEECCCCCEEHHHHHCCCCCCCCCHHHHHHHHH
HVSSVYWRGNSDNPQMQRVYGTAWGSAKDLKGYLDRVELAKLVDHRKLGKELDLFSLPDE
HHHHHEECCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
IGPGLALFHVKGGIIRSEMEQYARLRHLEEGYNFVYSPHITKRDLFERSGHLQWYGQSMF
HCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHCCCEEEECCCCC
PPMRLDKDSCSQGFDYYLKPMNCPFHSLVFSSQPRSYRQLPLRLAEFGTVYRYEQSGAIH
CCCCCCHHHHCCCCCEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCEEEEECCCCHH
GLARVRGLTQDDAHIYATRESFEDEVSKALQFTISLLGDYGLDQFYIEISTRDASGKFLG
HHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCC
SDEDWAYATHILQKVAQDSGLQTRDDPGGAAFYGPKISVQAKDAIGRYWQMSTIQLDFNL
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCEEEEEEHHHHCCEEEEEEEEEEECC
PERFGLFYTDRAGERKRPIMVHRALFGSFERFFAVLTEHYAGAFPPWLSPEQVVALPVTS
HHHHCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCC
AHIPYLEEFVSRFSSRLIRARVDYMQDRLPKKIRSYVKEKIPFVLVAGDRDLTNRTVAIR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEE
FRDGTQISDLPIQKCFDGICASIDRKKQIQTRIDFDSVLE
ECCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12606174