Click here to switch to the map view.

The map label for this gene is dnaJ1

Identifier: 28572641

GI number: 28572641

Start: 529351

End: 530397

Strand: Reverse

Name: dnaJ1

Synonym: TW492

Alternate gene names: 28572641

Gene position: 530397-529351 (Counterclockwise)

Preceding gene: 28572642

Following gene: 28572640

Centisome position: 57.28

GC content: 44.32

Gene sequence:

>1047_bases
ATGGAAGATTTATATGGCATTCTTGGTGTTGACCATGATGCGAGTGTTGACGAAATAAGAAGAGCTTATAGGCGCCTTGC
GCGTGAGTTGCATCCCGATATAAATCCGGATTCAGCTGATCGTTTTAAGGCTGTGACACATGCTTACAATATTTTGAGCG
ACCCTGAACAGCGTCAACGGTATGATCGGCATGTATCAGGTGGTTTTTCGTCTGATTTTAATCTGTCTGATCTATTCCAG
AGTTTTTTTGATACATCTGCTGAATTTCAGAGAGGCTCTGATTTACTTGTCAATATTGATATTGACCTAAAAACAGCTAT
TTATGGCGGATCACAGGTTGTAAAGATTGACTCACTCGTTGTTTGTGATGTGTGTAATGGCACTCGGAGTGAGCCGGGAT
ATAAGGCCGAGGTATGTTTTGACTGCAACGGTTCTGGTGTAGTCAGGGGTGAGGTAAGGACGACGCTTGGCAATTTGATT
ACCCAGAATACATGCTCGAAGTGCCGAGGTAATGGCGAGAGGATAGATCATCCCTGCAGGAGATGTTACGGTAACGGGAG
CCGCAGTGCCCCCAGAGATATTACAATCAATATTCCCCCCGGGGTAGAAACCGGAATGAGAATAAAAATCCCGAATATGG
GCAATGCCGGCGGGGCAATGCCAGGTGATTTATATGTTGATTGCAAGGTTAAAGAACATCCTTATTTTCTCCGTGACGGT
CAGGATCTGTACTGCCGACTCGATATAAGCCTCGTTGACGCCTTACTTGGCACAAAGGTAAAAATTGACAGCTTAGATGG
AGAGCTTGCTGTTGTTATTCCAGCTCTGAGTCAGAATAGGGATGTGATTCGGATTGCGAATAAAGGCGCAGTGACTCTGA
GGGGAGGAAAGGGCGATCTTTGTATTGTTCTGAATGTATTGCTCATGCAGAAATTAGATCCAGAACACCGTGCGTTACTG
AAAAAGATTATGCCTAACCCACCAAAACCGAAGCTTGCAAAGCGTACATCAGGATTTTTTTCGTGGCTGAAAAATAAGTT
TACATAA

Upstream 100 bases:

>100_bases
TTGTCAGGGTGAAAGGGTTTATTCATGTCCCTTGAGCTTCGGATTTGTGGTATGCCTTGTAATTTTTGGGCTATCTTTCT
GAATTTTTGACCTTTGTAAG

Downstream 100 bases:

>100_bases
GATACCTTTCTAAAAAATTCTGTCGGTGTTATCATGAGCGGATTTTTTATTGCTGAGAACCTTTCTGAGCTATCAGAAGG
TGACACGGTTTTTCTATCAG

Product: chaperone protein DnaJ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MEDLYGILGVDHDASVDEIRRAYRRLARELHPDINPDSADRFKAVTHAYNILSDPEQRQRYDRHVSGGFSSDFNLSDLFQ
SFFDTSAEFQRGSDLLVNIDIDLKTAIYGGSQVVKIDSLVVCDVCNGTRSEPGYKAEVCFDCNGSGVVRGEVRTTLGNLI
TQNTCSKCRGNGERIDHPCRRCYGNGSRSAPRDITINIPPGVETGMRIKIPNMGNAGGAMPGDLYVDCKVKEHPYFLRDG
QDLYCRLDISLVDALLGTKVKIDSLDGELAVVIPALSQNRDVIRIANKGAVTLRGGKGDLCIVLNVLLMQKLDPEHRALL
KKIMPNPPKPKLAKRTSGFFSWLKNKFT

Sequences:

>Translated_348_residues
MEDLYGILGVDHDASVDEIRRAYRRLARELHPDINPDSADRFKAVTHAYNILSDPEQRQRYDRHVSGGFSSDFNLSDLFQ
SFFDTSAEFQRGSDLLVNIDIDLKTAIYGGSQVVKIDSLVVCDVCNGTRSEPGYKAEVCFDCNGSGVVRGEVRTTLGNLI
TQNTCSKCRGNGERIDHPCRRCYGNGSRSAPRDITINIPPGVETGMRIKIPNMGNAGGAMPGDLYVDCKVKEHPYFLRDG
QDLYCRLDISLVDALLGTKVKIDSLDGELAVVIPALSQNRDVIRIANKGAVTLRGGKGDLCIVLNVLLMQKLDPEHRALL
KKIMPNPPKPKLAKRTSGFFSWLKNKFT
>Mature_348_residues
MEDLYGILGVDHDASVDEIRRAYRRLARELHPDINPDSADRFKAVTHAYNILSDPEQRQRYDRHVSGGFSSDFNLSDLFQ
SFFDTSAEFQRGSDLLVNIDIDLKTAIYGGSQVVKIDSLVVCDVCNGTRSEPGYKAEVCFDCNGSGVVRGEVRTTLGNLI
TQNTCSKCRGNGERIDHPCRRCYGNGSRSAPRDITINIPPGVETGMRIKIPNMGNAGGAMPGDLYVDCKVKEHPYFLRDG
QDLYCRLDISLVDALLGTKVKIDSLDGELAVVIPALSQNRDVIRIANKGAVTLRGGKGDLCIVLNVLLMQKLDPEHRALL
KKIMPNPPKPKLAKRTSGFFSWLKNKFT

Specific function: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion. Unfolded proteins bind initially to dnaJ; upon

COG id: COG0484

COG function: function code O; DnaJ-class molecular chaperone with C-terminal Zn finger domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 J domain

Homologues:

Organism=Homo sapiens, GI205360838, Length=352, Percent_Identity=29.8295454545455, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI205360840, Length=352, Percent_Identity=29.8295454545455, Blast_Score=161, Evalue=8e-40,
Organism=Homo sapiens, GI4504511, Length=345, Percent_Identity=29.5652173913043, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI5031741, Length=354, Percent_Identity=30.225988700565, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI194328758, Length=283, Percent_Identity=30.7420494699647, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI194328760, Length=283, Percent_Identity=30.7420494699647, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI7706495, Length=368, Percent_Identity=30.4347826086957, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI201862587, Length=368, Percent_Identity=28.804347826087, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI201862518, Length=368, Percent_Identity=28.804347826087, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI56549115, Length=368, Percent_Identity=28.804347826087, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI194328762, Length=247, Percent_Identity=27.5303643724696, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI194306642, Length=100, Percent_Identity=42, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI194306640, Length=100, Percent_Identity=42, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI23503241, Length=100, Percent_Identity=38, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI68077168, Length=78, Percent_Identity=43.5897435897436, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI45504382, Length=71, Percent_Identity=45.0704225352113, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI68077166, Length=77, Percent_Identity=44.1558441558442, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI22749377, Length=99, Percent_Identity=37.3737373737374, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI4885495, Length=68, Percent_Identity=44.1176470588235, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI47777312, Length=143, Percent_Identity=32.8671328671329, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1786197, Length=372, Percent_Identity=34.1397849462366, Blast_Score=224, Evalue=6e-60,
Organism=Escherichia coli, GI1787235, Length=342, Percent_Identity=27.1929824561404, Blast_Score=115, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17553098, Length=348, Percent_Identity=29.8850574712644, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17553096, Length=348, Percent_Identity=29.8850574712644, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17507263, Length=341, Percent_Identity=30.791788856305, Blast_Score=139, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17563890, Length=326, Percent_Identity=27.6073619631902, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI212645553, Length=359, Percent_Identity=27.5766016713092, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17554644, Length=68, Percent_Identity=51.4705882352941, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115532476, Length=64, Percent_Identity=50, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17554874, Length=87, Percent_Identity=41.3793103448276, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324265, Length=368, Percent_Identity=28.5326086956522, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323870, Length=355, Percent_Identity=28.169014084507, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323119, Length=365, Percent_Identity=30.4109589041096, Blast_Score=108, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6321094, Length=375, Percent_Identity=25.6, Blast_Score=99, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6320888, Length=64, Percent_Identity=48.4375, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45552813, Length=366, Percent_Identity=27.0491803278689, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24646562, Length=352, Percent_Identity=28.9772727272727, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24646560, Length=352, Percent_Identity=28.9772727272727, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24646558, Length=352, Percent_Identity=28.9772727272727, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24646556, Length=352, Percent_Identity=28.9772727272727, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI21357547, Length=352, Percent_Identity=28.9772727272727, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI45552811, Length=366, Percent_Identity=27.0491803278689, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI45549272, Length=366, Percent_Identity=27.0491803278689, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI20129487, Length=282, Percent_Identity=33.3333333333333, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24584014, Length=282, Percent_Identity=33.3333333333333, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI19920464, Length=347, Percent_Identity=29.6829971181556, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI28574949, Length=333, Percent_Identity=23.7237237237237, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24641698, Length=66, Percent_Identity=50, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24641696, Length=66, Percent_Identity=50, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24658562, Length=70, Percent_Identity=44.2857142857143, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24658555, Length=70, Percent_Identity=44.2857142857143, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAJ_TROW8 (Q83NI2)

Other databases:

- EMBL:   BX251411
- RefSeq:   NP_789421.1
- ProteinModelPortal:   Q83NI2
- STRING:   Q83NI2
- GeneID:   1064696
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW492
- eggNOG:   COG0484
- HOGENOM:   HBG635315
- OMA:   THAYNIL
- ProtClustDB:   CLSK229840
- BioCyc:   TWHI218496:TW0466-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01152
- InterPro:   IPR012724
- InterPro:   IPR002939
- InterPro:   IPR001623
- InterPro:   IPR018253
- InterPro:   IPR008971
- InterPro:   IPR015609
- InterPro:   IPR003095
- InterPro:   IPR001305
- Gene3D:   G3DSA:1.10.287.110
- Gene3D:   G3DSA:2.10.230.10
- PANTHER:   PTHR11821
- PRINTS:   PR00625
- SMART:   SM00271

Pfam domain/function: PF00226 DnaJ; PF01556 DnaJ_C; PF00684 DnaJ_CXXCXGXG; SSF46565 DnaJ_N; SSF49493 HSP40_DnaJ_pep; SSF57938 HSP_DnaJ_cys-rich

EC number: NA

Molecular weight: Translated: 38521; Mature: 38521

Theoretical pI: Translated: 8.05; Mature: 8.05

Prosite motif: PS00636 DNAJ_1; PS50076 DNAJ_2; PS51188 ZF_CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDLYGILGVDHDASVDEIRRAYRRLARELHPDINPDSADRFKAVTHAYNILSDPEQRQR
CCCHHEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHH
YDRHVSGGFSSDFNLSDLFQSFFDTSAEFQRGSDLLVNIDIDLKTAIYGGSQVVKIDSLV
HHHHHCCCCCCCCCHHHHHHHHHCCCHHHCCCCCEEEEEEEEEEEEEECCCEEEEECCEE
VCDVCNGTRSEPGYKAEVCFDCNGSGVVRGEVRTTLGNLITQNTCSKCRGNGERIDHPCR
EEECCCCCCCCCCCEEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
RCYGNGSRSAPRDITINIPPGVETGMRIKIPNMGNAGGAMPGDLYVDCKVKEHPYFLRDG
HHCCCCCCCCCCEEEEECCCCCCCCCEEECCCCCCCCCCCCCCEEEEEEECCCCEEEECC
QDLYCRLDISLVDALLGTKVKIDSLDGELAVVIPALSQNRDVIRIANKGAVTLRGGKGDL
CEEEEEEEHHHHHHHHCCEEEEECCCCCEEEEEECCCCCCCEEEEECCCEEEEECCCCCH
CIVLNVLLMQKLDPEHRALLKKIMPNPPKPKLAKRTSGFFSWLKNKFT
HHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEDLYGILGVDHDASVDEIRRAYRRLARELHPDINPDSADRFKAVTHAYNILSDPEQRQR
CCCHHEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHH
YDRHVSGGFSSDFNLSDLFQSFFDTSAEFQRGSDLLVNIDIDLKTAIYGGSQVVKIDSLV
HHHHHCCCCCCCCCHHHHHHHHHCCCHHHCCCCCEEEEEEEEEEEEEECCCEEEEECCEE
VCDVCNGTRSEPGYKAEVCFDCNGSGVVRGEVRTTLGNLITQNTCSKCRGNGERIDHPCR
EEECCCCCCCCCCCEEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
RCYGNGSRSAPRDITINIPPGVETGMRIKIPNMGNAGGAMPGDLYVDCKVKEHPYFLRDG
HHCCCCCCCCCCEEEEECCCCCCCCCEEECCCCCCCCCCCCCCEEEEEEECCCCEEEECC
QDLYCRLDISLVDALLGTKVKIDSLDGELAVVIPALSQNRDVIRIANKGAVTLRGGKGDL
CEEEEEEEHHHHHHHHCCEEEEECCCCCEEEEEECCCCCCCEEEEECCCEEEEECCCCCH
CIVLNVLLMQKLDPEHRALLKKIMPNPPKPKLAKRTSGFFSWLKNKFT
HHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12606174