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The map label for this gene is aroB

Identifier: 28572552

GI number: 28572552

Start: 435142

End: 436284

Strand: Direct

Name: aroB

Synonym: TW399

Alternate gene names: 28572552

Gene position: 435142-436284 (Clockwise)

Preceding gene: 28572551

Following gene: 28572553

Centisome position: 46.99

GC content: 43.31

Gene sequence:

>1143_bases
GTGATGAAGAAGTACTCGTTGACAACGCACAGCACGGAAACTTGCCAGATCTTGTTTACAAGCGTGTCAAATGTGTTCAA
ATACATACCATCCGGGACACGCCGCATTCTTATTATGTACCAGGATTCTGTTTCACAGGTGTTACCAATTTTTTCTGCTG
CTTCGGGGGTTCAGTGTTATCGATACTTGATTCCAGATTCAGAATCAGCAAAGCAACTTGGTGTAGCCGAGCAGTGTTGG
AGATTTCTTGCTCAAAATAATTTCACTCGCTCCGATCTGATCGTAAGCTGCGGTGGTGGGGCAGCCTCAGACCTGTCTGG
ATTTGTAGCATCGTCCTATTTGCGGGGGATAAAGATTATACACATTCCCACAACTCTTATTGGCATGGTTGATGCGGCTA
TTGGTGGAAAAACGGGAATAAACCTTAAAGAGGGTAAGAACCTTGTTGGCTCCTTTTATTCCCCATATATTGTTTTGTGC
GATCCTTCAATGCTAACAACCCTCAATGAGGAGCATTTAAAATCAGGTCTTGCAGAGATAATAAAATGTGGGTTTATACA
GGATGAGAGTATCCTCAGCATTCTGGAACACAACGCGCAAGACCATATGGATTGCTCGCAGCGCGTATGTGCAGAAACTT
TACCGCCGAAACTCCTTGAAGAATTGATTCATAAAGCAGTATCTGTAAAGATCACAATGGTTGACTCTGATTTTAGAGAT
ACGCATAAGAGGCAATTTTTGAATTATGGTCATACATTAGCTCATGCCCTTGAGGCAGCCACCTCCCATAAGTTGTCTCA
CGGTCAGGCGGTATCCATCGGCATGGTGTATGCAGCACAGGTTGCTTTTGCAAAGGGTTTAATTGGCAGAAATATTTTGA
CGAGACATGAGCGAATTCTTGAAACATACGGCTTGCCAGTTTGTCCACCTGAGGTTCAGTGGCGCAACATTACTCCCTAC
ATGCAGCGTGATAAAAAGAATATGCAGAACAATGACACGGATAGCTACAAAGATTCACGAGAGATACCTCAAATCAGTAC
GCAGAGTAAACTAGTTTTACTACGTGACATCGCAAATCCTTTTATCACTTCGGTTTCTCATACGGTATTGCTTGAAGCGT
ATGAAGCCATGTTTCCTCAATAG

Upstream 100 bases:

>100_bases
TACGGTTTATTTACAATCGCTCTTGGCATCGAGAATTCTGATACCGTGCCTAGATTTTACTGTTGTCTTGCCGCAAGGTA
GGTTGTAAAGGCGGAATCTT

Downstream 100 bases:

>100_bases
AGGCGTATATTGTTCAGATCCTTTATCGTATACATAAAGGGTGTTTGCAGTGGCGAAATTCCAGGATAACCAAGTGGAGA
TGTGTGAGTAAGAAGAAAAT

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MMKKYSLTTHSTETCQILFTSVSNVFKYIPSGTRRILIMYQDSVSQVLPIFSAASGVQCYRYLIPDSESAKQLGVAEQCW
RFLAQNNFTRSDLIVSCGGGAASDLSGFVASSYLRGIKIIHIPTTLIGMVDAAIGGKTGINLKEGKNLVGSFYSPYIVLC
DPSMLTTLNEEHLKSGLAEIIKCGFIQDESILSILEHNAQDHMDCSQRVCAETLPPKLLEELIHKAVSVKITMVDSDFRD
THKRQFLNYGHTLAHALEAATSHKLSHGQAVSIGMVYAAQVAFAKGLIGRNILTRHERILETYGLPVCPPEVQWRNITPY
MQRDKKNMQNNDTDSYKDSREIPQISTQSKLVLLRDIANPFITSVSHTVLLEAYEAMFPQ

Sequences:

>Translated_380_residues
MMKKYSLTTHSTETCQILFTSVSNVFKYIPSGTRRILIMYQDSVSQVLPIFSAASGVQCYRYLIPDSESAKQLGVAEQCW
RFLAQNNFTRSDLIVSCGGGAASDLSGFVASSYLRGIKIIHIPTTLIGMVDAAIGGKTGINLKEGKNLVGSFYSPYIVLC
DPSMLTTLNEEHLKSGLAEIIKCGFIQDESILSILEHNAQDHMDCSQRVCAETLPPKLLEELIHKAVSVKITMVDSDFRD
THKRQFLNYGHTLAHALEAATSHKLSHGQAVSIGMVYAAQVAFAKGLIGRNILTRHERILETYGLPVCPPEVQWRNITPY
MQRDKKNMQNNDTDSYKDSREIPQISTQSKLVLLRDIANPFITSVSHTVLLEAYEAMFPQ
>Mature_380_residues
MMKKYSLTTHSTETCQILFTSVSNVFKYIPSGTRRILIMYQDSVSQVLPIFSAASGVQCYRYLIPDSESAKQLGVAEQCW
RFLAQNNFTRSDLIVSCGGGAASDLSGFVASSYLRGIKIIHIPTTLIGMVDAAIGGKTGINLKEGKNLVGSFYSPYIVLC
DPSMLTTLNEEHLKSGLAEIIKCGFIQDESILSILEHNAQDHMDCSQRVCAETLPPKLLEELIHKAVSVKITMVDSDFRD
THKRQFLNYGHTLAHALEAATSHKLSHGQAVSIGMVYAAQVAFAKGLIGRNILTRHERILETYGLPVCPPEVQWRNITPY
MQRDKKNMQNNDTDSYKDSREIPQISTQSKLVLLRDIANPFITSVSHTVLLEAYEAMFPQ

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=290, Percent_Identity=37.9310344827586, Blast_Score=161, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6320332, Length=344, Percent_Identity=30.8139534883721, Blast_Score=173, Evalue=4e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_TROW8 (Q83HU4)

Other databases:

- EMBL:   BX251411
- RefSeq:   NP_789332.1
- ProteinModelPortal:   Q83HU4
- SMR:   Q83HU4
- STRING:   Q83HU4
- GeneID:   1064685
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW399
- eggNOG:   COG0337
- HOGENOM:   HBG632303
- OMA:   FAAYQEI
- ProtClustDB:   PRK00002
- BioCyc:   TWHI218496:TW0377-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455
- TIGRFAMs:   TIGR01357

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 42256; Mature: 42256

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKKYSLTTHSTETCQILFTSVSNVFKYIPSGTRRILIMYQDSVSQVLPIFSAASGVQCY
CCCCEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCCHHEE
RYLIPDSESAKQLGVAEQCWRFLAQNNFTRSDLIVSCGGGAASDLSGFVASSYLRGIKII
EEECCCCCCHHHCCCHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCEEEE
HIPTTLIGMVDAAIGGKTGINLKEGKNLVGSFYSPYIVLCDPSMLTTLNEEHLKSGLAEI
EECHHHHHHHHHHCCCCCCCCHHHCCHHHHHHCCCEEEEECCHHHHHCCHHHHHHHHHHH
IKCGFIQDESILSILEHNAQDHMDCSQRVCAETLPPKLLEELIHKAVSVKITMVDSDFRD
HHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEEEECCCHHH
THKRQFLNYGHTLAHALEAATSHKLSHGQAVSIGMVYAAQVAFAKGLIGRNILTRHERIL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETYGLPVCPPEVQWRNITPYMQRDKKNMQNNDTDSYKDSREIPQISTQSKLVLLRDIANP
HHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
FITSVSHTVLLEAYEAMFPQ
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMKKYSLTTHSTETCQILFTSVSNVFKYIPSGTRRILIMYQDSVSQVLPIFSAASGVQCY
CCCCEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCCHHEE
RYLIPDSESAKQLGVAEQCWRFLAQNNFTRSDLIVSCGGGAASDLSGFVASSYLRGIKII
EEECCCCCCHHHCCCHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCEEEE
HIPTTLIGMVDAAIGGKTGINLKEGKNLVGSFYSPYIVLCDPSMLTTLNEEHLKSGLAEI
EECHHHHHHHHHHCCCCCCCCHHHCCHHHHHHCCCEEEEECCHHHHHCCHHHHHHHHHHH
IKCGFIQDESILSILEHNAQDHMDCSQRVCAETLPPKLLEELIHKAVSVKITMVDSDFRD
HHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEEEECCCHHH
THKRQFLNYGHTLAHALEAATSHKLSHGQAVSIGMVYAAQVAFAKGLIGRNILTRHERIL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETYGLPVCPPEVQWRNITPYMQRDKKNMQNNDTDSYKDSREIPQISTQSKLVLLRDIANP
HHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
FITSVSHTVLLEAYEAMFPQ
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12606174