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The map label for this gene is atpA

Identifier: 28572496

GI number: 28572496

Start: 372201

End: 373829

Strand: Direct

Name: atpA

Synonym: TW342

Alternate gene names: 28572496

Gene position: 372201-373829 (Clockwise)

Preceding gene: 28572495

Following gene: 28572497

Centisome position: 40.2

GC content: 48.74

Gene sequence:

>1629_bases
ATGTCTAAACAACCGATAATCACTTCTGAGGAAGTAAGGGGGGTTATCCGCAATCTCCTGGATTCAACTCTTTCTGCAGC
GAGAGAGGCAAATGAATTTGAGGTCGGCAGGGTTGTCGATGCAGCCGATGGCGTTGCTCATATTGAAGGCCTTCCGGCGC
TCATGGCGAGTGAGCTTGTCGAATTCTCTAATGGCACTTTCGGAGTCACGCTAAATCTGGATGAAGATTTGGCTGGAGTA
GTTGTTCTTGGGGAGTTTGATGGAATCGTTGAGGGAATGGATGTCAGGTCAACCGGACGGGTTCTATCAATTCCTGTTGG
CGACGCCTTTCTTGGTAGGGTTGTAGACCCACTTGGCCGTCCTGTAGATGGCTTAGGTGAAGTGCCCCACGAGACCTATA
GGGAGCTTGAATTACAAGCCGCAGGTGTTATGCAGCGGCGGTCTGTTCACGAGCCAATACAGACTGGGATAAAGGCCATT
GACACAATGATTCCAATCGGTAGGGGTCAACGCCAGCTTATTATTGGCGATAGGCAAACCGGAAAGACCACTATTGCAAT
TGACACAATTATCAATCAGAAAGATAACTGGTCGGACCCGGAGAAGCGTGTTTTTTGTATATATGTTGCTATTGGCCAAA
AGGGCTCGACAATTGCGGGGGTAAAGCGTGTCCTTGAAGAGGCGGGGTGTATGGAATATACGACCATAGTTGCAACCCCC
GCGTCTGATCCGGCGGGCTTCAAGTACATCGCTCCATATTCTGGATCTGCTATCGGTCAGCACTGGATGTATCAGGGCAG
GCATGTTCTCATTGTCTTTGATGACCTCAGCAAACAGGCGGAGGCTTACCGAGCGATTTCACTTCTCCTGCGGCGCCCCC
CAGGCCGTGAAGCGTATCCGGGTGATGTTTTTTATTTACATTCCCGGCTCTTGGAGCGTTGCGCGAAATTGTCAGACGAA
ATGGGTGGTGGTTCAATGACTGGCTTGCCGATTATCGAGACAAAGGCTAACGATATCTCTGCATATATACCGACTAATGT
TATTTCTATAACAGATGGCCAGATTTTTCTACAGTCAGATTTGTTCAATGCAAATCAGAGACCCGCAGTTGACGTGGGGA
TCTCGGTCTCCAGGGTTGGTGGTGACGCCCAGATAAAGTCGATTAAAAAAGTGTCTGGGATGCTAAAGTTGGAGCTTGCT
CAGTACAGGGCACTTGAGGCGTTTTCCATGTTTGCGTCTGATCTTGATGCTGTCAGCCGTCGCCAGCTTGACAGGGGCGC
AAGACTTTCTGAATTGTTGAGACAACAGCAACAGTCTCCTTATCCAGTTGAGGATCAGGTTGTGTCGATTTGGGTGGGGT
CGAATGGCTATATAGACGATATACCGCTTTCTGATGTATTAGATTTCGAACGTGATTTGCTGGAATACCTGAGAAATAGA
ACCTCTATTCTTGACGATTTGCGTACATGTGGTGACCTGACAGATGCTCTTCTCGAACGCTTGAAGGAGGCCGTAGAGTC
CTTTAAAAACAAGGTCTATTTTATGCGGGTCGATGAGCGCGAAAAGGATCCTCTGGAGGACGAGAATATAGGTCAGGAAG
AGTTAGTTCGTTCACGTCGGGCGAACTGA

Upstream 100 bases:

>100_bases
CAGGTGAATCATTCAGTGATAGATGATACTGTCGCTGTTCATCTGAATAACTTGGCTCTTTCTTTTGGTGCACTTGAAAC
TTTTAGCTGAAAAGGGGGAT

Downstream 100 bases:

>100_bases
AAGCTCGGAGGTTTTCTGTATGGGTGCGCAGCTTAGGGTATATCGCGGAAAAGCAGCCTCAGCATCGGTGACGAAGAAGA
TAACCAGCGCTATGGAATTG

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MSKQPIITSEEVRGVIRNLLDSTLSAAREANEFEVGRVVDAADGVAHIEGLPALMASELVEFSNGTFGVTLNLDEDLAGV
VVLGEFDGIVEGMDVRSTGRVLSIPVGDAFLGRVVDPLGRPVDGLGEVPHETYRELELQAAGVMQRRSVHEPIQTGIKAI
DTMIPIGRGQRQLIIGDRQTGKTTIAIDTIINQKDNWSDPEKRVFCIYVAIGQKGSTIAGVKRVLEEAGCMEYTTIVATP
ASDPAGFKYIAPYSGSAIGQHWMYQGRHVLIVFDDLSKQAEAYRAISLLLRRPPGREAYPGDVFYLHSRLLERCAKLSDE
MGGGSMTGLPIIETKANDISAYIPTNVISITDGQIFLQSDLFNANQRPAVDVGISVSRVGGDAQIKSIKKVSGMLKLELA
QYRALEAFSMFASDLDAVSRRQLDRGARLSELLRQQQQSPYPVEDQVVSIWVGSNGYIDDIPLSDVLDFERDLLEYLRNR
TSILDDLRTCGDLTDALLERLKEAVESFKNKVYFMRVDEREKDPLEDENIGQEELVRSRRAN

Sequences:

>Translated_542_residues
MSKQPIITSEEVRGVIRNLLDSTLSAAREANEFEVGRVVDAADGVAHIEGLPALMASELVEFSNGTFGVTLNLDEDLAGV
VVLGEFDGIVEGMDVRSTGRVLSIPVGDAFLGRVVDPLGRPVDGLGEVPHETYRELELQAAGVMQRRSVHEPIQTGIKAI
DTMIPIGRGQRQLIIGDRQTGKTTIAIDTIINQKDNWSDPEKRVFCIYVAIGQKGSTIAGVKRVLEEAGCMEYTTIVATP
ASDPAGFKYIAPYSGSAIGQHWMYQGRHVLIVFDDLSKQAEAYRAISLLLRRPPGREAYPGDVFYLHSRLLERCAKLSDE
MGGGSMTGLPIIETKANDISAYIPTNVISITDGQIFLQSDLFNANQRPAVDVGISVSRVGGDAQIKSIKKVSGMLKLELA
QYRALEAFSMFASDLDAVSRRQLDRGARLSELLRQQQQSPYPVEDQVVSIWVGSNGYIDDIPLSDVLDFERDLLEYLRNR
TSILDDLRTCGDLTDALLERLKEAVESFKNKVYFMRVDEREKDPLEDENIGQEELVRSRRAN
>Mature_541_residues
SKQPIITSEEVRGVIRNLLDSTLSAAREANEFEVGRVVDAADGVAHIEGLPALMASELVEFSNGTFGVTLNLDEDLAGVV
VLGEFDGIVEGMDVRSTGRVLSIPVGDAFLGRVVDPLGRPVDGLGEVPHETYRELELQAAGVMQRRSVHEPIQTGIKAID
TMIPIGRGQRQLIIGDRQTGKTTIAIDTIINQKDNWSDPEKRVFCIYVAIGQKGSTIAGVKRVLEEAGCMEYTTIVATPA
SDPAGFKYIAPYSGSAIGQHWMYQGRHVLIVFDDLSKQAEAYRAISLLLRRPPGREAYPGDVFYLHSRLLERCAKLSDEM
GGGSMTGLPIIETKANDISAYIPTNVISITDGQIFLQSDLFNANQRPAVDVGISVSRVGGDAQIKSIKKVSGMLKLELAQ
YRALEAFSMFASDLDAVSRRQLDRGARLSELLRQQQQSPYPVEDQVVSIWVGSNGYIDDIPLSDVLDFERDLLEYLRNRT
SILDDLRTCGDLTDALLERLKEAVESFKNKVYFMRVDEREKDPLEDENIGQEELVRSRRAN

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=478, Percent_Identity=55.0209205020921, Blast_Score=536, Evalue=1e-152,
Organism=Homo sapiens, GI4757810, Length=478, Percent_Identity=55.0209205020921, Blast_Score=536, Evalue=1e-152,
Organism=Homo sapiens, GI19913428, Length=310, Percent_Identity=30.6451612903226, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI19913426, Length=313, Percent_Identity=30.0319488817891, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI32189394, Length=354, Percent_Identity=23.1638418079096, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1790172, Length=515, Percent_Identity=49.9029126213592, Blast_Score=504, Evalue=1e-144,
Organism=Escherichia coli, GI1790170, Length=323, Percent_Identity=25.077399380805, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1788251, Length=360, Percent_Identity=26.1111111111111, Blast_Score=99, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI71988063, Length=481, Percent_Identity=54.4698544698545, Blast_Score=536, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI71988080, Length=481, Percent_Identity=54.4698544698545, Blast_Score=536, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI71988074, Length=481, Percent_Identity=50.9355509355509, Blast_Score=491, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17570191, Length=322, Percent_Identity=30.4347826086957, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17510931, Length=291, Percent_Identity=30.9278350515464, Blast_Score=121, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI25144756, Length=318, Percent_Identity=22.3270440251572, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=58, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319370, Length=483, Percent_Identity=54.6583850931677, Blast_Score=541, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6319603, Length=320, Percent_Identity=32.8125, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6322581, Length=455, Percent_Identity=22.4175824175824, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24658560, Length=506, Percent_Identity=52.5691699604743, Blast_Score=533, Evalue=1e-151,
Organism=Drosophila melanogaster, GI281361666, Length=322, Percent_Identity=30.1242236024845, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646341, Length=322, Percent_Identity=30.1242236024845, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI17136796, Length=322, Percent_Identity=30.1242236024845, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24638766, Length=318, Percent_Identity=22.9559748427673, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI28574560, Length=421, Percent_Identity=23.0403800475059, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_TROW8 (Q83HY2)

Other databases:

- EMBL:   BX251411
- RefSeq:   NP_789276.1
- ProteinModelPortal:   Q83HY2
- SMR:   Q83HY2
- STRING:   Q83HY2
- GeneID:   1064629
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW342
- eggNOG:   COG0056
- HOGENOM:   HBG565875
- OMA:   GSDRDIK
- PhylomeDB:   Q83HY2
- ProtClustDB:   PRK09281
- BioCyc:   TWHI218496:TW0321-MONOMER
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 59793; Mature: 59662

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQPIITSEEVRGVIRNLLDSTLSAAREANEFEVGRVVDAADGVAHIEGLPALMASELV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHEHHCCCHHHHHCCHHHHHHHHH
EFSNGTFGVTLNLDEDLAGVVVLGEFDGIVEGMDVRSTGRVLSIPVGDAFLGRVVDPLGR
HHCCCEEEEEEECCCCCCCEEEEECCCCHHCCCCCCCCCCEEEECCCHHHHHHHHHHHCC
PVDGLGEVPHETYRELELQAAGVMQRRSVHEPIQTGIKAIDTMIPIGRGQRQLIIGDRQT
CCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCC
GKTTIAIDTIINQKDNWSDPEKRVFCIYVAIGQKGSTIAGVKRVLEEAGCMEYTTIVATP
CCEEEEEEEEECCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEEEC
ASDPAGFKYIAPYSGSAIGQHWMYQGRHVLIVFDDLSKQAEAYRAISLLLRRPPGREAYP
CCCCCCEEEECCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCC
GDVFYLHSRLLERCAKLSDEMGGGSMTGLPIIETKANDISAYIPTNVISITDGQIFLQSD
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCCEEEEECCEEEEEEC
LFNANQRPAVDVGISVSRVGGDAQIKSIKKVSGMLKLELAQYRALEAFSMFASDLDAVSR
CCCCCCCCCEEECCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQLDRGARLSELLRQQQQSPYPVEDQVVSIWVGSNGYIDDIPLSDVLDFERDLLEYLRNR
HHHHCCCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
TSILDDLRTCGDLTDALLERLKEAVESFKNKVYFMRVDEREKDPLEDENIGQEELVRSRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHC
AN
CC
>Mature Secondary Structure 
SKQPIITSEEVRGVIRNLLDSTLSAAREANEFEVGRVVDAADGVAHIEGLPALMASELV
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHEHHCCCHHHHHCCHHHHHHHHH
EFSNGTFGVTLNLDEDLAGVVVLGEFDGIVEGMDVRSTGRVLSIPVGDAFLGRVVDPLGR
HHCCCEEEEEEECCCCCCCEEEEECCCCHHCCCCCCCCCCEEEECCCHHHHHHHHHHHCC
PVDGLGEVPHETYRELELQAAGVMQRRSVHEPIQTGIKAIDTMIPIGRGQRQLIIGDRQT
CCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCC
GKTTIAIDTIINQKDNWSDPEKRVFCIYVAIGQKGSTIAGVKRVLEEAGCMEYTTIVATP
CCEEEEEEEEECCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEEEC
ASDPAGFKYIAPYSGSAIGQHWMYQGRHVLIVFDDLSKQAEAYRAISLLLRRPPGREAYP
CCCCCCEEEECCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCC
GDVFYLHSRLLERCAKLSDEMGGGSMTGLPIIETKANDISAYIPTNVISITDGQIFLQSD
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCCEEEEECCEEEEEEC
LFNANQRPAVDVGISVSRVGGDAQIKSIKKVSGMLKLELAQYRALEAFSMFASDLDAVSR
CCCCCCCCCEEECCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQLDRGARLSELLRQQQQSPYPVEDQVVSIWVGSNGYIDDIPLSDVLDFERDLLEYLRNR
HHHHCCCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
TSILDDLRTCGDLTDALLERLKEAVESFKNKVYFMRVDEREKDPLEDENIGQEELVRSRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHC
AN
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12606174