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The map label for this gene is wecA [H]

Identifier: 28572490

GI number: 28572490

Start: 368207

End: 369307

Strand: Direct

Name: wecA [H]

Synonym: TW336

Alternate gene names: 28572490

Gene position: 368207-369307 (Clockwise)

Preceding gene: 28572489

Following gene: 28572491

Centisome position: 39.77

GC content: 42.51

Gene sequence:

>1101_bases
TTGATTGTTTATCTCTCTGTGGCCCTTTTTGCGGCGCTTGTTACTGCTACTTCGGTCTATTGTCTTTTGAAAATTGCCCC
GAAGTTTTGGGCGCTCAGGGAAGTGCGCCCTCGCGATGTGCACACAGTACCAACACTTCGCATAGGTGGGATACCCATGT
TTGTGGCATTTTTGTTTTCCATAGCACTCGCGAGGTTTATACCTTATTTTTCAGATGTCTTTCGTACAGCGGATCCGGTT
CTAACAAGCCTGGTTATAGCAGTTTCTGTTATAACGCTTTTGGGATTTTTAGACGATCTATTTGAGTTGCATTGGCTTAT
AAAGCTTTTGGGGCAAATCTTTTCTGCTGCAATAGTTAGTGTCATGAGCAGGGGTATTTTTCACTCCTTTACAGGTGGGG
ATCTTTCTTGGCTTCTTACCATTGCAAGTATCGTTCTGATTGTCACGACAATGAATGCAATTAACTTCATTGATGGGCTT
GATGGCCTGGCTGCTGGTGTCTGCCTCATTGGTAATGGGGTGTTTTTTGTTTACATATATTTCTTTACTCGTGAGATTTC
CCCGAGTAACTACTTTAACCTGGTCGGCCTTCTTGCGGCCATTTTGTTTGGAATATGTGCAGGGTTTATACCATTCAACT
GGAGACCTGCAAAGCTATTTATGGGTGATTCTGGGGCATTGCTTCTCGGGTTGGTTATGTCCGTTGCGGCCACGACAGCA
GTTGCTCAAGCAAGCGCCGTTACATTTGTAAGACGTGCACATTATGTTCCAGCATTTATCCCAATACTCCTTCCTTTTGC
TGTGCTCGGATTACCAATTTTGGATTTACTTTTTGCGATTATGAGGCGGCTTTTATCTTTTAAAAGTCCGTTTAATCCCG
ATAAAAAACATCTACACCATAGGATGCTGCATATGGGACACTCTTCTGTTGCGACTGTTGTTATTTTTTATGCTTGGAGT
GGGGTTGTTTCTGGTGGAATGTTACTTTTTTTGTTTACTTCGACGATTTTTGCCGTTCTTTTTTTGCTGTTTGGGGTGCT
TGTGTGTTTGATCTTTACGTTTTTACCCATAGTGAGGAAAAGGTCTTGGAATCGAAATTAA

Upstream 100 bases:

>100_bases
ATTCCGTGGAAATCTCTAGAAAAAGCCATGCAAATGAAGCTTGTGAAGCAGTGATCTGACATTACAGAGAACAATACGGT
TGTGTGGGGATGAATAGCAT

Downstream 100 bases:

>100_bases
AAATAACACCGGGTGTAACCTTGAGAAATAATGCAAGCTAATGGCTGCCTCGCGCACTAATAACGCCGACTCGGTTATCC
TGCTTTTTCGCAGGATTCTC

Product: glycosyl transferase

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-Phosphate GlcNAc-1-phosphate transferase [H]

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MIVYLSVALFAALVTATSVYCLLKIAPKFWALREVRPRDVHTVPTLRIGGIPMFVAFLFSIALARFIPYFSDVFRTADPV
LTSLVIAVSVITLLGFLDDLFELHWLIKLLGQIFSAAIVSVMSRGIFHSFTGGDLSWLLTIASIVLIVTTMNAINFIDGL
DGLAAGVCLIGNGVFFVYIYFFTREISPSNYFNLVGLLAAILFGICAGFIPFNWRPAKLFMGDSGALLLGLVMSVAATTA
VAQASAVTFVRRAHYVPAFIPILLPFAVLGLPILDLLFAIMRRLLSFKSPFNPDKKHLHHRMLHMGHSSVATVVIFYAWS
GVVSGGMLLFLFTSTIFAVLFLLFGVLVCLIFTFLPIVRKRSWNRN

Sequences:

>Translated_366_residues
MIVYLSVALFAALVTATSVYCLLKIAPKFWALREVRPRDVHTVPTLRIGGIPMFVAFLFSIALARFIPYFSDVFRTADPV
LTSLVIAVSVITLLGFLDDLFELHWLIKLLGQIFSAAIVSVMSRGIFHSFTGGDLSWLLTIASIVLIVTTMNAINFIDGL
DGLAAGVCLIGNGVFFVYIYFFTREISPSNYFNLVGLLAAILFGICAGFIPFNWRPAKLFMGDSGALLLGLVMSVAATTA
VAQASAVTFVRRAHYVPAFIPILLPFAVLGLPILDLLFAIMRRLLSFKSPFNPDKKHLHHRMLHMGHSSVATVVIFYAWS
GVVSGGMLLFLFTSTIFAVLFLLFGVLVCLIFTFLPIVRKRSWNRN
>Mature_366_residues
MIVYLSVALFAALVTATSVYCLLKIAPKFWALREVRPRDVHTVPTLRIGGIPMFVAFLFSIALARFIPYFSDVFRTADPV
LTSLVIAVSVITLLGFLDDLFELHWLIKLLGQIFSAAIVSVMSRGIFHSFTGGDLSWLLTIASIVLIVTTMNAINFIDGL
DGLAAGVCLIGNGVFFVYIYFFTREISPSNYFNLVGLLAAILFGICAGFIPFNWRPAKLFMGDSGALLLGLVMSVAATTA
VAQASAVTFVRRAHYVPAFIPILLPFAVLGLPILDLLFAIMRRLLSFKSPFNPDKKHLHHRMLHMGHSSVATVVIFYAWS
GVVSGGMLLFLFTSTIFAVLFLLFGVLVCLIFTFLPIVRKRSWNRN

Specific function: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55), the lipid intermediate involved in the synthesis of various bacter

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. WecA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790218, Length=304, Percent_Identity=23.6842105263158, Blast_Score=68, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000715 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 40371; Mature: 40371

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCC
>Mature Secondary Structure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CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]