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The map label for this gene is cdsA [H]

Identifier: 28572477

GI number: 28572477

Start: 354324

End: 355133

Strand: Direct

Name: cdsA [H]

Synonym: TW322

Alternate gene names: 28572477

Gene position: 354324-355133 (Clockwise)

Preceding gene: 28572476

Following gene: 28572478

Centisome position: 38.27

GC content: 43.33

Gene sequence:

>810_bases
ATGCTAAAACAAAGGGTACAGGCCCGCACGGGAAGGGATTTGGTCCTTGCAATCGGTGTGGGTCTTATTTTGGGCGGACT
GCTTCTCATTTCTCTTTTTGTCTTTCTGCATTTGTTTGTTCTGGTTTGCATACTTGTCGGAGTTACCTGCCTTGCCGAGA
TCTTTACAGCCACCCACACGCGCGGTATCTTCATAGTCCGCCCTTTCTTGACCTTGTCTACTGTTGTTCTGCCCGTATTG
GCATTCTTTTTTGCATCCTGGTTTTTACCGTCGATCGCGTTTTTCATGCTTACAATCCTGCTTGCCCAATTTTTTCTGCG
TGCCAGGTTTTCTTTACATTCATTATTCATTTTTTTGTATATACCAATTACCGTTTCACTCTTCGCATTTATTGCCGCAC
ATCCAACGGGAAGGTTATGGGTGTTTTTCATGCTTGTCACGGTAATTGCATCAGATACATTCTCGTACGTCTTTGGAACA
CTGTTCGGAAGGCATCTTCTTGCACCGCGTATAAGTCCAAATAAAACATGGGAGGGGCTCATAGGTGGTTTCTTTTCATC
TCTCTTTTTTGGCACACTAACAGGTATTTTGCTGCTTCACAAGTCATTGCTGTTCAGTGCAACTGCCGCCTCAATTCTGT
TTCTCTTTGCAATCCTTGGTGATTTAGCCGAGTCTTATATAAAGCGCAGACTTGGTGTTAAGGATATGAGCGGAATACTT
CCCGGGCATGGAGGAATGCTTGACAGAGTGGACTCAATGCTTTTAAATATTTTTCCAATTCTTTTGCTTGTGCACATGAA
TTTTGTGTAA

Upstream 100 bases:

>100_bases
GACATAAGGAGTCTGAGCTTCTTAGGCTTTGATCCAGCCCCAAGACTTATCCGCGAATCTGTAGTGTTTGAATGAGGCTG
CAATGCTTAGATATTTCTTC

Downstream 100 bases:

>100_bases
GGTACCCCATGCTCTCTGTCTCGACTGACACGGGGTTGTCGCCTGGCACGGTCCTTTATATCCGGGCAGAAAATCACTTT
CTTTGCAACATCTCGTTTTA

Product: integral membrane phospholipid biosynthetic nucleotidyltransferase

Products: NA

Alternate protein names: CDP-DAG synthase; CDP-DG synthase; CDP-diacylglycerol synthase; CDS; CDP-diglyceride pyrophosphorylase; CDP-diglyceride synthase; CTP:phosphatidate cytidylyltransferase [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MLKQRVQARTGRDLVLAIGVGLILGGLLLISLFVFLHLFVLVCILVGVTCLAEIFTATHTRGIFIVRPFLTLSTVVLPVL
AFFFASWFLPSIAFFMLTILLAQFFLRARFSLHSLFIFLYIPITVSLFAFIAAHPTGRLWVFFMLVTVIASDTFSYVFGT
LFGRHLLAPRISPNKTWEGLIGGFFSSLFFGTLTGILLLHKSLLFSATAASILFLFAILGDLAESYIKRRLGVKDMSGIL
PGHGGMLDRVDSMLLNIFPILLLVHMNFV

Sequences:

>Translated_269_residues
MLKQRVQARTGRDLVLAIGVGLILGGLLLISLFVFLHLFVLVCILVGVTCLAEIFTATHTRGIFIVRPFLTLSTVVLPVL
AFFFASWFLPSIAFFMLTILLAQFFLRARFSLHSLFIFLYIPITVSLFAFIAAHPTGRLWVFFMLVTVIASDTFSYVFGT
LFGRHLLAPRISPNKTWEGLIGGFFSSLFFGTLTGILLLHKSLLFSATAASILFLFAILGDLAESYIKRRLGVKDMSGIL
PGHGGMLDRVDSMLLNIFPILLLVHMNFV
>Mature_269_residues
MLKQRVQARTGRDLVLAIGVGLILGGLLLISLFVFLHLFVLVCILVGVTCLAEIFTATHTRGIFIVRPFLTLSTVVLPVL
AFFFASWFLPSIAFFMLTILLAQFFLRARFSLHSLFIFLYIPITVSLFAFIAAHPTGRLWVFFMLVTVIASDTFSYVFGT
LFGRHLLAPRISPNKTWEGLIGGFFSSLFFGTLTGILLLHKSLLFSATAASILFLFAILGDLAESYIKRRLGVKDMSGIL
PGHGGMLDRVDSMLLNIFPILLLVHMNFV

Specific function: Phospholipid biosynthesis. [C]

COG id: COG0575

COG function: function code I; CDP-diglyceride synthetase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDS family [H]

Homologues:

Organism=Homo sapiens, GI22035624, Length=170, Percent_Identity=30, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87081696, Length=164, Percent_Identity=35.9756097560976, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1787677, Length=105, Percent_Identity=39.0476190476191, Blast_Score=83, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000374 [H]

Pfam domain/function: PF01148 CTP_transf_1 [H]

EC number: =2.7.7.41 [H]

Molecular weight: Translated: 29899; Mature: 29899

Theoretical pI: Translated: 10.97; Mature: 10.97

Prosite motif: PS01315 CDS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKQRVQARTGRDLVLAIGVGLILGGLLLISLFVFLHLFVLVCILVGVTCLAEIFTATHT
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RGIFIVRPFLTLSTVVLPVLAFFFASWFLPSIAFFMLTILLAQFFLRARFSLHSLFIFLY
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPITVSLFAFIAAHPTGRLWVFFMLVTVIASDTFSYVFGTLFGRHLLAPRISPNKTWEGL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
IGGFFSSLFFGTLTGILLLHKSLLFSATAASILFLFAILGDLAESYIKRRLGVKDMSGIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCC
PGHGGMLDRVDSMLLNIFPILLLVHMNFV
CCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure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CCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]