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The map label for this gene is gnd [H]

Identifier: 28572428

GI number: 28572428

Start: 305928

End: 307358

Strand: Direct

Name: gnd [H]

Synonym: TW272

Alternate gene names: 28572428

Gene position: 305928-307358 (Clockwise)

Preceding gene: 28572427

Following gene: 28572431

Centisome position: 33.04

GC content: 49.13

Gene sequence:

>1431_bases
GTGCGGGCTGATATCGGTGTATATGGTCTTGCGGTTATGGGCAGTAATCTTGCGAGAAATTTTGCCGGCAAAGGTATCCG
GGTTGCTATTCATAACCGGTCATCCGACAGATCTAATTCCCTCGCACAGCAGCACAGTGAGTGTAATTTTATTGTTGCGA
AGGATGATAAAGATTTTATAGATTCACTCAGTTCGCCCAGAACTGTCCTTCTGATGGTTAAGGCTGGATCTATTGTGGAT
GAAGTTATAGCTCGACTCTCCACCTTTATGCAACCAGGAGATGTGATAATCGACGGTGGTAATTCTCTGTACACCGATAC
AATCAGGCGTGAGGAAGAACTCAAGGCAAGGGGGTTGCACTTTATAGGGCTTGGTGTTTCGGGCGGAGAGGTGGGCGCCC
TCGAAGGCCCCAGTCTTATGCCCGGAGGATCTGATTACGCTTATTCGATCGTTGGTCCTATGCTCGAGAAGATAGCCGCT
AGGGCGAATGGTGAGCCCTGTGTTGCGCACATAGGTCATAATGGCGCGGGACACTTTGTGAAGATGGTCCACAATGGCAT
TGAATACGCTGATATGCAAATAATTGCCGAGTCTTATGATCTTTTAAGACGGGGTTTGGGGCTCTCTCCGACGCGTATAT
CCGATATTTTTCGTGAGTGGAACAGCGGTGAGCTTGAGTCGTATTTAGTTGGAGTAACAGCTGACATACTTTCTCATAGA
GACAAGAGAACCGGAAAGCCGTTTGTTGATATTGTTCTCGACCAGGCTGGTGCAAAGGGAACCGGTGCTTGGACAGCGCA
GAACGCACTTGACCTTGGTGTTCCCGCCGGTTCCGTGTCTGAAGCAGTTTTTGCGCGCAGTCTTTCATCGGATGAACAGC
GTTGCCAGGTGCAACAGAAACTTTCTAGATCACAAGCATCAAGTCATGAAGCACCCTTGAAGGAGGCGGAGTTTATCGAT
GCTGTACGCAATGCCCTTTACTTGGCAAAGATACTTGCGTACTCTCAGGGTTTTAGAATTATTAGTGTTGCAGCCGCCAA
GCATGACTGGGGCATAGACCTTTCTGCCTGTGCACGAATCTGGCGTGCGGGCTGTATAATCCGGGCAGTTTTTCTGGATA
AAGTTGCCCATGAGTACAGTAAGAATCCGGACCTCACAAGTCTTATGTGTTCTCCGGGTTTTTCTGATGAATTGGTAGGC
AGGTTACGGTTTTTGAGGGAAGTTGTTGCTTCTGCAGCCCGCCTGGCTATTCCAGCACCTGTTTTTTCATCTCTCTTGTC
ATATATCGACGCGCTTGCTTCAGATCGCTTGCCTGCATGTCTGATTCAGGCGCAGAGAGATGATTTTGGTGCCCACACTT
ACAGGCGTGTCGACGTTCCGGGGATTTTTCATACCCTTTGGTCATCAGACCTGAGCGAAGTGCCCGCCTGA

Upstream 100 bases:

>100_bases
CGCAGGCTGGTAGCGCGTCTCGTTCGCAATGAGAAGGTCAGGGGTTCGAATCCCCTTAGCTCCACTCGCAGAACTTCGGT
AATGTTCAGATTGGAGCGCT

Downstream 100 bases:

>100_bases
AATACTTCTCGTGTTTCCGGATCCTAAAAACTATTCTCCAGCAACAGCGTGTTGTAATCCGCTCGGCCTTTCCGTGCCAG
GTACAGTCGTTGCGTTTCTT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: GNTZII [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MRADIGVYGLAVMGSNLARNFAGKGIRVAIHNRSSDRSNSLAQQHSECNFIVAKDDKDFIDSLSSPRTVLLMVKAGSIVD
EVIARLSTFMQPGDVIIDGGNSLYTDTIRREEELKARGLHFIGLGVSGGEVGALEGPSLMPGGSDYAYSIVGPMLEKIAA
RANGEPCVAHIGHNGAGHFVKMVHNGIEYADMQIIAESYDLLRRGLGLSPTRISDIFREWNSGELESYLVGVTADILSHR
DKRTGKPFVDIVLDQAGAKGTGAWTAQNALDLGVPAGSVSEAVFARSLSSDEQRCQVQQKLSRSQASSHEAPLKEAEFID
AVRNALYLAKILAYSQGFRIISVAAAKHDWGIDLSACARIWRAGCIIRAVFLDKVAHEYSKNPDLTSLMCSPGFSDELVG
RLRFLREVVASAARLAIPAPVFSSLLSYIDALASDRLPACLIQAQRDDFGAHTYRRVDVPGIFHTLWSSDLSEVPA

Sequences:

>Translated_476_residues
MRADIGVYGLAVMGSNLARNFAGKGIRVAIHNRSSDRSNSLAQQHSECNFIVAKDDKDFIDSLSSPRTVLLMVKAGSIVD
EVIARLSTFMQPGDVIIDGGNSLYTDTIRREEELKARGLHFIGLGVSGGEVGALEGPSLMPGGSDYAYSIVGPMLEKIAA
RANGEPCVAHIGHNGAGHFVKMVHNGIEYADMQIIAESYDLLRRGLGLSPTRISDIFREWNSGELESYLVGVTADILSHR
DKRTGKPFVDIVLDQAGAKGTGAWTAQNALDLGVPAGSVSEAVFARSLSSDEQRCQVQQKLSRSQASSHEAPLKEAEFID
AVRNALYLAKILAYSQGFRIISVAAAKHDWGIDLSACARIWRAGCIIRAVFLDKVAHEYSKNPDLTSLMCSPGFSDELVG
RLRFLREVVASAARLAIPAPVFSSLLSYIDALASDRLPACLIQAQRDDFGAHTYRRVDVPGIFHTLWSSDLSEVPA
>Mature_476_residues
MRADIGVYGLAVMGSNLARNFAGKGIRVAIHNRSSDRSNSLAQQHSECNFIVAKDDKDFIDSLSSPRTVLLMVKAGSIVD
EVIARLSTFMQPGDVIIDGGNSLYTDTIRREEELKARGLHFIGLGVSGGEVGALEGPSLMPGGSDYAYSIVGPMLEKIAA
RANGEPCVAHIGHNGAGHFVKMVHNGIEYADMQIIAESYDLLRRGLGLSPTRISDIFREWNSGELESYLVGVTADILSHR
DKRTGKPFVDIVLDQAGAKGTGAWTAQNALDLGVPAGSVSEAVFARSLSSDEQRCQVQQKLSRSQASSHEAPLKEAEFID
AVRNALYLAKILAYSQGFRIISVAAAKHDWGIDLSACARIWRAGCIIRAVFLDKVAHEYSKNPDLTSLMCSPGFSDELVG
RLRFLREVVASAARLAIPAPVFSSLLSYIDALASDRLPACLIQAQRDDFGAHTYRRVDVPGIFHTLWSSDLSEVPA

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=471, Percent_Identity=44.1613588110403, Blast_Score=375, Evalue=1e-104,
Organism=Escherichia coli, GI1788341, Length=468, Percent_Identity=49.5726495726496, Blast_Score=472, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17542558, Length=470, Percent_Identity=44.468085106383, Blast_Score=410, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6321977, Length=457, Percent_Identity=47.0459518599562, Blast_Score=399, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6321695, Length=453, Percent_Identity=45.2538631346578, Blast_Score=399, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24639279, Length=479, Percent_Identity=45.7202505219207, Blast_Score=385, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 51474; Mature: 51474

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRADIGVYGLAVMGSNLARNFAGKGIRVAIHNRSSDRSNSLAQQHSECNFIVAKDDKDFI
CCCCCCHHHHHHHCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEECCCHHHH
DSLSSPRTVLLMVKAGSIVDEVIARLSTFMQPGDVIIDGGNSLYTDTIRREEELKARGLH
HCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCEEEECCCEEEHHHHHHHHHHHHCCEE
FIGLGVSGGEVGALEGPSLMPGGSDYAYSIVGPMLEKIAARANGEPCVAHIGHNGAGHFV
EEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH
KMVHNGIEYADMQIIAESYDLLRRGLGLSPTRISDIFREWNSGELESYLVGVTADILSHR
HHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
DKRTGKPFVDIVLDQAGAKGTGAWTAQNALDLGVPAGSVSEAVFARSLSSDEQRCQVQQK
CCCCCCCHHHHEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHH
LSRSQASSHEAPLKEAEFIDAVRNALYLAKILAYSQGFRIISVAAAKHDWGIDLSACARI
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHH
WRAGCIIRAVFLDKVAHEYSKNPDLTSLMCSPGFSDELVGRLRFLREVVASAARLAIPAP
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHH
VFSSLLSYIDALASDRLPACLIQAQRDDFGAHTYRRVDVPGIFHTLWSSDLSEVPA
HHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRADIGVYGLAVMGSNLARNFAGKGIRVAIHNRSSDRSNSLAQQHSECNFIVAKDDKDFI
CCCCCCHHHHHHHCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEECCCHHHH
DSLSSPRTVLLMVKAGSIVDEVIARLSTFMQPGDVIIDGGNSLYTDTIRREEELKARGLH
HCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCEEEECCCEEEHHHHHHHHHHHHCCEE
FIGLGVSGGEVGALEGPSLMPGGSDYAYSIVGPMLEKIAARANGEPCVAHIGHNGAGHFV
EEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH
KMVHNGIEYADMQIIAESYDLLRRGLGLSPTRISDIFREWNSGELESYLVGVTADILSHR
HHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
DKRTGKPFVDIVLDQAGAKGTGAWTAQNALDLGVPAGSVSEAVFARSLSSDEQRCQVQQK
CCCCCCCHHHHEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHH
LSRSQASSHEAPLKEAEFIDAVRNALYLAKILAYSQGFRIISVAAAKHDWGIDLSACARI
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHH
WRAGCIIRAVFLDKVAHEYSKNPDLTSLMCSPGFSDELVGRLRFLREVVASAARLAIPAP
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHH
VFSSLLSYIDALASDRLPACLIQAQRDDFGAHTYRRVDVPGIFHTLWSSDLSEVPA
HHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10568751; 9298659 [H]