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The map label for this gene is pepA

Identifier: 28572420

GI number: 28572420

Start: 291425

End: 292933

Strand: Reverse

Name: pepA

Synonym: TW261

Alternate gene names: 28572420

Gene position: 292933-291425 (Counterclockwise)

Preceding gene: 28572421

Following gene: 28572419

Centisome position: 31.64

GC content: 48.44

Gene sequence:

>1509_bases
ATGAGTGATTACACGAATACTGTGACCGTAGAGATTACAAGTGACGATTCACTTGTGGCAGATGTCATCGTGGTTCCTGT
AGCTTCTGGCGCAGTGCCAAGGCTGCCCGAAGACTCTAAATTTAGAGCGTACGAGGATATCCTTCAAAAGCTTGGTGTAA
CAGGATCCAAGGATGAGCTCACTCGCATTCCCCTTGACGGTAGTAAACATGTTGTTCTGGCTTTTATAGGGGTTGGCAAG
GCATTTTCTGCGACAGAATTAATGTTCGCAGCTGGATCTGCGGTAAGGCAAATTGGTGCCAGATGTATTCAGATCGACTT
CTCTGTGACGCAGAAGGATAAGCTTAGTGCCATCGTAGAAGGTGCATTTCTTGGAGCATACAGATTTGATAAATATCGCA
GCAAGAAGAGCGAGTGTCCCGAAGTAATACGTGTCTCTCATAACATAAACGGCATAACGGATAGTGAGTGCAGGCAGATA
ATTGCCCGCGCTAAGGTTATTGCAGGATCAGTTGGCCTTGCGAAGGACCTTGTGAACACAACCGGGGATGACCTGTATCC
TGCGCAGTTTGCCAGTTTTGTTGCGAAGGACCTGGAGGGTATTGACCACATTTCTGTTGAATCTTGGGATGAAAAGCGCC
TTCAGGAAAAGTCTTGCGGTGGAATTCTTGGTGTTGGGCGCGGGTCTAATTTCCCGCCGCGGCTTGTGAAGATCTCGTAC
ACTCCCGGGCAATACAAGAAGCACTTGAGTTTGGTGGGTAAAGGAATCACTTTCGACACTGGTGGTTTGTCGCTAAAACC
GGCATCTGCAATGCTCGGCATGAAATACGACATGACCGGGGCCGCTAATGTATTTGCCGTGCTCAGAATTGTCGCTCTTC
TGCGTTTGTCTGTGAGGGTGACGGGGTGGTTATGTCTTGCGGAAAATATGCTGTCAGGAAGTGCTATCCGCCCTGGGGAT
ATACTTCGAACGTACAGCGGAAAAACGGTCGAGGTAACGAATACTGATGCAGAGGGCAGGTTAGTTTTAGCCGATGGGCT
TGCCCTTGCTGGTGACGAAAGGCCAGATGTAATTATTGATATTGCGACATTAACGGGCGCAGCAAAAGTTGCCCTAGGAG
AAAGTTGTTCGGGGCTTATGGGTAATAATCCCGACCTGCTTTGTTCGCTTGAGGTTGCGGCGAAAAGTGTTGGGGAGAAG
TTTCTTGCTGTCCCAATAGATGATGATGCCTTACAAAAGGCGTTAAAGTCTGATATCGCAGATATTGTCAATGTGCCAAC
TTCAAATAAAGTACCTGGGATGCAGTTTGGTGCTGTCTTTCTCAAAGAATTTGAGACAACAAATGACTCGGGCGAGGCTA
TCCCATGGGCCCATCTGGATGTTGCAGGTCCAGCAAATGCATCTTACGACACCGGATTTAATTCTTGCGGCCCGACTGGC
GTGGCTGTAAGGTCCCTTGTTGAATTTTGCCGATGCCTGTCTTCTGCTCCAGAGCGAAAGCTGTTCTAG

Upstream 100 bases:

>100_bases
TGCTGCTTGGGACTACATATAACCTGCTTTGTTGTAACATTTGAGATATGTTTATTTGGAAGGGATCTACTCGCGCGTGG
GCGCGCGCAGTCTGTTTAAC

Downstream 100 bases:

>100_bases
GGCATTATGGACTACGATCTGATAGTTCTTGGTGCGGGAAGTGCCGGTTACGCGACTGCTATACGCGCAACGCAATTAGG
TATGAAGGTTGCACTTGCTG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MSDYTNTVTVEITSDDSLVADVIVVPVASGAVPRLPEDSKFRAYEDILQKLGVTGSKDELTRIPLDGSKHVVLAFIGVGK
AFSATELMFAAGSAVRQIGARCIQIDFSVTQKDKLSAIVEGAFLGAYRFDKYRSKKSECPEVIRVSHNINGITDSECRQI
IARAKVIAGSVGLAKDLVNTTGDDLYPAQFASFVAKDLEGIDHISVESWDEKRLQEKSCGGILGVGRGSNFPPRLVKISY
TPGQYKKHLSLVGKGITFDTGGLSLKPASAMLGMKYDMTGAANVFAVLRIVALLRLSVRVTGWLCLAENMLSGSAIRPGD
ILRTYSGKTVEVTNTDAEGRLVLADGLALAGDERPDVIIDIATLTGAAKVALGESCSGLMGNNPDLLCSLEVAAKSVGEK
FLAVPIDDDALQKALKSDIADIVNVPTSNKVPGMQFGAVFLKEFETTNDSGEAIPWAHLDVAGPANASYDTGFNSCGPTG
VAVRSLVEFCRCLSSAPERKLF

Sequences:

>Translated_502_residues
MSDYTNTVTVEITSDDSLVADVIVVPVASGAVPRLPEDSKFRAYEDILQKLGVTGSKDELTRIPLDGSKHVVLAFIGVGK
AFSATELMFAAGSAVRQIGARCIQIDFSVTQKDKLSAIVEGAFLGAYRFDKYRSKKSECPEVIRVSHNINGITDSECRQI
IARAKVIAGSVGLAKDLVNTTGDDLYPAQFASFVAKDLEGIDHISVESWDEKRLQEKSCGGILGVGRGSNFPPRLVKISY
TPGQYKKHLSLVGKGITFDTGGLSLKPASAMLGMKYDMTGAANVFAVLRIVALLRLSVRVTGWLCLAENMLSGSAIRPGD
ILRTYSGKTVEVTNTDAEGRLVLADGLALAGDERPDVIIDIATLTGAAKVALGESCSGLMGNNPDLLCSLEVAAKSVGEK
FLAVPIDDDALQKALKSDIADIVNVPTSNKVPGMQFGAVFLKEFETTNDSGEAIPWAHLDVAGPANASYDTGFNSCGPTG
VAVRSLVEFCRCLSSAPERKLF
>Mature_501_residues
SDYTNTVTVEITSDDSLVADVIVVPVASGAVPRLPEDSKFRAYEDILQKLGVTGSKDELTRIPLDGSKHVVLAFIGVGKA
FSATELMFAAGSAVRQIGARCIQIDFSVTQKDKLSAIVEGAFLGAYRFDKYRSKKSECPEVIRVSHNINGITDSECRQII
ARAKVIAGSVGLAKDLVNTTGDDLYPAQFASFVAKDLEGIDHISVESWDEKRLQEKSCGGILGVGRGSNFPPRLVKISYT
PGQYKKHLSLVGKGITFDTGGLSLKPASAMLGMKYDMTGAANVFAVLRIVALLRLSVRVTGWLCLAENMLSGSAIRPGDI
LRTYSGKTVEVTNTDAEGRLVLADGLALAGDERPDVIIDIATLTGAAKVALGESCSGLMGNNPDLLCSLEVAAKSVGEKF
LAVPIDDDALQKALKSDIADIVNVPTSNKVPGMQFGAVFLKEFETTNDSGEAIPWAHLDVAGPANASYDTGFNSCGPTGV
AVRSLVEFCRCLSSAPERKLF

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=402, Percent_Identity=35.8208955223881, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI47155554, Length=326, Percent_Identity=34.3558282208589, Blast_Score=153, Evalue=4e-37,
Organism=Escherichia coli, GI1790710, Length=281, Percent_Identity=41.6370106761566, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI87082123, Length=324, Percent_Identity=36.1111111111111, Blast_Score=173, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17556903, Length=262, Percent_Identity=37.0229007633588, Blast_Score=141, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17565172, Length=317, Percent_Identity=25.5520504731861, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21355725, Length=459, Percent_Identity=29.6296296296296, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24661038, Length=459, Percent_Identity=29.1938997821351, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI21357381, Length=256, Percent_Identity=35.9375, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI221379063, Length=256, Percent_Identity=35.9375, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI221379062, Length=256, Percent_Identity=35.9375, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24662227, Length=407, Percent_Identity=28.2555282555283, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI20129969, Length=455, Percent_Identity=28.3516483516484, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI161077148, Length=411, Percent_Identity=28.2238442822384, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI20130057, Length=411, Percent_Identity=28.2238442822384, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI21355645, Length=432, Percent_Identity=27.0833333333333, Blast_Score=118, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24662223, Length=432, Percent_Identity=27.0833333333333, Blast_Score=118, Evalue=9e-27,
Organism=Drosophila melanogaster, GI19922386, Length=407, Percent_Identity=26.7813267813268, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI20129963, Length=420, Percent_Identity=27.3809523809524, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646701, Length=361, Percent_Identity=27.4238227146814, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24646703, Length=361, Percent_Identity=27.4238227146814, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21358201, Length=361, Percent_Identity=27.4238227146814, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_TROW8 (Q83I32)

Other databases:

- EMBL:   BX251410
- RefSeq:   NP_789200.1
- ProteinModelPortal:   Q83I32
- SMR:   Q83I32
- STRING:   Q83I32
- GeneID:   1064552
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW261
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- OMA:   NMHLMRY
- ProtClustDB:   PRK00913
- BioCyc:   TWHI218496:TW0245-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 53337; Mature: 53205

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 266-266 ACT_SITE 340-340

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDYTNTVTVEITSDDSLVADVIVVPVASGAVPRLPEDSKFRAYEDILQKLGVTGSKDEL
CCCCCCEEEEEEECCCCCEEHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCE
TRIPLDGSKHVVLAFIGVGKAFSATELMFAAGSAVRQIGARCIQIDFSVTQKDKLSAIVE
EECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHH
GAFLGAYRFDKYRSKKSECPEVIRVSHNINGITDSECRQIIARAKVIAGSVGLAKDLVNT
HHHHHHHHHHHHHHHHHCCHHHEEECCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHC
TGDDLYPAQFASFVAKDLEGIDHISVESWDEKRLQEKSCGGILGVGRGSNFPPRLVKISY
CCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEE
TPGQYKKHLSLVGKGITFDTGGLSLKPASAMLGMKYDMTGAANVFAVLRIVALLRLSVRV
CCCHHHHHHHHHCCCCEEECCCCEECCHHHHHCCEECCCCHHHHHHHHHHHHHHHHHHHH
TGWLCLAENMLSGSAIRPGDILRTYSGKTVEVTNTDAEGRLVLADGLALAGDERPDVIID
HHHHHHHHHHHCCCCCCCCHHHEECCCCEEEEECCCCCCEEEEECCEEECCCCCCCEEEE
IATLTGAAKVALGESCSGLMGNNPDLLCSLEVAAKSVGEKFLAVPIDDDALQKALKSDIA
EEECCCCHHEECCCCCCCCCCCCCCEEEEHHHHHHHCCCCEEEEECCHHHHHHHHHHHHH
DIVNVPTSNKVPGMQFGAVFLKEFETTNDSGEAIPWAHLDVAGPANASYDTGFNSCGPTG
HHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCHH
VAVRSLVEFCRCLSSAPERKLF
HHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SDYTNTVTVEITSDDSLVADVIVVPVASGAVPRLPEDSKFRAYEDILQKLGVTGSKDEL
CCCCCEEEEEEECCCCCEEHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCE
TRIPLDGSKHVVLAFIGVGKAFSATELMFAAGSAVRQIGARCIQIDFSVTQKDKLSAIVE
EECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHH
GAFLGAYRFDKYRSKKSECPEVIRVSHNINGITDSECRQIIARAKVIAGSVGLAKDLVNT
HHHHHHHHHHHHHHHHHCCHHHEEECCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHC
TGDDLYPAQFASFVAKDLEGIDHISVESWDEKRLQEKSCGGILGVGRGSNFPPRLVKISY
CCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEE
TPGQYKKHLSLVGKGITFDTGGLSLKPASAMLGMKYDMTGAANVFAVLRIVALLRLSVRV
CCCHHHHHHHHHCCCCEEECCCCEECCHHHHHCCEECCCCHHHHHHHHHHHHHHHHHHHH
TGWLCLAENMLSGSAIRPGDILRTYSGKTVEVTNTDAEGRLVLADGLALAGDERPDVIID
HHHHHHHHHHHCCCCCCCCHHHEECCCCEEEEECCCCCCEEEEECCEEECCCCCCCEEEE
IATLTGAAKVALGESCSGLMGNNPDLLCSLEVAAKSVGEKFLAVPIDDDALQKALKSDIA
EEECCCCHHEECCCCCCCCCCCCCCEEEEHHHHHHHCCCCEEEEECCHHHHHHHHHHHHH
DIVNVPTSNKVPGMQFGAVFLKEFETTNDSGEAIPWAHLDVAGPANASYDTGFNSCGPTG
HHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCHH
VAVRSLVEFCRCLSSAPERKLF
HHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12606174