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The map label for this gene is pepPI [H]

Identifier: 28572398

GI number: 28572398

Start: 262339

End: 263508

Strand: Reverse

Name: pepPI [H]

Synonym: TW238

Alternate gene names: 28572398

Gene position: 263508-262339 (Counterclockwise)

Preceding gene: 28572400

Following gene: 28572397

Centisome position: 28.46

GC content: 46.58

Gene sequence:

>1170_bases
ATGCGATGCCGCGCAAACGATACCTTCTACAGATACAGGCCAGATAGTTCATTTACCTGGCTTACAGGATGGGGATGTGA
AACTACCCCAGGTGCCGTTTTGGTTATCTATCCCGACACGAAGCCGGTACTGTTCTTTAAGCCACCGGCTGGAAAAAAAA
ACGATGACTTCTTTACGGATTCTCATAACGGTACATTCTGGATAGGATCTAGGCCCAGTTTGCAGGAAATAGAGACTCTT
TTGGGCATTACGTGCCGGGATATAAAGGACTTTAGATGCCCAACGGATAATGTGCTCTTATGCAAGACAAGAGGCAAGGA
TGCTGAAGAAATTAACGACTTGAAGGTTGCAATAAGCGAACTGAGACTTTTGAAGGATAGATGGGAAATCACCCAATTAC
AAAAAGCGGTCGATGCTACTGCTCAGGGCTTTGAGCGCGTCGTGAAATCGATAAACGAGGCCAAATCTGTTACGAATGGT
GAGCGCGTAATCGAAGGTGCATTTTACACTTCTGCTAGAAGTCTGGGTTATGAAACAGGCTACGAGACGATTGTTGCTGC
GGGTGCCAACGCATGTATTTTGCACTGGTCTGTAAATAATGGCCCGATTAATGATGGTGATCTGTTGCTTGTTGATGCTG
GGATTGAGCTTGAGACTTTGTACACAGCGGATATAACCAGAACAGTCCCCATAAGTGGAAAATTTACCGATGTACAAGCT
AAAGCCTATGAGGCTGTCCTTGAAGCTGCTGATGCAGCGTTTGACGCGGCCATGCCCGGTCAGCCGTTCCACAAAATGCA
CGAAGCTGCAATGGGGGTTATACGCCGACACCTCTCCGAATGGGGTATTTGTAAGGCCTCGCAAAACGAGTTTTATAGAA
GATACATGATCCACGGAACGGGACATCACCTAGGATTGGACGTGCATGACTGTGCCTTTGCCAAGCGCGAGAATTATCGT
AATGGAACGCTTGCAGATGGCATGGTGCTTACCATAGAGCCGGGATTGTATTTTCACAAAAATGACCTAACTGTTCCGAA
GGACTTTCGAGGAATTGGGGTAAGAATCGAAGATAACATACTCATAGCCTCAGATGGCCCTGTAAATATGTCGCGTGATA
TACCAAGGGCCCGAATTGATGTGGAACAGTGGATTCAACAAGCATCATGA

Upstream 100 bases:

>100_bases
GAAAATCCAGCAGAGTGAAGTTGCGAAATATACAGAAAAACGAAGACAAGCGGTTTGCGCGTTATTTCCGGGCAAGACAA
TAGTTGTTGAGGCCGGTGAT

Downstream 100 bases:

>100_bases
GTAAAAGTGTTTATATCTCAAGGGTCTGTGGCAGTTCGGTCCTCGGGCCAACAGGTGACAGATTGGGAAAGGTCAAAGAT
GTGTTGGGCACTCCGAGGCT

Product: Xaa-Pro aminopeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase I; Aminopeptidase P I; APP; PEPP I; X-Pro aminopeptidase I; Xaa-Pro aminopeptidase I [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MRCRANDTFYRYRPDSSFTWLTGWGCETTPGAVLVIYPDTKPVLFFKPPAGKKNDDFFTDSHNGTFWIGSRPSLQEIETL
LGITCRDIKDFRCPTDNVLLCKTRGKDAEEINDLKVAISELRLLKDRWEITQLQKAVDATAQGFERVVKSINEAKSVTNG
ERVIEGAFYTSARSLGYETGYETIVAAGANACILHWSVNNGPINDGDLLLVDAGIELETLYTADITRTVPISGKFTDVQA
KAYEAVLEAADAAFDAAMPGQPFHKMHEAAMGVIRRHLSEWGICKASQNEFYRRYMIHGTGHHLGLDVHDCAFAKRENYR
NGTLADGMVLTIEPGLYFHKNDLTVPKDFRGIGVRIEDNILIASDGPVNMSRDIPRARIDVEQWIQQAS

Sequences:

>Translated_389_residues
MRCRANDTFYRYRPDSSFTWLTGWGCETTPGAVLVIYPDTKPVLFFKPPAGKKNDDFFTDSHNGTFWIGSRPSLQEIETL
LGITCRDIKDFRCPTDNVLLCKTRGKDAEEINDLKVAISELRLLKDRWEITQLQKAVDATAQGFERVVKSINEAKSVTNG
ERVIEGAFYTSARSLGYETGYETIVAAGANACILHWSVNNGPINDGDLLLVDAGIELETLYTADITRTVPISGKFTDVQA
KAYEAVLEAADAAFDAAMPGQPFHKMHEAAMGVIRRHLSEWGICKASQNEFYRRYMIHGTGHHLGLDVHDCAFAKRENYR
NGTLADGMVLTIEPGLYFHKNDLTVPKDFRGIGVRIEDNILIASDGPVNMSRDIPRARIDVEQWIQQAS
>Mature_389_residues
MRCRANDTFYRYRPDSSFTWLTGWGCETTPGAVLVIYPDTKPVLFFKPPAGKKNDDFFTDSHNGTFWIGSRPSLQEIETL
LGITCRDIKDFRCPTDNVLLCKTRGKDAEEINDLKVAISELRLLKDRWEITQLQKAVDATAQGFERVVKSINEAKSVTNG
ERVIEGAFYTSARSLGYETGYETIVAAGANACILHWSVNNGPINDGDLLLVDAGIELETLYTADITRTVPISGKFTDVQA
KAYEAVLEAADAAFDAAMPGQPFHKMHEAAMGVIRRHLSEWGICKASQNEFYRRYMIHGTGHHLGLDVHDCAFAKRENYR
NGTLADGMVLTIEPGLYFHKNDLTVPKDFRGIGVRIEDNILIASDGPVNMSRDIPRARIDVEQWIQQAS

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=414, Percent_Identity=31.1594202898551, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI149589008, Length=435, Percent_Identity=27.3563218390805, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI260593665, Length=382, Percent_Identity=28.0104712041885, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI260593663, Length=263, Percent_Identity=31.1787072243346, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1789275, Length=431, Percent_Identity=29.6983758700696, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1788728, Length=252, Percent_Identity=30.1587301587302, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790282, Length=313, Percent_Identity=27.7955271565495, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17508215, Length=307, Percent_Identity=32.2475570032573, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI71989583, Length=331, Percent_Identity=26.5861027190332, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320922, Length=281, Percent_Identity=33.4519572953737, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6321118, Length=291, Percent_Identity=31.9587628865979, Blast_Score=126, Evalue=8e-30,
Organism=Drosophila melanogaster, GI19920384, Length=387, Percent_Identity=29.1989664082687, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI21357079, Length=316, Percent_Identity=32.5949367088608, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 43475; Mature: 43475

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRCRANDTFYRYRPDSSFTWLTGWGCETTPGAVLVIYPDTKPVLFFKPPAGKKNDDFFTD
CCCCCCCCEEEECCCCCEEEEEECCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCEEC
SHNGTFWIGSRPSLQEIETLLGITCRDIKDFRCPTDNVLLCKTRGKDAEEINDLKVAISE
CCCCEEEECCCCCHHHHHHHHCCCHHCCHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHH
LRLLKDRWEITQLQKAVDATAQGFERVVKSINEAKSVTNGERVIEGAFYTSARSLGYETG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEHHHHHHHHHCCCCCC
YETIVAAGANACILHWSVNNGPINDGDLLLVDAGIELETLYTADITRTVPISGKFTDVQA
CCEEEECCCCEEEEEEECCCCCCCCCCEEEEECCCEEEEEEEECCEEEEECCCCEECHHH
KAYEAVLEAADAAFDAAMPGQPFHKMHEAAMGVIRRHLSEWGICKASQNEFYRRYMIHGT
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEECCHHHHEEEEEEECC
GHHLGLDVHDCAFAKRENYRNGTLADGMVLTIEPGLYFHKNDLTVPKDFRGIGVRIEDNI
CCEECCCHHHHHHHHHCCCCCCCCCCCEEEEECCCEEEECCCCCCCCCCCEEEEEEECCE
LIASDGPVNMSRDIPRARIDVEQWIQQAS
EEECCCCCCCCCCCCHHEECHHHHHHHCC
>Mature Secondary Structure
MRCRANDTFYRYRPDSSFTWLTGWGCETTPGAVLVIYPDTKPVLFFKPPAGKKNDDFFTD
CCCCCCCCEEEECCCCCEEEEEECCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCEEC
SHNGTFWIGSRPSLQEIETLLGITCRDIKDFRCPTDNVLLCKTRGKDAEEINDLKVAISE
CCCCEEEECCCCCHHHHHHHHCCCHHCCHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHH
LRLLKDRWEITQLQKAVDATAQGFERVVKSINEAKSVTNGERVIEGAFYTSARSLGYETG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEHHHHHHHHHCCCCCC
YETIVAAGANACILHWSVNNGPINDGDLLLVDAGIELETLYTADITRTVPISGKFTDVQA
CCEEEECCCCEEEEEEECCCCCCCCCCEEEEECCCEEEEEEEECCEEEEECCCCEECHHH
KAYEAVLEAADAAFDAAMPGQPFHKMHEAAMGVIRRHLSEWGICKASQNEFYRRYMIHGT
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEECCHHHHEEEEEEECC
GHHLGLDVHDCAFAKRENYRNGTLADGMVLTIEPGLYFHKNDLTVPKDFRGIGVRIEDNI
CCEECCCHHHHHHHHHCCCCCCCCCCCEEEEECCCEEEECCCCCCCCCCCEEEEEEECCE
LIASDGPVNMSRDIPRARIDVEQWIQQAS
EEECCCCCCCCCCCCHHEECHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]