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The map label for this gene is ung

Identifier: 28572341

GI number: 28572341

Start: 221086

End: 221778

Strand: Direct

Name: ung

Synonym: TW179

Alternate gene names: 28572341

Gene position: 221086-221778 (Clockwise)

Preceding gene: 28572340

Following gene: 28572342

Centisome position: 23.88

GC content: 50.65

Gene sequence:

>693_bases
ATGGGCTATCTTCATGTTTTGGCGCAACGTGGCGTTATTCATGCGACATGGGTTTCTGCTCTGGAGCCGGTTTCATCCAA
TCTCGCCGCAATGGGGGATTGCTTGCGGTCGCTTCGCTCAAAGGGTGAGTCATTCTTACCGGCACCGCGTAATATTCTCA
GGGCTTTTCGCTATCCATTCGACTCTGTAAGGGTTCTTATAGTTGGCCAGGATCCGTATCCAACCCAAGGGCATCCAATT
GGTCTTAGCTTTGCTGTCGATCATAAGGTGCGTCCGCTTCCCGGCAGTCTGCAAAATATATACACTGAGTATCGAAGTGA
TTTGAACCTTGATCCGCCACAGCACGGTGATATAAGTCTTTGGTCGGAACGCGGTGTTATGCTCTTGAACAGGACTTTAA
CGGTCCGCCCGGGCATACCCTCAAGTCACAGAGGTCTTGGATGGGAAGAGATTACGCAGACTGCCGTTAGAGCTCTTGCG
GCCCGCGATGTTCCGCTGATTGCGATTTTGTGGGGCAGGCATGCACAGGAGCTTAAGTCTGTTCTACAGAGTGACAGGGT
TGCCATACTCGAATCTGTTCATCCAAGTCCTATGTCGGCCACGAGGGGCTTTTTCGGATCAAAGCCTTTCAGTAAAGCAA
ATGACCTTTTACGAGACCTTGGTTCCGCTCCAATTGATTGGCGTCTTACCTAA

Upstream 100 bases:

>100_bases
TCCCTATATAGGCTTTTCGGTTGTATTGGCATACTGCGCTGTCGCGTTCCTATTGGCATATTTCAGAAATACTAGACGTG
GTGGCATTCTCTAGCTGGGG

Downstream 100 bases:

>100_bases
TCGGGTCGAGAGAATAATTGTAAGCGGACACTGTGAGGGTCTTTAGAAGTTTTGATTGCCTTGGGCGGGATAAGCGTACC
GCTTTAACGATAGGGAAATT

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MGYLHVLAQRGVIHATWVSALEPVSSNLAAMGDCLRSLRSKGESFLPAPRNILRAFRYPFDSVRVLIVGQDPYPTQGHPI
GLSFAVDHKVRPLPGSLQNIYTEYRSDLNLDPPQHGDISLWSERGVMLLNRTLTVRPGIPSSHRGLGWEEITQTAVRALA
ARDVPLIAILWGRHAQELKSVLQSDRVAILESVHPSPMSATRGFFGSKPFSKANDLLRDLGSAPIDWRLT

Sequences:

>Translated_230_residues
MGYLHVLAQRGVIHATWVSALEPVSSNLAAMGDCLRSLRSKGESFLPAPRNILRAFRYPFDSVRVLIVGQDPYPTQGHPI
GLSFAVDHKVRPLPGSLQNIYTEYRSDLNLDPPQHGDISLWSERGVMLLNRTLTVRPGIPSSHRGLGWEEITQTAVRALA
ARDVPLIAILWGRHAQELKSVLQSDRVAILESVHPSPMSATRGFFGSKPFSKANDLLRDLGSAPIDWRLT
>Mature_229_residues
GYLHVLAQRGVIHATWVSALEPVSSNLAAMGDCLRSLRSKGESFLPAPRNILRAFRYPFDSVRVLIVGQDPYPTQGHPIG
LSFAVDHKVRPLPGSLQNIYTEYRSDLNLDPPQHGDISLWSERGVMLLNRTLTVRPGIPSSHRGLGWEEITQTAVRALAA
RDVPLIAILWGRHAQELKSVLQSDRVAILESVHPSPMSATRGFFGSKPFSKANDLLRDLGSAPIDWRLT

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI6224979, Length=169, Percent_Identity=46.1538461538462, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI19718751, Length=169, Percent_Identity=46.1538461538462, Blast_Score=146, Evalue=1e-35,
Organism=Escherichia coli, GI1788934, Length=200, Percent_Identity=38.5, Blast_Score=141, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17556304, Length=203, Percent_Identity=37.9310344827586, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6323620, Length=188, Percent_Identity=39.3617021276596, Blast_Score=121, Evalue=8e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_TROW8 (P67079)

Other databases:

- EMBL:   BX251410
- RefSeq:   NP_789121.1
- ProteinModelPortal:   P67079
- SMR:   P67079
- STRING:   P67079
- GeneID:   1064473
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW179
- eggNOG:   COG0692
- HOGENOM:   HBG605450
- OMA:   VMLLNRV
- ProtClustDB:   PRK05254
- BioCyc:   TWHI218496:TW0166-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 25458; Mature: 25326

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 71-71

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYLHVLAQRGVIHATWVSALEPVSSNLAAMGDCLRSLRSKGESFLPAPRNILRAFRYPF
CCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCC
DSVRVLIVGQDPYPTQGHPIGLSFAVDHKVRPLPGSLQNIYTEYRSDLNLDPPQHGDISL
CCEEEEEECCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEE
WSERGVMLLNRTLTVRPGIPSSHRGLGWEEITQTAVRALAARDVPLIAILWGRHAQELKS
ECCCCEEEEECEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHH
VLQSDRVAILESVHPSPMSATRGFFGSKPFSKANDLLRDLGSAPIDWRLT
HHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEC
>Mature Secondary Structure 
GYLHVLAQRGVIHATWVSALEPVSSNLAAMGDCLRSLRSKGESFLPAPRNILRAFRYPF
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCC
DSVRVLIVGQDPYPTQGHPIGLSFAVDHKVRPLPGSLQNIYTEYRSDLNLDPPQHGDISL
CCEEEEEECCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEE
WSERGVMLLNRTLTVRPGIPSSHRGLGWEEITQTAVRALAARDVPLIAILWGRHAQELKS
ECCCCEEEEECEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHH
VLQSDRVAILESVHPSPMSATRGFFGSKPFSKANDLLRDLGSAPIDWRLT
HHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12606174