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The map label for this gene is secA

Identifier: 28572302

GI number: 28572302

Start: 149502

End: 152045

Strand: Direct

Name: secA

Synonym: TW139

Alternate gene names: 28572302

Gene position: 149502-152045 (Clockwise)

Preceding gene: 28572301

Following gene: 28572303

Centisome position: 16.15

GC content: 47.56

Gene sequence:

>2544_bases
TTGTCGGTTAAATTGCTCGAGAGGATCCTGCGCGCCGGCGAGGGTCGCACCCTCAAGAGATTGCGTAATATAGCCCACAC
CGTCAATGCCATCGAGGACGAATATAAAGGCTGTACAGACGGTGAACTGCGCACTTTTGCTTTTGATCTCAAAGTTCGTC
ATCAGAATGGTGAGTCCCTTGACAGCATTCTTCCGGAAGCATTCGCAATGGTTAGAGAAGCCTCGTCTCGAACGCTGGGT
CTTAGGCATTTTGATGTTCAGATTATGGGTGGTGCCGCGTTACACATGGGGTATATTGCAGAAATGTTCACAGGTGAAGG
TAAAACTTTGGTTGCAACGCTCCCGGCTTTTCTCAATTCCCTCTCGGGTAACGGCGTCCATATAGTTACGGTGAACGATT
ACCTTGCTGGATATCACTCACAGCAAATGGGCAGGGTATACAAGGTATTGGGACTCGAGACCGGGGTTATTTTGGCTGAT
CAGGATCCCTCAACGCGTGCTCAACAATACAGGGCGGATATCACTTATGGAACTAATAACGAGTTTGGGTTTGATTATCT
TCGGGATAACATGGCCTGGAGTTGCGCCGAGAGAGTTCAAAGGGGTCATAATTTTGTGATCCTCGACGAGGTAGATTCAA
TTTTGATTGATGAGGCAAGGACTCCTCTAATTATCTCCGGGTCGTCAAGTGGTGAAGTGAGCAGGTGGTTTGTTGAGTTC
GCGGGTATTGCACGTGCGCTGACTGCCGGTGAGGATTATGATGTTGACGAGAGAAAACACACGGTTGGCGTTCTCGAGCC
GGGTATAGCCAAGGTTGAGGATCTGCTTGGTATAAGCAATCTGTATGAGTCTGTTAACACCCCTCTTATATCGTTTTTGA
ACAACTCGATAAAAGCTAAAGAGCTTTTCAAGCGCGATCGCGACTATGTCGTGCTTGATGGTGAAGTGATGATAGTTGAT
GAACATACCGGTCGTATTTTGAGTGGGCGTCGTTACAATGAGGGGCTTCATCAGGCAATAGAGGCAAAAGAGGGCGTTGA
AATCAAGGCGGAAAACCAAACACTTGCAACGGTTACTTTGCAAAATTATTTTCGTCTCTATAAAAAAATCTCCGGCATGA
CGGGCACCGCAGTAACAGAGGCCTCTGAGTTCATGTCGACGTACAAACTGCCTGTTGTGTCCATTCCGACCAATAAGCCA
AATATACGTAAGGACCATCCGGATGTCGTCTATAAGAATGAGCAGATAAAGTTCGAAAATCTTGCTGATCATGTTCGTGA
GTGTTACACTCGTGGCCAGCCAGTTCTGATCGGTACAACGAGTGTTGAAAAAAGTGAATATGTTTCAAAACTTCTTTCAA
AGCGTGGGGTCAGACATGAGGTGTTGAACGCAAAGAATCACGCAAAAGAGGCCCGGATAGTGGCAGAGGCTGGCAGACTT
CGTGCTGTTACTGTTGCAACCAATATGGCTGGCAGGGGTACTGATATCATCCTTGGAGGTAATCCAGAGGTCTTGACTGC
GGTGGAATTGCGCAGAAAAGGTCTTGATCCATCAAAAGACCCCGAAAGATATGAACAGGCTTGGAGTTCAGCATTTCCGA
AGCTGCATAGGAGAACCAGAGAAGAGGCCGAAAAGGTTATAGAAGCTGGTGGCCTTATGGTAATTGGCACAGAGCGGCAT
GAAAGCAGAAGGATAGATAACCAGCTTCGCGGGAGGTCAGGCAGACAGGGTGATCCGGGTGAGAGTCGTTTCTATCTTTC
CCTAACAGATGATCTTATGAGGAAGTTTAATCCCGGGGCGGCATCGGCCCTCGCTGCACGAGTGCCCGATGACACTGCAA
TTGAGTCAAAATTAGTCAGTCGTGCAATACGGTCAGCTCAGGCTCAGGTTGAGAGTTTAAATGCTGAAACTCGCAAAAAT
GTCCTCAAATACGACGATGTACTAAACCGACAGCGTGCGGCGATATACACCGACAGAAGCCGTATTCTGGAAGGCGGTGA
TATAGCAGACAGGGTACAGGCTTTCCTTTCGGACGCAATTGAGGAAATCATAAACAGTCATGCAGTTACGGCATGGGATT
TTGACGCCCTGTGGGCCGACTTGAAGACAATTTATCCCGTTGGCATCAGCATAGAGGAATTGACAGATGAGGCGGGCGGA
ATGGGCAGAATAACACCAGATTTTGTTATGCGAGAGATTCTGTCTGATGCAAAATTCGCCTATGAAAAGCGCGAGAGCGA
GATAGGCCCTGAGTCTATGCGTGATCTTGAGCGCAAGGTTGTTCTTTCCGTGATTGATAGATGTTGGCGTGATCATTTAT
ACGAGATGGAATATCTGAAAGAAGGGATAGGCCTCCGCGCGATGGCTCAAAGAGATCCTTTGGTTGAGTATCAAAAGGAG
GGCTTTGATATGTTTGAGGCAATGATGGGGCGAATTCGCGAAGAAAGTATCGGTTACCTGTTTAATATTGATGCCCAAGT
AAGCTCCAACTCACCGAGCGATGCAAGAAACCGCCCAATTGAGCATGACGATAATGCTGTCTAA

Upstream 100 bases:

>100_bases
ATTACCGCCTATGGCAATCAGATACGAAACGCCCCAGGAACACTTAGAGGACATAATAGAATGAAAGTTGTTGTTTCACC
ATTTGAAGGGGTAAGTTAAT

Downstream 100 bases:

>100_bases
TGTAGTTGCTATCCATTATTTCCTGCGCATCTTCGGATTTTTGTCATAGGCATTTCTGTAGCCTGTATTGTTTCTTCTTT
TGCCTGGCCAAGATTACGGA

Product: preprotein translocase subunit SecA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 847; Mature: 846

Protein sequence:

>847_residues
MSVKLLERILRAGEGRTLKRLRNIAHTVNAIEDEYKGCTDGELRTFAFDLKVRHQNGESLDSILPEAFAMVREASSRTLG
LRHFDVQIMGGAALHMGYIAEMFTGEGKTLVATLPAFLNSLSGNGVHIVTVNDYLAGYHSQQMGRVYKVLGLETGVILAD
QDPSTRAQQYRADITYGTNNEFGFDYLRDNMAWSCAERVQRGHNFVILDEVDSILIDEARTPLIISGSSSGEVSRWFVEF
AGIARALTAGEDYDVDERKHTVGVLEPGIAKVEDLLGISNLYESVNTPLISFLNNSIKAKELFKRDRDYVVLDGEVMIVD
EHTGRILSGRRYNEGLHQAIEAKEGVEIKAENQTLATVTLQNYFRLYKKISGMTGTAVTEASEFMSTYKLPVVSIPTNKP
NIRKDHPDVVYKNEQIKFENLADHVRECYTRGQPVLIGTTSVEKSEYVSKLLSKRGVRHEVLNAKNHAKEARIVAEAGRL
RAVTVATNMAGRGTDIILGGNPEVLTAVELRRKGLDPSKDPERYEQAWSSAFPKLHRRTREEAEKVIEAGGLMVIGTERH
ESRRIDNQLRGRSGRQGDPGESRFYLSLTDDLMRKFNPGAASALAARVPDDTAIESKLVSRAIRSAQAQVESLNAETRKN
VLKYDDVLNRQRAAIYTDRSRILEGGDIADRVQAFLSDAIEEIINSHAVTAWDFDALWADLKTIYPVGISIEELTDEAGG
MGRITPDFVMREILSDAKFAYEKRESEIGPESMRDLERKVVLSVIDRCWRDHLYEMEYLKEGIGLRAMAQRDPLVEYQKE
GFDMFEAMMGRIREESIGYLFNIDAQVSSNSPSDARNRPIEHDDNAV

Sequences:

>Translated_847_residues
MSVKLLERILRAGEGRTLKRLRNIAHTVNAIEDEYKGCTDGELRTFAFDLKVRHQNGESLDSILPEAFAMVREASSRTLG
LRHFDVQIMGGAALHMGYIAEMFTGEGKTLVATLPAFLNSLSGNGVHIVTVNDYLAGYHSQQMGRVYKVLGLETGVILAD
QDPSTRAQQYRADITYGTNNEFGFDYLRDNMAWSCAERVQRGHNFVILDEVDSILIDEARTPLIISGSSSGEVSRWFVEF
AGIARALTAGEDYDVDERKHTVGVLEPGIAKVEDLLGISNLYESVNTPLISFLNNSIKAKELFKRDRDYVVLDGEVMIVD
EHTGRILSGRRYNEGLHQAIEAKEGVEIKAENQTLATVTLQNYFRLYKKISGMTGTAVTEASEFMSTYKLPVVSIPTNKP
NIRKDHPDVVYKNEQIKFENLADHVRECYTRGQPVLIGTTSVEKSEYVSKLLSKRGVRHEVLNAKNHAKEARIVAEAGRL
RAVTVATNMAGRGTDIILGGNPEVLTAVELRRKGLDPSKDPERYEQAWSSAFPKLHRRTREEAEKVIEAGGLMVIGTERH
ESRRIDNQLRGRSGRQGDPGESRFYLSLTDDLMRKFNPGAASALAARVPDDTAIESKLVSRAIRSAQAQVESLNAETRKN
VLKYDDVLNRQRAAIYTDRSRILEGGDIADRVQAFLSDAIEEIINSHAVTAWDFDALWADLKTIYPVGISIEELTDEAGG
MGRITPDFVMREILSDAKFAYEKRESEIGPESMRDLERKVVLSVIDRCWRDHLYEMEYLKEGIGLRAMAQRDPLVEYQKE
GFDMFEAMMGRIREESIGYLFNIDAQVSSNSPSDARNRPIEHDDNAV
>Mature_846_residues
SVKLLERILRAGEGRTLKRLRNIAHTVNAIEDEYKGCTDGELRTFAFDLKVRHQNGESLDSILPEAFAMVREASSRTLGL
RHFDVQIMGGAALHMGYIAEMFTGEGKTLVATLPAFLNSLSGNGVHIVTVNDYLAGYHSQQMGRVYKVLGLETGVILADQ
DPSTRAQQYRADITYGTNNEFGFDYLRDNMAWSCAERVQRGHNFVILDEVDSILIDEARTPLIISGSSSGEVSRWFVEFA
GIARALTAGEDYDVDERKHTVGVLEPGIAKVEDLLGISNLYESVNTPLISFLNNSIKAKELFKRDRDYVVLDGEVMIVDE
HTGRILSGRRYNEGLHQAIEAKEGVEIKAENQTLATVTLQNYFRLYKKISGMTGTAVTEASEFMSTYKLPVVSIPTNKPN
IRKDHPDVVYKNEQIKFENLADHVRECYTRGQPVLIGTTSVEKSEYVSKLLSKRGVRHEVLNAKNHAKEARIVAEAGRLR
AVTVATNMAGRGTDIILGGNPEVLTAVELRRKGLDPSKDPERYEQAWSSAFPKLHRRTREEAEKVIEAGGLMVIGTERHE
SRRIDNQLRGRSGRQGDPGESRFYLSLTDDLMRKFNPGAASALAARVPDDTAIESKLVSRAIRSAQAQVESLNAETRKNV
LKYDDVLNRQRAAIYTDRSRILEGGDIADRVQAFLSDAIEEIINSHAVTAWDFDALWADLKTIYPVGISIEELTDEAGGM
GRITPDFVMREILSDAKFAYEKRESEIGPESMRDLERKVVLSVIDRCWRDHLYEMEYLKEGIGLRAMAQRDPLVEYQKEG
FDMFEAMMGRIREESIGYLFNIDAQVSSNSPSDARNRPIEHDDNAV

Specific function: Part of the Sec protein translocase complex. Interacts with the secYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular mo

COG id: COG0653

COG function: function code U; Preprotein translocase subunit SecA (ATPase, RNA helicase)

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm (By similarity). Note=Distribution is 50-50 (By similarity)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the secA family

Homologues:

Organism=Escherichia coli, GI1786287, Length=856, Percent_Identity=46.9626168224299, Blast_Score=733, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SECA_TROW8 (Q83NT4)

Other databases:

- EMBL:   BX251410
- RefSeq:   NP_789082.1
- HSSP:   P0A5Y8
- ProteinModelPortal:   Q83NT4
- SMR:   Q83NT4
- STRING:   Q83NT4
- GeneID:   1064434
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW139
- eggNOG:   COG0653
- HOGENOM:   HBG284200
- OMA:   GGMVLHD
- ProtClustDB:   PRK12904
- BioCyc:   TWHI218496:TW0127-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01382
- InterPro:   IPR000185
- InterPro:   IPR020937
- InterPro:   IPR011115
- InterPro:   IPR014018
- InterPro:   IPR011130
- InterPro:   IPR011116
- Gene3D:   G3DSA:1.10.3060.10
- PRINTS:   PR00906
- SMART:   SM00957
- SMART:   SM00958
- TIGRFAMs:   TIGR00963

Pfam domain/function: PF07517 SecA_DEAD; PF01043 SecA_PP_bind; PF07516 SecA_SW; SSF81767 SecA_PP_bd; SSF81886 SecA_SW

EC number: NA

Molecular weight: Translated: 94930; Mature: 94798

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS01312 SECA; PS51196 SECA_MOTOR_DEAD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVKLLERILRAGEGRTLKRLRNIAHTVNAIEDEYKGCTDGELRTFAFDLKVRHQNGESL
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCCH
DSILPEAFAMVREASSRTLGLRHFDVQIMGGAALHMGYIAEMFTGEGKTLVATLPAFLNS
HHHHHHHHHHHHHHCCCEECEEEEEEEEECCHHHHHHHHHHHHCCCCCEEEHHHHHHHHC
LSGNGVHIVTVNDYLAGYHSQQMGRVYKVLGLETGVILADQDPSTRAQQYRADITYGTNN
CCCCCEEEEEECHHHHCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHCEEEECCCC
EFGFDYLRDNMAWSCAERVQRGHNFVILDEVDSILIDEARTPLIISGSSSGEVSRWFVEF
CCCHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHCCCCCEEEECCCCCCHHHHHHHH
AGIARALTAGEDYDVDERKHTVGVLEPGIAKVEDLLGISNLYESVNTPLISFLNNSIKAK
HHHHHHHHCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHH
ELFKRDRDYVVLDGEVMIVDEHTGRILSGRRYNEGLHQAIEAKEGVEIKAENQTLATVTL
HHHHCCCCEEEECCEEEEEECCCCCEECCCCHHHHHHHHHHHCCCCEEEECCCEEEEEEH
QNYFRLYKKISGMTGTAVTEASEFMSTYKLPVVSIPTNKPNIRKDHPDVVYKNEQIKFEN
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCEEECCCCCCHHH
LADHVRECYTRGQPVLIGTTSVEKSEYVSKLLSKRGVRHEVLNAKNHAKEARIVAEAGRL
HHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHCCCE
RAVTVATNMAGRGTDIILGGNPEVLTAVELRRKGLDPSKDPERYEQAWSSAFPKLHRRTR
EEEEEEECCCCCCCEEEECCCCCEEHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
EEAEKVIEAGGLMVIGTERHESRRIDNQLRGRSGRQGDPGESRFYLSLTDDLMRKFNPGA
HHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHHHHCCCCH
ASALAARVPDDTAIESKLVSRAIRSAQAQVESLNAETRKNVLKYDDVLNRQRAAIYTDRS
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHEEECHH
RILEGGDIADRVQAFLSDAIEEIINSHAVTAWDFDALWADLKTIYPVGISIEELTDEAGG
HHCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHCCCCCCHHHHHHHCCC
MGRITPDFVMREILSDAKFAYEKRESEIGPESMRDLERKVVLSVIDRCWRDHLYEMEYLK
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGIGLRAMAQRDPLVEYQKEGFDMFEAMMGRIREESIGYLFNIDAQVSSNSPSDARNRPI
CCCCCEEHHHCCCHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHCCCC
EHDDNAV
CCCCCCC
>Mature Secondary Structure 
SVKLLERILRAGEGRTLKRLRNIAHTVNAIEDEYKGCTDGELRTFAFDLKVRHQNGESL
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCCH
DSILPEAFAMVREASSRTLGLRHFDVQIMGGAALHMGYIAEMFTGEGKTLVATLPAFLNS
HHHHHHHHHHHHHHCCCEECEEEEEEEEECCHHHHHHHHHHHHCCCCCEEEHHHHHHHHC
LSGNGVHIVTVNDYLAGYHSQQMGRVYKVLGLETGVILADQDPSTRAQQYRADITYGTNN
CCCCCEEEEEECHHHHCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHCEEEECCCC
EFGFDYLRDNMAWSCAERVQRGHNFVILDEVDSILIDEARTPLIISGSSSGEVSRWFVEF
CCCHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHCCCCCEEEECCCCCCHHHHHHHH
AGIARALTAGEDYDVDERKHTVGVLEPGIAKVEDLLGISNLYESVNTPLISFLNNSIKAK
HHHHHHHHCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHH
ELFKRDRDYVVLDGEVMIVDEHTGRILSGRRYNEGLHQAIEAKEGVEIKAENQTLATVTL
HHHHCCCCEEEECCEEEEEECCCCCEECCCCHHHHHHHHHHHCCCCEEEECCCEEEEEEH
QNYFRLYKKISGMTGTAVTEASEFMSTYKLPVVSIPTNKPNIRKDHPDVVYKNEQIKFEN
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCEEECCCCCCHHH
LADHVRECYTRGQPVLIGTTSVEKSEYVSKLLSKRGVRHEVLNAKNHAKEARIVAEAGRL
HHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHCCCE
RAVTVATNMAGRGTDIILGGNPEVLTAVELRRKGLDPSKDPERYEQAWSSAFPKLHRRTR
EEEEEEECCCCCCCEEEECCCCCEEHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
EEAEKVIEAGGLMVIGTERHESRRIDNQLRGRSGRQGDPGESRFYLSLTDDLMRKFNPGA
HHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHHHHCCCCH
ASALAARVPDDTAIESKLVSRAIRSAQAQVESLNAETRKNVLKYDDVLNRQRAAIYTDRS
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHEEECHH
RILEGGDIADRVQAFLSDAIEEIINSHAVTAWDFDALWADLKTIYPVGISIEELTDEAGG
HHCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHCCCCCCHHHHHHHCCC
MGRITPDFVMREILSDAKFAYEKRESEIGPESMRDLERKVVLSVIDRCWRDHLYEMEYLK
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGIGLRAMAQRDPLVEYQKEGFDMFEAMMGRIREESIGYLFNIDAQVSSNSPSDARNRPI
CCCCCEEHHHCCCHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHCCCC
EHDDNAV
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12606174