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The map label for this gene is menB [H]

Identifier: 28572285

GI number: 28572285

Start: 128106

End: 129023

Strand: Direct

Name: menB [H]

Synonym: TW120

Alternate gene names: 28572285

Gene position: 128106-129023 (Clockwise)

Preceding gene: 28572273

Following gene: 28572286

Centisome position: 13.84

GC content: 50.98

Gene sequence:

>918_bases
GTGGGTGAATCTAAAGGTGCTCCCACCTTTGATACACTCCAACATGTGTTGCTTAGTGAGCTGTTTGACCCGGACCTTTG
GGTGGCGCATGAGGGCTTCGAAGCTTGTGATGTAACGTATCACACAGCTCCTGGGGTTGCACGTATTGCATTTAACAGAC
CAGAGATTAGAAATGCGTTTCGACCCGAAACTGTTGATCAGCTTTATGCTGCGCTAGATCATGCACGGGTCAGCGATAAA
ATCGGTGCTGTTTTACTGACAGGCAATGGCCCATCCCCGCGCGACGGTATCCGTGCTTTTTGTGCAGGGGGCGATCAGAA
AACACGCCGGAGGGATGGATACGCATACAGCGATTCCCACCGTTCTTCGAGGATGCATATTCTTGAAGTCCAAAGACTGA
TTCGCTTTATGCCAAAGCCTGTTATTGCATTGGTAAACGGGTGGGCTGCGGGTGGTGGACATTCCTTGCACGTTGTGTGC
GATCTCAGTATTGCAAGCCTTGAGCATGCCAAATTCAAGCAAACAGACGCAACTGTAGCAAGTTTTGACTCAGGTTTTGG
AAGCGCCTATTTCGCCCGACAGGTCGGGCAGAAGTTTGCACGCGAGGTCTGTTTTCTTGCGGCAGAATATGACGCTAAAA
CCGCTCTCGAAAAAGGTGCGGTTAATGCTGTGGTTGCGCATGAGTATCTTGAGCAGACCGGATACGAATGGGCCCGGAGG
ATTCTTGAGCAGTCACCGACTTCGATACGTATGTTTAAATACGCGCTAAATGCCGTTGATGATGGCCTGGTCGGACAGCA
GATTTTTGCAGGCGAGGCCACACGCCTTGCGTATGCAACAGATGAGTCAAAAGAAGGGCGTGACGCATTCCTCGAAAAAC
GTCGGCCAGACTGGTCAAGCTTTCCCTGGAGCTTCTAG

Upstream 100 bases:

>100_bases
ACGCACAGATTTTGCCTTGTATGAGATAACCCCATAGTGAATCACTGACGTAATTGAATCACAGTTATTTATCGGGTTTG
TTATTCATCGGGTTTAATGT

Downstream 100 bases:

>100_bases
TATGACCAAGGCTCTCATGCGGGGGCAAATTACACTTGACTCTGTAAAAAGAGTCCTTGAGGACGAGCGATTTGCTATTT
GTGCGTCAGAAGAGCCTCTC

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MGESKGAPTFDTLQHVLLSELFDPDLWVAHEGFEACDVTYHTAPGVARIAFNRPEIRNAFRPETVDQLYAALDHARVSDK
IGAVLLTGNGPSPRDGIRAFCAGGDQKTRRRDGYAYSDSHRSSRMHILEVQRLIRFMPKPVIALVNGWAAGGGHSLHVVC
DLSIASLEHAKFKQTDATVASFDSGFGSAYFARQVGQKFAREVCFLAAEYDAKTALEKGAVNAVVAHEYLEQTGYEWARR
ILEQSPTSIRMFKYALNAVDDGLVGQQIFAGEATRLAYATDESKEGRDAFLEKRRPDWSSFPWSF

Sequences:

>Translated_305_residues
MGESKGAPTFDTLQHVLLSELFDPDLWVAHEGFEACDVTYHTAPGVARIAFNRPEIRNAFRPETVDQLYAALDHARVSDK
IGAVLLTGNGPSPRDGIRAFCAGGDQKTRRRDGYAYSDSHRSSRMHILEVQRLIRFMPKPVIALVNGWAAGGGHSLHVVC
DLSIASLEHAKFKQTDATVASFDSGFGSAYFARQVGQKFAREVCFLAAEYDAKTALEKGAVNAVVAHEYLEQTGYEWARR
ILEQSPTSIRMFKYALNAVDDGLVGQQIFAGEATRLAYATDESKEGRDAFLEKRRPDWSSFPWSF
>Mature_304_residues
GESKGAPTFDTLQHVLLSELFDPDLWVAHEGFEACDVTYHTAPGVARIAFNRPEIRNAFRPETVDQLYAALDHARVSDKI
GAVLLTGNGPSPRDGIRAFCAGGDQKTRRRDGYAYSDSHRSSRMHILEVQRLIRFMPKPVIALVNGWAAGGGHSLHVVCD
LSIASLEHAKFKQTDATVASFDSGFGSAYFARQVGQKFAREVCFLAAEYDAKTALEKGAVNAVVAHEYLEQTGYEWARRI
LEQSPTSIRMFKYALNAVDDGLVGQQIFAGEATRLAYATDESKEGRDAFLEKRRPDWSSFPWSF

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=264, Percent_Identity=29.9242424242424, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI31542718, Length=259, Percent_Identity=28.1853281853282, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI4502327, Length=259, Percent_Identity=27.7992277992278, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1788597, Length=283, Percent_Identity=48.7632508833922, Blast_Score=254, Evalue=6e-69,
Organism=Escherichia coli, GI1787659, Length=260, Percent_Identity=28.8461538461538, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1787660, Length=265, Percent_Identity=32.0754716981132, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI87082183, Length=270, Percent_Identity=28.8888888888889, Blast_Score=88, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17554946, Length=258, Percent_Identity=32.1705426356589, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25145438, Length=264, Percent_Identity=30.3030303030303, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17540714, Length=217, Percent_Identity=30.4147465437788, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17540306, Length=259, Percent_Identity=27.7992277992278, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17536985, Length=240, Percent_Identity=25.4166666666667, Blast_Score=64, Evalue=1e-10,
Organism=Drosophila melanogaster, GI20129971, Length=257, Percent_Identity=28.7937743190661, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24653477, Length=257, Percent_Identity=28.7937743190661, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24653139, Length=265, Percent_Identity=27.5471698113208, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 33812; Mature: 33681

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGESKGAPTFDTLQHVLLSELFDPDLWVAHEGFEACDVTYHTAPGVARIAFNRPEIRNAF
CCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHCEEEECCCCEEEEECCCHHHHHCC
RPETVDQLYAALDHARVSDKIGAVLLTGNGPSPRDGIRAFCAGGDQKTRRRDGYAYSDSH
CCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHCCCCCCCCC
RSSRMHILEVQRLIRFMPKPVIALVNGWAAGGGHSLHVVCDLSIASLEHAKFKQTDATVA
CCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEEEECHHHHHHHHHHHHCCCHHH
SFDSGFGSAYFARQVGQKFAREVCFLAAEYDAKTALEKGAVNAVVAHEYLEQTGYEWARR
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
ILEQSPTSIRMFKYALNAVDDGLVGQQIFAGEATRLAYATDESKEGRDAFLEKRRPDWSS
HHHCCCCHHHHHHHHHHHHCCCHHCHHHHCCCCCEEEEECCCCCCHHHHHHHHCCCCCCC
FPWSF
CCCCC
>Mature Secondary Structure 
GESKGAPTFDTLQHVLLSELFDPDLWVAHEGFEACDVTYHTAPGVARIAFNRPEIRNAF
CCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHCEEEECCCCEEEEECCCHHHHHCC
RPETVDQLYAALDHARVSDKIGAVLLTGNGPSPRDGIRAFCAGGDQKTRRRDGYAYSDSH
CCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHCCCCCCCCC
RSSRMHILEVQRLIRFMPKPVIALVNGWAAGGGHSLHVVCDLSIASLEHAKFKQTDATVA
CCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEEEECHHHHHHHHHHHHCCCHHH
SFDSGFGSAYFARQVGQKFAREVCFLAAEYDAKTALEKGAVNAVVAHEYLEQTGYEWARR
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
ILEQSPTSIRMFKYALNAVDDGLVGQQIFAGEATRLAYATDESKEGRDAFLEKRRPDWSS
HHHCCCCHHHHHHHHHHHHCCCHHCHHHHCCCCCEEEEECCCCCCHHHHHHHHCCCCCCC
FPWSF
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA