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The map label for this gene is guaB2

Identifier: 28572254

GI number: 28572254

Start: 84872

End: 85993

Strand: Direct

Name: guaB2

Synonym: TW086

Alternate gene names: NA

Gene position: 84872-85993 (Clockwise)

Preceding gene: 28572253

Following gene: 28572255

Centisome position: 9.17

GC content: 50.18

Gene sequence:

>1122_bases
ATGGAAGTCGGTTTTTCCAGAAATGCCAGAAGAGCTTTTTCGCTCGATGAAGTTGCTGTTGTTCCGAGCAGGCGTACCCG
TCACTCTAGTGAGGTATCAATCGAGTGGAAGATGGATGCTTTCTCTTTTGACACACCGATTATTTCTTCTCCAGCGGACT
CTGTTGTCTCACCAAGCACGATTGTTGAACTGTCCGAATTTGGCTGTCTTGGTATTTTGGATCTCGAAGGTGTTTGGACA
CGTTACGAGAATCCAGAACCTGTCCTGCGCGAGATTTCTGCACTGCCGGAGGAAAAAGCGTGTCTTGGCCTTCAGAAAAT
ATACTCGGAGCCAATTAAACGGCACCTACTGGAAAGGCGCTTGCAGGAGCTTCGCGATGCAGGGGTGATTGTTGCAGGTT
GCCTTTCTCCGCAAACCACAAATGCGCTTTACAAGAGTGTAATCTCAGCGGGCGTAGATATTTTTGTCATTCGTGGGGGC
ACTGTATCCGCTGAACATGTTTCAAAGAGTGACAATGTTCTAAACCTGAAGAGGTTTATATACGAGCTAGATGTTCCAGT
TATGGTGGGCGGTGTTGCAACCTATACTGCGGCCTTGCACATGATGCGCACCGGCGCGGCCGGGGTTTTGGTCGGTTTTG
GCGGATGCGCAGGATCAACGAACCATGCTTCACTTGGAATAAAGGTGCCTATGGCAACTGCAATAGCAGATGTTGCAGCG
GCAAGAAAAGATTATTTGGATGAATCTGGAGGGCGATATGTTCAAGTAATTGCCGACGGGAGCATGAACACCAGCGGTAT
GGCTGTGAATGCATTAGCTCTCGGTGCTGATGCGGTAATGATGGGAACTCCACTTGTACGCTCGACAACCTCTCCGGGAT
TCGGGTACCACTGGGGTAGAGAGGCCCATCACATGACTTTACCGAGGGGTCGACGCGCCTACATAGGGCAAACTGCCTCT
TTGCAGGAGATTATCCAGGGCCCGGGACATTCCCCAGATGGAACGGTAAATTTTGCAGGAGCAATTCGACGAGCGGTTGC
ACTGGCTGGCTTTCAAGATCTGAAGAATTTTCAGCGGGTCGAGATGGTTGTTATACAGGACCAACGACGGTGTTGTGCCT
AA

Upstream 100 bases:

>100_bases
AAAGGTCGGTTTGTAAGAATCACCTCAGCTGGACTAAAAGAGTCACATCCGCATGATATTGAAATGATTGTCGAAACCCC
AAACTACAGAACGTAGACTT

Downstream 100 bases:

>100_bases
GGCATATTTCAAGCTCTCCAGTCTATTACTCCTGGCGCCATTTCTTGTGGTTTCATTTTGTTTTGTTTACCTTGGGTTTT
GGCAACTTTCGCGCTCATAT

Product: inosine 5-monophosphate dehydrogenase

Products: xanthosine 5'-phosphate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MEVGFSRNARRAFSLDEVAVVPSRRTRHSSEVSIEWKMDAFSFDTPIISSPADSVVSPSTIVELSEFGCLGILDLEGVWT
RYENPEPVLREISALPEEKACLGLQKIYSEPIKRHLLERRLQELRDAGVIVAGCLSPQTTNALYKSVISAGVDIFVIRGG
TVSAEHVSKSDNVLNLKRFIYELDVPVMVGGVATYTAALHMMRTGAAGVLVGFGGCAGSTNHASLGIKVPMATAIADVAA
ARKDYLDESGGRYVQVIADGSMNTSGMAVNALALGADAVMMGTPLVRSTTSPGFGYHWGREAHHMTLPRGRRAYIGQTAS
LQEIIQGPGHSPDGTVNFAGAIRRAVALAGFQDLKNFQRVEMVVIQDQRRCCA

Sequences:

>Translated_373_residues
MEVGFSRNARRAFSLDEVAVVPSRRTRHSSEVSIEWKMDAFSFDTPIISSPADSVVSPSTIVELSEFGCLGILDLEGVWT
RYENPEPVLREISALPEEKACLGLQKIYSEPIKRHLLERRLQELRDAGVIVAGCLSPQTTNALYKSVISAGVDIFVIRGG
TVSAEHVSKSDNVLNLKRFIYELDVPVMVGGVATYTAALHMMRTGAAGVLVGFGGCAGSTNHASLGIKVPMATAIADVAA
ARKDYLDESGGRYVQVIADGSMNTSGMAVNALALGADAVMMGTPLVRSTTSPGFGYHWGREAHHMTLPRGRRAYIGQTAS
LQEIIQGPGHSPDGTVNFAGAIRRAVALAGFQDLKNFQRVEMVVIQDQRRCCA
>Mature_373_residues
MEVGFSRNARRAFSLDEVAVVPSRRTRHSSEVSIEWKMDAFSFDTPIISSPADSVVSPSTIVELSEFGCLGILDLEGVWT
RYENPEPVLREISALPEEKACLGLQKIYSEPIKRHLLERRLQELRDAGVIVAGCLSPQTTNALYKSVISAGVDIFVIRGG
TVSAEHVSKSDNVLNLKRFIYELDVPVMVGGVATYTAALHMMRTGAAGVLVGFGGCAGSTNHASLGIKVPMATAIADVAA
ARKDYLDESGGRYVQVIADGSMNTSGMAVNALALGADAVMMGTPLVRSTTSPGFGYHWGREAHHMTLPRGRRAYIGQTAS
LQEIIQGPGHSPDGTVNFAGAIRRAVALAGFQDLKNFQRVEMVVIQDQRRCCA

Specific function: Unknown

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001093
- InterPro:   IPR005992 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: 1.1.1.205

Molecular weight: Translated: 40110; Mature: 40110

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVGFSRNARRAFSLDEVAVVPSRRTRHSSEVSIEWKMDAFSFDTPIISSPADSVVSPST
CCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEEEECCEECCCCCCCCCCCCCCCCHH
IVELSEFGCLGILDLEGVWTRYENPEPVLREISALPEEKACLGLQKIYSEPIKRHLLERR
HHHHHHCCEEEEEECCCHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LQELRDAGVIVAGCLSPQTTNALYKSVISAGVDIFVIRGGTVSAEHVSKSDNVLNLKRFI
HHHHHHCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCEECHHHHCCCCCHHHHHHHH
YELDVPVMVGGVATYTAALHMMRTGAAGVLVGFGGCAGSTNHASLGIKVPMATAIADVAA
HHCCCCEEECHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEECHHHHHHHHHHH
ARKDYLDESGGRYVQVIADGSMNTSGMAVNALALGADAVMMGTPLVRSTTSPGFGYHWGR
HHHHHHHCCCCCEEEEEECCCCCCCCEEEEEEHCCCCCCEECCCCCCCCCCCCCCCCCCC
EAHHMTLPRGRRAYIGQTASLQEIIQGPGHSPDGTVNFAGAIRRAVALAGFQDLKNFQRV
CCCEEECCCCCHHHCCCCHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHE
EMVVIQDQRRCCA
EEEEEECCHHCCC
>Mature Secondary Structure
MEVGFSRNARRAFSLDEVAVVPSRRTRHSSEVSIEWKMDAFSFDTPIISSPADSVVSPST
CCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEEEECCEECCCCCCCCCCCCCCCCHH
IVELSEFGCLGILDLEGVWTRYENPEPVLREISALPEEKACLGLQKIYSEPIKRHLLERR
HHHHHHCCEEEEEECCCHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LQELRDAGVIVAGCLSPQTTNALYKSVISAGVDIFVIRGGTVSAEHVSKSDNVLNLKRFI
HHHHHHCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCEECHHHHCCCCCHHHHHHHH
YELDVPVMVGGVATYTAALHMMRTGAAGVLVGFGGCAGSTNHASLGIKVPMATAIADVAA
HHCCCCEEECHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEECHHHHHHHHHHH
ARKDYLDESGGRYVQVIADGSMNTSGMAVNALALGADAVMMGTPLVRSTTSPGFGYHWGR
HHHHHHHCCCCCEEEEEECCCCCCCCEEEEEEHCCCCCCEECCCCCCCCCCCCCCCCCCC
EAHHMTLPRGRRAYIGQTASLQEIIQGPGHSPDGTVNFAGAIRRAVALAGFQDLKNFQRV
CCCEEECCCCCHHHCCCCHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHE
EMVVIQDQRRCCA
EEEEEECCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: inosine 5'-phosphate; NAD+; H2O

Specific reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA