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The map label for this gene is guaB1 [H]

Identifier: 28572253

GI number: 28572253

Start: 83392

End: 84867

Strand: Direct

Name: guaB1 [H]

Synonym: TW085

Alternate gene names: 28572253

Gene position: 83392-84867 (Clockwise)

Preceding gene: 28572252

Following gene: 28572254

Centisome position: 9.01

GC content: 50.95

Gene sequence:

>1476_bases
GTGCACCCCCATAAGCTTTCCGGAGTTGGGCTCACGTATGACGATGTTATGCTCGTTCCTGGGCGCTCTGATGTTTTGCC
CAGTCAGGTTAACTTCGGTAGTTTTCTCACCCGGCGTATAAGACTCTCGGCGCCGCTTGTGTCGGCTGCGATGGATACCG
TTACAGAGTCTGGTATGGCTGTTGCGATGGCCCGTCTTGGTGGTGTTGGGGTTATCCATCGCAATATGTCGATTGCGGAC
CAGGCAGAGCACGTAACTCGTGTAAAGCTGAGTGAGTCAGGCATGATCACGAGGCCCGTTTCTGTTTCTCCCGATCTGAC
CTTGGAGGAAGTCGAGCAGCGTTGTTCGCGTTACAAGATATCCGGATTCCCTGTGGTCGATGAGGACAACACTCTGCTTG
GGATAGTTACAAGCCGCGATATGTGGCCCTATAGGCACGAGCATCGCGCTTCTGTCCGTGTTTCAGAGGTTATGACAAGG
TCTCCCCTAATTACCGCTTCGCCAAATATATCTTCAGAGGAAGCACGGGACTTGCTCTACAAGCACAGACTGGAGAAGCT
GCCGCTTGTGGATGAGCATGGTCGACTCTTTGGTCTTATTACGGTAAAGGATTTTGTAAACCGCCAGCGTTATCCGTTTG
CAACCAAGGACAAGAATGGATGCCTGATCGTTGGTGCAGCAATTGGCTTCTTTGGTGATGCATATGACAGAGCCCTTGCT
TTGGCTGCTGCAGGTGTTGATTTCATTGTCGTTGATACGGCCAATGGTTATTCTGATGGAGCCCTGAAGATGATAAATCG
CCTGAAAAACGATTCAACCTTTGCCGACATTGACATAATTGGTGGTAATGTCGCGACCGGTGATGGTGCGAAGGCACTGA
TTGACTCTGGCGCTGATGCTGTTAAGGTTGGGATTGGCCCGGGTTCGATTTGTACCACCCGGGTTATAGCAGGTGTTGGG
GTTCCGCAGATAACGGCTATATACGAGTGCGCGCAAACATCATCGGTTCCAATAATTGCGGATGGTGGACTGCATTATTC
TGGCGATATCGCAAAAGCCCTGGTTGCCGGGGCCAAGTCCGTTATGTTGGGCGGACTTCTCGCCGGTTGTGATGAAAGCC
CGGGGGAGTTAATATCCCGTGGTGGGAAGCAGTACAAGATCTACAGAGGAATGGGTTCTGCAGGCGCCATGCAGGCCAGG
GCATCCTACTCTCGTGATAGATATTTTCAGCATGATCTGGATTCGCACCCCATTGCCGAGGGTGTTGAAGGGCAAGTGCC
ACATACCGGTTCTGTCAGCACGGTTTTTTACCAATTACTGGGAGGGCTCAGGCAGTCTATGTTTTATGTCGGCTGCAGGG
ATATCAATGAACTGCAGGATAAAGGTCGGTTTGTAAGAATCACCTCAGCTGGACTAAAAGAGTCACATCCGCATGATATT
GAAATGATTGTCGAAACCCCAAACTACAGAACGTAG

Upstream 100 bases:

>100_bases
AGTACACGATCTTGGCTTCAAGGGATGTGCTCGCGGTTGTTCATCGGTAACCGACTCTTTTAGCCCGTTCCTCTTGCGTA
CCATTCGGTAGCGTGTTGTT

Downstream 100 bases:

>100_bases
ACTTATGGAAGTCGGTTTTTCCAGAAATGCCAGAAGAGCTTTTTCGCTCGATGAAGTTGCTGTTGTTCCGAGCAGGCGTA
CCCGTCACTCTAGTGAGGTA

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MHPHKLSGVGLTYDDVMLVPGRSDVLPSQVNFGSFLTRRIRLSAPLVSAAMDTVTESGMAVAMARLGGVGVIHRNMSIAD
QAEHVTRVKLSESGMITRPVSVSPDLTLEEVEQRCSRYKISGFPVVDEDNTLLGIVTSRDMWPYRHEHRASVRVSEVMTR
SPLITASPNISSEEARDLLYKHRLEKLPLVDEHGRLFGLITVKDFVNRQRYPFATKDKNGCLIVGAAIGFFGDAYDRALA
LAAAGVDFIVVDTANGYSDGALKMINRLKNDSTFADIDIIGGNVATGDGAKALIDSGADAVKVGIGPGSICTTRVIAGVG
VPQITAIYECAQTSSVPIIADGGLHYSGDIAKALVAGAKSVMLGGLLAGCDESPGELISRGGKQYKIYRGMGSAGAMQAR
ASYSRDRYFQHDLDSHPIAEGVEGQVPHTGSVSTVFYQLLGGLRQSMFYVGCRDINELQDKGRFVRITSAGLKESHPHDI
EMIVETPNYRT

Sequences:

>Translated_491_residues
MHPHKLSGVGLTYDDVMLVPGRSDVLPSQVNFGSFLTRRIRLSAPLVSAAMDTVTESGMAVAMARLGGVGVIHRNMSIAD
QAEHVTRVKLSESGMITRPVSVSPDLTLEEVEQRCSRYKISGFPVVDEDNTLLGIVTSRDMWPYRHEHRASVRVSEVMTR
SPLITASPNISSEEARDLLYKHRLEKLPLVDEHGRLFGLITVKDFVNRQRYPFATKDKNGCLIVGAAIGFFGDAYDRALA
LAAAGVDFIVVDTANGYSDGALKMINRLKNDSTFADIDIIGGNVATGDGAKALIDSGADAVKVGIGPGSICTTRVIAGVG
VPQITAIYECAQTSSVPIIADGGLHYSGDIAKALVAGAKSVMLGGLLAGCDESPGELISRGGKQYKIYRGMGSAGAMQAR
ASYSRDRYFQHDLDSHPIAEGVEGQVPHTGSVSTVFYQLLGGLRQSMFYVGCRDINELQDKGRFVRITSAGLKESHPHDI
EMIVETPNYRT
>Mature_491_residues
MHPHKLSGVGLTYDDVMLVPGRSDVLPSQVNFGSFLTRRIRLSAPLVSAAMDTVTESGMAVAMARLGGVGVIHRNMSIAD
QAEHVTRVKLSESGMITRPVSVSPDLTLEEVEQRCSRYKISGFPVVDEDNTLLGIVTSRDMWPYRHEHRASVRVSEVMTR
SPLITASPNISSEEARDLLYKHRLEKLPLVDEHGRLFGLITVKDFVNRQRYPFATKDKNGCLIVGAAIGFFGDAYDRALA
LAAAGVDFIVVDTANGYSDGALKMINRLKNDSTFADIDIIGGNVATGDGAKALIDSGADAVKVGIGPGSICTTRVIAGVG
VPQITAIYECAQTSSVPIIADGGLHYSGDIAKALVAGAKSVMLGGLLAGCDESPGELISRGGKQYKIYRGMGSAGAMQAR
ASYSRDRYFQHDLDSHPIAEGVEGQVPHTGSVSTVFYQLLGGLRQSMFYVGCRDINELQDKGRFVRITSAGLKESHPHDI
EMIVETPNYRT

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=459, Percent_Identity=41.1764705882353, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI217035146, Length=453, Percent_Identity=41.0596026490066, Blast_Score=312, Evalue=6e-85,
Organism=Homo sapiens, GI156616279, Length=453, Percent_Identity=41.0596026490066, Blast_Score=311, Evalue=1e-84,
Organism=Homo sapiens, GI34328928, Length=453, Percent_Identity=41.0596026490066, Blast_Score=311, Evalue=1e-84,
Organism=Homo sapiens, GI34328930, Length=453, Percent_Identity=41.0596026490066, Blast_Score=310, Evalue=1e-84,
Organism=Homo sapiens, GI217035152, Length=463, Percent_Identity=40.3887688984881, Blast_Score=305, Evalue=7e-83,
Organism=Homo sapiens, GI217035148, Length=453, Percent_Identity=40.3973509933775, Blast_Score=300, Evalue=2e-81,
Organism=Homo sapiens, GI217035150, Length=453, Percent_Identity=38.6313465783664, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI50541956, Length=226, Percent_Identity=43.3628318584071, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI50541954, Length=226, Percent_Identity=43.3628318584071, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI50541952, Length=226, Percent_Identity=43.3628318584071, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI50541948, Length=226, Percent_Identity=43.3628318584071, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI156104880, Length=230, Percent_Identity=40.4347826086956, Blast_Score=167, Evalue=2e-41,
Organism=Escherichia coli, GI1788855, Length=491, Percent_Identity=48.0651731160896, Blast_Score=400, Evalue=1e-113,
Organism=Escherichia coli, GI1786293, Length=225, Percent_Identity=39.1111111111111, Blast_Score=157, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71994385, Length=485, Percent_Identity=36.0824742268041, Blast_Score=275, Evalue=4e-74,
Organism=Caenorhabditis elegans, GI71994389, Length=433, Percent_Identity=37.6443418013857, Blast_Score=256, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI17560440, Length=226, Percent_Identity=40.2654867256637, Blast_Score=167, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6323585, Length=461, Percent_Identity=40.5639913232104, Blast_Score=324, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6322012, Length=486, Percent_Identity=39.7119341563786, Blast_Score=322, Evalue=8e-89,
Organism=Saccharomyces cerevisiae, GI6323464, Length=486, Percent_Identity=40.5349794238683, Blast_Score=317, Evalue=4e-87,
Organism=Saccharomyces cerevisiae, GI6319352, Length=347, Percent_Identity=40.3458213256484, Blast_Score=239, Evalue=6e-64,
Organism=Saccharomyces cerevisiae, GI6319353, Length=133, Percent_Identity=42.8571428571429, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24641071, Length=488, Percent_Identity=39.5491803278689, Blast_Score=315, Evalue=6e-86,
Organism=Drosophila melanogaster, GI24641073, Length=488, Percent_Identity=39.5491803278689, Blast_Score=315, Evalue=6e-86,
Organism=Drosophila melanogaster, GI28571163, Length=444, Percent_Identity=39.1891891891892, Blast_Score=276, Evalue=2e-74,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52833; Mature: 52833

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPHKLSGVGLTYDDVMLVPGRSDVLPSQVNFGSFLTRRIRLSAPLVSAAMDTVTESGMA
CCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCHH
VAMARLGGVGVIHRNMSIADQAEHVTRVKLSESGMITRPVSVSPDLTLEEVEQRCSRYKI
HHHHHHCCEEEEECCCCHHHHHHHHEEEEECCCCCEECCCCCCCCCCHHHHHHHHHHEEC
SGFPVVDEDNTLLGIVTSRDMWPYRHEHRASVRVSEVMTRSPLITASPNISSEEARDLLY
CCCCEECCCCCEEEEEECCCCCCCCHHHHHHEEHHHHHHCCCCEEECCCCCHHHHHHHHH
KHRLEKLPLVDEHGRLFGLITVKDFVNRQRYPFATKDKNGCLIVGAAIGFFGDAYDRALA
HHHHHHCCCCCCCCCEEEEEEEHHHHCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHH
LAAAGVDFIVVDTANGYSDGALKMINRLKNDSTFADIDIIGGNVATGDGAKALIDSGADA
HHHCCCEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEECCEEECCCCCHHHHHCCCCE
VKVGIGPGSICTTRVIAGVGVPQITAIYECAQTSSVPIIADGGLHYSGDIAKALVAGAKS
EEEECCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEECCCCEECCHHHHHHHHHHHH
VMLGGLLAGCDESPGELISRGGKQYKIYRGMGSAGAMQARASYSRDRYFQHDLDSHPIAE
HHHHHHHHCCCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
GVEGQVPHTGSVSTVFYQLLGGLRQSMFYVGCRDINELQDKGRFVRITSAGLKESHPHDI
CCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCHHHHHHCCCEEEEEECCCCCCCCCCE
EMIVETPNYRT
EEEEECCCCCC
>Mature Secondary Structure
MHPHKLSGVGLTYDDVMLVPGRSDVLPSQVNFGSFLTRRIRLSAPLVSAAMDTVTESGMA
CCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCHH
VAMARLGGVGVIHRNMSIADQAEHVTRVKLSESGMITRPVSVSPDLTLEEVEQRCSRYKI
HHHHHHCCEEEEECCCCHHHHHHHHEEEEECCCCCEECCCCCCCCCCHHHHHHHHHHEEC
SGFPVVDEDNTLLGIVTSRDMWPYRHEHRASVRVSEVMTRSPLITASPNISSEEARDLLY
CCCCEECCCCCEEEEEECCCCCCCCHHHHHHEEHHHHHHCCCCEEECCCCCHHHHHHHHH
KHRLEKLPLVDEHGRLFGLITVKDFVNRQRYPFATKDKNGCLIVGAAIGFFGDAYDRALA
HHHHHHCCCCCCCCCEEEEEEEHHHHCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHH
LAAAGVDFIVVDTANGYSDGALKMINRLKNDSTFADIDIIGGNVATGDGAKALIDSGADA
HHHCCCEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEECCEEECCCCCHHHHHCCCCE
VKVGIGPGSICTTRVIAGVGVPQITAIYECAQTSSVPIIADGGLHYSGDIAKALVAGAKS
EEEECCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEECCCCEECCHHHHHHHHHHHH
VMLGGLLAGCDESPGELISRGGKQYKIYRGMGSAGAMQARASYSRDRYFQHDLDSHPIAE
HHHHHHHHCCCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
GVEGQVPHTGSVSTVFYQLLGGLRQSMFYVGCRDINELQDKGRFVRITSAGLKESHPHDI
CCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCHHHHHHCCCEEEEEECCCCCCCCCCE
EMIVETPNYRT
EEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]