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The map label for this gene is menA [H]

Identifier: 28572248

GI number: 28572248

Start: 72796

End: 73707

Strand: Direct

Name: menA [H]

Synonym: TW080

Alternate gene names: 28572248

Gene position: 72796-73707 (Clockwise)

Preceding gene: 28572247

Following gene: 28572249

Centisome position: 7.86

GC content: 47.26

Gene sequence:

>912_bases
GTGGCCTTGGAGAAACGCAGAAGAAAAAAGAAAAGAAGCTTGATACTGCCGTGGCTACTTGCTTCCCGCCCGGCCACCCT
CATTGTTTCCCTGTCGGCAGTTTCGCTTGGGTGGGGTGCTGCACTTCTGACCGTCACCGGAAGAAAGGCTTCACTTTTAT
TAGTTGCTCTTGCGGCATTGACCGCTGTTTTACTCCAGATTGGTGCGAATTACATCAACGACTATGGGGATGGAATACGC
GGCGCAGATTCCAATAGGTCGCACGCCTCGCGGCGCCTTACAGCCTCAGGCGCTAATCCGTTTTCGGTTCTGACGACTGG
TCTTTCATTTTTGATTGCCGCTGCAGGCTCTGGACTGATTGCCGTTATCCTCACCCAGAGGTGGCAGCTCATCTTAGTCG
GTGTGTTTTCGATTGCTGCTGCTTACCTGTACACTGCAGGACCTTTCCCGTACGCTTATTTCGGACTTGGGGAATTGTCT
GTTTTTATTTTTTTCGGACCCGTAACAGTTATCGGGACTGTCTTTCTGTTGTCTGGAATTGTTACACTGTCATCTTTTCT
GGTAGCTGTTGTTGCAGGTTCATGGTCTGCCGCCATTCTGCTTATGAATAATTTGCGTGATCACGAAAGTGATATGCAGA
GCAATAAACGTACCTTCTCCGTTTTGTTTGGGGTCTTAATTGCCAGGATAGTTTGCATTGCTCTGATTGCTGTGCCCTAC
ATTGTAGTCGCGATTCTGTTAATCGAGTTGCCTTTTATTGGCTATGTTTTTTTAACCCTTCTCCTCAGCGCGCCAATTGT
GATAATTTTGGCCACTGCCGTGACTTCAAAAGAGTTTGCAATAGCTTTTAGGCTTGGGATCATTTGTCTGATTCCATTTG
CAATATTTTTTACTTGGGGACTTGCTAGCTAG

Upstream 100 bases:

>100_bases
AGGCAACTCCCGGTGAGTATACGGTGGAGTTCTCTATTGACGGTTTTAGTTCATCAAAGTATAACTTTGTTCTACAGTAG
TTAAGTCGATTATAAGGATT

Downstream 100 bases:

>100_bases
ATGAATCTGGCACTGTAATTTTTGCATTCGAGCCTGTGTCCTTGGTAATGCCAATGTGGCGTTATAACTGCCCCAGTGTT
ATTCCTGTAAACGCGCGGGG

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MALEKRRRKKKRSLILPWLLASRPATLIVSLSAVSLGWGAALLTVTGRKASLLLVALAALTAVLLQIGANYINDYGDGIR
GADSNRSHASRRLTASGANPFSVLTTGLSFLIAAAGSGLIAVILTQRWQLILVGVFSIAAAYLYTAGPFPYAYFGLGELS
VFIFFGPVTVIGTVFLLSGIVTLSSFLVAVVAGSWSAAILLMNNLRDHESDMQSNKRTFSVLFGVLIARIVCIALIAVPY
IVVAILLIELPFIGYVFLTLLLSAPIVIILATAVTSKEFAIAFRLGIICLIPFAIFFTWGLAS

Sequences:

>Translated_303_residues
MALEKRRRKKKRSLILPWLLASRPATLIVSLSAVSLGWGAALLTVTGRKASLLLVALAALTAVLLQIGANYINDYGDGIR
GADSNRSHASRRLTASGANPFSVLTTGLSFLIAAAGSGLIAVILTQRWQLILVGVFSIAAAYLYTAGPFPYAYFGLGELS
VFIFFGPVTVIGTVFLLSGIVTLSSFLVAVVAGSWSAAILLMNNLRDHESDMQSNKRTFSVLFGVLIARIVCIALIAVPY
IVVAILLIELPFIGYVFLTLLLSAPIVIILATAVTSKEFAIAFRLGIICLIPFAIFFTWGLAS
>Mature_302_residues
ALEKRRRKKKRSLILPWLLASRPATLIVSLSAVSLGWGAALLTVTGRKASLLLVALAALTAVLLQIGANYINDYGDGIRG
ADSNRSHASRRLTASGANPFSVLTTGLSFLIAAAGSGLIAVILTQRWQLILVGVFSIAAAYLYTAGPFPYAYFGLGELSV
FIFFGPVTVIGTVFLLSGIVTLSSFLVAVVAGSWSAAILLMNNLRDHESDMQSNKRTFSVLFGVLIARIVCIALIAVPYI
VVAILLIELPFIGYVFLTLLLSAPIVIILATAVTSKEFAIAFRLGIICLIPFAIFFTWGLAS

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=251, Percent_Identity=30.6772908366534, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1790365, Length=284, Percent_Identity=32.7464788732394, Blast_Score=105, Evalue=5e-24,
Organism=Drosophila melanogaster, GI17737429, Length=225, Percent_Identity=27.5555555555556, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 32324; Mature: 32193

Theoretical pI: Translated: 10.61; Mature: 10.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALEKRRRKKKRSLILPWLLASRPATLIVSLSAVSLGWGAALLTVTGRKASLLLVALAAL
CCCHHHHHHHHHCEEHHHHHHCCCHHEEEEHHHHHHCCCCEEEEECCCHHHHHHHHHHHH
TAVLLQIGANYINDYGDGIRGADSNRSHASRRLTASGANPFSVLTTGLSFLIAAAGSGLI
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCE
AVILTQRWQLILVGVFSIAAAYLYTAGPFPYAYFGLGELSVFIFFGPVTVIGTVFLLSGI
EHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCHHHHHHHHEEHHHHHHHHHHHHHHH
VTLSSFLVAVVAGSWSAAILLMNNLRDHESDMQSNKRTFSVLFGVLIARIVCIALIAVPY
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVVAILLIELPFIGYVFLTLLLSAPIVIILATAVTSKEFAIAFRLGIICLIPFAIFFTWG
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
LAS
CCC
>Mature Secondary Structure 
ALEKRRRKKKRSLILPWLLASRPATLIVSLSAVSLGWGAALLTVTGRKASLLLVALAAL
CCHHHHHHHHHCEEHHHHHHCCCHHEEEEHHHHHHCCCCEEEEECCCHHHHHHHHHHHH
TAVLLQIGANYINDYGDGIRGADSNRSHASRRLTASGANPFSVLTTGLSFLIAAAGSGLI
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCE
AVILTQRWQLILVGVFSIAAAYLYTAGPFPYAYFGLGELSVFIFFGPVTVIGTVFLLSGI
EHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCHHHHHHHHEEHHHHHHHHHHHHHHH
VTLSSFLVAVVAGSWSAAILLMNNLRDHESDMQSNKRTFSVLFGVLIARIVCIALIAVPY
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVVAILLIELPFIGYVFLTLLLSAPIVIILATAVTSKEFAIAFRLGIICLIPFAIFFTWG
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
LAS
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]