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The map label for this gene is der [H]

Identifier: 28572231

GI number: 28572231

Start: 49945

End: 52005

Strand: Direct

Name: der [H]

Synonym: TW061

Alternate gene names: 28572231

Gene position: 49945-52005 (Clockwise)

Preceding gene: 28572230

Following gene: 28572233

Centisome position: 5.39

GC content: 48.37

Gene sequence:

>2061_bases
GTGGACTTTACTAGTATAGTTGCAATCGATGGTCCTGCCGGCAGCGGAAAAAGTTCTGTTGGTCGGGCCGTTGCTCAATA
TTTAGGGTATGGTTTTCTGCCAACCGGAAGCTATTACCGTGCCTTTGCGTTTCTGCTAGATCAGACTAAAGACCTTGATA
GTCAGTTGGATAGCTTCATTTCGTCCGTGCGTAATGATCTTGATCCGTACAATAGCGGGTTTAACGTGCATATTGATGAT
AGTCCGTTTTTTGGGTCATCAGGTATATCCGCATCATCGAGGAATATTGCCTCTGAGCTAAACAACCCGGAAATAACCTC
AAAAACTGCCGCTGTGGCGCGCAACAAAAGTGTACGAGTGCGCCTCAACGAGTATTTTAGAAAGCTATGTTCTGAAAGTA
TTTATCCGGCCATTGTCCTTGAGGGGCGCGATGCAACAACTGTGATAGCACCAAATGCAAGGGTGAAAATATTCTTGACA
GCCTCGCTGGTTAAACGAGCAGCTCGGCGCTCCGAACAGCTGTCTTCCGAACCTCCAAATTCCGTACTGGAAGCTTTACG
TCAAAGAGATGAGGCAGACAACGCAGTGACTGACTTTCTGTCAGATGACAGCTCCAGAATTACTCTGGACACGAGCGATC
TGACTTTCTCGGAATCGGTTGCCCGAGTGCTTGAAGTGATTGAACAAGCTGGAATGCCGTTTGTCTCAGATAAATGGGTT
GGAGAGAATGCCGATGTGCTTGCGGCTTCTGGGGAACTTGGAGCAACAGTTGTGATTGTTGGCCGGCCAAATGTTGGAAA
ATCAGCCCTTGTAAACTGCATCCTCGGGCGCAGAGAGGCTGTAGTGGAGAATCGTCCGGGCGTTACAAGAGATCGTGTTG
TTTACCCGGCATTTTGGGCAGGCAGACCATTTACTCTTGTTGATACCGGCGGCTGGGAGTGTGATGCCGAGGGCCTTGAT
GCTGAGGTCGTGGCTCAGGCAGAAATTGGCATGAGTATTGCGGACATAATCATTTTTGTGGTTGATGTTCAGCATGGCCC
GGTTAGCACTGATGCAGTTATCGCCCGGAATCTACAACGACAGAATAAGCCAATCTTTCTTGTTGCAAATAAAGCTGATA
ATGCCAGCAGTGACTCAGATGTGGCGCAATTTTGGTCTCTCGGATTAGGTCAGCCGTATGCCTGTAGCGCGACGCATGGC
CGGGGAGTTGCAGATCTTATGGATATAGTCATGCAGTCTGCCCAAGTCCATACGCCAAGTTTTTGTTCAGGTGCACCACG
GGTAGCGCTAATTGGCCGGCCAAATGTTGGAAAATCGAGCTTAATAAACCAACTGACGAATTCAAGAAGAGCAATTGTTG
ATGATCTCGCTGGGACGACACGTGATCCGCTTGATGCTTTGGCGGTTATAGGGGATAAATCATGGCTCTTTGTCGATACT
GCAGGTCTTAGAAGAAAGTTCAAATCACAAAAAGGCGCAGATTTCTATGCTTATCTCCGTGCAACAACCGTTTTACGGCG
TACTGAAATTGCTTTATTGTTGCTTGATGCGAGTCACGCAATTACTGAACAGGATGTGCGTATAGCAGAAATGGTTGTTG
AAAGCGGCCGAGCCCTGGTAATTGCCATAAATAAATGGGATTTGCTGGATGAAGAGCGACGTTATTGGCTTGAACGTGAA
ATAGATAACACTTTTTTCCGCTTTGCCTGGGCACCCCGGGTGAATATTTCCGCAAGAACGGGCCGGGGCGTAAAACAGTT
GGCCACAGCGCTTCAAACCGCCTTGACAAACTGGAACACGCGTCTGAACACTGCTCGCGTGAATCATTTTTTACAACGCA
TTACGCGTGAGCAGCCCCATCCGACCAGGGGTGGCAGGAGGCCAAGAATCTTATTTGCCAGCCAGACAGGGGTTGCCCCA
CCGACTTTTACACTGTTTACAACAGGTTTTCTTGAACCAACCTACCGGCGATTCTTGCAAAAGTCCATACGCTCACAACA
CAGCTTTACAGGATCCCCAATTATTCTGAGTGTGAAAATTCGAGCAAGTCGGAACCGCTAG

Upstream 100 bases:

>100_bases
TGGAAGATTTGCATTTTGAACATGCAAATAACCTCGGGGTTGTAAAGCTATCGGTATCAAACAAGGACAGGTGTCGATTG
ATGGACACTTTGGAAGATAA

Downstream 100 bases:

>100_bases
GATATTGCGTCAATAATTGTTTTGAACTTTAATGTGCTTTCTTCAAGTTCTTTTTGCGGGATGCTTGACTTCACTATTCC
ACACCCGGCAAAAGCTTTTA

Product: bifunctional cytidylate kinase/GTP-binding protein

Products: NA

Alternate protein names: GTP-binding protein EngA [H]

Number of amino acids: Translated: 686; Mature: 686

Protein sequence:

>686_residues
MDFTSIVAIDGPAGSGKSSVGRAVAQYLGYGFLPTGSYYRAFAFLLDQTKDLDSQLDSFISSVRNDLDPYNSGFNVHIDD
SPFFGSSGISASSRNIASELNNPEITSKTAAVARNKSVRVRLNEYFRKLCSESIYPAIVLEGRDATTVIAPNARVKIFLT
ASLVKRAARRSEQLSSEPPNSVLEALRQRDEADNAVTDFLSDDSSRITLDTSDLTFSESVARVLEVIEQAGMPFVSDKWV
GENADVLAASGELGATVVIVGRPNVGKSALVNCILGRREAVVENRPGVTRDRVVYPAFWAGRPFTLVDTGGWECDAEGLD
AEVVAQAEIGMSIADIIIFVVDVQHGPVSTDAVIARNLQRQNKPIFLVANKADNASSDSDVAQFWSLGLGQPYACSATHG
RGVADLMDIVMQSAQVHTPSFCSGAPRVALIGRPNVGKSSLINQLTNSRRAIVDDLAGTTRDPLDALAVIGDKSWLFVDT
AGLRRKFKSQKGADFYAYLRATTVLRRTEIALLLLDASHAITEQDVRIAEMVVESGRALVIAINKWDLLDEERRYWLERE
IDNTFFRFAWAPRVNISARTGRGVKQLATALQTALTNWNTRLNTARVNHFLQRITREQPHPTRGGRRPRILFASQTGVAP
PTFTLFTTGFLEPTYRRFLQKSIRSQHSFTGSPIILSVKIRASRNR

Sequences:

>Translated_686_residues
MDFTSIVAIDGPAGSGKSSVGRAVAQYLGYGFLPTGSYYRAFAFLLDQTKDLDSQLDSFISSVRNDLDPYNSGFNVHIDD
SPFFGSSGISASSRNIASELNNPEITSKTAAVARNKSVRVRLNEYFRKLCSESIYPAIVLEGRDATTVIAPNARVKIFLT
ASLVKRAARRSEQLSSEPPNSVLEALRQRDEADNAVTDFLSDDSSRITLDTSDLTFSESVARVLEVIEQAGMPFVSDKWV
GENADVLAASGELGATVVIVGRPNVGKSALVNCILGRREAVVENRPGVTRDRVVYPAFWAGRPFTLVDTGGWECDAEGLD
AEVVAQAEIGMSIADIIIFVVDVQHGPVSTDAVIARNLQRQNKPIFLVANKADNASSDSDVAQFWSLGLGQPYACSATHG
RGVADLMDIVMQSAQVHTPSFCSGAPRVALIGRPNVGKSSLINQLTNSRRAIVDDLAGTTRDPLDALAVIGDKSWLFVDT
AGLRRKFKSQKGADFYAYLRATTVLRRTEIALLLLDASHAITEQDVRIAEMVVESGRALVIAINKWDLLDEERRYWLERE
IDNTFFRFAWAPRVNISARTGRGVKQLATALQTALTNWNTRLNTARVNHFLQRITREQPHPTRGGRRPRILFASQTGVAP
PTFTLFTTGFLEPTYRRFLQKSIRSQHSFTGSPIILSVKIRASRNR
>Mature_686_residues
MDFTSIVAIDGPAGSGKSSVGRAVAQYLGYGFLPTGSYYRAFAFLLDQTKDLDSQLDSFISSVRNDLDPYNSGFNVHIDD
SPFFGSSGISASSRNIASELNNPEITSKTAAVARNKSVRVRLNEYFRKLCSESIYPAIVLEGRDATTVIAPNARVKIFLT
ASLVKRAARRSEQLSSEPPNSVLEALRQRDEADNAVTDFLSDDSSRITLDTSDLTFSESVARVLEVIEQAGMPFVSDKWV
GENADVLAASGELGATVVIVGRPNVGKSALVNCILGRREAVVENRPGVTRDRVVYPAFWAGRPFTLVDTGGWECDAEGLD
AEVVAQAEIGMSIADIIIFVVDVQHGPVSTDAVIARNLQRQNKPIFLVANKADNASSDSDVAQFWSLGLGQPYACSATHG
RGVADLMDIVMQSAQVHTPSFCSGAPRVALIGRPNVGKSSLINQLTNSRRAIVDDLAGTTRDPLDALAVIGDKSWLFVDT
AGLRRKFKSQKGADFYAYLRATTVLRRTEIALLLLDASHAITEQDVRIAEMVVESGRALVIAINKWDLLDEERRYWLERE
IDNTFFRFAWAPRVNISARTGRGVKQLATALQTALTNWNTRLNTARVNHFLQRITREQPHPTRGGRRPRILFASQTGVAP
PTFTLFTTGFLEPTYRRFLQKSIRSQHSFTGSPIILSVKIRASRNR

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis [H]

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain [H]

Homologues:

Organism=Escherichia coli, GI87082120, Length=464, Percent_Identity=31.4655172413793, Blast_Score=242, Evalue=7e-65,
Organism=Escherichia coli, GI1787139, Length=236, Percent_Identity=27.9661016949153, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323665, Length=190, Percent_Identity=28.4210526315789, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI45550813, Length=149, Percent_Identity=35.5704697986577, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR016484
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 75265; Mature: 75265

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFTSIVAIDGPAGSGKSSVGRAVAQYLGYGFLPTGSYYRAFAFLLDQTKDLDSQLDSFI
CCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SSVRNDLDPYNSGFNVHIDDSPFFGSSGISASSRNIASELNNPEITSKTAAVARNKSVRV
HHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHCCCCEEE
RLNEYFRKLCSESIYPAIVLEGRDATTVIAPNARVKIFLTASLVKRAARRSEQLSSEPPN
EHHHHHHHHHCCCCCCEEEECCCCCEEEECCCCEEEEEEEHHHHHHHHHHHHHHCCCCCH
SVLEALRQRDEADNAVTDFLSDDSSRITLDTSDLTFSESVARVLEVIEQAGMPFVSDKWV
HHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEECCCCC
GENADVLAASGELGATVVIVGRPNVGKSALVNCILGRREAVVENRPGVTRDRVVYPAFWA
CCCCCEEEECCCCCEEEEEEECCCCCHHHHHHHHHCCHHHHHCCCCCCCCCCEEEEEEEC
GRPFTLVDTGGWECDAEGLDAEVVAQAEIGMSIADIIIFVVDVQHGPVSTDAVIARNLQR
CCCEEEEECCCCCCCCCCCCHHEEEHHHHCCHHHHEEEEEEECCCCCCCHHHHHHHHHHH
QNKPIFLVANKADNASSDSDVAQFWSLGLGQPYACSATHGRGVADLMDIVMQSAQVHTPS
CCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCEECCCCCCCHHHHHHHHHHHCCCCCCC
FCSGAPRVALIGRPNVGKSSLINQLTNSRRAIVDDLAGTTRDPLDALAVIGDKSWLFVDT
CCCCCCCEEEEECCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHEECCCCEEEEEC
AGLRRKFKSQKGADFYAYLRATTVLRRTEIALLLLDASHAITEQDVRIAEMVVESGRALV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHEEEEEEEECCHHHHHHHHHHHHHHHHCCCEEE
IAINKWDLLDEERRYWLEREIDNTFFRFAWAPRVNISARTGRGVKQLATALQTALTNWNT
EEECCCCCCCHHHHHHHHHHHCCCEEEEEECCCCEEECCCCCCHHHHHHHHHHHHHCCCC
RLNTARVNHFLQRITREQPHPTRGGRRPRILFASQTGVAPPTFTLFTTGFLEPTYRRFLQ
CCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECCCCHHHHHHHH
KSIRSQHSFTGSPIILSVKIRASRNR
HHHHHHCCCCCCCEEEEEEEECCCCC
>Mature Secondary Structure
MDFTSIVAIDGPAGSGKSSVGRAVAQYLGYGFLPTGSYYRAFAFLLDQTKDLDSQLDSFI
CCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SSVRNDLDPYNSGFNVHIDDSPFFGSSGISASSRNIASELNNPEITSKTAAVARNKSVRV
HHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHCCCCEEE
RLNEYFRKLCSESIYPAIVLEGRDATTVIAPNARVKIFLTASLVKRAARRSEQLSSEPPN
EHHHHHHHHHCCCCCCEEEECCCCCEEEECCCCEEEEEEEHHHHHHHHHHHHHHCCCCCH
SVLEALRQRDEADNAVTDFLSDDSSRITLDTSDLTFSESVARVLEVIEQAGMPFVSDKWV
HHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEECCCCC
GENADVLAASGELGATVVIVGRPNVGKSALVNCILGRREAVVENRPGVTRDRVVYPAFWA
CCCCCEEEECCCCCEEEEEEECCCCCHHHHHHHHHCCHHHHHCCCCCCCCCCEEEEEEEC
GRPFTLVDTGGWECDAEGLDAEVVAQAEIGMSIADIIIFVVDVQHGPVSTDAVIARNLQR
CCCEEEEECCCCCCCCCCCCHHEEEHHHHCCHHHHEEEEEEECCCCCCCHHHHHHHHHHH
QNKPIFLVANKADNASSDSDVAQFWSLGLGQPYACSATHGRGVADLMDIVMQSAQVHTPS
CCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCEECCCCCCCHHHHHHHHHHHCCCCCCC
FCSGAPRVALIGRPNVGKSSLINQLTNSRRAIVDDLAGTTRDPLDALAVIGDKSWLFVDT
CCCCCCCEEEEECCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHEECCCCEEEEEC
AGLRRKFKSQKGADFYAYLRATTVLRRTEIALLLLDASHAITEQDVRIAEMVVESGRALV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHEEEEEEEECCHHHHHHHHHHHHHHHHCCCEEE
IAINKWDLLDEERRYWLEREIDNTFFRFAWAPRVNISARTGRGVKQLATALQTALTNWNT
EEECCCCCCCHHHHHHHHHHHCCCEEEEEECCCCEEECCCCCCHHHHHHHHHHHHHCCCC
RLNTARVNHFLQRITREQPHPTRGGRRPRILFASQTGVAPPTFTLFTTGFLEPTYRRFLQ
CCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECCCCHHHHHHHH
KSIRSQHSFTGSPIILSVKIRASRNR
HHHHHHCCCCCCCEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA