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The map label for this gene is pgm [C]

Identifier: 28572192

GI number: 28572192

Start: 16396

End: 18048

Strand: Reverse

Name: pgm [C]

Synonym: TW017

Alternate gene names: 28572192

Gene position: 18048-16396 (Counterclockwise)

Preceding gene: 28572193

Following gene: 28572185

Centisome position: 1.95

GC content: 48.76

Gene sequence:

>1653_bases
ATGAATATTCTGCGGAAGGCAAGCTTGTGGATTGAGAATGATCCGGTGGCGATCACACGCTTGGAAATGCGCAGACTTCT
GGCTGAAAGTGAAAAAACTGGTGACGTGCGTGAGCTCGAAGAGAGGCTGTCTAAGACGCTGGAGTTCGGAACTGCAGGAC
TAAGGGCACCGCAGGGTGCTGGATTTAATCGCGTGAATGCCGTCGTGACGGCGCAGGCTGCAAATGCACTGTCTCAATTT
CTTTTAGAAGAAAACCGGGGCAGAACGCTGGTTATTGGCTATGACGGAAGATACAATTCACAGCTCTGGGCAAGAAATAC
TGCGCGGATTGCTAGCAGTTACGATATAACAGCTCTGATTATGCCAAGGGCTCTACCAACACCCCTTTTGGCATTTGCAG
TGCGGCAGCTTGGTGCTGCTGCGGGGGTTATGGTAACCGCCTCCCATAATCCCCGCGAATACAACGGGTACAAAGTGTAT
CTCGGAGGAGAAGACAAGGGTGCACAAATACCTGATACTGCAGCGGCAAAAATTGCCAAAAATTTGAGAGATGAAGTCGC
GTATAGCGATATACCAATGAAAGATAGTTACGGAATTCTTGATGAGGAGATTATCGAGGCCTACCTGTCCCGTACAGCAA
AAGCAATTAAGCGACAGTTTGGCTCACCAAAGGCTGATCTAAAGATATGCCACACAGCTATGCATGGTGTTGGTCACGAG
ATCTTTGTACGCCTCATGGAAAAATTGGGTTTCCACAACCTGGTGTTCGTTGAAGAGCAAAAAATGCCAGACCCGGCATT
TCCAACCTTGCCGTTTCCAAACCCAGAAGAAAAGGGTGCATTGGATTTAGCATTTGAAACAGCACGGCTTGCAGAGTGTG
ACATAATCATTGCTAATGACCCCGATGCCGATCGGGTTGCAGTTGCACATCCGGATGGAAAGGTTTTTACTGGTAATGAA
ATAGGCGCCCTACTTGGTGTTGAAATTGCGCGCATGCAACGCGGTCACGGGGTACTGTCAAACAGCATGGTTTCTTCACC
GATAATGCGCCGTATAGCTGAGACCTACGGAATGCAACATGTGGAGACGCCAACCGGATTTAAATGGGTTGCGCGTGTGC
CAGATATCTGTTTTGGTTTTGAAGAGGCCTTGGGGTACATGATTCATCCAGAGCTTGTAAGGGACAAAGATGGCCTATCG
GCCGGCGCCGCCATTGCCACCATAGCTGCCTCTCAAAAGGCCCAAGGTCGAAGCCTCAGAGATTGTCTAGATGACCTGCA
AAGCAAGCTTGGGTATTTTAGGAGCACCCAGTATGCCGTTCGCATGGCATCACTTGATAGTGTGCAGGCTGTTATGCAAA
ACCTTAGAGCAGAATCGCTGAACAAAATTGGTCGATTTAGAGTAACAAAATATCGTGATCTACTGTTCGGGAGCCCGCCG
GTGGATCTGCTTGAGTTTAATCTGGGACAAGATATTGATGATCTGTTTGGGCGACTAATAGTTAGGCCAAGTGGAACGGA
ATTAAAACTAAAGTGTTACATAGACAGTGTTGCTAAGACGCCCGATGGCGCCGAGCAGCTTCTGTCGGAGCTAACTTATG
CCTGCAAAAACCTCTTATGCGAAACAAGCCGCCGTGGTGGCGCAGAAAACTAG

Upstream 100 bases:

>100_bases
TGTAAGCGAACAGGCTAGACAAAAAACTTCAGCATTTCTCGTAGAGCTCATTCGTGACATCGGGCAAGATCTATCGGGCA
GGAAATAACAGGGTAGCCAT

Downstream 100 bases:

>100_bases
GCCACCAGGCACAGCGTACATGACAGTAGTCCCTGAAACATATTTTTGACAAAACCAAACGGCGGGAATTACTTATACCG
CTGGAAAAGATCACTGGGAC

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM [H]

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MNILRKASLWIENDPVAITRLEMRRLLAESEKTGDVRELEERLSKTLEFGTAGLRAPQGAGFNRVNAVVTAQAANALSQF
LLEENRGRTLVIGYDGRYNSQLWARNTARIASSYDITALIMPRALPTPLLAFAVRQLGAAAGVMVTASHNPREYNGYKVY
LGGEDKGAQIPDTAAAKIAKNLRDEVAYSDIPMKDSYGILDEEIIEAYLSRTAKAIKRQFGSPKADLKICHTAMHGVGHE
IFVRLMEKLGFHNLVFVEEQKMPDPAFPTLPFPNPEEKGALDLAFETARLAECDIIIANDPDADRVAVAHPDGKVFTGNE
IGALLGVEIARMQRGHGVLSNSMVSSPIMRRIAETYGMQHVETPTGFKWVARVPDICFGFEEALGYMIHPELVRDKDGLS
AGAAIATIAASQKAQGRSLRDCLDDLQSKLGYFRSTQYAVRMASLDSVQAVMQNLRAESLNKIGRFRVTKYRDLLFGSPP
VDLLEFNLGQDIDDLFGRLIVRPSGTELKLKCYIDSVAKTPDGAEQLLSELTYACKNLLCETSRRGGAEN

Sequences:

>Translated_550_residues
MNILRKASLWIENDPVAITRLEMRRLLAESEKTGDVRELEERLSKTLEFGTAGLRAPQGAGFNRVNAVVTAQAANALSQF
LLEENRGRTLVIGYDGRYNSQLWARNTARIASSYDITALIMPRALPTPLLAFAVRQLGAAAGVMVTASHNPREYNGYKVY
LGGEDKGAQIPDTAAAKIAKNLRDEVAYSDIPMKDSYGILDEEIIEAYLSRTAKAIKRQFGSPKADLKICHTAMHGVGHE
IFVRLMEKLGFHNLVFVEEQKMPDPAFPTLPFPNPEEKGALDLAFETARLAECDIIIANDPDADRVAVAHPDGKVFTGNE
IGALLGVEIARMQRGHGVLSNSMVSSPIMRRIAETYGMQHVETPTGFKWVARVPDICFGFEEALGYMIHPELVRDKDGLS
AGAAIATIAASQKAQGRSLRDCLDDLQSKLGYFRSTQYAVRMASLDSVQAVMQNLRAESLNKIGRFRVTKYRDLLFGSPP
VDLLEFNLGQDIDDLFGRLIVRPSGTELKLKCYIDSVAKTPDGAEQLLSELTYACKNLLCETSRRGGAEN
>Mature_550_residues
MNILRKASLWIENDPVAITRLEMRRLLAESEKTGDVRELEERLSKTLEFGTAGLRAPQGAGFNRVNAVVTAQAANALSQF
LLEENRGRTLVIGYDGRYNSQLWARNTARIASSYDITALIMPRALPTPLLAFAVRQLGAAAGVMVTASHNPREYNGYKVY
LGGEDKGAQIPDTAAAKIAKNLRDEVAYSDIPMKDSYGILDEEIIEAYLSRTAKAIKRQFGSPKADLKICHTAMHGVGHE
IFVRLMEKLGFHNLVFVEEQKMPDPAFPTLPFPNPEEKGALDLAFETARLAECDIIIANDPDADRVAVAHPDGKVFTGNE
IGALLGVEIARMQRGHGVLSNSMVSSPIMRRIAETYGMQHVETPTGFKWVARVPDICFGFEEALGYMIHPELVRDKDGLS
AGAAIATIAASQKAQGRSLRDCLDDLQSKLGYFRSTQYAVRMASLDSVQAVMQNLRAESLNKIGRFRVTKYRDLLFGSPP
VDLLEFNLGQDIDDLFGRLIVRPSGTELKLKCYIDSVAKTPDGAEQLLSELTYACKNLLCETSRRGGAEN

Specific function: This Enzyme Participates In Both The Breakdown And Synthesis Of Glucose. [C]

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=587, Percent_Identity=32.5383304940375, Blast_Score=242, Evalue=8e-64,
Organism=Homo sapiens, GI31377548, Length=578, Percent_Identity=32.3529411764706, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI290463102, Length=551, Percent_Identity=25.5898366606171, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI21361621, Length=485, Percent_Identity=26.5979381443299, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI133922562, Length=536, Percent_Identity=25.7462686567164, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1786904, Length=512, Percent_Identity=25.1953125, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71993870, Length=591, Percent_Identity=33.8409475465313, Blast_Score=251, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI71993878, Length=333, Percent_Identity=34.5345345345345, Blast_Score=172, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6323934, Length=607, Percent_Identity=32.7841845140033, Blast_Score=236, Evalue=6e-63,
Organism=Drosophila melanogaster, GI20129809, Length=586, Percent_Identity=34.641638225256, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI24651977, Length=522, Percent_Identity=35.2490421455939, Blast_Score=266, Evalue=4e-71,
Organism=Drosophila melanogaster, GI24653722, Length=499, Percent_Identity=31.6633266533066, Blast_Score=204, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.8 [H]

Molecular weight: Translated: 60556; Mature: 60556

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILRKASLWIENDPVAITRLEMRRLLAESEKTGDVRELEERLSKTLEFGTAGLRAPQGA
CCCCCCCCCEECCCCEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
GFNRVNAVVTAQAANALSQFLLEENRGRTLVIGYDGRYNSQLWARNTARIASSYDITALI
CCCHHHHEEEHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHCCHHHHHCCCCEEEEE
MPRALPTPLLAFAVRQLGAAAGVMVTASHNPREYNGYKVYLGGEDKGAQIPDTAAAKIAK
ECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHH
NLRDEVAYSDIPMKDSYGILDEEIIEAYLSRTAKAIKRQFGSPKADLKICHTAMHGVGHE
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHH
IFVRLMEKLGFHNLVFVEEQKMPDPAFPTLPFPNPEEKGALDLAFETARLAECDIIIAND
HHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHCEEEEEEECC
PDADRVAVAHPDGKVFTGNEIGALLGVEIARMQRGHGVLSNSMVSSPIMRRIAETYGMQH
CCCCCEEEECCCCCEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
VETPTGFKWVARVPDICFGFEEALGYMIHPELVRDKDGLSAGAAIATIAASQKAQGRSLR
CCCCCCCHHHHHCCHHHHCHHHHCCCCCCHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHH
DCLDDLQSKLGYFRSTQYAVRMASLDSVQAVMQNLRAESLNKIGRFRVTKYRDLLFGSPP
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VDLLEFNLGQDIDDLFGRLIVRPSGTELKLKCYIDSVAKTPDGAEQLLSELTYACKNLLC
HHHHHCCCCCCHHHHHHHEEECCCCCCEEEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHH
ETSRRGGAEN
HHHCCCCCCC
>Mature Secondary Structure
MNILRKASLWIENDPVAITRLEMRRLLAESEKTGDVRELEERLSKTLEFGTAGLRAPQGA
CCCCCCCCCEECCCCEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
GFNRVNAVVTAQAANALSQFLLEENRGRTLVIGYDGRYNSQLWARNTARIASSYDITALI
CCCHHHHEEEHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHCCHHHHHCCCCEEEEE
MPRALPTPLLAFAVRQLGAAAGVMVTASHNPREYNGYKVYLGGEDKGAQIPDTAAAKIAK
ECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHH
NLRDEVAYSDIPMKDSYGILDEEIIEAYLSRTAKAIKRQFGSPKADLKICHTAMHGVGHE
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHH
IFVRLMEKLGFHNLVFVEEQKMPDPAFPTLPFPNPEEKGALDLAFETARLAECDIIIAND
HHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHCEEEEEEECC
PDADRVAVAHPDGKVFTGNEIGALLGVEIARMQRGHGVLSNSMVSSPIMRRIAETYGMQH
CCCCCEEEECCCCCEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
VETPTGFKWVARVPDICFGFEEALGYMIHPELVRDKDGLSAGAAIATIAASQKAQGRSLR
CCCCCCCHHHHHCCHHHHCHHHHCCCCCCHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHH
DCLDDLQSKLGYFRSTQYAVRMASLDSVQAVMQNLRAESLNKIGRFRVTKYRDLLFGSPP
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VDLLEFNLGQDIDDLFGRLIVRPSGTELKLKCYIDSVAKTPDGAEQLLSELTYACKNLLC
HHHHHCCCCCCHHHHHHHEEECCCCCCEEEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHH
ETSRRGGAEN
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]